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Catalyzing Innovation in Pharma IT
Keeping AstraZeneca Ahead of Disruptive Technology
Rob Hernandez
Data Analytics lead – ...
The explosive pace of technological change means we all
need to be empowered to embrace new approaches
Big Data Is Reshaping Our World
Big Data & AI are changing our lives
 Mapping and Navigation
 Image Recognition
 Langua...
Technology has already disrupted other industries
Mobile service that
enabled you to find
better ways to travel
On-demand,...
Technology giants are now coming after health
Opened their own lab to
test own drug treatments
Major tech companies
sharin...
6
Technology Giants Applying Big Data analytics to health
AstraZeneca
A global science-led biopharmaceutical company
Our business is providing innovative, effective medicines
that ...
“Science led, IT driven”
- Dave Smoley CIO, AstraZeneca
9
Chief Technology Office
Competency Centres Enterprise Architecture
Uplift Govern
• Find, validate and prove the
value of...
Technology Incubation labs
10
Drive Technology
Leadership
• Accelerate innovation
culture
• Support learning between
funct...
Act as a technology catalyst
Tech Videos
Tech News
Tech Register
Tech Adoption
We enable communication about
technology, t...
Recent focus areas – DATA is key
12
NLP & Emotion Detection Predictive Modelling
Genomics Analysis
Big Data Analytics
Cybe...
Big Data affects all aspects of pharma
 Machine Learning highlighted by
multiple AZ IT leaders as key to their
areas.
 M...
Predictive modelling PoCs: 20+ use cases across AZ
Evaluated innovative Data Science
technology.
Partnered with business f...
Predictive
Modelling
The PoCs served to highlight gaps
Capture Data
Need to capture the right data,
manage it and make it
...
Big Unstructured Data – R&D Search applications
A single search platform supporting all of AZ
Scientific Partners
R&D News...
Can we get it to work?Can we teach it information from the internet?Can we get it returning information about AZ?How about...
AI Chatbots
Smart
Speaker
18
Automated Service desks Patient drug adherence Cognitive meeting rooms
“By 2020, 85% of custo...
Today AZ has less than 20 digital
health initiatives in flight, relatively
uncoordinated.
Digital Health – The upcoming da...
Developed video extraction  Text
AZ CHATBOT
PROACT
Developed a mobile app to
capture patient videos and diaries
to unders...
Internet of Things & The Physical Web
21
Industrial Sensors
Smart Buttons
Beacons
Shipment Tracking
All brought together o...
And we are all finding our own direction
Astra
Zeneca
Genomics Initiative,
2M sequenced to
transform drug
discovery.
Start-ups
Contact
Acknowledgements
Nick Brown, Adrian Wong, Josh Mesout,
Hariprasad Radhakrishnan, Steve Woodward
and many...
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Catalysing Innovation in Pharma IT: Keeping AstraZeneca Ahead of Disruptive Technology

Presentation by Rob Hernandez (senior data scientist) in my team at 14th Annual Pharmaceutical IT Congress in London on September 28th 2016 . Brief overview about how our world and more specifically the pharmaceutical industry is being disrupted by technology. We share some emerging technology areas that we are focusing on, demonstrating value to our R&D, Operations and Commercial teams but also how we catalyse innovation across our IT organisation. Examples include exploratory work on AI chatbots, video facial sentiment detection, scientific search and sensor technology.

Catalysing Innovation in Pharma IT: Keeping AstraZeneca Ahead of Disruptive Technology

  1. 1. Catalyzing Innovation in Pharma IT Keeping AstraZeneca Ahead of Disruptive Technology Rob Hernandez Data Analytics lead – Tech Incubation Labs, Office of the CTO 28 September 2016
  2. 2. The explosive pace of technological change means we all need to be empowered to embrace new approaches
  3. 3. Big Data Is Reshaping Our World Big Data & AI are changing our lives  Mapping and Navigation  Image Recognition  Language Translation  Self-repairing hardware  Natural language processing  Autonomous car  Healthcare reasoning  Home automation  Personal Assistants  Fraud Detection  Security Surveillance  Movie & Music Recommendation
  4. 4. Technology has already disrupted other industries Mobile service that enabled you to find better ways to travel On-demand, app- based legal music distribution through streaming Go-to-device, more intimate, shocked the PC industry Displaced telecoms companies through free chat Displaced retailers and changed home entertainment Online rental service to enable you to rent and find vacation homes
  5. 5. Technology giants are now coming after health Opened their own lab to test own drug treatments Major tech companies sharing better analysis tools Pivoted from photos to printing stem cells ! Major tech companies creating Joint Ventures
  6. 6. 6 Technology Giants Applying Big Data analytics to health
  7. 7. AstraZeneca A global science-led biopharmaceutical company Our business is providing innovative, effective medicines that make a real difference to patients
  8. 8. “Science led, IT driven” - Dave Smoley CIO, AstraZeneca
  9. 9. 9 Chief Technology Office Competency Centres Enterprise Architecture Uplift Govern • Find, validate and prove the value of 10x technologies • Catalyse best technology across AstraZeneca • User Experience (UX) • Mobility • Develop internal expertise with best practice, training, guidelines, standards and communities • Simplify & Modernise our technology environment • Define future technology roadmaps • digital transformation and business innovation strategy Tech Incubation Labs Scout Driving Technology Leadership Create new value by leveraging innovative technologies across AstraZeneca and AZIT.
  10. 10. Technology Incubation labs 10 Drive Technology Leadership • Accelerate innovation culture • Support learning between functional silos • Position IT as a strategic partner Bring Emerging Technology In • Reframe problems • Leverage new technology to improve operations • Exploit new business opportunities 2 3 External Perspective • Tech Trends • Best practice • Pharma and other industries • Potentially disruptive developments trends start-ups VCs presentations news register showcase tools 1 scout validate proof of concepts
  11. 11. Act as a technology catalyst Tech Videos Tech News Tech Register Tech Adoption We enable communication about technology, track internal tech and innovation and act as expert advisors on trends.
  12. 12. Recent focus areas – DATA is key 12 NLP & Emotion Detection Predictive Modelling Genomics Analysis Big Data Analytics Cyber Security Threat DetectionArtificial Intelligence IoT - Sensors Blockchain
  13. 13. Big Data affects all aspects of pharma  Machine Learning highlighted by multiple AZ IT leaders as key to their areas.  Multiple areas in the business looking for predictive modelling solutions but need expertise. Volumes of Data  Next Generation Sequencing  Whole body imaging  Tissue Microarrays  Sales force optimisation  Clinical trial statistical analytics  High Throughput Screening  Toxicogenomics  Open Innovation Approaches  PowerPoint/Excel content  Structured databases  Predictive Chemistry Modelling  Unstructured data  Real-time news sentiment  experimental data capture  Wearable sensor information  Log analytics in Operations Streaming of Data Variety of Data Complexity of Data We’re data driven company: We need data driven decisions
  14. 14. Predictive modelling PoCs: 20+ use cases across AZ Evaluated innovative Data Science technology. Partnered with business functions to work through use cases. End goal: Democratise Predictive Modelling & ML at AZ. Predict disease exacerbation from clinical data Predict machine breakdown from sensor & log data Predict clinician behaviour from Sales / interaction data Predict drug response from RWE data
  15. 15. Predictive Modelling The PoCs served to highlight gaps Capture Data Need to capture the right data, manage it and make it accessible in the right way. Working through the use cases helped us understand the steps we need to put in place for successful projects. Understand ML Need to increase awareness of machine learning, what it can and can’t do and how to frame problems in the right way. Wrangle Data Every data challenge involves transforming, wrangling and cleaning up the data. Partner with Business Work closely with the right stakeholders. Understand the decisions that will be driven by the models and the potential value of the predictions.
  16. 16. Big Unstructured Data – R&D Search applications A single search platform supporting all of AZ Scientific Partners R&D News Alerts R&D ChemSearch Mobile Apps Find People at AZR&D Intelligence
  17. 17. Can we get it to work?Can we teach it information from the internet?Can we get it returning information about AZ?How about information from our Intranet?Can we apply it to a real use case? “We believe Artificial Intelligence and Conversational UI will disrupt the technical landscape in AstraZeneca” The next search front ends could be chatbots We started off by integrating our prototype into our Teams Slack channel
  18. 18. AI Chatbots Smart Speaker 18 Automated Service desks Patient drug adherence Cognitive meeting rooms “By 2020, 85% of customer interactions will be managed without a human” (Gartner) Smartphone Virtual Assistant Messenger Chatbot Conversational UI Natural Language Processing Text Analytics Machine Learning Google, Amazon and Apple changing from “Mobile First” to “AI First”
  19. 19. Today AZ has less than 20 digital health initiatives in flight, relatively uncoordinated. Digital Health – The upcoming data deluge PROACT Patient Reported Opinions About Clinical Trials Turbu+ Smart Inhaler, Mobile App, Web Portal Flight Deck A centralised approach for mobile app demand management Microservices A mobile-centric microservices strategy focused on digital health CTO are creating a mobile service foundation now. A common data layer, for data streaming, storage and advanced analytics Supporting R&D and Commercial.
  20. 20. Developed video extraction  Text AZ CHATBOT PROACT Developed a mobile app to capture patient videos and diaries to understand drug tolerability and potential side effects in phase 1 clinical trials. Developed facial expression  Sentiment
  21. 21. Internet of Things & The Physical Web 21 Industrial Sensors Smart Buttons Beacons Shipment Tracking All brought together on one cloud platform Wearables “By 2020, there will be 21 Billion connected devices” - Gartner
  22. 22. And we are all finding our own direction Astra Zeneca Genomics Initiative, 2M sequenced to transform drug discovery.
  23. 23. Start-ups Contact Acknowledgements Nick Brown, Adrian Wong, Josh Mesout, Hariprasad Radhakrishnan, Steve Woodward and many other AZ colleagues 23 Email rob.hernandez@astrazeneca.com UK Tech Lab Director nick.brown@astrazeneca.com Scouting for disruptive 10X technologies We can be your conduit into AstraZeneca Venture Capital Institutes Innovative Companies Mobile Digital Health Creative Tech Big Data IoT DevOps

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