GIATE mibbi2010

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  • Slide #1: 'Scope of guidelines' Please describe the technologies and/or biological subjects addressed by the MI project in question.
  • Slide #2: 'Level of implementation' Has a journal or funder recommended your MI specification; is there software, a CV/ontology or a database that supports it?
  • Slide #3: Status, contributors, funding. How active is your project, who contributes and who (if anyone) pays for the work.
  • GIATE mibbi2010

    1. 1. Guidelines for Information About Therapy Experiments (GIATE) Alejandra Gonz ález Beltrán 1 Joint work with Richard Begent 2 and May Yong 2 1 UCL Computational and Systems Medicine 2 UCL Cancer Institute 2 nd MIBBI Workshop November 30th to December 3rd, 2010 Ruedesheim/Rhein, Germany
    2. 2. GIATE – Scope: therapy experiments across many levels supporting translational research <ul><li>GIATE framework: links different levels, resources, standards </li></ul><ul><li>Experiment design: target, agent </li></ul><ul><li>Experimental models </li></ul><ul><ul><li>Molecular </li></ul></ul><ul><ul><ul><li>E.g. protocol, dose regimen, bond study, agent distribution study </li></ul></ul></ul><ul><ul><li>Cellular </li></ul></ul><ul><ul><ul><li>E.g. cell culture conditions, genetic/epigenetic profile, distribution studies </li></ul></ul></ul><ul><ul><li>Animal </li></ul></ul><ul><ul><ul><li>E.g. organism, developmental stage, genetic/epigenetic profile, pharmacokinetics and pharmacodynamics studies, outcomes </li></ul></ul></ul><ul><ul><li>Clinical </li></ul></ul><ul><ul><ul><li>E.g. eligibility and exclusion criteria, genetic/epigenetic profiles, pharmacokinetics and pharmacodynamics studies, outcomes </li></ul></ul></ul>
    3. 3. GIATE - Level of Implementation – Initial phase <ul><ul><li>Adopted by the Antibody Society </li></ul></ul><ul><li>GIATE checklist </li></ul><ul><li>GIATE classification scheme: list of CDEs, caDSR, NCIt </li></ul><ul><li>GIATE-Tab: spreadsheet </li></ul><ul><li>GIATE website </li></ul><ul><li>GIATE use cases </li></ul><ul><li>GIATE ontology </li></ul><ul><li>GIATE information into RDF </li></ul><ul><li>GIATE on the ISA infrastructure </li></ul>
    4. 4. GIATE – Status, Contributors, Funding <ul><li>Contributors: </li></ul><ul><ul><li>GIATE resources: Dr May Yong, Prof Richard Begent, Dr Alejandra Gonzalez-Beltran </li></ul></ul><ul><ul><li>GIATE use cases: Dr Alan Green, Gairin Dancey </li></ul></ul><ul><li>Funding </li></ul><ul><ul><li>CRUK, NIHR, EPSRC, MRC: UCL Experimental Cancer Medicine Centre, UCL and KCL Comprehensive Cancer Imaging Centre </li></ul></ul><ul><ul><li>Computational and Systems Medicine project, MRC grant G0802528 “Translational Research Initiative” </li></ul></ul>
    5. 5. Thank you!

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