1. Submitted by
NILIMA T.S.

2. NORTH AMERICAN
BLASTOMYCOSIS
 Caused by Blastomyces dermatiditis.
CLINICAL FEATURES
-Tiny miliary abscess or pustules.
-crateriform lesions.
-Fever.
-weight loss.
-productive cough.

3. NORTH AMERICAN
BLASTOMYCOSIS

4. NORTH AMERICAN
BLASTOMYCOSIS
-DOUBLY REFRACTILE
CAPSULE

5. ORAL MANIFESTATION
 Tiny ulcer.
 Abscess formation.
HISTOLOGIC FEATURES
 Inflamed connective tissue.
 Giant cells and macrophages.
 Round organism with doubly refractile capsule.
 Microabscess.

6. SOUTH AMERICAN
BLASTOMYCOSIS
 Caused by Blastomyces brasiliensis.
 Fungus varies 10um to60um in diameter and is larger
than that of north american blastomycosis.

7. SOUTH AMERICAN BLASTOMYCOSIS

8. HISTOPLASMOSIS
 Also called Darling’s disease.
 Caused by Histoplasma capsulatum.
CLINICAL FEATURES
 Low grade fever.
 Splenomegaly.
 Hepatomegaly.
 Lymphadenopathy.

9. HISTOPLASMOSIS

10. ORAL MANIFESTATION
 Nodular,ulcerative or vegetative lesions.
 Ulcerated areas covered by nonspecific gray
membrane.
 Common on buccal mucosa,gingiva,tongue,palate or
lips.

11. HISTOLOGIC FEATURES
 Organism appear as tiny intracellular structures
measuring a little more than 1um in diameter.
TREATMENT:
 Amphotericin B

12. HISTOPLASMOSIS

13. CANDIDIASIS
 Caused by Candida albicans .
CLASSIFICATION:
Primary Candidiasis:
Acute forms
-Psuedomembranous
-Erythematous

14.  Chronic forms
-Hyperplstic
Nodular
Plaque-like
-Erythematous
-Psuedomembranous
 Candida associated lesions
-Denture stomatitis

15. -Angular cheilitis
-Mediam rhomboid glossitis
 Keratinized primary lesions super infected with
Candida
-Leukoplakia
-Lichen planus
-Lupus erythematosus
SECONDARY ORAL CANDIDIASIS

16. ATROPHIC CANDIDIASIS

17. ERYTHEMATOUS CANDIDIASIS

18. HYPERPLASTIC CANDIDIASIS

19. TREATMENT
 Nystatin
 Clotrimazole
 Amphotericin B
 Miconazole

20. PHYCOMYCOSIS
 Also called as Mucormycosis,Zygomycosis.
 Caused by Mucorales and Entomophthorales.
CLINICAL FEATURES
 2 main types-Superficial
-Visceral
 Visceral-Pulmonary
-Gastrointestinal
-Rhinocerebral

21. ZYGOMYCOSIS

22. HISTOLOGIC FEATURES
 Organisms appear large,nonseptate hyphae with
branching at obtuse angles.
 Round or ovoid sporangia.
TREATMENT
 Control of predisposing factors.
 Surgical excision
 Amphotericin B

23. ZYGOMYCOSIS

24. RHINOSPORIDIOSIS
 Caused by Rhinosporidium seeberi.
CLINICAL FEATURES
 Mucoid discharge.
 Soft polypoid growth spreading to pharynx and larynx.
 Lesions are vascular.

25. HISTOLOGIC FEATURES
 Sporangia containing large number of round or ovoid
endospores,each 5-7um in diameter.
 Focal abscess formation and multinucleated giant
cells.
TREATMENT
 Surgical removal.

26. COCCIDIODOMYCOSIS
 Caused by Coccidiodes immitis.
CLINICAL FEATURES
 2 forms-Primary nondisseminated and Progressive
disseminated.

27. ORAL MANIFESTATION
 Proliferative granulomatous and ulcerated lesions.
 Lytic lesions of jaw.
HISTOLOGIC FEATURES
 Foci of coagulation necrosis.
 Endospores within large spherules.
TREATMENT
 Amphotericin B

28. CRYPTOCOCCOSIS
 Also called as Tolurosis ,European blastomycosis.
 Caused by cryptococcus neoformans.
CLINICAL FEATURES
 Multiple brown papules.
 Occurs in patients with malignant lymphoma.

29. ORAL MANIFESTATIONS
 Non specific single or multiple ulcers.
HISTOLOGIC FEATURES
 Gram positive, budding,yeast-like cell with thick
gelatinous capsule.
 Measures 5-20um with a clear halo.
TREATMENT
 Amphotericin B