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REabSORb :
a STENT THaT
DISaPPEaRS
IDEa GENERaTED &
PRESENTED bY :
MINaL CHaUHaN - 7
MaLVIKa baNSaL 11
SHILPa TaHaKaR -
JOURNEY
1)
2)
3)
4)
5)
6)
7)
8)
9)

INTRODUCTION
CURRENT SITUaTION
MaRKET STUDY
PRE LaUNCH SURVEY
NEW PRODUCT DEVELOPMENT
...
JOURNEY
1)
2)
3)
4)
5)
6)
7)
8)
9)

INTRODUCTION
CURRENT SITUaTION
MaRKET STUDY
PRE LaUNCH SURVEY
NEW PRODUCT DEVELOPMENT
...
aTHEROSCLEROSI
S
 Commonest cause of coronary artery blockage
 Results in a fixed blockage
 May be accompanied by coron...
CYCLE
STENT

 A mesh 'tube'
 Inserted into a natural passage/conduit in the body
 Treats narrow or weak arteries
 Stents usually are made of metal mesh, but
sometimes they're made of fabric
 Fabric stents, also called stent grafts, a...
 Figure A shows the location of the heart and coronary arteries
 Figure B shows the deflated balloon catheter and closed...
RISKS RELaTED TO STENTS
 Blood clot at the stent site
 Blood clots can cause a heart attack, stroke, or other
serious pr...
JOURNEY
1)
2)
3)
4)
5)
6)
7)
8)
9)

INTRODUCTION
CURRENT SITUaTION
MaRKET STUDY
PRE LaUNCH SURVEY
NEW PRODUCT DEVELOPMENT
...
STRAIN TAKES TOLL ON
HEART
 Hypertension : three times higher in urban citizens
than their rural counterparts
 9% of pop...
JOURNEY
1)
2)
3)
4)
5)
6)
7)
8)
9)

INTRODUCTION
CURRENT SITUATION
MARKET STUDY
PRE LAUNCH SURVEY
NEW PRODUCT DEVELOPMENT
...
JOURNEY
1)
2)
3)
4)
5)
6)
7)
8)
9)

INTRODUCTION
CURRENT SITUATION
MARKET STUDY
PRE LAUNCH SURVEY
NEW PRODUCT DEVELOPMENT
...
STRATEGIES
 Meeting doctors
 Understanding consumer requirements
 Analyzing current problems
 Conducting survey throug...
Which is the most commonly used STENT ?
Which kind of STENT is a better option?
JOURNEY
1)
2)
3)
4)
5)
6)
7)
8)
9)

INTRODUCTION
CURRENT SITUATION
MARKET STUDY
PRE LAUNCH SURVEY
NEW PRODUCT DEVELOPMENT
...
BASIC DESIGN
 Circumferential PLLA hoops
 150 µm thick
 Hoops directly joined by bridges
COMPONENT
S

 PLLA (Poly-L-Lactic Acid) Backbone
 PDLLA (Poly-D, L-Lactic Acid) Coating
 Drugs coated on it include :
V...
 Both the backbone and coating will degrade to
lactic acid (Kreb’s cycle)
 Drugs coated on it are to serve their respect...
JOURNEY
1)
2)
3)
4)
5)
6)
7)
8)
9)

INTRODUCTION
CURRENT SITUATION
MARKET STUDY
PRE LAUNCH SURVEY
NEW PRODUCT DEVELOPMENT
...
StrategieS
 Spreading awareness
 Contacting doctors & MRs
 One on one presentations
 Hiring professionals for personal...
JOUrNeY
1)
2)
3)
4)
5)
6)
7)
8)
9)

iNtrODUCtiON
CUrreNt SitUatiON
MarKet StUDY
Pre LaUNCH SUrVeY
NeW PrODUCt DeVeLOPMeNt
...
 Polymers are biocompatible
 100% drug elution in 4 months
 Complete healing of endothelium possible
 No corrosion or ...
JOUrNeY
1)
2)
3)
4)
5)
6)
7)
8)
9)

iNtrODUCtiON
CUrreNt SitUatiON
MarKet StUDY
Pre LaUNCH SUrVeY
NeW PrODUCt DeVeLOPMeNt
...
 Reduced stent thrombosis
 Reduction in therapy time
 Limited chances of re-placement requirement
JOUrNeY
1)
2)
3)
4)
5)
6)
7)
8)
9)

iNtrODUCtiON
CUrreNt SitUatiON
MarKet StUDY
Pre LaUNCH SUrVeY
NeW PrODUCt DeVeLOPMeNt
...
aSSUMPtiON
S
 Pre-supposed approval by FDA
 Rs. 90,000 : average cost of a stent in India
 Based on historical preceden...
triaL BUDget
BreaKDOWN COST INCURRED*
TRIAL REQUIREMENTS
(Rs.)
FOLLOW UP, 5 YRS, 50
1,00,000 * 5 * 50 =
PATIENTS
2,50,00,0...
reFereNCe
http://blog.mediligence.com/2007/05/12/drug-eluting-stents-2
S

/

http://www.abbottvascular.com
http://www.bioa...
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
REABSORB : AN ABSORBABLE STENT
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REABSORB : AN ABSORBABLE STENT

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REABSORB : AN ABSORBABLE STENT

  1. 1. REabSORb : a STENT THaT DISaPPEaRS IDEa GENERaTED & PRESENTED bY : MINaL CHaUHaN - 7 MaLVIKa baNSaL 11 SHILPa TaHaKaR -
  2. 2. JOURNEY 1) 2) 3) 4) 5) 6) 7) 8) 9) INTRODUCTION CURRENT SITUaTION MaRKET STUDY PRE LaUNCH SURVEY NEW PRODUCT DEVELOPMENT POST LaUNCH STRaTEGY bENEFITS EXPECTED OUTCOME SUPPLEMENTaRY SLIDES
  3. 3. JOURNEY 1) 2) 3) 4) 5) 6) 7) 8) 9) INTRODUCTION CURRENT SITUaTION MaRKET STUDY PRE LaUNCH SURVEY NEW PRODUCT DEVELOPMENT POST LaUNCH STRaTEGY bENEFITS EXPECTED OUTCOME SUPPLEMENTaRY SLIDES
  4. 4. aTHEROSCLEROSI S  Commonest cause of coronary artery blockage  Results in a fixed blockage  May be accompanied by coronary spasm
  5. 5. CYCLE
  6. 6. STENT  A mesh 'tube'  Inserted into a natural passage/conduit in the body  Treats narrow or weak arteries
  7. 7.  Stents usually are made of metal mesh, but sometimes they're made of fabric  Fabric stents, also called stent grafts, are used in larger arteries  Some stents are coated with medicine that is slowly and continuously released into the artery
  8. 8.  Figure A shows the location of the heart and coronary arteries  Figure B shows the deflated balloon catheter and closed stent inserted into the narrow coronary artery  The inset image shows a cross-section of the artery with the inserted balloon catheter and closed stent  In figure C, the balloon is inflated, expanding the stent and compressing the plaque against the artery wall  Figure D shows the stent-widened artery. The inset image shows a crosssection of the compressed plaque and stent-widened artery
  9. 9. RISKS RELaTED TO STENTS  Blood clot at the stent site  Blood clots can cause a heart attack, stroke, or other serious problems  Stents coated with medicine may raise the risk of dangerous blood clots
  10. 10. JOURNEY 1) 2) 3) 4) 5) 6) 7) 8) 9) INTRODUCTION CURRENT SITUaTION MaRKET STUDY PRE LaUNCH SURVEY NEW PRODUCT DEVELOPMENT POST LaUNCH STRaTEGY bENEFITS EXPECTED OUTCOME SUPPLEMENTaRY SLIDES
  11. 11. STRAIN TAKES TOLL ON HEART  Hypertension : three times higher in urban citizens than their rural counterparts  9% of population in the age bracket of 40-70 undergo angioplasty every year  BMS is the most popular choice  Several post surgery complications are involved
  12. 12. JOURNEY 1) 2) 3) 4) 5) 6) 7) 8) 9) INTRODUCTION CURRENT SITUATION MARKET STUDY PRE LAUNCH SURVEY NEW PRODUCT DEVELOPMENT POST LAUNCH STRATEGY BENEFITS EXPECTED OUTCOME SUPPLEMENTARY SLIDES
  13. 13. JOURNEY 1) 2) 3) 4) 5) 6) 7) 8) 9) INTRODUCTION CURRENT SITUATION MARKET STUDY PRE LAUNCH SURVEY NEW PRODUCT DEVELOPMENT POST LAUNCH STRATEGY BENEFITS EXPECTED OUTCOME SUPPLEMENTARY SLIDES
  14. 14. STRATEGIES  Meeting doctors  Understanding consumer requirements  Analyzing current problems  Conducting survey through questionnaires
  15. 15. Which is the most commonly used STENT ?
  16. 16. Which kind of STENT is a better option?
  17. 17. JOURNEY 1) 2) 3) 4) 5) 6) 7) 8) 9) INTRODUCTION CURRENT SITUATION MARKET STUDY PRE LAUNCH SURVEY NEW PRODUCT DEVELOPMENT POST LAUNCH STRATEGY BENEFITS EXPECTED OUTCOME SUPPLEMENTARY SLIDES
  18. 18. BASIC DESIGN  Circumferential PLLA hoops  150 µm thick  Hoops directly joined by bridges
  19. 19. COMPONENT S  PLLA (Poly-L-Lactic Acid) Backbone  PDLLA (Poly-D, L-Lactic Acid) Coating  Drugs coated on it include : VEGF (Vascular Endothelial Growth Factor) to  promote healing  ASPIRIN to reduce the ability of blood to clot easily  STATIN to help in reabsorbing cholesterol
  20. 20.  Both the backbone and coating will degrade to lactic acid (Kreb’s cycle)  Drugs coated on it are to serve their respective function  Entire stent should dissolve in 2-3 yrs without any side effects
  21. 21. JOURNEY 1) 2) 3) 4) 5) 6) 7) 8) 9) INTRODUCTION CURRENT SITUATION MARKET STUDY PRE LAUNCH SURVEY NEW PRODUCT DEVELOPMENT POST LAUNCH STRATEGY BENEFITS EXPECTED OUTCOME SUPPLEMENTARY SLIDES
  22. 22. StrategieS  Spreading awareness  Contacting doctors & MRs  One on one presentations  Hiring professionals for personal selling  Taking feedback
  23. 23. JOUrNeY 1) 2) 3) 4) 5) 6) 7) 8) 9) iNtrODUCtiON CUrreNt SitUatiON MarKet StUDY Pre LaUNCH SUrVeY NeW PrODUCt DeVeLOPMeNt POSt LaUNCH StrategY BeNeFitS eXPeCteD OUtCOMe SUPPLeMeNtarY SLiDeS
  24. 24.  Polymers are biocompatible  100% drug elution in 4 months  Complete healing of endothelium possible  No corrosion or dislocation
  25. 25. JOUrNeY 1) 2) 3) 4) 5) 6) 7) 8) 9) iNtrODUCtiON CUrreNt SitUatiON MarKet StUDY Pre LaUNCH SUrVeY NeW PrODUCt DeVeLOPMeNt POSt LaUNCH StrategY BeNeFitS eXPeCteD OUtCOMe SUPPLeMeNtarY SLiDeS
  26. 26.  Reduced stent thrombosis  Reduction in therapy time  Limited chances of re-placement requirement
  27. 27. JOUrNeY 1) 2) 3) 4) 5) 6) 7) 8) 9) iNtrODUCtiON CUrreNt SitUatiON MarKet StUDY Pre LaUNCH SUrVeY NeW PrODUCt DeVeLOPMeNt POSt LaUNCH StrategY BeNeFitS eXPeCteD OUtCOMe SUPPLeMeNtarY SLiDeS
  28. 28. aSSUMPtiON S  Pre-supposed approval by FDA  Rs. 90,000 : average cost of a stent in India  Based on historical precedence, our price 2.5 lakh at initial entry  20% hurdle rate  Total cost inclusive of trials : 8 crores  Profit Margin of 65%
  29. 29. triaL BUDget BreaKDOWN COST INCURRED* TRIAL REQUIREMENTS (Rs.) FOLLOW UP, 5 YRS, 50 1,00,000 * 5 * 50 = PATIENTS 2,50,00,000 ANGIOGRAPHY, 50 20,000 * 2 * 50 = PATIENTS 20,00,000 RESOURCE COST, 50 60,000 * 50 = PATIENTS 30,00,000 MEDICAL COST, 50 10,000 * 5 * 50 = PATIENTS 25,00,000 IVUs COST, 50 50,000 * 50 = PATIENTS 25,00,000 MISCELLANEOUS COSTS 2,00,000 TOTAL TRIAL COST 3,52,00,000 * ALL FIGURES ARE IN APPROXIMATION
  30. 30. reFereNCe http://blog.mediligence.com/2007/05/12/drug-eluting-stents-2 S / http://www.abbottvascular.com http://www.bioabsorbabletx.com http://www.vascularconcepts.com http://www.revespcardiol.org/en/influencia-trombosis-del-stentrelacion/articulo/13150746/ http://www.cxvascular.com http://www.nbcnews.com http://www.nhlbi.nih.gov http://www.news-medical.net/health/Stent-Types.aspx

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