CBGW Diane Panrucker Panel

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This is a presentation from the Canadian Bovine Genomics Workshop held in Calgary, Alberta on Sept.14, 2009.
The workshop was the first step in developing a national bovine genomics strategy for Canada.

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  • Seedstock Perspective Excellent Questions Small Bites
  • Perfect Cow Feet,legs udder calve every year for 15-20 years docile right color polled calf grows like stink Cow does her thing in near desert, mountain slopes, near north Not perfect – then maternal breed complements a terminal sire Bonus hybrid vigor
  • Selection based on these characteristic have allowed for the fine tuning that individual producers need in order to respond to the market drivers within their particular environment. Eg. Central ab tan continental vs south British   The major downside of traditional selection is the length of generation time required to establish proofs of genetic change in an animal produces one calf per year and at least 3 years for this calf to reach production age.
  • Cattle Selection using genomics will potentially allow marker assisted selection for economic, production and convenience traits more directly resulting in an accelerated rate of genetic change. Increase uniformity, predictability and accuracy of carcass value in live seedstock Increase profitability through feed efficiency Identification of convenience traits such as polled, colour and docility etc. Improved predictability with regard to animal health, (For example, innate resistance to BVD, Johne’s disease, genetic defects. Etc.) Traceability Internationally recognized parentage identification/verification including multi-sire groups
  • If all breeders select for the same markers will breed distinctions disappear into a homogenous beef breed? Can we get everything we need in one breed? Can marker assisted selection be used to reinforce breed distinctions or will there be a tendency to homogenize all breeds based on current market drivers? How important is variation to the overall survival and productivity of the cattle industry?   Clearly, different production environments will require the ability to quickly adapt to change in market or ecological constraints. We need to reaffirm the necessity for the propagation of specific breeds.
  • One of the major challenges many purebred breeders face is having the lack of access to carcass data. It remains difficult to get carcass information back to the breeders before the animal progeny is slaughtered The Canadian Gelbvieh Association (CGA), like most breeds was fortunate to receive the Gov of Canada “Sustaining the Genetic Quality of Ruminants” (SGQR) grant in 2005. The CGA took a portion of this grant and applied it to run Genestar DNA profiles on all active sires (AI and pasture) using the marker panel offered at that time by Bovigen. These markers included 3 marbling and 3 tenderness SNPs. In addition the CGA offered to subsidized ultrasound on these and all calendar year bull prospects. Correlation between ultrasound and snp’s were not always perfect but results were nonetheless very interesting.   The American Gelbvieh Association (AGA) also invested in testing a significant number of sires. As both Canada and US have international EPD’s the ultimate goal is the addition of all DnA data to improve the accuracy of Carcass EPD’s by incorporating SNP results.   To continue this research into genomic technology, we have entered into an agreement with the University of Alberta AB GP to collect samples from all active Gelbvieh sires and cows. To date, we have an estimated 68% of registered Gelbvieh cattle collected. This number includes sires, dams and their progeny including deads. In addition, The U of A is providing parentage testing on all active sires, embryo calves and donors.
  • CBGW Diane Panrucker Panel

    1. 1. ALMA Alberta Livestock & Meat Agency Ltd. Canadian Bovine Genomics Workshop September 14, 2009 Calgary, Alberta
    2. 2. Questions to Panel 1 Participants Diane Panrucker
    3. 3. <ul><li>Currently, purebred breeders use measurements of phenotype traits to genetically select for: </li></ul><ul><li>  </li></ul><ul><ul><li>Optimal production, convenience, and carcass traits </li></ul></ul><ul><ul><li>Environmental Adaptation </li></ul></ul><ul><ul><li>Breed complementarities </li></ul></ul><ul><ul><li>Hybrid vigor </li></ul></ul>
    4. 4. <ul><li>Selection based on phenotype has resulted in the fine tuning that individual breeds need in order to respond to the market drivers within their particular environment. </li></ul><ul><li>The major downside of traditional selection is the length of generation time required to establish proofs of change. </li></ul>
    5. 5. <ul><li>Marker assisted selection can be applied to economic, production and convenience traits more directly, resulting in an accelerated rate of genetic change. </li></ul><ul><ul><li>Increase uniformity, predictability and accuracy of carcass value in live seedstock </li></ul></ul><ul><ul><li>Increase profitability through feed efficiency </li></ul></ul><ul><ul><li>Identification of convenience traits such as polled, colour and docility etc. </li></ul></ul><ul><ul><li>Improved predictability with regard to animal health, (For example, genetic defects, innate resistance to BVD, Johne’s disease) </li></ul></ul><ul><ul><li>Traceability </li></ul></ul><ul><ul><li>Internationally recognized parentage identification/verification including multi-sire groups </li></ul></ul>
    6. 6. <ul><li>Can marker assisted selection be used to reinforce breed distinctions or will there be a tendency to homogenize all breeds based on current market drivers? </li></ul><ul><li>How important is variation to the overall survival and productivity of the cattle industry? </li></ul><ul><li>Do we need to reaffirm the necessity for the propagation of specific breeds? </li></ul><ul><li>Widely different production environments will require the ability to quickly adapt to change in market or environmental constraints. </li></ul>
    7. 7. <ul><li>“ Those that benefit the most economically are those that have the most control of the end product. The more sectors within the production chain, the less the economic rewards will flow to the beginning of the chain. Risk, on the other hand, is spread more evenly throughout the sectors.” anonymous </li></ul><ul><li>Incentive for investing in technology, new or old, must show a reasonable expectation of economic benefit to those paying the cost. </li></ul>
    8. 8. <ul><li>Applied research, like industry, is driven by market forces. Commercialization of technology as an end product must stand up to supply and demand i.e. those that benefit must be willing to pay. </li></ul><ul><li>Risk/Benefit must be shared by both research and commercialization. </li></ul>
    9. 9. <ul><li>Major challenge facing CGA is the lack of access to carcass data back to breeders. </li></ul><ul><li>“ Sustaining the Genetic Quality of Ruminants” (SGQR) grant in 2005 provided opportunities: </li></ul><ul><li>DNA profiles on all active sires (AI and pasture) using the marker panel offered at that time by Bovigen. </li></ul><ul><li>Subsidized ultrasound was done on the above sires and all calendar year bull prospects. </li></ul><ul><li>Correlation between ultrasound and SNP’s were not always perfect but results were nonetheless very interesting. </li></ul>
    10. 10. <ul><li>To continue this research using genomic technology, the CGA has entered into an agreement with Dr. Moore’s group at the University of Alberta to collect samples from active Gelbvieh sires, cows and their progeny including the dead. </li></ul><ul><li>To date, we have an estimated 68% of the Gelbvieh herd collected. </li></ul><ul><li>The U of A is providing parentage testing on all active cattle, embryo calves and donors. </li></ul>
    11. 11. <ul><li>CGA has international EPD’s and mandatory ROP since 1996 </li></ul><ul><li>The ultimate goal is the addition of all SNP data to existing carcass and ultrasound data to improve the accuracy of Carcass EPD’s or GDP’s internationally. </li></ul><ul><li>The AGA has also invested in the testing a significant number of sires using available SNP’s . </li></ul><ul><li>Many individuals have independently provided SNP data on select sires and dams </li></ul>
    12. 12. <ul><li>Canada has become well known for the quality of our cow herd. As we are not now, nor do we expect to be, a low cost producer, it is to our advantage to instead promote the quality, uniformity, and health of our genetic base. </li></ul><ul><li>Our genetics, when coupled with favorable environment and climate, high health standards, and a relatively stable economy would help in branding superior Canadian beef. </li></ul>
    13. 13. <ul><ul><li>Accelerated selection of superior traits </li></ul></ul><ul><ul><li>Increased predictability, uniformity and consistency </li></ul></ul><ul><ul><li>Improved herd health </li></ul></ul><ul><ul><li>Traceability </li></ul></ul>

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