Anatomy and Physiology Article New approach to regenerating skeletal muscle article 12 05_12
Potential New Approach to strength and improves the survival rate ofRegenerating Skeletal Muscle the affected animals. This is the first study to demonstrate the functional and stableTissue integration of AFS cells into skeletal muscle, highlighting their value as a cellNAME ________________ DATE_____ per# source for the treatment of muscular dystrophies.ScienceDaily (June 1, 2012) — Aninnovative strategy for regenerating skeletal However, the research is still at a relativelymuscle tissue using cells derived from the early stage as the work has only been carriedamniotic fluid is outlined in new research out in animal models.published by scientists at the UCL Instituteof Child Health. Dr Coppi said: "Spinal muscular atrophy is a genetic disease affecting one in 6,000 births.The paper shows that damaged muscle It is currently incurable and in its mosttissues can be treated with cells derived severe form children with the condition mayfrom the fluids which surround the fetus not survive long into childhood. Childrenduring development, leading to satisfactory with a less severe form face the prospect ofregeneration and muscle activity. The progressive muscle wasting, loss of mobilitytreatment resulted in longer survival in mice and motor function. There is an urgent needaffected by a muscle variant of spinal for improved treatments.muscular atrophy. This is the first time thatregeneration of diseased muscle tissue hasbeen obtained using cells derived from "We are excited by this potential newamniotic fluid. approach for regenerating skeletal muscle tissue, but much more research is needed. We now need to perform more in-depthThe research appears in the journal Stem studies with human AFS cells in mouseCells, is authored by Dr Paolo de Coppi models to see if it is viable to use cells(UCL Institute of Child Health and surgeon derived from the amniotic fluid to treatat Great Ormond Street Hospital) and diseases affecting skeletal muscle tissue."colleagues in Paris and Padova, andrepresents an impressive development in the Review Questions (Cornell Format)growing field of regenerative medicine. 1. When was the article published?Muscle derived stem cells are presentlyconsidered the best source for muscle 2. Where have researchers isolated cellsregeneration. However they cannot be used used to aid in muscle regeneration?to treat muscular dystrophies because thestem cells themselves are affected in 3. What disease affected the mice in theindividuals with these conditions. Due to study?this challenge, other cell sources have beenexplored but so far no definitive treatment 4. What was this research exciting andhas been successful. also important in the regeneration of muscle tissue.De Coppis team has demonstrated thatintravenous transplantation of amniotic fluidstem (AFS) cells enhances the muscle
5. What type of cells are currently considered to be the best for muscle regeneration?6. Why can’t they be used to treat muscular dystrophies?7. What did De Coppi’s team demonstrate using intravenous transplantation of amniotic fluid stem cells in regards to muscle function?8. What type of models has this research only been carried out in?9. What type of challenges do children with less server forms of spinal muscular atrophy face?10. What is the nest step in the research presented in the article?