Malignant neoplasms of nose

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Malignant neoplasms of nose

  1. 1. MALIGNANT NEOPLASMS OF NASAL CAVITY BY: MOHIT KADYAN ROLL NO: 26
  2. 2. TUMORS OF NASAL CAVITY CARCINOMA OF NASAL CAVITY -SQUAMOUS CELL CARCINOMA -ADENOCARCINOMA MALIGNANT MELANOMA OLFACTORY NEUROBLASTOMA LYMPHOMA PLASMACYTOMA OTHERS SARCOMA AND HAEMANGIOPERICYTOMA
  3. 3. 1. SQUAMOUS CELL CARCINOMA • It is the most common variety , seen in about 80% of cases • Above 50 years of age • It may arise from -vestibule, -anterior part of nasal septum or -lateral wall of nasal cavity. • Vestibular: arises from lateral wall of vestibule and extends into collumela , nasal floor, and upper lip . • Septal: arises from mucocutaneous junction causing burning and sore nose . It is termed as “nose-picker’s cancer’’. • Lateral wall: most common site , extends into ethmoid or maxillary sinus , presents as polypoidal mass in lateral wall of nose
  4. 4. • Vestibular spreads to parotid nodes while septal and lateral wall neoplasms show low metastatic tendency. Treatment: Combination of radiotherapy and surgery Metastasis:
  5. 5. Adenocarcinoma and adenoid cystic carcinoma. •They arise from the glands of mucous membranes , mostly involve upper part of the lateral wall of nasal cavity.
  6. 6. 2. Malignant melanoma • Usually seen in persons about 50 yrs of age. • Cell of origion is MELANOCYTE • It presents as slaty-gray or bluish-black polypoid mass. • Anterior part is most common site followed by middle and inferior turbinate. • Amelanotic are the non-pigmented varieties
  7. 7. METASTASIS: • Tumour spreads to cervical nodes by blood and lymphatic route TREATMENT: • Surgical incision is the treatment , radiotherapy and chemotherapy are avoided as it supresses immunity
  8. 8. 3. Olfactory neuroblastoma • Tumour of olfactory placode can be seen in any age group. • Cherry red , polypoidal mass in upper nasal cavity. • Bleeds on biopsy as it is highly vascular.
  9. 9. Metastasis: • Lymph node or systemic metastasis can occur Treatment: • Can be cured by radiotherapy alone • Surgical excision is followed presently along with radiation • Craniofacial resection may be required for tumors of cribriform plate.
  10. 10. 4.Haemangiopericytoma • Rare tumour of vascular origin seen in 60-70 yrs of age. • Cell of origion is ‘’pericyte’’ which surround capillaries • Patients present with epistaxis • Tumour bleeds on biopsy • Treatment is surgical excision and radiotherapy is tried for recurrent and inoperable cases.
  11. 11. 5. Plasmocytoma • Affects males over 40 yrs of age • Solitary plasmocytoma without any osseous disease can be seen in the nasal cavity • Treatment is by radiation followed 3 months later by surgery , if regression doesn’t occur • long term follow up is advised to exclude development of Multiple myeloma.
  12. 12. 6. Sarcomas • Osteogenic sarcoma , chondrosarcoma, rhabdomyosarcoma , angiosarcoma , malignant histiocytoma are other rare tumours affecting the nose.
  13. 13. 7. lymphoma • Rarely a non-hodgkin lymphoma presents on septum of nose.
  14. 14. Thank You

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