15 27/03/2012 DRUGS USED TO TREAT Anti Androgens Gonadorelin analogues Alkylating drugs All have significant side effects
16 27/03/2012 OVER TREATMENT Biopsies are highly inflammatory PSA & other tests do not have high reliability Many drugs cause other problems Ignores causes Use of invasive surgery despite low levels of hormones
17 27/03/2012 CONSEQUENCES of CONVENTIONAL TREATMENTS Surgery: Jones in 1895 and Peeters in 2005 Journal of Surgery both observed: Surgical removal of the primary tumour activates cancer Radiation: Destabilises - DNA – burns and thus is highly inflammatory Chemotherapy: Limited value - destructive of good and bad cells ONLY works IN S phase – does not address cause – long term issues
19 27/03/2012 PREVENTION Cancer is a Preventable Disease that Requires Major Lifestyle Changes B.B Aggwal et al. MD Anderson Cancer Research Centre Pharm Res. 2008 September; 25(9): 2097–2116. Pub. online 2008 Jul 15. doi: 10.1007/s11095-008-9661-9. 2.8M Cancer cases per year are preventable Martin Wiseman Project Director World Cancer Research Fund 2011 EARLY DETECTION & SURGERY IS NOT PREVENTION
20 27/03/2012 Other protocols For those who choose chemo: I have a supporting protocol to prevent side effects and limit the damage For those who choose radiation: I have a supporting protocol to prevent lesions common in 60% of cases. None of my patients have experienced these.
22 27/03/2012 A MEDICAL HERBALIST TREATS THE CAUSESWe address the physiological drivers:Decrease inflammationStrengthen body resistance/ vitality - reduce/eliminatebacteria & viruses, ENSURE proper lymphatic drainageManage stress; reduce excess hormonesIncrease immunity and immune surveillance by the bodyEnsure major organs function normallyCytotoxicity for cancerous cells andfinally return the body to HOMEOSTASIS
23 27/03/2012 PLANTS AND CANCER There is a substantial amount of evidence base showing how plants can reverse cancer both in a general and specific context. The specific plants chosen depend on the patient‘s needs – there is no one size fits all.Plants it is rare to have side effects and thereare no long term negative consequences
24 27/03/2012 SOME PLANTS USED IN PROSTATE CANCER Curcuma longa – the perfect anti cancer plant/ drug - mediates 98 metabolic pathways; inhibits 14 types of cancer Serenoa serulata: ―Lipids/sterols known to be inhibitor of 5alpha reductase‖ Performed better than Finasteride in clinical trials Capsicum minimum: ― inhibits growth of androgen independent prostate cancer cells carrying the common P53 mutation‖ Cimicifuga racemosa L. Nutt ― inhibits androgen sensitive and insensitive cells by apoptosis‖ c.
27 27/03/2012 STRENGTHEN THE BODY We look at all aspects of bodily function, identify the stressed functions, provide appropriate herbal support e.g. the heart Eliminate pathogenic bacteria Eliminate or control viruses Role of Thyroid
28 27/03/2012 MANAGE STRESS The GAS syndrome – Hans Selye - Canadian Stress is known to deplete immunity and increase the rate of Prostate Growth. It releases pro inflammatory cytokines which act as stimulants MH has a significant number of plants called adaptogens ideally suited to manage stress: Astragalas membranaceous Glycorrihiza glabra Withania somniferum Panax Ginseng
29 27/03/2012 MANAGE HORMONES Testosterone is produced by the testicular Leydig cells under the influence of pulsatile secretion of luteinizing hormone— releasing hormone from the anterior hypothalamus, which in turn is regulated by negative feedback inhibition of the pituitary-gonadal axis by circulating testosterone. Most testosterone in circulation is bound to sex hormone— binding globulin and albumin. Only 1% to 2% of testosterone exists in the free, unbound form that diffuses into target cells of the prostate, testis, adrenal gland, skin, muscle, bone, and adipose tissue, where it is irreversibly converted into a more potent biologically active metabolite, dihydrotestosterone (DHT),by action of 5α-reductase (5αR) There are herbs which modify every single step of this pathway e.g. Vitex, Serenoa, Cimicifuga, Urtica Radix
30 27/03/2012 INCREASE IMMUNITY Prostate cancer is linked to a depressed or depleted immune system; this reduces immune surveillance which results in the dysfunction of Cells Some Medical Herbs which increase immunity are: Eccinachea spp. Astragalas membranaceous Panax ginseng Phytolacca decandra Recent Noble prize winner for Chemistry tried to synthesise a drug for dendritic cells – Echinacea does this
31 27/03/2012 DETOX THE BODY Ensure major organs, bowels, lungs, urinary system are in proper working order i.e. excretion, diuretics Ensure proper drainage of tissues to provide for excretion i.e. lymphatics Stimulate the circulatory tissues to deliver proper nutrients to tissues And stimulate the drainage of those tissues.
32 27/03/2012 DIET Balanced diet high in fruit and vegetables Avoid refined carbs Probiotics – goats yoghourt High protein Minimise fats especially saturated fats For my patients I give specific advice to their circumstances
33 27/03/2012 VITAMIN D Vitamin D is poorly understood ; currently 8 forms identified - most common form - Vitamin D3 Involved in the Pathogenesis of cancer, hypertension, MS, auto immune, osteoporosis, osteoarthritis, pulmonary disease, Crohns, diabetes, thyroid function, blood clotting, liver function AR signaling pathway is affected by vitamin D, which is known to promote growth inhibitory effects in prostate cancer. Most Canadians deficient. Grant W, et.al. An estimate of the economic burden and premature deaths due to vitamin D deficiency in Canada, Molecular Nutrition and Food Research, volume 54, Issue 8, p. 1172-1181, août 2010.
34 27/03/2012 LIFESTYLE CHANGES Essentialto beating cancer as it is lifestyle that has contributed to the disease Exercise - improves oxygen flow to theprostate Stop smoking BMI less than 24 Relax Hydrotherapy Tai Chi Qi Gong Acupuncture etc