Prostate cancer

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Morwenna discusses the role of herbal medicine in the prevention and treatment of prostrate cancer.

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Prostate cancer

  1. 1. 27/03/2012 PROSTATE CANCERA TALK FOR THE PROSTATE CANCER NETWORK TORONTO BY MORWENNA GIVEN MEDICAL HERBALISTBA MA (OXON) BSC M.OHA BHG RH 1 WWW.MEDICUSHERBIS.COM
  2. 2. 2 27/03/2012 WHO AM I?I am a medical herbalist, trained in University, Hospital and clinics With a practise in downtown Toronto focussing on cancer & precancerous conditions e.g prostatitis & BPH Due time constraints a fuller version of this talk can be found on: WWW.MEDICUSHERBIS.COM ©
  3. 3. 3 27/03/2012 WHO AM I?Iam a medical herbalist, trained in University, Hospital and clinics With a practise in downtown Toronto focussing on cancer & precancerous conditions e.g prostatitis & BPH Due time constraints a fuller version of this talk can be found on: WWW.MEDICUSHERBIS.COM ©
  4. 4. 4 27/03/2012HOW AM I TRAINED? ©
  5. 5. 5 27/03/2012 WHAT IS A MEDICAL HERBALIST?A person who treats medical disease ‗wholistically‘ on an evidence based basis with whole plant extracts A person who has trained in University, hospital, clinic environments A person who treats the cause of the problem not just the symptom We are specialists in the use of medicinal plants and their ability to resolve disease ©
  6. 6. 6 27/03/2012 WHAT IS CANCER?Cancer is an endocrine metabolicdisease; a disease which travelsthrough glands affecting all thechemical and physical processeswhich allow the body to functioncreating Inflammation & Uncontrolledgrowth of cells ©
  7. 7. 7 27/03/2012CANCER TAKES @ 10-15 YRS TO DEVELOP INTO A TUMOUR As a Medical Herbalist I monitor signs for cancer long before a tumour is visible ©
  8. 8. 8 27/03/2012 CANCER IS CANCER WHEREVER IT IS LOCATED IN THE BODY If cancer is detected in the prostate it is called prostate cancer because of the way conventional medicine is organised; It remains an endocrine metabolic disease throughout the body not confined one area. 90% OF ALL CANCERS ARE CAUSED BY ENVIRONMENTAL FACTORS ©
  9. 9. 9 27/03/2012WHEN CANCER IS SHOWN IT IS already CHRONIC disease ©
  10. 10. 10 27/03/2012CAUSES OF PROSTATE CANCER (diet) Nobel prize winner 1931 Warburg – identified the principal metabolic (glycolytic) switch of cancer - i.e. excess sugars in the body ©
  11. 11. 11 27/03/2012 Physiological DRIVERS OF PROSTATE CANCER Poor blood flow to prostatic tissues Poor excretion from prostatic tissues Inflammation –drugs conventional & social Weak or disrupted innate bodily immune/ mechanisms including excess hormones Decreased immune surveillance Blockage – lymphatic drainage – bacteria - viruses Bodily & mental stress Other conditions associated e.g. thyroid malfunction ©
  12. 12. 12 27/03/2012 TESTS PSA Urine PCA3, Prostascint , PAP CTC & Chromagranin A Following radical prostatectomy zinc, vitamin D, osteocalcin are good predictors ―The majority incorrectly equated improved survival and early detection with lives saved by screening. About one half (47%) incorrectly reported that discovering cancer in screened, as opposed to unscreened, populations is evidence that screening saves lives.‖ In fact screening provides 0.4% reduction in 1000 inmortality in 5 years ( European trials ) ©
  13. 13. 13 27/03/2012 TESTS (There are others) Elevated CRP indicates the degree of inflammation Homocysteine shows DNA stability Free PSA is a better marker than PSA PAP gives a probable spread beyond the gland Prolactin is a cell proliferator and cell stimulant ©
  14. 14. 14 27/03/2012CONVENTIONAL TREATMENTS None address cause ©
  15. 15. 15 27/03/2012 DRUGS USED TO TREAT Anti Androgens Gonadorelin analogues Alkylating drugs All have significant side effects
  16. 16. 16 27/03/2012 OVER TREATMENT Biopsies are highly inflammatory PSA & other tests do not have high reliability Many drugs cause other problems Ignores causes Use of invasive surgery despite low levels of hormones
  17. 17. 17 27/03/2012 CONSEQUENCES of CONVENTIONAL TREATMENTS Surgery: Jones in 1895 and Peeters in 2005 Journal of Surgery both observed: Surgical removal of the primary tumour activates cancer Radiation: Destabilises - DNA – burns and thus is highly inflammatory Chemotherapy: Limited value - destructive of good and bad cells ONLY works IN S phase – does not address cause – long term issues
  18. 18. 18 27/03/2012 WATCHFUL WAITING A GOLDEN OPPORTUNITYI DO NOT BELIEVE THAT WAITING IS A GOOD SOLUTION because CANCER CAN CONTINUE TO DEVELOP As IT IS A CHRONIC METABOLIC DISEASE BUT AFTER A PROSTECTOMY PLANTS CAN INHIBIT THE METABOLIC PROGRESS OF CANCER ©
  19. 19. 19 27/03/2012 PREVENTION Cancer is a Preventable Disease that Requires Major Lifestyle Changes B.B Aggwal et al. MD Anderson Cancer Research Centre Pharm Res. 2008 September; 25(9): 2097–2116. Pub. online 2008 Jul 15. doi: 10.1007/s11095-008-9661-9. 2.8M Cancer cases per year are preventable Martin Wiseman Project Director World Cancer Research Fund 2011  EARLY DETECTION & SURGERY IS NOT PREVENTION
  20. 20. 20 27/03/2012 Other protocols For those who choose chemo: I have a supporting protocol to prevent side effects and limit the damage For those who choose radiation: I have a supporting protocol to prevent lesions common in 60% of cases. None of my patients have experienced these.
  21. 21. 21 27/03/2012PLANTS CAN BLOCK EVERYMAJOR CANCER PATHWAY ©
  22. 22. 22 27/03/2012 A MEDICAL HERBALIST TREATS THE CAUSESWe address the physiological drivers:Decrease inflammationStrengthen body resistance/ vitality - reduce/eliminatebacteria & viruses, ENSURE proper lymphatic drainageManage stress; reduce excess hormonesIncrease immunity and immune surveillance by the bodyEnsure major organs function normallyCytotoxicity for cancerous cells andfinally return the body to HOMEOSTASIS
  23. 23. 23 27/03/2012 PLANTS AND CANCER There is a substantial amount of evidence base showing how plants can reverse cancer both in a general and specific context. The specific plants chosen depend on the patient‘s needs – there is no one size fits all.Plants it is rare to have side effects and thereare no long term negative consequences
  24. 24. 24 27/03/2012 SOME PLANTS USED IN PROSTATE CANCER Curcuma longa – the perfect anti cancer plant/ drug - mediates 98 metabolic pathways; inhibits 14 types of cancer Serenoa serulata: ―Lipids/sterols known to be inhibitor of 5alpha reductase‖ Performed better than Finasteride in clinical trials Capsicum minimum: ― inhibits growth of androgen independent prostate cancer cells carrying the common P53 mutation‖ Cimicifuga racemosa L. Nutt ― inhibits androgen sensitive and insensitive cells by apoptosis‖ c.
  25. 25. 25 27/03/2012 STRATEGIES WHICH ADDRESSTHE PHYSIOLOGICAL DRIVERS: DECREASE INFLAMMATION STRENGTHEN THE BODY MANAGE STRESS MANAGE HORMONES INCREASE IMMUNITY DETOX THE BODY DIET & LIFESTYLE ADDRESS OTHER ISSUES ©
  26. 26. 26 27/03/2012 DECREASE INFLAMMATION All chronic conditions are caused by persistent inflammation The inflammatory cascade is governed by eicosanoids (Cox) which produce prostaglandins, leukotrienes and TNF/TGF Unhealthy diet & lifestyle can cause cells to over react producing high levels of prostaglandins resulting in a chronic feedback loop Inflammation increases angiogenesis. Increases VEGF which causes cells to proliferate and ILGF which in turn is influenced by age, weight, and exercise MH has many anti inflammatory herbs e.g. Boswellia , Curcuma longa, Salix ©
  27. 27. 27 27/03/2012 STRENGTHEN THE BODY We look at all aspects of bodily function, identify the stressed functions, provide appropriate herbal support e.g. the heart Eliminate pathogenic bacteria Eliminate or control viruses Role of Thyroid
  28. 28. 28 27/03/2012 MANAGE STRESS The GAS syndrome – Hans Selye - Canadian Stress is known to deplete immunity and increase the rate of Prostate Growth. It releases pro inflammatory cytokines which act as stimulants MH has a significant number of plants called adaptogens ideally suited to manage stress: Astragalas membranaceous Glycorrihiza glabra Withania somniferum Panax Ginseng
  29. 29. 29 27/03/2012 MANAGE HORMONES Testosterone is produced by the testicular Leydig cells under the influence of pulsatile secretion of luteinizing hormone— releasing hormone from the anterior hypothalamus, which in turn is regulated by negative feedback inhibition of the pituitary-gonadal axis by circulating testosterone. Most testosterone in circulation is bound to sex hormone— binding globulin and albumin. Only 1% to 2% of testosterone exists in the free, unbound form that diffuses into target cells of the prostate, testis, adrenal gland, skin, muscle, bone, and adipose tissue, where it is irreversibly converted into a more potent biologically active metabolite, dihydrotestosterone (DHT),by action of 5α-reductase (5αR) There are herbs which modify every single step of this pathway e.g. Vitex, Serenoa, Cimicifuga, Urtica Radix
  30. 30. 30 27/03/2012 INCREASE IMMUNITY Prostate cancer is linked to a depressed or depleted immune system; this reduces immune surveillance which results in the dysfunction of Cells Some Medical Herbs which increase immunity are: Eccinachea spp. Astragalas membranaceous Panax ginseng Phytolacca decandra Recent Noble prize winner for Chemistry tried to synthesise a drug for dendritic cells – Echinacea does this
  31. 31. 31 27/03/2012 DETOX THE BODY Ensure major organs, bowels, lungs, urinary system are in proper working order i.e. excretion, diuretics Ensure proper drainage of tissues to provide for excretion i.e. lymphatics Stimulate the circulatory tissues to deliver proper nutrients to tissues And stimulate the drainage of those tissues.
  32. 32. 32 27/03/2012 DIET Balanced diet high in fruit and vegetables Avoid refined carbs Probiotics – goats yoghourt High protein Minimise fats especially saturated fats For my patients I give specific advice to their circumstances
  33. 33. 33 27/03/2012 VITAMIN D Vitamin D is poorly understood ; currently 8 forms identified - most common form - Vitamin D3 Involved in the Pathogenesis of cancer, hypertension, MS, auto immune, osteoporosis, osteoarthritis, pulmonary disease, Crohns, diabetes, thyroid function, blood clotting, liver function AR signaling pathway is affected by vitamin D, which is known to promote growth inhibitory effects in prostate cancer. Most Canadians deficient. Grant W, et.al. An estimate of the economic burden and premature deaths due to vitamin D deficiency in Canada, Molecular Nutrition and Food Research, volume 54, Issue 8, p. 1172-1181, août 2010.
  34. 34. 34 27/03/2012 LIFESTYLE CHANGES Essentialto beating cancer as it is lifestyle that has contributed to the disease Exercise - improves oxygen flow to theprostate Stop smoking BMI less than 24 Relax Hydrotherapy Tai Chi Qi Gong Acupuncture etc
  35. 35. 35 27/03/2012 CARERS Therole of the carer is vitally important but often exhausting. Herbalists have a wide range of plants to deal with the personal health of the carer together with specific plants for stress The diet and lifestyle changes I suggest are for the good health of the carer too.! ©
  36. 36. 36 27/03/2012 CASE STUDY 15/05/06 56yrs West Indian poor urinary flow, pain, nocturia, haematuria, anejaculation, chest pain, back pain BMI 25 PMH: Angina, vasectomy, poor diet, no drugs or supplements DRE: enlarged irregular nodular prostate PSA: 5000+ ng/ml Biopsy: Gleason 9 Grade 5 Isotopic bone scan : osteosclerotic bone meets lumbar spine, lower ribs, pelvis & femur ©
  37. 37. 37 27/03/2012 CASE STUDY RESULT 15/05/06 PSA 5000 ng/ml 15/06/06 PSA 1000 ng/ml 17/07/06 PSA 300 ng/ml 02/08/06 PSA 0.9 ng/ml 19/03/07 PSA 0.7 ng/ml On every visit modify the RX if required & check bloods No pain, no urgency, flow normal, no nocturia ©
  38. 38. 38 27/03/2012 SUPPLEMENTS There are some specific supplements beneficial in prostate cancer such as lycopene Retail supplements are not allowed by law to have a medical effect and thus the doses maybe inappropriate Always consult your professional practitioner first before purchasing ©
  39. 39. 39 27/03/2012 Supplements illegalto sell a medically efficacious dose most are not pharmaceutical grade no evidence base / extrapolation claims Contents /label/marketing claim Unnecessary No consideration of individual needs Failure to address polysupplementation ©
  40. 40. 40 27/03/2012 CAUTIONS PLEASE NOTE IT IS ADVISED, THAT ANY PLANTS MENTIONED IN THIS TALK, ARE ONLY USED UNDER PROFESSIONAL GUIDANCE. BOTANICAL MEDICINE AS SUPPLIED BY A PROFESSIONAL IS NOT AVAILABLE OVER THE RETAIL COUNTER. It is not advisable to self treat A professional: will recognise all the issues within the body Select herbs that will impact positively on these issues without causing problems in order to co exist with orthodox drugs, ©
  41. 41. 41 27/03/2012REFERENCES & EVIDENCE BASE www. Pubmed, Science directIhave a full list of references for those who are interested – if you would like either to email me or put your name down tonight I will send them to you. ©
  42. 42. 42 27/03/2012 THANK YOU MORWENNA GIVENWWW.MEDICUSHERBIS.COM © 2012

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