Layar Merah Herbs
• Concern on the importance of
skin tone
• A fair and spotless skin, is
considered a sign of beauty
and reveals certain so...
• Surgery is costly, risky and
expensive
• Surgery is aggressive and
invasive
• Cosmetics is Natural, Safe and
Effective
•...
• Dual action
• Prevents – Reduces melanin synthesis
• Treats – Evens out skin tone, reduces spots in
number and intensity...
• Instant skin tone whitening effect
• Long-term brightening effect
• Instant radiance boosting and moisturizing
• Decreas...
• Reduces spots in number and
intensity, regardless of their
origin
• Reduces both tyrosinase
enzyme formation and activit...
• Several test were performed to assess the in vitro
efficacy
• PPARγ binding affinity
• Study on depigmentation activity ...
• The active ingredients of Whitening
Cream shows a good affinity to bind
to PPARγ and act as a natural
agonist
• It reduc...
• In vitro evaluation of melanin diminution
• Application of 4 mg/cm² of whitening creams on the surface
of reconstructed ...
• Chromatometric measure of the degree of pigmentation of
tissues. Quantification of the color of tissues using a Chroma
M...
• In vitro evaluation of melanin
diminution shows it has a
significative whitening activity of
around 25%. Melanin diminut...
• In vivo efficacy
• 20 Asian volunteers
• 3% cosmetic formulation with active ingredient on one side of
the face, and pla...
• Normal skin :
• It decreases the intensity of skin
pigmentation
• The ITA° parameter increases up to
28% in skin without...
• The depigmenting potential of the active ingredient of the
Whitening Cream was assessed using human tanned in
vitro reco...
• Objectivation : Illuminating
• It contains mica to boost radiance of the skin for a radian, healthy looking
appearance
•...
• Skin whitening facial treatments
• Specific anti-spot facial treatments
• Skin lightening body lotions
• Anti-spot hand ...
• Discontinue use of other products 3 days prior to beginning
use of Whitening Cream
• Cleanse skin thoroughly
• Apply Whi...
• You should take a SKIN ALLERGY TEST with the cream
before applying these products to your face and skin
• The best way t...
• Titanium dioxide
• Aluminum hydroxide
• Glycyrrhiza glabra (Licorice) Root Extract
• Alpha-arbutin
• Boerhavia diffusa R...
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Whitening cream

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Whitening cream

  1. 1. Layar Merah Herbs
  2. 2. • Concern on the importance of skin tone • A fair and spotless skin, is considered a sign of beauty and reveals certain social status. • A skin with a dull tone, spots and irregular pigmentation looks much older than the real age • Differences in skin color is due to melanin • Increase in melanin by external aggression and aging leads to changes in skin tone
  3. 3. • Surgery is costly, risky and expensive • Surgery is aggressive and invasive • Cosmetics is Natural, Safe and Effective • Whitening Cream decreases skin tone evenly and uniformly and reduces different types of spots
  4. 4. • Dual action • Prevents – Reduces melanin synthesis • Treats – Evens out skin tone, reduces spots in number and intensity • Reduces process of spontaneous melanin synthesis • Prevents an accumulation of melanin in the skin by reducing melanocyte dendrites • Reduces tyrosinase enzyme formation by 63%, therefore it reduces melanogenesis • Decreases the amount of pigment synthesized by melanocytes by 34%, without affecting their viability • Modulates melanocyte gene expression • Resulting in whitening of skin
  5. 5. • Instant skin tone whitening effect • Long-term brightening effect • Instant radiance boosting and moisturizing • Decreases skin tone evenly and uniformly and reduces different types of spots • Lightening active ingredient in Whitening Cream diminishes melanogenic activity and decreases skin tone and spots • Tissue enlightment • Preventing or inhibiting skin pigmentation • Whitening Cream has an intelligent depigmentant; its activity is higher in areas with spots and thus evens skin color
  6. 6. • Reduces spots in number and intensity, regardless of their origin • Reduces both tyrosinase enzyme formation and activity, as well as melanin synthesis, all without affecting melanocyte viability. • Decreases skin tone in a uniform and homogenous way • It reduces the number and intensity of different types of hyperpigmentation spots.
  7. 7. • Several test were performed to assess the in vitro efficacy • PPARγ binding affinity • Study on depigmentation activity in human melanocytes : • Evaluation of tyrosinase expression • Evaluation of tyrosinase activity • Evaluation of melanin quantity • Incubation of NHEM cells (Normal Human Epidermal Melanocytes) was conducted at a concentration of 0.7% for 6 and 9 days.
  8. 8. • The active ingredients of Whitening Cream shows a good affinity to bind to PPARγ and act as a natural agonist • It reduces tyrosinase enzyme formation by 63%, therefore it reduces melanogenesis • It reduces tyrosinase activity by 55% • It decreases the amount of pigment synthesized by melanocytes by 34%, without affecting their viability • It prevents an accumulation of melanin in the skin by reducing melanocyte dendrites
  9. 9. • In vitro evaluation of melanin diminution • Application of 4 mg/cm² of whitening creams on the surface of reconstructed skin day 0, 1, 5, 6, 7, 8 • Spectrophotometric measurement of the rate of melanin compared to a control after 9 days • In vitro evaluation of skin lightening : ∆E • Epidermis color measurement was performed before starting treatment (Day 0) and 24h after the last application of Whitening Cream on tissues containing melanocytes and keratinocytes from African-american donors (spontaneus production of melanin) • Application of 4 mg/cm² of whitening creams on the surface of reconstructed skin day 0, 1, 5, 6, 7, 8
  10. 10. • Chromatometric measure of the degree of pigmentation of tissues. Quantification of the color of tissues using a Chroma Minolta CR-400. Recording parameters L * (lightness), a * and b * (chromaticity coordinates) Colour difference ∆E • In vitro evaluation of skin lightening : ∆ ITA° • Same than for ΔE with a skin spontaneus production of melanin using a Chroma Minolta CR-400 and calculation of Δ ITA°. ITA angle defines the degree of skin pigmentation darker skin have lower ITA° values
  11. 11. • In vitro evaluation of melanin diminution shows it has a significative whitening activity of around 25%. Melanin diminution is linked to the inhibilition of tyrasinase • In vitro evaluation of skin lightening : ∆E, shows a higher ∆E shows a higher darkening ; it has a significant whitening activity • After 9 days of treatment the ITA° values for tissues treated are higher than untreated tissues indicating a lighter tissue coloration compared to untreated tissues. It reduce the process of spontaneous melanin synthesis during the test
  12. 12. • In vivo efficacy • 20 Asian volunteers • 3% cosmetic formulation with active ingredient on one side of the face, and placebo on the other. • 56 days of twice daily application. • Two areas of the same volunteer: Normal skin and spotted skin
  13. 13. • Normal skin : • It decreases the intensity of skin pigmentation • The ITA° parameter increases up to 28% in skin without spots, with a mean variation of 3% • Skin with spots : • It lightens hyperpigmented areas getting a smooth and uniform complexion • Whitening Cream has an intelligent depigmentant; its activity is higher in areas with spots and thus evens skin color • It reduces spots in number and intensity, regardless of their origin
  14. 14. • The depigmenting potential of the active ingredient of the Whitening Cream was assessed using human tanned in vitro reconstructed epidermis. This in vitro experimental study was based on the measurement of melanin content and on the coloration of tissues after 9 days topical treatment. The results show that it imparts : • Significant melanin reduction • Tissue enlightment • This corroborates the down-regulating effect on melanin level. These good results of melanin contents diminution and lighter coloration after treatment prove the whitening and depigmenting properties of the active ingredient
  15. 15. • Objectivation : Illuminating • It contains mica to boost radiance of the skin for a radian, healthy looking appearance • Objectivation : Moisturizing • It has moisturizing properties thanks to the polymeric coating • Cosmetic benefits • Instant whitening effect with a natural complexion – Lighten skin tone or provide an even skin complexion • Instant illuminating effect and moisturizing – A radiance-boosting complexion perfector that smoothes and evens the skin for a luminous glow and radiant, healthy-looking appearance • Long-term whitening effect with a surface treatment based on an efficient whitening active – Preventing or inhibiting skin pigmentation
  16. 16. • Skin whitening facial treatments • Specific anti-spot facial treatments • Skin lightening body lotions • Anti-spot hand treatments • Throat and neckline treatments • Photo-aging treatments • Anti-age treatments
  17. 17. • Discontinue use of other products 3 days prior to beginning use of Whitening Cream • Cleanse skin thoroughly • Apply Whitening Cream to skin twice daily, gently massage until all traces of cream disappear into the skin • For best results, apply twice daily until desired results are achieved • Apply in the morning • Allergic reactions are NOT COMMON and only happen to a select group of people with very sensitive skin • People with sensitive skin may react to the preservative ingredients in the cream
  18. 18. • You should take a SKIN ALLERGY TEST with the cream before applying these products to your face and skin • The best way to prevent an allergic reaction is to know if one will occur • Prior to using the cream, apply a thin layer to a tiny spot on the face that can be covered by your hair • Throughout the day, observe it to see if the spot becomes puffy, itchy or warm • If all three occur, then you have an allergic reaction to the cream and should not use it at all
  19. 19. • Titanium dioxide • Aluminum hydroxide • Glycyrrhiza glabra (Licorice) Root Extract • Alpha-arbutin • Boerhavia diffusa Root Extract

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