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Iron supplementation therapy is problematic. With today's non-
heme iron products there are many difficulties. Tolerance, ...
Medical studies show that heme iron is
very well tolerated:
"Side effects of iron supplements in
blood donors: superior to...
Tolerance
The process of developing side-effects over
time is of great concern for chronics
and those who have to medicate...
Tolerance
It is practically virtually impossible for a
poisoning overdose by heme iron.
hemeiron.com
Iron poisoning is an ...
Efficacy
"A number of dietary factors influence
non-heme iron absorption. Ascorbate and
citrate increase iron uptake in pa...
Synthethic or not?
Non-heme iron represents the
majority of iron humans consume in
their diets and is the type of iron in
...
Supplements
OptiFer® tablets are based on natural
bovine heme iron and will safely and
efficiently keep iron counts at an
...
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What you need to know about heme iron

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Iron supplementation therapy is problematic. With today's non-heme iron products there are many difficulties. Tolerance, efficacy, risks and so on. This presentation will focus on these issues comparing the current situation with a
new way of therapy, heme iron-based supplementation

Published in: Health & Medicine
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What you need to know about heme iron

  1. 1. Iron supplementation therapy is problematic. With today's non- heme iron products there are many difficulties. Tolerance, efficacy, risks and so on. There are two kinds of iron in the diet that are bio-available. These are: heme iron (in meats, fish etc.) and so-called non-heme iron in vegetables. Heme iron is taken up at a much higher rate. Today these cathegories are also represented in iron supplementation. Hemoglobin of bovine origin is a raw-material used in heme iron products such as the OptiFer® line by Swedish company FerroCare/MediTec. Virtually all other oral supplements are made with chemical/synthetic non-heme iron. This presentation will focus on these issues comparing the current situation with a new way of therapy, heme iron-based supplementation
  2. 2. Medical studies show that heme iron is very well tolerated: "Side effects of iron supplements in blood donors: superior tolerance of heme iron" J Lab Clin Med. 1994 Apr;123(4):561-4. The single biggest problem with the usual non-heme iron oral preparations is tolerance. Sooner or later these products will give gastric problems. A general feeling of nausea and outright symptoms, such as pain and digestive problems. Tolerance National Institutes of Health
  3. 3. Tolerance The process of developing side-effects over time is of great concern for chronics and those who have to medicate over longer time. Too often this leads to a forced abandonment of the oral therapy. The remaining alternative is then costly, uncomfortable and even painful intravenous therapy. This can also lead to a so-called organic stress, since this method of supplementation is not natural. hemeiron.com Heme iron preparations can be used over longer time with no change in tolerance or efficacy. hemeiron.com
  4. 4. Tolerance It is practically virtually impossible for a poisoning overdose by heme iron. hemeiron.com Iron poisoning is an iron overload caused by a large excess of iron intake and usually refers to an acute overload rather than a gradual one. The term has been primarily associated with young children who consumed large quantities of iron supplement pills, which resemble sweets and are widely used, including by pregnant women—see overnutrition (approximately 3 grams is lethal for a 2 year old). Wikipedia Linus Pauling Institute
  5. 5. Efficacy "A number of dietary factors influence non-heme iron absorption. Ascorbate and citrate increase iron uptake in part by acting as weak chelators to help solubilize the metal in the duodenum.. Conversely iron absorption is inhibited by plant phytates and tannins." Information Center for Sickle Cell and Thalassemic Disorders "Although uptake of heme iron in enterocytes is affected little by consumption of other foods, absorption of non-heme is relatively inefficient and can be altered substantially by co- consumption of certain dietary elements." GP General Practice Notebook – a UK medical reference
  6. 6. Synthethic or not? Non-heme iron represents the majority of iron humans consume in their diets and is the type of iron in most supplements. Iron disorders Institute Meat, especially red meat is the best source of heme iron. When we eat meat we consume the blood proteins, the hemoglobin and myoglobin contained in the flesh of the animal. Heme iron is easily absorbed by the body and the best source of iron for people who are iron deficient. Iron disorders Institute Iron is found in the diet in two forms—heme iron, which is well absorbed, and nonheme iron, which is poorly absorbed. Mayoclinic Heme iron is organic and natural, not synthethic Iron can be supplemented by the oral route using various pharmacological forms, such as iron(II) sulfate (this is the most common and cheapest salt, and in complex with gluconate, dextran, carbonyl iron, and other salts. Sometimes ascorbic acid (vitamin C) is added for better absorption Wikipedia
  7. 7. Supplements OptiFer® tablets are based on natural bovine heme iron and will safely and efficiently keep iron counts at an optimal level www.meditec.se www.hemeiron.com

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