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Blood glucose homeostasis


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Blood glucose homeostasis- Hormonal regulation and clinical significance

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Blood glucose homeostasis

  2. 2. •Overview•Regulation of blood glucose•Hormonal control of bloodglucose•Hypoglycemia and itsclinical aspect•Hyperglycemia and itsclinical aspect•Summary
  3. 3. Insulin Glucagon Catecholamine Glucocorticoids Growth Thyroid s hormone hormonesAbsorbtion ofglucosePeripheraluptakeGlycolysisGluconeogenesisglycogenesisGlucogenolysisLipogenesisLipolysisProteincatabolismNet effect onblood glucose
  4. 4. G.H
  5. 5. These 3 is called whipple’s triad
  6. 6. Hypoglycemia Fasting Post parandialHypoglycemia Hypoglycemia (FH) (PPH)
  7. 7. Alchohol NAD+ lactateAlchoholdehydrogenase NADH+ pyruvate H++ acetaldehyde NAD+ malateAcetaldehydedehydrogenase NADH+ H++ OAA acetate Inhibition of gluconeogenesis Acetyl CoA
  8. 8. Clinical Manifestations
  9. 9. These are due todeprivation of glucose to brain cells
  10. 10. Always associated with tachycardiaThese are due to realease of catecholamines especially adrenaline
  11. 11. Biochemistry class notes (DR. Namrata) InternetRespected teachers of bichemistry department