Click http://www.guidechem.com/cas-745/74578-69-1.html for suppliers of this product5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-...
MOLECULAR WEIGHT : 661.63COMPOUND DESCRIPTOR : DrugHumanSYNONYMS/TRADE NAMES :* Cefatriaxone hydrate* Ceftriaxone sodium h...
SPECIES OBSERVED : Human - manDOSE/DURATION : 800 mg/kg/49D-ITOXIC EFFECTS :Blood - agranulocytosisBlood - changes in leuk...
SPECIES OBSERVED : Rodent - mouseDOSE/DURATION : >10 gm/kgTOXIC EFFECTS :Details of toxic effects not reported other than ...
Volume(issue)/page/year: 18,1751,1984TYPE OF TEST : TDLo - Lowest published toxic doseROUTE OF EXPOSURE : IntravenousSPECI...
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74578 69-1

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74578 69-1

  1. 1. Click http://www.guidechem.com/cas-745/74578-69-1.html for suppliers of this product5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-,sodium salt (1:2), (6R,7R)- (cas 74578-69-1)MSDSMSDS: 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl)-, sodium salt, hydrate (2:4:7)(6R-(6-alpha,7-beta(Z)))-CAS : 74578-69-1SYNONYMS : * Cefatriaxone hydrate* Ceftriaxone sodium hydrate* Cephtriaxone* Ro 13-9904* Ro 13-9904/001* Rocephin* X 13-9904Catalog of Chemical Suppliers, Buyers, Custom Synthesis Companies And Equipment Manufacturers[ 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl)-, sodium salt, hydrate(2:4:7)(6R-(6-alpha,7-beta(Z)))- 74578-69-1 ]*** CHEMICAL IDENTIFICATION ***RTECS NUMBER : XI0368800CHEMICAL NAME : 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl)-, sodium salt, hydrate (2:4:7)(6R-(6-alpha,7-beta(Z)))-CAS REGISTRY NUMBER : 74578-69-1LAST UPDATED : 199512DATA ITEMS CITED : 12MOLECULAR FORMULA : C18-H16-N8-O7-S3.2Na.7/2H2-O
  2. 2. MOLECULAR WEIGHT : 661.63COMPOUND DESCRIPTOR : DrugHumanSYNONYMS/TRADE NAMES :* Cefatriaxone hydrate* Ceftriaxone sodium hydrate* Cephtriaxone* Ro 13-9904* Ro 13-9904/001* Rocephin* X 13-9904*** HEALTH HAZARD DATA ***** ACUTE TOXICITY DATA **TYPE OF TEST : TDLo - Lowest published toxic doseROUTE OF EXPOSURE : IntramuscularSPECIES OBSERVED : Human - infantDOSE/DURATION : 16 mg/kg/3D-ITOXIC EFFECTS :Brain and Coverings - meningeal changesBlood - changes in leukocyte (WBC) countNutritional and Gross Metabolic - body temperature increaseREFERENCE :CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, JournalFulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962-Volume(issue)/page/year: 32,360,1993TYPE OF TEST : TDLo - Lowest published toxic doseROUTE OF EXPOSURE : Multiple routesSPECIES OBSERVED : Human - womanDOSE/DURATION : 640 mg/kg/32D-ITOXIC EFFECTS :Gastrointestinal - nausea or vomitingBlood - agranulocytosisNutritional and Gross Metabolic - body temperature increaseREFERENCE :IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013,Israel) V.1- 1965- Volume(issue)/page/year: 29,52,1993TYPE OF TEST : TDLo - Lowest published toxic doseROUTE OF EXPOSURE : Multiple routes
  3. 3. SPECIES OBSERVED : Human - manDOSE/DURATION : 800 mg/kg/49D-ITOXIC EFFECTS :Blood - agranulocytosisBlood - changes in leukocyte (WBC) countREFERENCE :IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013,Israel) V.1- 1965- Volume(issue)/page/year: 29,52,1993TYPE OF TEST : LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE : OralSPECIES OBSERVED : Rodent - ratDOSE/DURATION : >10 gm/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueREFERENCE :49ZAA4 "Ceftriaxon (Rocephin) ein Neues Parenterales Cephalosporin,Hahnenklee - Symposion, 9th, 1981," Dettli, L., et al. eds., Harz, Fed. Rep.Ger., S8-10, 1982 Volume(issue)/page/year: -,91,1982TYPE OF TEST : LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE : SubcutaneousSPECIES OBSERVED : Rodent - ratDOSE/DURATION : >5 gm/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueREFERENCE :49ZAA4 "Ceftriaxon (Rocephin) ein Neues Parenterales Cephalosporin,Hahnenklee - Symposion, 9th, 1981," Dettli, L., et al. eds., Harz, Fed. Rep.Ger., S8-10, 1982 Volume(issue)/page/year: -,91,1982TYPE OF TEST : LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE : IntravenousSPECIES OBSERVED : Rodent - ratDOSE/DURATION : 1900 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueREFERENCE :49ZAA4 "Ceftriaxon (Rocephin) ein Neues Parenterales Cephalosporin,Hahnenklee - Symposion, 9th, 1981," Dettli, L., et al. eds., Harz, Fed. Rep.Ger., S8-10, 1982 Volume(issue)/page/year: -,91,1982TYPE OF TEST : LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE : Oral
  4. 4. SPECIES OBSERVED : Rodent - mouseDOSE/DURATION : >10 gm/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueREFERENCE :49ZAA4 "Ceftriaxon (Rocephin) ein Neues Parenterales Cephalosporin,Hahnenklee - Symposion, 9th, 1981," Dettli, L., et al. eds., Harz, Fed. Rep.Ger., S8-10, 1982 Volume(issue)/page/year: -,91,1982TYPE OF TEST : LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE : SubcutaneousSPECIES OBSERVED : Rodent - mouseDOSE/DURATION : >5 gm/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueREFERENCE :49ZAA4 "Ceftriaxon (Rocephin) ein Neues Parenterales Cephalosporin,Hahnenklee - Symposion, 9th, 1981," Dettli, L., et al. eds., Harz, Fed. Rep.Ger., S8-10, 1982 Volume(issue)/page/year: -,91,1982TYPE OF TEST : LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE : IntravenousSPECIES OBSERVED : Rodent - mouseDOSE/DURATION : 2200 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueREFERENCE :JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968-Volume(issue)/page/year: 33,783,1980** OTHER MULTIPLE DOSE TOXICITY DATA **TYPE OF TEST : TDLo - Lowest published toxic doseROUTE OF EXPOSURE : IntravenousSPECIES OBSERVED : Rodent - ratDOSE/DURATION : 51450 mg/kg/42D-ITOXIC EFFECTS :Skin and Appendages - dermatitis, other (after systemic exposure)Related to Chronic Data - deathREFERENCE :KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, KandaSuda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
  5. 5. Volume(issue)/page/year: 18,1751,1984TYPE OF TEST : TDLo - Lowest published toxic doseROUTE OF EXPOSURE : IntravenousSPECIES OBSERVED : Rodent - ratDOSE/DURATION : 42875 mg/kg/5W-ITOXIC EFFECTS :Gastrointestinal - other changesSkin and Appendages - dermatitis, other (after systemic exposure)Nutritional and Gross Metabolic - weight loss or decreased weight gainREFERENCE :KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, KandaSuda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-Volume(issue)/page/year: 18,1793,1984TYPE OF TEST : TDLo - Lowest published toxic doseROUTE OF EXPOSURE : IntravenousSPECIES OBSERVED : Mammal - dogDOSE/DURATION : 21840 mg/kg/13W-ITOXIC EFFECTS :liver - change in gall bladder structure or functionRelated to Chronic Data - deathREFERENCE :KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, KandaSuda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-Volume(issue)/page/year: 18,1855,1984*** END OF RECORD ***

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