Acitretin 노출AbstractWe assessed the pregnancy outcome of nine women inadvertently transfused with acitretin-contaminated blood products in South Korea. A total of 18 women matched to cases by age,gravidity, and singleton- or twin-pregnancy, and who were transfused with blood products notcontaminated with acitretin, was also recruited. There were nine babies born in the case group.No differences (p > 0.05) were observed between cases and controls in the gestational age atdelivery (38.3 +/- 1.6 weeks vs 37.8 +/- 2.2 weeks), birth weight (3,146 +/- 874 g vs 3,106 +/-568 g), rate of pre-term deliveries (22.2% vs 11.1%) and rate of low birth weight (<2,500 g)(33.3% vs 16.7%). There was no case of malformation or neurological abnormalities born ineither group. In conclusion, inadvertent exposure to acitretin-contaminated blood productswas not associated with adverse pregnancy outcomes, probably because of the removal ofacitretin and etretinate during the manufacturing process of blood products.
갑상선질환 Lab. test Frequency TSH, below 3.9 % (26/659) TSH, high 3.3 % ( 22/659) 갑상선항진증 : 조산, 임신중독증 성장장애, 사산 갑상선저하증 : 지능저하, 저체중증, 임신중독증, 조기태반박리, 사산
당뇨병 0.5% (3/572) 핚국마더세이프젂문상담센터 2010 9MalformationsPercent of 8 8.8 In diabetic women 7 6 Counseling(n=601) 5 5.6 No counseling(n=612) Counseling No counseling 4 All women(n=1855) All women 3 2 1 (Lancet 1992) 1.0 0 1
0.5% (3/572)핚국마더세이프젂문상담센터 2010 간질(Epilepsy) Drug Abnormalities Affected Catego. 1-2% with monotherapyValproate NTD, Clefts, Skeletal abnormalities, developmental delay 9-12% with polytherapy D Fetal hydantoin sd: craniofacial anomalies, finger nail hypoplasia,Phenytoin Growth deficiency, cardiac defects, clefts, developmental 5-11% D delayCarbamazepine Fetal hydantoin sd, spina bifida 1-2% DPhenobarbital Clefts, cardiac anomalies, Urinary tract malformations 10-20% D Inhibits dihydrofolate reductase, lowering fetal folate levels, 4-fold with monotherapyLamotrigine Registry data suggest increased risk for clefts 10-fold with polytherapy CTopiramate Registry data suggest increased risk for clefts 2% C Theoretical-skeletal abnormalities and impaired growth in a Too few cases reported toLevetriacetam nimals ant doses similar to or greater than human therapeu assess risk C tic doses