Zinc in body


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Zinc in body

  1. 1. Zinc In Body By: Shaheryar Ahmed Ranjha
  2. 2. Contents: • • • • • • • • • Zinc: a micronutrient Zinc-Rich Foods and RDA Absorption Distribution Excretion Functions Clinical Aspect and Significance Therapeutic Significance in treatment of Diarrhoea Synopsis
  3. 3. Zinc- a micronutrient: • 3rd most abundant trace element in body • Essential for the proper function of cellular metabolism • About 100 enzymes rely on zinc to help them catalyze vital chemical reactions • Protects cell membranes from oxidative damage and stabilizes the structure of cell proteins •Zinc proteins bind to DNA and help the cells to do what • Important for growth, gestation and disease prevention • Helps control the release of hormones and the transmission of nerve impulses
  4. 4. Zinc Rich Foods Do you take any of these food daily, if yes? so you are taking in zinc!!
  5. 5. Recommended Daily Allowance of Zinc: The Recommended Dietary Allowance (RDA for zinc: Infants 0 - 6 months: 2* milligrams per day (mg/day) 7 - 12 months: 3* mg/day *Adequate Intake (AI) Children 1 - 3 years: 3 mg/day 4 - 8 years: 5 mg/day 9 - 13 years: 8 mg/day Adolescents and Adults Males age 14 and over: 11 mg/day Females age 14 to 18 years: 9 mg/day Females age 19 and over: 8 mg/day Pregnant and lactating mothers: 25mg/day The best way to get the daily requirement of essential minerals is to eat a balanced diet that contains a variety of foods.
  6. 6. Absorption: • In humans, zinc is absorbed mainly in the Dudoneum and Ileum • 33 percent is accepted as the average zinc absorption in humans • zinc may be more bio-available from drinking water than from food • The pancreas secretes a zinc binding factor which helps in the absorption of zinc • HIGH amounts of Calcium phosphate and phytic acid interfere with zinc absorption • Zinc-deprived humans absorb this element with increased efficiency, whereas humans on a high-zinc diet show a reduced efficiency of absorption
  7. 7. Distribution: •Zinc absorbed from the intestine is carried to the liver bound to albumin •Zinc is present in the human body in the concentration of 0.3 mg/ kg body weight •Zinc is abundant in red and white blood cells , with zinc found in the erythrocytes largely bound to carbonic anhydrase •The remaining plasma zinc is primarily bound to albumin •Redistribution of zinc can occur under stress
  8. 8. Excretion: • Zinc is primarily excreted via the gastrointestinal tract • Excretory mechanisms contribute to zinc homeostasis; • Under normal circumstances, about 0.5 mg of zinc may be lost in perspiration, and about an equal amount is lost in daily urine • Although the kidney nephrons appear capable of secreting and reabsorbing zinc, urinary zinc does not appear to fluctuate with diet • High-protein diets, however, are reported to increase urinary zinc
  9. 9. Functions: Zinc plays a vital role in the following:  Enzyme Action  Vitamin A metabolism  Insulin Secretion  Growth and Reproduction  Wound Healing  Biosynthesis of Mononucleotides  Binding of regulatory proteins to DNA  Three Unique Motifs  Zinc- finger Motif
  10. 10. Clinical Aspect: ZINC- DEFICIENCY DISEASE Acrodermatitis Enteropathica • A rare inherited disease of abnormal zinc absorption • Autosomal recessive • Characterized by dermatologic, ophthalmologic, gastrointestinal and neuropsychiatric features along with growth retardation and hypogonadism OTHERS Depressed Immune Response Hypogeusis Night Blindness Zinc decreases copper absorption in the body
  11. 11. Clinical Significance: • • • • • • • • • • Diabetes mellitus Leaukemias Malignancies Atherosclerosis Wound Healing Hepatic Diseases Acute myocardial infarction Sickle cell anemia Dermatitis Clinical Syndrome- Rickets (mutation at Calcitriol receptor)
  12. 12. Therapeutic Significance in treatment of Diarrhoea: • No other treatment has been proven as efficacious as zinc in reducing the duration of acute diarrhoea in children of developing countries • Antibiotics, antiparasitic, antimotility, antisecretory drugs and enzymes are overused and • Decreasing the occurrence of prolonged and persistent diarrhoea by zinc administration may substantially reduce the number of childhood diarrhoea deaths
  13. 13. Synopsis: • • • • • • • • What is zinc? and what does it do? How much zinc do we need? What are the sources of zinc? How is zinc absorbed in the body? How is zinc distributed in the body? How is zinc excreted from the body? What is the clinical significance of zinc? What is the therapeutic significance of zinc?
  14. 14. Thank you