Pedigrees lesson

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Pedigrees lesson

  1. 1. Pedigree charts
  2. 2. Pedigree chartsWhy do we use them?Because experimental crosses with humans are notpossible.Then what information do we use to determineinheritance of traits?-Medical history-Historical data-Family records
  3. 3. Pedigree chartsSome symbols to remember: Normal female Female with phenotype of interest Normal male Male with phenotype of interest Normal (sex is unknown) Person with phenotype of interest (unknown sex) Female heterozygous for recessive allele Male heterozygous for recessive allele
  4. 4. Pedigree chartsSome symbols to remember: Roman numerals I represent generation II First born Last born siblings
  5. 5. Pedigree chartsSome symbols to remember:III One-egg Two-egg Monozygotic dizygotic Identical twins fraternal twins
  6. 6. Pedigree chartsHow do we use a pedigree chart?When people have children… Mother’s family Father’s familyIIIIII If this child had a genetic disease, we can trace who it came from by completing the pedigree from family and medical records
  7. 7. Pedigree chartsHemophilia in the royal familyIIIIIIIV0
  8. 8. Pedigree chartsHemophilia
  9. 9. Pedigree chartsHemophilia in the royal family
  10. 10. Pedigree chartsRoyal Family Historical Record
  11. 11. Pedigree chartsAlbino
  12. 12. Pedigree chartsPedigree showing albinism
  13. 13. Pedigree chartsTay Sachs
  14. 14. Pedigree chartsPedigree showing Tay Sachs
  15. 15. Pedigree charts Autosomal recessive: Involves a recessive allele on a non-sex chromosome Autosomal dominant: Involves a dominant allele on a non-sex chromosome X-linked recessive: Involves a recessive allele on the X-chromosome X-linked dominant: Involves a dominant allele on the X-chromosome Y-linked: Involves an allele on the Y-chromosome

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