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AIM:
Where did life originate from?
“…sparked by just the right
                  combination of physical events
                  & chemical processes…”


             AIM:
Where did life originate from?
Bacteria Archae- Protista Plantae Fungi   Animalia
                          0    Cenozoic                                                       bacteria
                               Mesozoic                    Colonization of land
                               Paleozoic                   by animals
                         500
                                                           Appearance of animals
                                                           and land plants
                        1000                               First multicellular
                               PROTEROZOIC




                                                           organisms

                        1500                               Oldest definite fossils
Millions of years ago




                                                           of eukaryotes
                                             PRECAMBRIAN




                        2000                               Appearance of oxygen
                                                           in atmosphere

                        2500                               Oldest definite fossils
                                                           of prokaryotes
                               ARCHEAN




                        3000

                        3500
                                                           Molten-hot surface of
                        4000                               earth becomes cooler


                        4500                               Formation of earth
Bacteria Archae- Protista Plantae Fungi   Animalia
                          0    Cenozoic                                                       bacteria
                               Mesozoic                    Colonization of land
                               Paleozoic                   by animals
                         500
                                                           Appearance of animals
                                                           and land plants
                        1000                               First multicellular
                               PROTEROZOIC




                                                           organisms

                        1500                               Oldest definite fossils
Millions of years ago




                                                           of eukaryotes
                                             PRECAMBRIAN




                        2000                               Appearance of oxygen
                                                           in atmosphere

                        2500                               Oldest definite fossils
                                                           of prokaryotes
                               ARCHEAN




                        3000
                                                                                          The evolutionary tree of
                        3500                                                              life can be documented
                                                           Molten-hot surface of
                                                           earth becomes cooler
                                                                                          with evidence.
                        4000
                                                                                          The Origin of Life on
                        4500                               Formation of earth             Earth is another story…
What is Life?
What is Life?
 § First we have to define LIFE…
What is Life?
 § First we have to define LIFE…
   u   organized as cells
What is Life?
 § First we have to define LIFE…
   u   organized as cells
   u   respond to stimuli
What is Life?
 § First we have to define LIFE…
   u   organized as cells
   u   respond to stimuli
   u   regulate internal processes
What is Life?
 § First we have to define LIFE…
   u   organized as cells
   u   respond to stimuli
   u   regulate internal processes
        § homeostasis
What is Life?
 § First we have to define LIFE…
   u   organized as cells
   u   respond to stimuli
   u   regulate internal processes
        § homeostasis
   u   use energy to grow
What is Life?
 § First we have to define LIFE…
   u   organized as cells
   u   respond to stimuli
   u   regulate internal processes
        § homeostasis
   u   use energy to grow
        § metabolism
What is Life?
 § First we have to define LIFE…
   u   organized as cells
   u   respond to stimuli
   u   regulate internal processes
        § homeostasis
   u   use energy to grow
        § metabolism
   u   develop
What is Life?
 § First we have to define LIFE…
   u   organized as cells
   u   respond to stimuli
   u   regulate internal processes
        § homeostasis
   u   use energy to grow
        § metabolism
   u   develop
        § change & mature
         within lifetime
What is Life?
 § First we have to define LIFE…
   u   organized as cells
   u   respond to stimuli
   u   regulate internal processes
        § homeostasis
   u   use energy to grow
        § metabolism
   u   develop
        § change & mature
         within lifetime
   u   reproduce
What is Life?
 § First we have to define LIFE…
   u   organized as cells
   u   respond to stimuli
   u   regulate internal processes
        § homeostasis
   u   use energy to grow
        § metabolism
   u   develop
        § change & mature
         within lifetime
   u   reproduce
        § heredity
What is Life?
 § First we have to define LIFE…
   u   organized as cells
   u   respond to stimuli
   u   regulate internal processes
        § homeostasis
   u   use energy to grow
        § metabolism
   u   develop
        § change & mature
         within lifetime
   u   reproduce
        § heredity
            w DNA / RNA
What is Life?
 § First we have to define LIFE…
   u   organized as cells
   u   respond to stimuli
   u   regulate internal processes
        § homeostasis
   u   use energy to grow
        § metabolism
   u   develop
        § change & mature
         within lifetime
   u   reproduce
        § heredity
            w DNA / RNA
        § adaptation & evolution
The Origin of Life is Hypothesis
The Origin of Life is Hypothesis
The Origin of Life is Hypothesis
 § Special Creation
The Origin of Life is Hypothesis
 § Special Creation
   u   Was life created by a
       supernatural or divine force?
The Origin of Life is Hypothesis
 § Special Creation
   u   Was life created by a
       supernatural or divine force?
   u   not testable
The Origin of Life is Hypothesis
 § Special Creation
    u   Was life created by a
        supernatural or divine force?
    u   not testable
 § Extraterrestrial Origin
The Origin of Life is Hypothesis
 § Special Creation
    u   Was life created by a
        supernatural or divine force?
    u   not testable
 § Extraterrestrial Origin
    u   Was the original source of
        organic (carbon) materials
        comets & meteorites striking
        early Earth?
The Origin of Life is Hypothesis
 § Special Creation
    u   Was life created by a
        supernatural or divine force?
    u   not testable
 § Extraterrestrial Origin
    u   Was the original source of
        organic (carbon) materials
        comets & meteorites striking
        early Earth?
    u   Heavy bombardment 4bya
        may have delivered organic
        compound and water to Earth
The Origin of Life is Hypothesis
 § Special Creation
    u   Was life created by a
        supernatural or divine force?
    u   not testable
 § Extraterrestrial Origin
    u   Was the original source of
        organic (carbon) materials
        comets & meteorites striking
        early Earth?
    u   Heavy bombardment 4bya
        may have delivered organic
        compound and water to Earth
    u   testable
The Origin of Life is Hypothesis
 § Special Creation
    u   Was life created by a
        supernatural or divine force?
    u   not testable
 § Extraterrestrial Origin
    u   Was the original source of
        organic (carbon) materials
        comets & meteorites striking
        early Earth?
    u   Heavy bombardment 4bya
        may have delivered organic
        compound and water to Earth
    u   testable
 § Spontaneous Abiotic Origin
The Origin of Life is Hypothesis
 § Special Creation
    u   Was life created by a
        supernatural or divine force?
    u   not testable
 § Extraterrestrial Origin
    u   Was the original source of
        organic (carbon) materials
        comets & meteorites striking
        early Earth?
    u   Heavy bombardment 4bya
        may have delivered organic
        compound and water to Earth
    u   testable
 § Spontaneous Abiotic Origin
    u   Did life evolve spontaneously
        from inorganic molecules?
The Origin of Life is Hypothesis
 § Special Creation
    u   Was life created by a
        supernatural or divine force?
    u   not testable
 § Extraterrestrial Origin
    u   Was the original source of
        organic (carbon) materials
        comets & meteorites striking
        early Earth?
    u   Heavy bombardment 4bya
        may have delivered organic
        compound and water to Earth
    u   testable
 § Spontaneous Abiotic Origin
    u   Did life evolve spontaneously
        from inorganic molecules?
    u   testable
Origin of Organic Compounds
Origin of Organic Compounds
Possible locations that would have allowed
   the synthesis of organic compounds:
Origin of Organic Compounds
  Possible locations that would have allowed
      the synthesis of organic compounds:
§ Hydrothermal vents deep in the ocean
  release chemicals, creating unusual
  chemical conditions
Origin of Organic Compounds
  Possible locations that would have allowed
      the synthesis of organic compounds:
§ Hydrothermal vents deep in the ocean
  release chemicals, creating unusual
  chemical conditions
§ Extraterrestrial origin: Scientists have
  shown that organic compounds could have
  formed in cold interstellar space and then
  delivered to Earth by meteors or comets
Origin of Organic Compounds
  Possible locations that would have allowed
      the synthesis of organic compounds:
§ Hydrothermal vents deep in the ocean
  release chemicals, creating unusual
  chemical conditions
§ Extraterrestrial origin: Scientists have
  shown that organic compounds could have
  formed in cold interstellar space and then
  delivered to Earth by meteors or comets
§ Chemical reactions in the atmosphere and in
  water, on the surface of the Earth
Spontaneous Origin of Life
Spontaneous Origin of Life
Pasteur disproved “spontaneous generation”
Spontaneous Origin of Life
Pasteur disproved “spontaneous generation”
Spontaneous Origin of Life
Pasteur disproved “spontaneous generation”
  Oldest bacterial fossil date back to 1.9 bya
Spontaneous Origin of Life
Pasteur disproved “spontaneous generation”
  Oldest bacterial fossil date back to 1.9 bya
Spontaneous Origin of Life
   Pasteur disproved “spontaneous generation”
     Oldest bacterial fossil date back to 1.9 bya

Processes that would have been needed for
Spontaneous Origin of Life
   Pasteur disproved “spontaneous generation”
     Oldest bacterial fossil date back to 1.9 bya

Processes that would have been needed for
      the first cells to form include:
Spontaneous Origin of Life
     Pasteur disproved “spontaneous generation”
       Oldest bacterial fossil date back to 1.9 bya

   Processes that would have been needed for
         the first cells to form include:
1. Chemical reactions to produce simple organic
     molecules (ex. amino acids) from inorganic
       molecules (ex. water, carbon dioxide)
Spontaneous Origin of Life
     Pasteur disproved “spontaneous generation”
       Oldest bacterial fossil date back to 1.9 bya

   Processes that would have been needed for
         the first cells to form include:
1. Chemical reactions to produce simple organic
     molecules (ex. amino acids) from inorganic
       molecules (ex. water, carbon dioxide)
Spontaneous Origin of Life
        Pasteur disproved “spontaneous generation”
          Oldest bacterial fossil date back to 1.9 bya

     Processes that would have been needed for
           the first cells to form include:
  1. Chemical reactions to produce simple organic
       molecules (ex. amino acids) from inorganic
         molecules (ex. water, carbon dioxide)

2. Assembly of these organic molecules into polymers
                   (ex. polypeptides)
Spontaneous Origin of Life
        Pasteur disproved “spontaneous generation”
          Oldest bacterial fossil date back to 1.9 bya

     Processes that would have been needed for
           the first cells to form include:
  1. Chemical reactions to produce simple organic
       molecules (ex. amino acids) from inorganic
         molecules (ex. water, carbon dioxide)

2. Assembly of these organic molecules into polymers
                   (ex. polypeptides)
Spontaneous Origin of Life
        Pasteur disproved “spontaneous generation”
          Oldest bacterial fossil date back to 1.9 bya

     Processes that would have been needed for
           the first cells to form include:
  1. Chemical reactions to produce simple organic
       molecules (ex. amino acids) from inorganic
         molecules (ex. water, carbon dioxide)

2. Assembly of these organic molecules into polymers
                   (ex. polypeptides)
  3. Formation of polymers that can self replicate to
        allow for the inheritance of characteristics
Spontaneous Origin of Life
        Pasteur disproved “spontaneous generation”
          Oldest bacterial fossil date back to 1.9 bya

     Processes that would have been needed for
           the first cells to form include:
  1. Chemical reactions to produce simple organic
       molecules (ex. amino acids) from inorganic
         molecules (ex. water, carbon dioxide)

2. Assembly of these organic molecules into polymers
                   (ex. polypeptides)
  3. Formation of polymers that can self replicate to
        allow for the inheritance of characteristics
Spontaneous Origin of Life
        Pasteur disproved “spontaneous generation”
          Oldest bacterial fossil date back to 1.9 bya

     Processes that would have been needed for
           the first cells to form include:
  1. Chemical reactions to produce simple organic
       molecules (ex. amino acids) from inorganic
         molecules (ex. water, carbon dioxide)

2. Assembly of these organic molecules into polymers
                   (ex. polypeptides)
  3. Formation of polymers that can self replicate to
        allow for the inheritance of characteristics
4. Packaging of these molecules into membranes with
         an internal chemistry different from the
Conditions on early Earth
Conditions on early Earth
 § Reducing atmosphere
Conditions on early Earth
 § Reducing atmosphere
   u   water vapor (H2O), CO2, N2, NOx, H2, NH3,
       CH4, H2S
Conditions on early Earth
 § Reducing atmosphere
   u   water vapor (H2O), CO2, N2, NOx, H2, NH3,
       CH4, H2S




                  What’s missing
                    from that
                   atmosphere?
Conditions on early Earth
 § Reducing atmosphere
   u   water vapor (H2O), CO2, N2, NOx, H2, NH3,
       CH4, H2S
   u   lots of available H & its electron




                  What’s missing
                    from that
                   atmosphere?
Conditions on early Earth
 § Reducing atmosphere
   u   water vapor (H2O), CO2, N2, NOx, H2, NH3,
       CH4, H2S
   u   lots of available H & its electron
                                   low O2 =
                                   organic molecules
                                   do not breakdown
                                   as quickly

                  What’s missing
                    from that
                   atmosphere?
Conditions on early Earth
 § Reducing atmosphere
   u   water vapor (H2O), CO2, N2, NOx, H2, NH3,
       CH4, H2S
   u   lots of available H & its electron
   u   no free oxygen             low O2 =
                                   organic molecules
                                   do not breakdown
                                   as quickly

                  What’s missing
                    from that
                   atmosphere?
Conditions on early Earth
 § Reducing atmosphere
   u   water vapor (H2O), CO2, N2, NOx, H2, NH3,
       CH4, H2S
   u   lots of available H & its electron
   u   no free oxygen             low O2 =
                                   organic molecules
 § Energy source                   do not breakdown
                                   as quickly

                  What’s missing
                    from that
                   atmosphere?
Conditions on early Earth
 § Reducing atmosphere
   u   water vapor (H2O), CO2, N2, NOx, H2, NH3,
       CH4, H2S
   u   lots of available H & its electron
   u   no free oxygen             low O2 =
                                   organic molecules
 § Energy source                   do not breakdown
   u   lightning, UV radiation,    as quickly
       volcanic
                  What’s missing
                    from that
                   atmosphere?
Electrodes discharge
                                            sparks

Origin of Organic Molecules         (lightning simulation)




                                                CH4
                      Water vapor
                                                    H2
                                              NH3
                       Mixture of gases
                       (quot;primitive               Condenser
                       atmospherequot;)


                                                      Water




                                             Condensed
                                             liquid with
                                             complex,
                                             organic
                  Heated water               molecules
                   (quot;oceanquot;)
Electrodes discharge
                                            sparks

Origin of Organic Molecules         (lightning simulation)



§ Abiotic synthesis
                                                CH4
                      Water vapor
                                                    H2
                                              NH3
                       Mixture of gases
                       (quot;primitive               Condenser
                       atmospherequot;)


                                                      Water




                                             Condensed
                                             liquid with
                                             complex,
                                             organic
                  Heated water               molecules
                   (quot;oceanquot;)
Electrodes discharge
                                                   sparks

Origin of Organic Molecules                (lightning simulation)



§ Abiotic synthesis
  u   1920                   Water vapor
                                                       CH4

      Oparin & Haldane                                     H2
      propose reducing                               NH3
                              Mixture of gases
      atmosphere              (quot;primitive               Condenser
      hypothesis              atmospherequot;)


                                                             Water




                                                    Condensed
                                                    liquid with
                                                    complex,
                                                    organic
                         Heated water               molecules
                          (quot;oceanquot;)
Electrodes discharge
                                                   sparks

Origin of Organic Molecules                (lightning simulation)



§ Abiotic synthesis
  u   1920                   Water vapor
                                                       CH4

      Oparin & Haldane                                     H2
      propose reducing                               NH3
                              Mixture of gases
      atmosphere              (quot;primitive               Condenser
      hypothesis              atmospherequot;)

  u   1953                                                   Water
      Miller & Urey
      test hypothesis

                                                    Condensed
                                                    liquid with
                                                    complex,
                                                    organic
                         Heated water               molecules
                          (quot;oceanquot;)
Electrodes discharge
                                                   sparks

Origin of Organic Molecules                (lightning simulation)



§ Abiotic synthesis
  u   1920                   Water vapor
                                                       CH4

      Oparin & Haldane                                     H2
      propose reducing                               NH3
                              Mixture of gases
      atmosphere              (quot;primitive               Condenser
      hypothesis              atmospherequot;)

  u   1953                                                   Water
      Miller & Urey
      test hypothesis
      § formed organic
        compounds                                   Condensed
                                                    liquid with
                                                    complex,
                                                    organic
                         Heated water               molecules
                          (quot;oceanquot;)
Electrodes discharge
                                                   sparks

Origin of Organic Molecules                (lightning simulation)



§ Abiotic synthesis
  u   1920                   Water vapor
                                                       CH4

      Oparin & Haldane                                     H2
      propose reducing                               NH3
                              Mixture of gases
      atmosphere              (quot;primitive               Condenser
      hypothesis              atmospherequot;)

  u   1953                                                   Water
      Miller & Urey
      test hypothesis
      § formed organic
        compounds                                   Condensed
         w amino acids                              liquid with
                                                    complex,
                                                    organic
                         Heated water               molecules
                          (quot;oceanquot;)
Electrodes discharge
                                                   sparks

Origin of Organic Molecules                (lightning simulation)



§ Abiotic synthesis
  u   1920                   Water vapor
                                                       CH4

      Oparin & Haldane                                     H2
      propose reducing                               NH3
                              Mixture of gases
      atmosphere              (quot;primitive               Condenser
      hypothesis              atmospherequot;)

  u   1953                                                   Water
      Miller & Urey
      test hypothesis
      § formed organic
        compounds                                   Condensed
         w amino acids                              liquid with
                                                    complex,
         w adenine       Heated water
                                                    organic
                                                    molecules
                          (quot;oceanquot;)
Stanley Miller

                                University of Chicago


       produced
    -amino acids
  -hydrocarbons
-nitrogen bases
 -other organics


         It’s ALIVE!
Phospholipids
Phospholipids
 § Hydrophobic or hydrophilic?
   u   fatty acid tails = hydrophobic
   u   PO4 = hydrophilic head
   u   dual “personality”
Phospholipids
 § Hydrophobic or hydrophilic?
   u   fatty acid tails = hydrophobic
   u   PO4 = hydrophilic head
   u   dual “personality”




       interaction with H2O
       is complex & very
       important!
Phospholipids
 § Hydrophobic or hydrophilic?
    u   fatty acid tails = hydrophobic
    u   PO4 = hydrophilic head
    u   dual “personality”

It likes water
& also pushes
   it away!

        interaction with H2O
        is complex & very
        important!
Phospholipids in water
Phospholipids in water
 § Hydrophilic heads attracted to H2O
Phospholipids in water
 § Hydrophilic heads attracted to H2O
 § Hydrophobic tails “hide” from H2O
Phospholipids in water
 § Hydrophilic heads attracted to H2O
 § Hydrophobic tails “hide” from H2O
   u   can self-assemble into “bubbles”
Phospholipids in water
 § Hydrophilic heads attracted to H2O
 § Hydrophobic tails “hide” from H2O
   u   can self-assemble into “bubbles”
       § can also form bilayer
Phospholipids in water
 § Hydrophilic heads attracted to H2O
 § Hydrophobic tails “hide” from H2O
   u   can self-assemble into “bubbles”
       § can also form bilayer




                                 bilayer
Phospholipids in water
 § Hydrophilic heads attracted to H2O
 § Hydrophobic tails “hide” from H2O
   u   can self-assemble into “bubbles”
       § can also form bilayer
       § early evolutionary stage of cell?


                                       bilayer
Origin of Cells (Protobionts)
§ Bubbles → separate inside from outside
             → metabolism & reproduction
Origin of Cells (Protobionts)
     § Bubbles → separate inside from outside
                  → metabolism & reproduction




  Bubbles…
Tiny bubbles…
Dawn of natural selection
Origin of Genetics
Dawn of natural selection
Origin of Genetics
§ RNA is likely first genetic material
Dawn of natural selection
Origin of Genetics
§ RNA is likely first genetic material
  u   multi-functional
Dawn of natural selection
Origin of Genetics
§ RNA is likely first genetic material
  u   multi-functional
  u   codes information
Dawn of natural selection
Origin of Genetics
§ RNA is likely first genetic material
  u   multi-functional
  u   codes information
      § self-replicating molecule
Dawn of natural selection
Origin of Genetics
§ RNA is likely first genetic material
  u   multi-functional
  u   codes information
      § self-replicating molecule
      § makes inheritance possible
Dawn of natural selection
Origin of Genetics
§ RNA is likely first genetic material
  u   multi-functional
  u   codes information
      § self-replicating molecule
      § makes inheritance possible
      § natural selection & evolution
Dawn of natural selection
Origin of Genetics
§ RNA is likely first genetic material
  u   multi-functional
  u   codes information
      § self-replicating molecule
      § makes inheritance possible
      § natural selection & evolution
  u   enzyme functions
Dawn of natural selection
Origin of Genetics
§ RNA is likely first genetic material
  u   multi-functional
  u   codes information
      § self-replicating molecule
      § makes inheritance possible
      § natural selection & evolution
  u   enzyme functions
  u   transport molecule
Dawn of natural selection
Origin of Genetics
§ RNA is likely first genetic material
  u   multi-functional
  u   codes information
      § self-replicating molecule
      § makes inheritance possible
      § natural selection & evolution
  u   enzyme functions
  u   transport molecule
      § tRNA & mRNA
Key Events in Origin of Life
Key Events in Origin of Life
 § Key events in
  evolutionary
  history of life on
  Earth
Key Events in Origin of Life
 § Key events in
  evolutionary
  history of life on
  Earth
   u   life originated
       3.5–4.0 bya
Prokaryotes
§ Prokaryotes dominated life
 on Earth from 3.5–2.0 bya
Prokaryotes
§ Prokaryotes dominated life
 on Earth from 3.5–2.0 bya
Prokaryotes
§ Prokaryotes dominated life
 on Earth from 3.5–2.0 bya


  3.5 billion year old
   fossil of bacteria
Prokaryotes
§ Prokaryotes dominated life
 on Earth from 3.5–2.0 bya


  3.5 billion year old
   fossil of bacteria        modern bacteria




                                 chains of one-celled
                                   cyanobacteria
Stromatolites
Fossilized mats of
prokaryotes resemble
modern microbial
colonies
Stromatolites
Fossilized mats of
prokaryotes resemble
modern microbial
colonies
Stromatolites
Fossilized mats of
prokaryotes resemble
modern microbial
colonies
Stromatolites
Fossilized mats of
prokaryotes resemble
modern microbial
colonies
Oxygen atmosphere
Oxygen atmosphere
Oxygen atmosphere
 § Oxygen begins to accumulate 2.7 bya
Oxygen atmosphere
 § Oxygen begins to accumulate 2.7 bya
   u   reducing → oxidizing atmosphere
Oxygen atmosphere
 § Oxygen begins to accumulate 2.7 bya
   u   reducing → oxidizing atmosphere
       § evidence in banded iron in rocks = rusting
Oxygen atmosphere
 § Oxygen begins to accumulate 2.7 bya
   u   reducing → oxidizing atmosphere
       § evidence in banded iron in rocks = rusting
       § makes aerobic respiration possible
Oxygen atmosphere
 § Oxygen begins to accumulate 2.7 bya
   u   reducing → oxidizing atmosphere
       § evidence in banded iron in rocks = rusting
       § makes aerobic respiration possible
   u   photosynthetic
Oxygen atmosphere
 § Oxygen begins to accumulate 2.7 bya
   u   reducing → oxidizing atmosphere
       § evidence in banded iron in rocks = rusting
       § makes aerobic respiration possible
   u   photosynthetic
   u   algae)
~2 bya
 First Eukaryotes



                                nuclear envelope
          plasma
          membrane




DNA
        cell wall    plasma
                     membrane
~2 bya
 First Eukaryotes



                                        nuclear envelope
                  plasma
                  membrane




DNA
                cell wall    plasma
                             membrane
  Prokaryotic
     cell
~2 bya
    First Eukaryotes



                                            nuclear envelope
infolding of the      plasma
plasma membrane       membrane




  DNA
                    cell wall    plasma
                                 membrane
      Prokaryotic
         cell
~2 bya
    First Eukaryotes



                                                         nuclear envelope
infolding of the      plasma
plasma membrane       membrane




  DNA
                    cell wall                 plasma
                                Prokaryotic   membrane
      Prokaryotic
         cell                   ancestor of
                                eukaryotic
                                   cells
~2 bya
    First Eukaryotes



                                                               nuclear envelope
                                              endoplasmic
infolding of the      plasma                  reticulum (ER)
plasma membrane       membrane




  DNA
                    cell wall                 plasma
                                Prokaryotic   membrane
      Prokaryotic
         cell                   ancestor of
                                eukaryotic
                                   cells
~2 bya
    First Eukaryotes



                                                               nuclear envelope
                                              endoplasmic
infolding of the      plasma                  reticulum (ER)
plasma membrane       membrane
                                                                      nucleus




  DNA
                    cell wall                 plasma
                                Prokaryotic   membrane
      Prokaryotic
         cell                   ancestor of
                                eukaryotic
                                   cells
~2 bya
    First Eukaryotes



                                                                nuclear envelope
                                              endoplasmic
infolding of the      plasma                  reticulum (ER)
plasma membrane       membrane
                                                                       nucleus




  DNA
                    cell wall                 plasma
                                Prokaryotic   membrane
      Prokaryotic                                              Eukaryotic
         cell                   ancestor of                       cell
                                eukaryotic
                                   cells
~2 bya
    First Eukaryotes
     § Development of internal membranes

                                                                nuclear envelope
                                              endoplasmic
infolding of the      plasma                  reticulum (ER)
plasma membrane       membrane
                                                                       nucleus




  DNA
                    cell wall                 plasma
                                Prokaryotic   membrane
      Prokaryotic                                              Eukaryotic
         cell                   ancestor of                       cell
                                eukaryotic
                                   cells
~2 bya
    First Eukaryotes
     § Development of internal membranes
          u   create internal micro-environments

                                                                nuclear envelope
                                              endoplasmic
infolding of the      plasma                  reticulum (ER)
plasma membrane       membrane
                                                                       nucleus




  DNA
                    cell wall                 plasma
                                Prokaryotic   membrane
      Prokaryotic                                              Eukaryotic
         cell                   ancestor of                       cell
                                eukaryotic
                                   cells
~2 bya
    First Eukaryotes
     § Development of internal membranes
          u   create internal micro-environments
          u   advantage: specialization = increase efficiency
                                                                nuclear envelope
                                              endoplasmic
infolding of the      plasma                  reticulum (ER)
plasma membrane       membrane
                                                                       nucleus




  DNA
                    cell wall                 plasma
                                Prokaryotic   membrane
      Prokaryotic                                              Eukaryotic
         cell                   ancestor of                       cell
                                eukaryotic
                                   cells
Endosymbiosis




 internal membrane
       system




                     Endosymbiosis
Endosymbiosis




 internal membrane
       system




                     Endosymbiosis
Endosymbiosis
§ Evolution of eukaryotes



  internal membrane
        system




                        Endosymbiosis
Endosymbiosis
  § Evolution of eukaryotes



      internal membrane
            system




                          Endosymbiosis




  Ancestral
eukaryotic cell
Endosymbiosis
  § Evolution of eukaryotes
     u   origin of mitochondria




      internal membrane
            system




                                  Endosymbiosis




  Ancestral
eukaryotic cell
Endosymbiosis
  § Evolution of eukaryotes
     u   origin of mitochondria




      internal membrane
                            aerobic bacterium
            system




                                   Endosymbiosis




  Ancestral
eukaryotic cell
Endosymbiosis
  § Evolution of eukaryotes
     u   origin of mitochondria
     u   engulfed aerobic bacteria,
         but did not digest them

      internal membrane
                            aerobic bacterium
            system




                                      Endosymbiosis




  Ancestral
eukaryotic cell
Endosymbiosis
  § Evolution of eukaryotes
     u   origin of mitochondria
     u   engulfed aerobic bacteria,
         but did not digest them
     u   mutually beneficial relationship
      internal membrane
                             aerobic bacterium
            system




                                    Endosymbiosis




  Ancestral
eukaryotic cell
Endosymbiosis
  § Evolution of eukaryotes
     u   origin of mitochondria
     u   engulfed aerobic bacteria,
         but did not digest them
     u   mutually beneficial relationship
      internal membrane
                             aerobic bacterium      mitochondrion
            system




                                    Endosymbiosis




  Ancestral
eukaryotic cell
Endosymbiosis
  § Evolution of eukaryotes
     u   origin of mitochondria
     u   engulfed aerobic bacteria,
         but did not digest them
     u   mutually beneficial relationship
      internal membrane
                             aerobic bacterium       mitochondrion
            system




                                    Endosymbiosis




  Ancestral                                        Eukaryotic cell
eukaryotic cell                                  with mitochondrion
Endosymbiosis




            Endosymbiosis   mitochondrion
Endosymbiosis
 § Evolution of eukaryotes




                 Endosymbiosis   mitochondrion
Eukaryotic
Endosymbiosis                       cell with
                                 mitochondrion
 § Evolution of eukaryotes




                 Endosymbiosis     mitochondrion
Eukaryotic
Endosymbiosis                             cell with
                                       mitochondrion
 § Evolution of eukaryotes
   u   origin of chloroplasts




                       Endosymbiosis     mitochondrion
Eukaryotic
Endosymbiosis                              cell with
                                        mitochondrion
 § Evolution of eukaryotes
   u   origin of chloroplasts




                       photosynthetic
                         bacterium




                       Endosymbiosis      mitochondrion
Eukaryotic
Endosymbiosis                                 cell with
                                           mitochondrion
 § Evolution of eukaryotes
   u   origin of chloroplasts
   u   engulfed photosynthetic bacteria,
       but did not digest them


                      photosynthetic
                        bacterium




                      Endosymbiosis          mitochondrion
Eukaryotic
Endosymbiosis                                 cell with
                                           mitochondrion
 § Evolution of eukaryotes
   u   origin of chloroplasts
   u   engulfed photosynthetic bacteria,
       but did not digest them
   u   mutually beneficial relationship
                      photosynthetic
                        bacterium




                      Endosymbiosis          mitochondrion
Eukaryotic
Endosymbiosis                                    cell with
                                              mitochondrion
 § Evolution of eukaryotes
      u   origin of chloroplasts
      u   engulfed photosynthetic bacteria,
          but did not digest them
      u   mutually beneficial relationship
                         photosynthetic
                           bacterium



chloroplast

                         Endosymbiosis          mitochondrion
Eukaryotic
Endosymbiosis                                    cell with
                                              mitochondrion
 § Evolution of eukaryotes
      u   origin of chloroplasts
      u   engulfed photosynthetic bacteria,
          but did not digest them
      u   mutually beneficial relationship
                         photosynthetic
                           bacterium



chloroplast

                         Endosymbiosis          mitochondrion

         Eukaryotic cell with
     chloroplast & mitochondrion
Theory of Endosymbiosis
Theory of Endosymbiosis



                          Lynn Margulis
Theory of Endosymbiosis
§ Evidence


                          Lynn Margulis
Theory of Endosymbiosis
§ Evidence
  u   structural


                          Lynn Margulis
Theory of Endosymbiosis
§ Evidence
  u   structural
       § mitochondria & chloroplasts
        resemble bacterial structure
                                       Lynn Margulis
Theory of Endosymbiosis
§ Evidence
  u   structural
       § mitochondria & chloroplasts
        resemble bacterial structure
  u   genetic                          Lynn Margulis
Theory of Endosymbiosis
§ Evidence
  u   structural
       § mitochondria & chloroplasts
        resemble bacterial structure
  u   genetic                              Lynn Margulis
       § mitochondria & chloroplasts
        have their own circular DNA, like bacteria
Theory of Endosymbiosis
§ Evidence
  u   structural
       § mitochondria & chloroplasts
        resemble bacterial structure
  u   genetic                              Lynn Margulis
       § mitochondria & chloroplasts
        have their own circular DNA, like bacteria
  u   functional
Theory of Endosymbiosis
§ Evidence
  u   structural
       § mitochondria & chloroplasts
        resemble bacterial structure
  u   genetic                              Lynn Margulis
       § mitochondria & chloroplasts
        have their own circular DNA, like bacteria
  u   functional
       § mitochondria & chloroplasts
        move freely within the cell
Theory of Endosymbiosis
§ Evidence
  u   structural
       § mitochondria & chloroplasts
        resemble bacterial structure
  u   genetic                              Lynn Margulis
       § mitochondria & chloroplasts
        have their own circular DNA, like bacteria
  u   functional
       § mitochondria & chloroplasts
         move freely within the cell
       § mitochondria & chloroplasts
         reproduce independently
         from the cell

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Asli amil baba in Karachi asli amil baba in LahoreAsli amil baba in Karachi asli amil baba in Lahore
Asli amil baba in Karachi asli amil baba in Lahore
 

1.8

  • 1. AIM: Where did life originate from?
  • 2. “…sparked by just the right combination of physical events & chemical processes…” AIM: Where did life originate from?
  • 3. Bacteria Archae- Protista Plantae Fungi Animalia 0 Cenozoic bacteria Mesozoic Colonization of land Paleozoic by animals 500 Appearance of animals and land plants 1000 First multicellular PROTEROZOIC organisms 1500 Oldest definite fossils Millions of years ago of eukaryotes PRECAMBRIAN 2000 Appearance of oxygen in atmosphere 2500 Oldest definite fossils of prokaryotes ARCHEAN 3000 3500 Molten-hot surface of 4000 earth becomes cooler 4500 Formation of earth
  • 4. Bacteria Archae- Protista Plantae Fungi Animalia 0 Cenozoic bacteria Mesozoic Colonization of land Paleozoic by animals 500 Appearance of animals and land plants 1000 First multicellular PROTEROZOIC organisms 1500 Oldest definite fossils Millions of years ago of eukaryotes PRECAMBRIAN 2000 Appearance of oxygen in atmosphere 2500 Oldest definite fossils of prokaryotes ARCHEAN 3000 The evolutionary tree of 3500 life can be documented Molten-hot surface of earth becomes cooler with evidence. 4000 The Origin of Life on 4500 Formation of earth Earth is another story…
  • 6. What is Life? § First we have to define LIFE…
  • 7. What is Life? § First we have to define LIFE… u organized as cells
  • 8. What is Life? § First we have to define LIFE… u organized as cells u respond to stimuli
  • 9. What is Life? § First we have to define LIFE… u organized as cells u respond to stimuli u regulate internal processes
  • 10. What is Life? § First we have to define LIFE… u organized as cells u respond to stimuli u regulate internal processes § homeostasis
  • 11. What is Life? § First we have to define LIFE… u organized as cells u respond to stimuli u regulate internal processes § homeostasis u use energy to grow
  • 12. What is Life? § First we have to define LIFE… u organized as cells u respond to stimuli u regulate internal processes § homeostasis u use energy to grow § metabolism
  • 13. What is Life? § First we have to define LIFE… u organized as cells u respond to stimuli u regulate internal processes § homeostasis u use energy to grow § metabolism u develop
  • 14. What is Life? § First we have to define LIFE… u organized as cells u respond to stimuli u regulate internal processes § homeostasis u use energy to grow § metabolism u develop § change & mature within lifetime
  • 15. What is Life? § First we have to define LIFE… u organized as cells u respond to stimuli u regulate internal processes § homeostasis u use energy to grow § metabolism u develop § change & mature within lifetime u reproduce
  • 16. What is Life? § First we have to define LIFE… u organized as cells u respond to stimuli u regulate internal processes § homeostasis u use energy to grow § metabolism u develop § change & mature within lifetime u reproduce § heredity
  • 17. What is Life? § First we have to define LIFE… u organized as cells u respond to stimuli u regulate internal processes § homeostasis u use energy to grow § metabolism u develop § change & mature within lifetime u reproduce § heredity w DNA / RNA
  • 18. What is Life? § First we have to define LIFE… u organized as cells u respond to stimuli u regulate internal processes § homeostasis u use energy to grow § metabolism u develop § change & mature within lifetime u reproduce § heredity w DNA / RNA § adaptation & evolution
  • 19. The Origin of Life is Hypothesis
  • 20. The Origin of Life is Hypothesis
  • 21. The Origin of Life is Hypothesis § Special Creation
  • 22. The Origin of Life is Hypothesis § Special Creation u Was life created by a supernatural or divine force?
  • 23. The Origin of Life is Hypothesis § Special Creation u Was life created by a supernatural or divine force? u not testable
  • 24. The Origin of Life is Hypothesis § Special Creation u Was life created by a supernatural or divine force? u not testable § Extraterrestrial Origin
  • 25. The Origin of Life is Hypothesis § Special Creation u Was life created by a supernatural or divine force? u not testable § Extraterrestrial Origin u Was the original source of organic (carbon) materials comets & meteorites striking early Earth?
  • 26. The Origin of Life is Hypothesis § Special Creation u Was life created by a supernatural or divine force? u not testable § Extraterrestrial Origin u Was the original source of organic (carbon) materials comets & meteorites striking early Earth? u Heavy bombardment 4bya may have delivered organic compound and water to Earth
  • 27. The Origin of Life is Hypothesis § Special Creation u Was life created by a supernatural or divine force? u not testable § Extraterrestrial Origin u Was the original source of organic (carbon) materials comets & meteorites striking early Earth? u Heavy bombardment 4bya may have delivered organic compound and water to Earth u testable
  • 28. The Origin of Life is Hypothesis § Special Creation u Was life created by a supernatural or divine force? u not testable § Extraterrestrial Origin u Was the original source of organic (carbon) materials comets & meteorites striking early Earth? u Heavy bombardment 4bya may have delivered organic compound and water to Earth u testable § Spontaneous Abiotic Origin
  • 29. The Origin of Life is Hypothesis § Special Creation u Was life created by a supernatural or divine force? u not testable § Extraterrestrial Origin u Was the original source of organic (carbon) materials comets & meteorites striking early Earth? u Heavy bombardment 4bya may have delivered organic compound and water to Earth u testable § Spontaneous Abiotic Origin u Did life evolve spontaneously from inorganic molecules?
  • 30. The Origin of Life is Hypothesis § Special Creation u Was life created by a supernatural or divine force? u not testable § Extraterrestrial Origin u Was the original source of organic (carbon) materials comets & meteorites striking early Earth? u Heavy bombardment 4bya may have delivered organic compound and water to Earth u testable § Spontaneous Abiotic Origin u Did life evolve spontaneously from inorganic molecules? u testable
  • 31. Origin of Organic Compounds
  • 32. Origin of Organic Compounds Possible locations that would have allowed the synthesis of organic compounds:
  • 33. Origin of Organic Compounds Possible locations that would have allowed the synthesis of organic compounds: § Hydrothermal vents deep in the ocean release chemicals, creating unusual chemical conditions
  • 34. Origin of Organic Compounds Possible locations that would have allowed the synthesis of organic compounds: § Hydrothermal vents deep in the ocean release chemicals, creating unusual chemical conditions § Extraterrestrial origin: Scientists have shown that organic compounds could have formed in cold interstellar space and then delivered to Earth by meteors or comets
  • 35. Origin of Organic Compounds Possible locations that would have allowed the synthesis of organic compounds: § Hydrothermal vents deep in the ocean release chemicals, creating unusual chemical conditions § Extraterrestrial origin: Scientists have shown that organic compounds could have formed in cold interstellar space and then delivered to Earth by meteors or comets § Chemical reactions in the atmosphere and in water, on the surface of the Earth
  • 37. Spontaneous Origin of Life Pasteur disproved “spontaneous generation”
  • 38. Spontaneous Origin of Life Pasteur disproved “spontaneous generation”
  • 39. Spontaneous Origin of Life Pasteur disproved “spontaneous generation” Oldest bacterial fossil date back to 1.9 bya
  • 40. Spontaneous Origin of Life Pasteur disproved “spontaneous generation” Oldest bacterial fossil date back to 1.9 bya
  • 41. Spontaneous Origin of Life Pasteur disproved “spontaneous generation” Oldest bacterial fossil date back to 1.9 bya Processes that would have been needed for
  • 42. Spontaneous Origin of Life Pasteur disproved “spontaneous generation” Oldest bacterial fossil date back to 1.9 bya Processes that would have been needed for the first cells to form include:
  • 43. Spontaneous Origin of Life Pasteur disproved “spontaneous generation” Oldest bacterial fossil date back to 1.9 bya Processes that would have been needed for the first cells to form include: 1. Chemical reactions to produce simple organic molecules (ex. amino acids) from inorganic molecules (ex. water, carbon dioxide)
  • 44. Spontaneous Origin of Life Pasteur disproved “spontaneous generation” Oldest bacterial fossil date back to 1.9 bya Processes that would have been needed for the first cells to form include: 1. Chemical reactions to produce simple organic molecules (ex. amino acids) from inorganic molecules (ex. water, carbon dioxide)
  • 45. Spontaneous Origin of Life Pasteur disproved “spontaneous generation” Oldest bacterial fossil date back to 1.9 bya Processes that would have been needed for the first cells to form include: 1. Chemical reactions to produce simple organic molecules (ex. amino acids) from inorganic molecules (ex. water, carbon dioxide) 2. Assembly of these organic molecules into polymers (ex. polypeptides)
  • 46. Spontaneous Origin of Life Pasteur disproved “spontaneous generation” Oldest bacterial fossil date back to 1.9 bya Processes that would have been needed for the first cells to form include: 1. Chemical reactions to produce simple organic molecules (ex. amino acids) from inorganic molecules (ex. water, carbon dioxide) 2. Assembly of these organic molecules into polymers (ex. polypeptides)
  • 47. Spontaneous Origin of Life Pasteur disproved “spontaneous generation” Oldest bacterial fossil date back to 1.9 bya Processes that would have been needed for the first cells to form include: 1. Chemical reactions to produce simple organic molecules (ex. amino acids) from inorganic molecules (ex. water, carbon dioxide) 2. Assembly of these organic molecules into polymers (ex. polypeptides) 3. Formation of polymers that can self replicate to allow for the inheritance of characteristics
  • 48. Spontaneous Origin of Life Pasteur disproved “spontaneous generation” Oldest bacterial fossil date back to 1.9 bya Processes that would have been needed for the first cells to form include: 1. Chemical reactions to produce simple organic molecules (ex. amino acids) from inorganic molecules (ex. water, carbon dioxide) 2. Assembly of these organic molecules into polymers (ex. polypeptides) 3. Formation of polymers that can self replicate to allow for the inheritance of characteristics
  • 49. Spontaneous Origin of Life Pasteur disproved “spontaneous generation” Oldest bacterial fossil date back to 1.9 bya Processes that would have been needed for the first cells to form include: 1. Chemical reactions to produce simple organic molecules (ex. amino acids) from inorganic molecules (ex. water, carbon dioxide) 2. Assembly of these organic molecules into polymers (ex. polypeptides) 3. Formation of polymers that can self replicate to allow for the inheritance of characteristics 4. Packaging of these molecules into membranes with an internal chemistry different from the
  • 51. Conditions on early Earth § Reducing atmosphere
  • 52. Conditions on early Earth § Reducing atmosphere u water vapor (H2O), CO2, N2, NOx, H2, NH3, CH4, H2S
  • 53. Conditions on early Earth § Reducing atmosphere u water vapor (H2O), CO2, N2, NOx, H2, NH3, CH4, H2S What’s missing from that atmosphere?
  • 54. Conditions on early Earth § Reducing atmosphere u water vapor (H2O), CO2, N2, NOx, H2, NH3, CH4, H2S u lots of available H & its electron What’s missing from that atmosphere?
  • 55. Conditions on early Earth § Reducing atmosphere u water vapor (H2O), CO2, N2, NOx, H2, NH3, CH4, H2S u lots of available H & its electron low O2 = organic molecules do not breakdown as quickly What’s missing from that atmosphere?
  • 56. Conditions on early Earth § Reducing atmosphere u water vapor (H2O), CO2, N2, NOx, H2, NH3, CH4, H2S u lots of available H & its electron u no free oxygen low O2 = organic molecules do not breakdown as quickly What’s missing from that atmosphere?
  • 57. Conditions on early Earth § Reducing atmosphere u water vapor (H2O), CO2, N2, NOx, H2, NH3, CH4, H2S u lots of available H & its electron u no free oxygen low O2 = organic molecules § Energy source do not breakdown as quickly What’s missing from that atmosphere?
  • 58. Conditions on early Earth § Reducing atmosphere u water vapor (H2O), CO2, N2, NOx, H2, NH3, CH4, H2S u lots of available H & its electron u no free oxygen low O2 = organic molecules § Energy source do not breakdown u lightning, UV radiation, as quickly volcanic What’s missing from that atmosphere?
  • 59. Electrodes discharge sparks Origin of Organic Molecules (lightning simulation) CH4 Water vapor H2 NH3 Mixture of gases (quot;primitive Condenser atmospherequot;) Water Condensed liquid with complex, organic Heated water molecules (quot;oceanquot;)
  • 60. Electrodes discharge sparks Origin of Organic Molecules (lightning simulation) § Abiotic synthesis CH4 Water vapor H2 NH3 Mixture of gases (quot;primitive Condenser atmospherequot;) Water Condensed liquid with complex, organic Heated water molecules (quot;oceanquot;)
  • 61. Electrodes discharge sparks Origin of Organic Molecules (lightning simulation) § Abiotic synthesis u 1920 Water vapor CH4 Oparin & Haldane H2 propose reducing NH3 Mixture of gases atmosphere (quot;primitive Condenser hypothesis atmospherequot;) Water Condensed liquid with complex, organic Heated water molecules (quot;oceanquot;)
  • 62. Electrodes discharge sparks Origin of Organic Molecules (lightning simulation) § Abiotic synthesis u 1920 Water vapor CH4 Oparin & Haldane H2 propose reducing NH3 Mixture of gases atmosphere (quot;primitive Condenser hypothesis atmospherequot;) u 1953 Water Miller & Urey test hypothesis Condensed liquid with complex, organic Heated water molecules (quot;oceanquot;)
  • 63. Electrodes discharge sparks Origin of Organic Molecules (lightning simulation) § Abiotic synthesis u 1920 Water vapor CH4 Oparin & Haldane H2 propose reducing NH3 Mixture of gases atmosphere (quot;primitive Condenser hypothesis atmospherequot;) u 1953 Water Miller & Urey test hypothesis § formed organic compounds Condensed liquid with complex, organic Heated water molecules (quot;oceanquot;)
  • 64. Electrodes discharge sparks Origin of Organic Molecules (lightning simulation) § Abiotic synthesis u 1920 Water vapor CH4 Oparin & Haldane H2 propose reducing NH3 Mixture of gases atmosphere (quot;primitive Condenser hypothesis atmospherequot;) u 1953 Water Miller & Urey test hypothesis § formed organic compounds Condensed w amino acids liquid with complex, organic Heated water molecules (quot;oceanquot;)
  • 65. Electrodes discharge sparks Origin of Organic Molecules (lightning simulation) § Abiotic synthesis u 1920 Water vapor CH4 Oparin & Haldane H2 propose reducing NH3 Mixture of gases atmosphere (quot;primitive Condenser hypothesis atmospherequot;) u 1953 Water Miller & Urey test hypothesis § formed organic compounds Condensed w amino acids liquid with complex, w adenine Heated water organic molecules (quot;oceanquot;)
  • 66. Stanley Miller University of Chicago produced -amino acids -hydrocarbons -nitrogen bases -other organics It’s ALIVE!
  • 68. Phospholipids § Hydrophobic or hydrophilic? u fatty acid tails = hydrophobic u PO4 = hydrophilic head u dual “personality”
  • 69. Phospholipids § Hydrophobic or hydrophilic? u fatty acid tails = hydrophobic u PO4 = hydrophilic head u dual “personality” interaction with H2O is complex & very important!
  • 70. Phospholipids § Hydrophobic or hydrophilic? u fatty acid tails = hydrophobic u PO4 = hydrophilic head u dual “personality” It likes water & also pushes it away! interaction with H2O is complex & very important!
  • 72. Phospholipids in water § Hydrophilic heads attracted to H2O
  • 73. Phospholipids in water § Hydrophilic heads attracted to H2O § Hydrophobic tails “hide” from H2O
  • 74. Phospholipids in water § Hydrophilic heads attracted to H2O § Hydrophobic tails “hide” from H2O u can self-assemble into “bubbles”
  • 75. Phospholipids in water § Hydrophilic heads attracted to H2O § Hydrophobic tails “hide” from H2O u can self-assemble into “bubbles” § can also form bilayer
  • 76. Phospholipids in water § Hydrophilic heads attracted to H2O § Hydrophobic tails “hide” from H2O u can self-assemble into “bubbles” § can also form bilayer bilayer
  • 77. Phospholipids in water § Hydrophilic heads attracted to H2O § Hydrophobic tails “hide” from H2O u can self-assemble into “bubbles” § can also form bilayer § early evolutionary stage of cell? bilayer
  • 78. Origin of Cells (Protobionts) § Bubbles → separate inside from outside → metabolism & reproduction
  • 79. Origin of Cells (Protobionts) § Bubbles → separate inside from outside → metabolism & reproduction Bubbles… Tiny bubbles…
  • 80. Dawn of natural selection Origin of Genetics
  • 81. Dawn of natural selection Origin of Genetics § RNA is likely first genetic material
  • 82. Dawn of natural selection Origin of Genetics § RNA is likely first genetic material u multi-functional
  • 83. Dawn of natural selection Origin of Genetics § RNA is likely first genetic material u multi-functional u codes information
  • 84. Dawn of natural selection Origin of Genetics § RNA is likely first genetic material u multi-functional u codes information § self-replicating molecule
  • 85. Dawn of natural selection Origin of Genetics § RNA is likely first genetic material u multi-functional u codes information § self-replicating molecule § makes inheritance possible
  • 86. Dawn of natural selection Origin of Genetics § RNA is likely first genetic material u multi-functional u codes information § self-replicating molecule § makes inheritance possible § natural selection & evolution
  • 87. Dawn of natural selection Origin of Genetics § RNA is likely first genetic material u multi-functional u codes information § self-replicating molecule § makes inheritance possible § natural selection & evolution u enzyme functions
  • 88. Dawn of natural selection Origin of Genetics § RNA is likely first genetic material u multi-functional u codes information § self-replicating molecule § makes inheritance possible § natural selection & evolution u enzyme functions u transport molecule
  • 89. Dawn of natural selection Origin of Genetics § RNA is likely first genetic material u multi-functional u codes information § self-replicating molecule § makes inheritance possible § natural selection & evolution u enzyme functions u transport molecule § tRNA & mRNA
  • 90. Key Events in Origin of Life
  • 91. Key Events in Origin of Life § Key events in evolutionary history of life on Earth
  • 92. Key Events in Origin of Life § Key events in evolutionary history of life on Earth u life originated 3.5–4.0 bya
  • 93. Prokaryotes § Prokaryotes dominated life on Earth from 3.5–2.0 bya
  • 94. Prokaryotes § Prokaryotes dominated life on Earth from 3.5–2.0 bya
  • 95. Prokaryotes § Prokaryotes dominated life on Earth from 3.5–2.0 bya 3.5 billion year old fossil of bacteria
  • 96. Prokaryotes § Prokaryotes dominated life on Earth from 3.5–2.0 bya 3.5 billion year old fossil of bacteria modern bacteria chains of one-celled cyanobacteria
  • 97. Stromatolites Fossilized mats of prokaryotes resemble modern microbial colonies
  • 98. Stromatolites Fossilized mats of prokaryotes resemble modern microbial colonies
  • 99. Stromatolites Fossilized mats of prokaryotes resemble modern microbial colonies
  • 100. Stromatolites Fossilized mats of prokaryotes resemble modern microbial colonies
  • 103. Oxygen atmosphere § Oxygen begins to accumulate 2.7 bya
  • 104. Oxygen atmosphere § Oxygen begins to accumulate 2.7 bya u reducing → oxidizing atmosphere
  • 105. Oxygen atmosphere § Oxygen begins to accumulate 2.7 bya u reducing → oxidizing atmosphere § evidence in banded iron in rocks = rusting
  • 106. Oxygen atmosphere § Oxygen begins to accumulate 2.7 bya u reducing → oxidizing atmosphere § evidence in banded iron in rocks = rusting § makes aerobic respiration possible
  • 107. Oxygen atmosphere § Oxygen begins to accumulate 2.7 bya u reducing → oxidizing atmosphere § evidence in banded iron in rocks = rusting § makes aerobic respiration possible u photosynthetic
  • 108. Oxygen atmosphere § Oxygen begins to accumulate 2.7 bya u reducing → oxidizing atmosphere § evidence in banded iron in rocks = rusting § makes aerobic respiration possible u photosynthetic u algae)
  • 109. ~2 bya First Eukaryotes nuclear envelope plasma membrane DNA cell wall plasma membrane
  • 110. ~2 bya First Eukaryotes nuclear envelope plasma membrane DNA cell wall plasma membrane Prokaryotic cell
  • 111. ~2 bya First Eukaryotes nuclear envelope infolding of the plasma plasma membrane membrane DNA cell wall plasma membrane Prokaryotic cell
  • 112. ~2 bya First Eukaryotes nuclear envelope infolding of the plasma plasma membrane membrane DNA cell wall plasma Prokaryotic membrane Prokaryotic cell ancestor of eukaryotic cells
  • 113. ~2 bya First Eukaryotes nuclear envelope endoplasmic infolding of the plasma reticulum (ER) plasma membrane membrane DNA cell wall plasma Prokaryotic membrane Prokaryotic cell ancestor of eukaryotic cells
  • 114. ~2 bya First Eukaryotes nuclear envelope endoplasmic infolding of the plasma reticulum (ER) plasma membrane membrane nucleus DNA cell wall plasma Prokaryotic membrane Prokaryotic cell ancestor of eukaryotic cells
  • 115. ~2 bya First Eukaryotes nuclear envelope endoplasmic infolding of the plasma reticulum (ER) plasma membrane membrane nucleus DNA cell wall plasma Prokaryotic membrane Prokaryotic Eukaryotic cell ancestor of cell eukaryotic cells
  • 116. ~2 bya First Eukaryotes § Development of internal membranes nuclear envelope endoplasmic infolding of the plasma reticulum (ER) plasma membrane membrane nucleus DNA cell wall plasma Prokaryotic membrane Prokaryotic Eukaryotic cell ancestor of cell eukaryotic cells
  • 117. ~2 bya First Eukaryotes § Development of internal membranes u create internal micro-environments nuclear envelope endoplasmic infolding of the plasma reticulum (ER) plasma membrane membrane nucleus DNA cell wall plasma Prokaryotic membrane Prokaryotic Eukaryotic cell ancestor of cell eukaryotic cells
  • 118. ~2 bya First Eukaryotes § Development of internal membranes u create internal micro-environments u advantage: specialization = increase efficiency nuclear envelope endoplasmic infolding of the plasma reticulum (ER) plasma membrane membrane nucleus DNA cell wall plasma Prokaryotic membrane Prokaryotic Eukaryotic cell ancestor of cell eukaryotic cells
  • 119. Endosymbiosis internal membrane system Endosymbiosis
  • 120. Endosymbiosis internal membrane system Endosymbiosis
  • 121. Endosymbiosis § Evolution of eukaryotes internal membrane system Endosymbiosis
  • 122. Endosymbiosis § Evolution of eukaryotes internal membrane system Endosymbiosis Ancestral eukaryotic cell
  • 123. Endosymbiosis § Evolution of eukaryotes u origin of mitochondria internal membrane system Endosymbiosis Ancestral eukaryotic cell
  • 124. Endosymbiosis § Evolution of eukaryotes u origin of mitochondria internal membrane aerobic bacterium system Endosymbiosis Ancestral eukaryotic cell
  • 125. Endosymbiosis § Evolution of eukaryotes u origin of mitochondria u engulfed aerobic bacteria, but did not digest them internal membrane aerobic bacterium system Endosymbiosis Ancestral eukaryotic cell
  • 126. Endosymbiosis § Evolution of eukaryotes u origin of mitochondria u engulfed aerobic bacteria, but did not digest them u mutually beneficial relationship internal membrane aerobic bacterium system Endosymbiosis Ancestral eukaryotic cell
  • 127. Endosymbiosis § Evolution of eukaryotes u origin of mitochondria u engulfed aerobic bacteria, but did not digest them u mutually beneficial relationship internal membrane aerobic bacterium mitochondrion system Endosymbiosis Ancestral eukaryotic cell
  • 128. Endosymbiosis § Evolution of eukaryotes u origin of mitochondria u engulfed aerobic bacteria, but did not digest them u mutually beneficial relationship internal membrane aerobic bacterium mitochondrion system Endosymbiosis Ancestral Eukaryotic cell eukaryotic cell with mitochondrion
  • 129. Endosymbiosis Endosymbiosis mitochondrion
  • 130. Endosymbiosis § Evolution of eukaryotes Endosymbiosis mitochondrion
  • 131. Eukaryotic Endosymbiosis cell with mitochondrion § Evolution of eukaryotes Endosymbiosis mitochondrion
  • 132. Eukaryotic Endosymbiosis cell with mitochondrion § Evolution of eukaryotes u origin of chloroplasts Endosymbiosis mitochondrion
  • 133. Eukaryotic Endosymbiosis cell with mitochondrion § Evolution of eukaryotes u origin of chloroplasts photosynthetic bacterium Endosymbiosis mitochondrion
  • 134. Eukaryotic Endosymbiosis cell with mitochondrion § Evolution of eukaryotes u origin of chloroplasts u engulfed photosynthetic bacteria, but did not digest them photosynthetic bacterium Endosymbiosis mitochondrion
  • 135. Eukaryotic Endosymbiosis cell with mitochondrion § Evolution of eukaryotes u origin of chloroplasts u engulfed photosynthetic bacteria, but did not digest them u mutually beneficial relationship photosynthetic bacterium Endosymbiosis mitochondrion
  • 136. Eukaryotic Endosymbiosis cell with mitochondrion § Evolution of eukaryotes u origin of chloroplasts u engulfed photosynthetic bacteria, but did not digest them u mutually beneficial relationship photosynthetic bacterium chloroplast Endosymbiosis mitochondrion
  • 137. Eukaryotic Endosymbiosis cell with mitochondrion § Evolution of eukaryotes u origin of chloroplasts u engulfed photosynthetic bacteria, but did not digest them u mutually beneficial relationship photosynthetic bacterium chloroplast Endosymbiosis mitochondrion Eukaryotic cell with chloroplast & mitochondrion
  • 139. Theory of Endosymbiosis Lynn Margulis
  • 140. Theory of Endosymbiosis § Evidence Lynn Margulis
  • 141. Theory of Endosymbiosis § Evidence u structural Lynn Margulis
  • 142. Theory of Endosymbiosis § Evidence u structural § mitochondria & chloroplasts resemble bacterial structure Lynn Margulis
  • 143. Theory of Endosymbiosis § Evidence u structural § mitochondria & chloroplasts resemble bacterial structure u genetic Lynn Margulis
  • 144. Theory of Endosymbiosis § Evidence u structural § mitochondria & chloroplasts resemble bacterial structure u genetic Lynn Margulis § mitochondria & chloroplasts have their own circular DNA, like bacteria
  • 145. Theory of Endosymbiosis § Evidence u structural § mitochondria & chloroplasts resemble bacterial structure u genetic Lynn Margulis § mitochondria & chloroplasts have their own circular DNA, like bacteria u functional
  • 146. Theory of Endosymbiosis § Evidence u structural § mitochondria & chloroplasts resemble bacterial structure u genetic Lynn Margulis § mitochondria & chloroplasts have their own circular DNA, like bacteria u functional § mitochondria & chloroplasts move freely within the cell
  • 147. Theory of Endosymbiosis § Evidence u structural § mitochondria & chloroplasts resemble bacterial structure u genetic Lynn Margulis § mitochondria & chloroplasts have their own circular DNA, like bacteria u functional § mitochondria & chloroplasts move freely within the cell § mitochondria & chloroplasts reproduce independently from the cell