Organic compounds – health hazards

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A brief introduction and overview of the health hazards presented by volatile organic compounds in the workplace

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Organic compounds – health hazards

  1. 1. Mike Slater
  2. 2. Organic Compounds containing carbon (with some important exceptions)
  3. 3. Inorganic Compounds that aren’t organic!
  4. 4. Aromatic Compounds Compounds containing benzene rings benzene naphthalene benzo(a)pyrene CH3 CH3 CH3 toluene m-xylene
  5. 5. Aliphatic Compounds Organic compounds that aren’t aromatic!
  6. 6. Many organiccompounds arehighly volatileVolatile organiccompounds (VOCs)
  7. 7. Concentrationdepends on vapourpressureIncreases withtemperatureLow vapour pressuregives lower vapourconcentration
  8. 8. Where is exposure toVOCs likely to occur?
  9. 9. Industrial solvents
  10. 10. Paints
  11. 11. Adhesives
  12. 12. Cleaning
  13. 13. Volatile OrganicCompoundsGeneric effects
  14. 14. Acute:Depression ofcentral nervoussystem
  15. 15. Narcosis increases with: Number of carbon atoms Number of carbon containing side groups Halogenation Alcohol groups Degree of unsaturation
  16. 16. Acute:IrritationExtraction of fat /lipids from cellmembranes
  17. 17. IrriationIncreased effect with  number of functional groups  unsaturated compounds
  18. 18. Sub - acute:Defatting of skin -dermatitis http://www.cdc.gov/niosh/topics/skin/occderm-slides/ocderm8.html
  19. 19. Chronic:Neurotoxicity
  20. 20. Chronic:Effects on otherorgans
  21. 21. Chronic:TeratogensEffects ondeveloping foetus
  22. 22. Summary of generic effects ofvolatile organic compoundsAcute Narcosis IrritationSub acute DermatitisChronic Neurotoxicity Effects on other organs Some are teratogens
  23. 23. Individual compoundsalso have their ownspecific effects
  24. 24. n-Hexane can causeperipheral neuritis
  25. 25. Benzene - is a knownhuman carcinogencausing leukaemia
  26. 26. CHCH2Styrene ishighly irritant styrene
  27. 27. Many Polycyclic AromaticHydrocarbons (PAHs) can causebladder and other cancers benzo(a)pyrene
  28. 28. http://www.slideshare.net/mikeslatermike@diamondenv.co.ukhttp://diamondenv.wordpress.comTwitter: @diamondenvMike Slater
  29. 29. Mike Slater, Diamond Environmental Ltd. (mike@diamondenv.co.uk) This presentation is distributed under the Creative Commons Attribution-NonCommercial-ShareAlike UK:International Licence

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