Growth Regulation
regulated by the anterior pituitary
growth hormone (GH) – levels dictate amount of
growth in developing ...
Growth Hormone Regulation
hypothalamus
growth hormone
releasing hormone
(GHRH)

growth hormone
inhibiting hormone
(GHIH)
a...
Growth Hormone Effects
cartilage & bone – increased length and width of

skeleton

muscle cells – increased cell number
...
Growth Hormone Abnormalities
1. Dwarfism
2. Gigantism
3. Acromegaly
1. Dwarfism
Cause:
decreased GH secretion during childhood

Result:
limited height (4 feet tall)
normal proportions
1. Dwarfism
2. Gigantism
Cause:
increased GH secretion during childhood

Symptom:
height much taller than average

Treatment:
surge...
2. Gigantism
3. Acromegaly
Cause:
increased GH secretion as an adult

Symptom:
bone lengthening has stopped


bone width increases

...
08b growth regulation
08b growth regulation
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08b growth regulation

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08b growth regulation

  1. 1. Growth Regulation regulated by the anterior pituitary growth hormone (GH) – levels dictate amount of growth in developing organism peptide hormone
  2. 2. Growth Hormone Regulation hypothalamus growth hormone releasing hormone (GHRH) growth hormone inhibiting hormone (GHIH) anterior pituitary GH half-life is 20 – 30 min growth hormone (GH)
  3. 3. Growth Hormone Effects cartilage & bone – increased length and width of skeleton muscle cells – increased cell number (hyperplasia) and cell size (hypertrophy) ribosome function – increased protein production fat metabolism – fatty acids as energy source
  4. 4. Growth Hormone Abnormalities 1. Dwarfism 2. Gigantism 3. Acromegaly
  5. 5. 1. Dwarfism Cause: decreased GH secretion during childhood Result: limited height (4 feet tall) normal proportions
  6. 6. 1. Dwarfism
  7. 7. 2. Gigantism Cause: increased GH secretion during childhood Symptom: height much taller than average Treatment: surgery if hypersecretion due to tumor growth on pituitary
  8. 8. 2. Gigantism
  9. 9. 3. Acromegaly Cause: increased GH secretion as an adult Symptom: bone lengthening has stopped  bone width increases Treatment: surgery if hypersecretion due to tumor growth on pituitary

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