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Présenta i cours3

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Présenta i cours3

  1. 1. •Les gènes des TCROrganisation et réarrangement des gènes des TCR- L’organisation des locus TCR est la même que celle des Ig. TCR (TCRA) et (TCRG) on trouve des gènes V, J et C, TCR (TCRB) et (TCRD) sont organisés en V, D, J et C.Les gènes TCRA et D sont en 14q11.2, le locus TCRD est intégré danslocus TCRA (entre les gènes V et les segments J).Le locus TCRG est en 7p15 et le locus TCRB en 7q35.
  2. 2. TCR : Récepteurs des LTDeux types TCR, les TCR / et les TCR / . 90% des LT circulant portentdes TCR / , 10% restant portent des TCR / . - La reconnaissance Ag est assurée par le paratope des TCR, - la transduction du signal est assurée par le complexe CD3. Ce dernier est formé de 5 chaine différentes : , les chaines et possèdent 3 motifs ITAM, les chaines et en possèdent un seul. Le complexe TCR/CD3 est associé avec un CD4 ou CD8 qui interagissent respectivement avec HLA classe II et classe I.
  3. 3. - La construction des TCR se fait par un ensemble derecombinaisons des différents segments pour chaque locus (avecexclusion allélique).- Les mécanismes de recombinaisons sont les mêmes décrits dansle cas des Ig.- LT , les gènes TCRA et TCRB sont réarrangés (V -J -C etV -D -J -C ), - les réarrangements des TCRG sont éliminés sous forme d’ADN circulaire (épisome). - Cependant comme les gènes TCRG sont imbriqués dans les gènes TCRA, les gènes V des TCRG sont conservés pour les réarrangements des gènes TCRA.
  4. 4. Mécanisme moléculaire de la diversité des TCR-Diversité de jonction: réarrangement des gènes V-J ou V-D-J.-Diversité combinatoire TCR par rapport aux TCR-Une lecture possible dans les trois cadres de lecture de ARNm.- Les mutations somatiques des gènes des TCR ne sont pasune source importante de variabilité
  5. 5. •Les gènes des molécules de surface des NK
  6. 6. - Mécanismes de mort cellulaire induits par les LTc et les NK- Induction du signal d’apoptose- Marqueurs de surface des NK, description des gènes etfonction de la molécule : KIR, NKG2D, LFA1 et les RIL.

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