Mycotic infections

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Mycotic infections

  1. 1. Submitted by NILIMA T.S.
  2. 2. NORTH AMERICAN BLASTOMYCOSIS  Caused by Blastomyces dermatiditis. CLINICAL FEATURES -Tiny miliary abscess or pustules. -crateriform lesions. -Fever. -weight loss. -productive cough.
  3. 3. NORTH AMERICAN BLASTOMYCOSIS
  4. 4. NORTH AMERICAN BLASTOMYCOSIS -DOUBLY REFRACTILE CAPSULE
  5. 5. ORAL MANIFESTATION  Tiny ulcer.  Abscess formation. HISTOLOGIC FEATURES  Inflamed connective tissue.  Giant cells and macrophages.  Round organism with doubly refractile capsule.  Microabscess.
  6. 6. SOUTH AMERICAN BLASTOMYCOSIS  Caused by Blastomyces brasiliensis.  Fungus varies 10um to60um in diameter and is larger than that of north american blastomycosis.
  7. 7. SOUTH AMERICAN BLASTOMYCOSIS
  8. 8. HISTOPLASMOSIS  Also called Darling’s disease.  Caused by Histoplasma capsulatum. CLINICAL FEATURES  Low grade fever.  Splenomegaly.  Hepatomegaly.  Lymphadenopathy.
  9. 9. HISTOPLASMOSIS
  10. 10. ORAL MANIFESTATION  Nodular,ulcerative or vegetative lesions.  Ulcerated areas covered by nonspecific gray membrane.  Common on buccal mucosa,gingiva,tongue,palate or lips.
  11. 11. HISTOLOGIC FEATURES  Organism appear as tiny intracellular structures measuring a little more than 1um in diameter. TREATMENT:  Amphotericin B
  12. 12. HISTOPLASMOSIS
  13. 13. CANDIDIASIS  Caused by Candida albicans . CLASSIFICATION: Primary Candidiasis: Acute forms -Psuedomembranous -Erythematous
  14. 14.  Chronic forms -Hyperplstic Nodular Plaque-like -Erythematous -Psuedomembranous  Candida associated lesions -Denture stomatitis
  15. 15. -Angular cheilitis -Mediam rhomboid glossitis  Keratinized primary lesions super infected with Candida -Leukoplakia -Lichen planus -Lupus erythematosus SECONDARY ORAL CANDIDIASIS
  16. 16. ATROPHIC CANDIDIASIS
  17. 17. ERYTHEMATOUS CANDIDIASIS
  18. 18. HYPERPLASTIC CANDIDIASIS
  19. 19. TREATMENT  Nystatin  Clotrimazole  Amphotericin B  Miconazole
  20. 20. PHYCOMYCOSIS  Also called as Mucormycosis,Zygomycosis.  Caused by Mucorales and Entomophthorales. CLINICAL FEATURES  2 main types-Superficial -Visceral  Visceral-Pulmonary -Gastrointestinal -Rhinocerebral
  21. 21. ZYGOMYCOSIS
  22. 22. HISTOLOGIC FEATURES  Organisms appear large,nonseptate hyphae with branching at obtuse angles.  Round or ovoid sporangia. TREATMENT  Control of predisposing factors.  Surgical excision  Amphotericin B
  23. 23. ZYGOMYCOSIS
  24. 24. RHINOSPORIDIOSIS  Caused by Rhinosporidium seeberi. CLINICAL FEATURES  Mucoid discharge.  Soft polypoid growth spreading to pharynx and larynx.  Lesions are vascular.
  25. 25. HISTOLOGIC FEATURES  Sporangia containing large number of round or ovoid endospores,each 5-7um in diameter.  Focal abscess formation and multinucleated giant cells. TREATMENT  Surgical removal.
  26. 26. COCCIDIODOMYCOSIS  Caused by Coccidiodes immitis. CLINICAL FEATURES  2 forms-Primary nondisseminated and Progressive disseminated.
  27. 27. ORAL MANIFESTATION  Proliferative granulomatous and ulcerated lesions.  Lytic lesions of jaw. HISTOLOGIC FEATURES  Foci of coagulation necrosis.  Endospores within large spherules. TREATMENT  Amphotericin B
  28. 28. CRYPTOCOCCOSIS  Also called as Tolurosis ,European blastomycosis.  Caused by cryptococcus neoformans. CLINICAL FEATURES  Multiple brown papules.  Occurs in patients with malignant lymphoma.
  29. 29. ORAL MANIFESTATIONS  Non specific single or multiple ulcers. HISTOLOGIC FEATURES  Gram positive, budding,yeast-like cell with thick gelatinous capsule.  Measures 5-20um with a clear halo. TREATMENT  Amphotericin B

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