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Practical radiological approach to a case of intersex

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Practical radiological approach to a case of intersex

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Practical radiological approach to a case of intersex

  1. 1. • Intersex • DSD = Disorders of Sex Development
  2. 2. • Disorders of sex development (DSDs) are congenital conditions in which the development of chromosomal, gonadal, or anatomic sex is atypical.
  3. 3. • DSDs can be classified broadly into four categories on the basis of gonadal histologic features: 1. Female pseudohermaphroditism (46,XX with two ovaries) 2. Male pseudohermaphroditism (46,XY with two testes) 3. True hermaphroditism (ovotesticular DSD) (both ovarian and testicular tissues) 4. Gonadal dysgenesis, either mixed (a testis and a streak gonad) or pure (bilateral streak gonads).
  4. 4. TDF (testis determining factor) Testis MIS (müllerian inhibiting substance)Testosterone Müllerian duct Wolffian duct

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