Lupus Nephritis

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Lupus Nephritis

  1. 1. Lupus Nephritis
  2. 3. RBC Casts
  3. 4. WHO Class I Lupus Nephritis Minimal Mesangial Immunoperoxidase staining shows C1q
  4. 5. WHO Class II Immunoperoxidase stain: Mesangial IgG deposits
  5. 6. WHO Class II Lupus Nephritis Mesangial Proliferative
  6. 7. WHO Class III Lupus Nephritis (Focal Proliferative) Hematoxylin/Lissamine Green Stain: ≤50% of the glomerular tuft involvement With areas of focal necrosis
  7. 8. WHO Class III Lupus Nephritis
  8. 9. WHO Class III Lupus Nephritis
  9. 10. WHO Class IV Lupus Nephritis Diffuse Proliferative Immunoperoxidase Stain: ≥50% of the Glomerular Tuft involved
  10. 11. WHO Class IV Lupus Nephritis H & E Stain: Diffuse increase in matrix and hypercellularity
  11. 12. WHO Class V Membranous EM: Electron-dense immune deposits on the outer surface of BM, separated by “ spikes” of exuberant BM-like material (mainly laminin)
  12. 13. WHO Class V Lupus Nephritis Silver Methenamine Stain: Silver positive spikes along the peripheral capillary wall
  13. 14. WHO Class V Lupus Nephritis
  14. 15. WHO Class VI Lupus Nephritis Advanced Sclerosis Hematoxylin/Lissamine Green Stain: Sclerosis of ≥90% of the glomerulus
  15. 16. WHO Class VI Lupus Nephritis

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