Theise Upaya 2 2008

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Theise Upaya 2 2008

  1. 1. Zen Body, Yogic Healing William C. Bushell, PhD MIT and Tibet House (Director of East/West Studies) New York City Neil Soten Theise, MD Depts. Of Pathology and Medicine Beth Israel Medical Center – Albert Einstein College of Medicine New York City
  2. 2. Put group portrait from menla conference HERE
  3. 3. What kind of models?
  4. 4. for example, 2 models from Ancient Greece: Is the body made of… indivisible subunits or an endlessly divisible fluid
  5. 9. Models of the body are perspective/technique dependent Look at it this way (cell membranes): the body is made of cells Look at it that way (organelles): the body is an endlessly divisible fluid
  6. 10. Models are perspective/technique dependent Look at it this way (cell membranes): the body is made of cells Look at it that way (organelles): the body is an endlessly divisible fluid Yet another way (the genome): … overlapping spatial/temporal fields of molecular organization
  7. 11. Put group portrait from menla conference HERE
  8. 12. “ There’s no such thing as a central dogma into which everything will fit...any mechanism you can think of, you will find -- even if it is the most bizarre kind of thinking. “ Anything... “ So if the material tells you, ‘It may be this,’ allow that. Don’t turn it aside and call it an exception, an aberration, a contaminant. “ So many good clues have been lost that way.“ “ A Feeling for the Organism” Evelyn Fox Keller, 1983 Nobel-laureate Barbara McClintock:
  9. 13. regeneration aging longevity protection
  10. 14. regeneration
  11. 15. regeneration tissue repair & restitution following cell loss or injury
  12. 16. regeneration longevity
  13. 17. regeneration aging longevity
  14. 18. regeneration aging longevity protection
  15. 19. regeneration aging longevity protection
  16. 20. GLOBAL/SYSTEMIC interventions
  17. 21. Cognitive Behavioral Practices GLOBAL/SYSTEMIC interventions
  18. 22. Cognitive ( mindfulness, visualization, analytical etc. ) Behavioral Practices GLOBAL/SYSTEMIC interventions
  19. 23. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions
  20. 24. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects
  21. 25. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects Site Specific, Tissue Regeneration
  22. 26. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Site Specific, Tissue Regeneration
  23. 27. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking Site Specific, Tissue Regeneration
  24. 28. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Site Specific, Tissue Regeneration
  25. 29. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation e.g. Melatonin!! Site Specific, Tissue Regeneration
  26. 30. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation e.g. Melatonin!!
  27. 33. Abbasoglu O et al, 1995. The effect of the pineal gland On liver regeneration in rats, J Hepatology 23: 578-81. Bellipanni G et al, 2005. Effects of melatonin in perimenopausal and menopausal women: our personal experience, Annals of the NY Academy of Sciences 1057: 393-402 Bubenik GA, 2002. Gastrointestinal melatonin: localization, function, and clinical relevance, Digestive Disease Science 47: 2336-48. Castagnino HE et al, 2002. Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining, Neurology Endocrinology Letters 23(5-6): 391-5. Conti et al, 2000. Evidence for melatonin synthesis in mouse and human bone marrow cells. J Pineal Res. 2000 May;28(4):193-202. Csaba G, 1993. Presence in and effects of pineal indoleamines at very low level of phylogeny, Experientia 49: 627-34. Danilova N et al, 2004. Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development, FASEB J 18: 751-3. Dundar K et al, 2005. Protective effects of exogenously administered or endogenously produced melatonin on hyperbaric oxygen-induced oxidative stress in the rat brain, Clinical & Experimental Pharmacology and Physiology 32(11): 926-30. Erkanli K et al, 2005. Melatonin protects against ischemia/reperfusion injury in skeletal muscle, J Pineal Research 39(3): 238-42. Escames G et al, 2006. Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice, J Pineal Research 40(1): 71-8. Esrefoglu M et al, 2005. Potent therapeutic effect of melatonin on aging skin in pinealectomized rats, J Pineal Research 39(3): 231-7. Feng Z et al, 2006. Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer’s disease, Free Radicals in Biology & Medicine 40(1): 101-9. Girotti L et al, 2003. Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure, Endocrine 22(3): 245-8. Karasek M, 2004. Melatonin, human aging, and age-related diseases, Experimental Gerontology 39(11-12): 1723-9. Kobayashi H, et al, 2005. A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors. FASEB J. 2005 Oct;19(12):1710-2. Lesnikov VA & Pierpaoli W, 1994. Pineal cross-transplantation (old-to-young and young-to-old) as evidence for an endogenous “aging clock” Annals of the NY Academy of Sciences 719: 456-60. Maestroni GJM et al, 1988. Pineal melatonin, its fundamental immunoregulatory role in aging and cancer, Annals of the NY Academy of Sciences 521: 140-8. Pierpaoli W, 1998. Neuroimmunomodulation of aging: a program in the pineal gland Annals of the NY Academy of Sciences 840: 491-7. Pierpaoli & Maestroni GJM, 1987. Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its antiaging effects, Immunology Letters 16: 355-62. Sainz RM et al, 2003. Melatonin and cell death: differential actions on normal and cancer cells, Cellular & Molecular Life Science 60: 1407-26. Slominski A, et al, 2005. On the role of melatonin in skin physiology and pathology. Endocrine. 2005 Jul;27(2):137-48. MELATONIN
  28. 34. <ul><li>Effects of Melatonin </li></ul><ul><li>Cytoprotection </li></ul>
  29. 35. <ul><li>Effects of Melatonin </li></ul><ul><li>Cytoprotection </li></ul><ul><li>Regeneration </li></ul>
  30. 36. <ul><li>Effects of Melatonin </li></ul><ul><li>Cytoprotection </li></ul><ul><li>Regeneration </li></ul><ul><li>Oncostasis </li></ul>
  31. 39. <ul><li>Effects of Melatonin </li></ul><ul><li>Cytoprotection </li></ul><ul><li>Regeneration </li></ul><ul><li>Oncostasis </li></ul><ul><li>Longevity…? </li></ul>
  32. 41. <ul><li>Other Molecules </li></ul><ul><li>Modulated in Meditation, </li></ul><ul><li>e.g. </li></ul><ul><li>Arginine vasopressin </li></ul><ul><li>DHEA </li></ul><ul><li>Nitric Oxide </li></ul>
  33. 42. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Cell trafficking Site Specific, Tissue Regeneration
  34. 43. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Cell trafficking Nerve signaling Site Specific, Tissue Regeneration
  35. 44. Neil’s stuff #2
  36. 45. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Cell trafficking Nerve signaling Site Specific, Tissue Regeneration
  37. 46. Bill’s stuff #2
  38. 47. Bill’s stuff #2 NOT ONLY!
  39. 48. A MIND – BODY CONNECTION nerves connect to liver stem cells
  40. 49. <ul><li>Yogic Practices </li></ul><ul><li>and the Vagus </li></ul><ul><li>Meditation </li></ul>
  41. 50. <ul><li>Yogic Practices </li></ul><ul><li>and the Vagus </li></ul><ul><li>Meditation </li></ul><ul><li>Mantrayana </li></ul>
  42. 51. <ul><li>Yogic Practices </li></ul><ul><li>and the Vagus </li></ul><ul><li>Meditation </li></ul><ul><li>Mantrayana </li></ul><ul><li>Pranayama </li></ul>
  43. 52. <ul><li>Yogic Practices </li></ul><ul><li>and the Vagus </li></ul><ul><li>Meditation </li></ul><ul><li>Mantrayana </li></ul><ul><li>Pranayama </li></ul><ul><li>Asana </li></ul>
  44. 53. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking
  45. 54. Bioelectromagnetism Definitions!
  46. 55. Bioelectromagnetism NOT necessarily “ energy” or “chi” or or or or or…
  47. 56. Bioelectromagnetism Electron or ionic flux
  48. 57. Bioelectromagnetism Electron or ionic flux Nerve conduction Tissue flux Molecular level ( DNA )
  49. 58. Bioelectromagnetism Electron or ionic flux Nerve conduction Tissue flux Molecular level ( DNA )
  50. 62. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking Site Specific, Tissue Regeneration
  51. 64. Nerves Cell Trafficking Humoral factors Bioelectomagnetic
  52. 65. Nerves Cell Trafficking Humoral factors Bioelectomagnetic Yoga Asanas Chi Kung Acupuncture Pranayama Meditation
  53. 66. Macroscopic body Microscopic body Nanoscopic body Quantum body
  54. 67. Macroscopic body Microscopic body Nanoscopic body Quantum body e.g. physical therapy surgery e.g. cell therapies e.g. molecular medicine antibiotics e.g. electromagnetics
  55. 68. Macroscopic body Microscopic body Nanoscopic body Quantum body e.g. yoga tai chi e.g. acupuncture? e.g. traditional remedies e.g. energy healing? meditation?
  56. 69. Macroscopic body Microscopic body Nanoscopic body Quantum body Coarse Body ? Energy Body ? Subtle Body ? Indo-Tibetan Medicine/Physiology
  57. 70. Macroscopic body Microscopic body Nanoscopic body Quantum body Coarse Body ? Energy Body ? Subtle Body ? Indo-Tibetan Medicine/Physiology
  58. 71. From the global to the local: Pathways for the transduction of Indo-Sino-Tibetan cognitive behavioral practices into site specific, tissue regenerative effects. William C Bushell & Neil D. Theise Beyond cell doctrine: Complexity thery informs alternate models of the bdy For cross cultural dialogue Neil D. Theise www.neiltheise.com

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