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HOL
                              A   L CO

A Delightful Poison?
                          Marilyn Herie PhD, RSW
           Director, TEACH Project, Centre for Addiction and Mental Health
     Director, Collaborative Program in Addiction Studies, University of Toronto
   Assistant Professor (Status Only) Factor‐Inwentash Faculty of Social Work, U of T
“Alcohol may be man’s worst enemy, but
the bible says love your enemy.”
                       - Frank Sinatra
"He was a wise man who invented beer."
                    -Plato
1. A feature that
   resonated for me
2. A question I want to
   think through
3. A seed I could plant
   now
Learning Objectives
At the end of this session, you will be able to:
1. Identify the physical effects of alcohol
2. Define low‐risk drinking and reflect on where your 
    own and others’ drinking fits into Canadian drinking 
    norms
3. Explain why women and older adults are at higher 
    risk for alcohol‐related problems
4. Use simple screening tools to detect who might be 
    at risk for alcohol problems
5. Access credible and evidence‐based online 
    resources, self‐help and treatment programs.
Addiction: A binary construct?
Addiction: A continuum of severity




No Alcohol              Severe Alcohol
Problems                     Problems
Psychoactive Drug Classes

1)   Depressants
2)   Opiates/Opioids
3)   Stimulants
4)   Hallucinogens
5)   Psychiatric Medications
Depressants
Opiates/Opioids
Stimulants



    methamphetimine.co.uk
Hallucinogens




                psychology.wikia.com
Psychiatric Medications
www.camh.ca
What is standard?
= 14 grams or .6 oz of pure alcohol


http://www2.ku.edu
http://wcu.edu
Women:
                     10 drinks per week
                     2 drinks per day

                     Men:
                     15 drinks per week
                     3 drinks per day



http://www.camh.ca
How much do Canadians drink?
Turn to the person next    Canadian Men = 
to you and tell them 
your guess of the 
                             ________ standard drinks
percentage of Canadian 
men and Canadian 
women who drink more       Canadian women = 
than 14 standard drinks 
in a typical week.           ________ standard drinks
Jolinda almost never drinks at
home with her family, but
occasionally on week ends she
gets together with a group of
female friends for dinner and
conversation. On the rare
occasions when she has more
than one or two drinks she says
that she feels drunk and dizzy.
Jolinda is known among her
social group as the one who “can’t
hold her liquor,” and is sometimes
the subject of friendly teasing
among the group.
Alex loves to entertain and
socialize with friends and family.
His dinner parties are legendary for
their fine food and wine, and
creating new recipes and shopping
for hard-to-find ingredients is one of
his favourite hobbies. If he were
asked to quantify his drinking, Alex
wouldn’t know where to start –
alcohol is very much a part of his
life, yet he has a successful career
and a close relationship with his
adult children, although his wife
sometimes “nags” him about his
drinking. Although he drinks a lot
on many occasions, his friends
have only rarely ever seen him
“drunk”.
•Tolerance
•Cross‐tolerance
•Potentiation
POTENTIATION

         X
Absorption and Metabolism
mucous membranes    esophagus
          (mouth)



                          stomach (up to 20%)




 large intestine



                     small intestine (up to 80%)
brain

                                           esophagus



                      liver
                  pancreas                 stomach




   Alcohol is metabolized in the body mainly by the
   liver. The brain, pancreas, and stomach also
   metabolize alcohol.


http://pubs.niaaa.nih.gov/publications/AA72/AA72.htm
Enzyme in the liver
            transforms ethanol into a
            toxic compound
                                  A known
                                  carcinogen,
Chemical name                     quickly broken
for alcohol                       down…
                                                         Further broken
                                                         down to carbon
                                                         dioxide and
                                                         water

                                         …by another
                                         enzyme into…
  Other enzymes:
  cytochrome P450 2E1 (CYP2E1)
  catalase


  http://pubs.niaaa.nih.gov/publications/AA72/AA72.htm
.0554




http://caaneo.ca/about/blog/?page_id=30
.0875




http://caaneo.ca/about/blog/?page_id=30
Physical Effects of Alcohol
http://www.drugabuse.gov/publications/teaching-packets/brain-actions-cocaine-
    opiates-marijuana/section-ii-introduction-to-reward-system/2-reward-pathw
Effects on the Brain
• Limbic system: complex monitoring system 
  including memory and emotion
• Cerebellum: motor coordination, also 
  emotion and memory
• Cerebral Cortex: think, plan, behave 
  intelligently and social interaction – damage 
  can impair problem‐solving, memory and 
  learning
Effects on the Cerebellum

                       CONTROL     ALCOHOL




       Reduction in size of brain cells and brain
                    mass shrinks
Sullivan et al., Neuropsychology
What are the 
heart risks of 
chronic 
heavy or 
binge 
drinking?
• Alcoholic 
                cardiomyopathy
              • Arrhythmias
              • Strokes
              • Hypertension
              Binge drinkers are
              40% more likely to
              suffer any kind of
              stroke
NIAAA, 2011
“There is now little doubt that 
      moderate alcohol consumption is 
      associated with reduced coronary 
      heart disease risk in both men and 
      women.”



Herie and Skinner, 2010
Moderate drinking can…
• Reduce/inhibit build up of fat in arteries and 
  raise HDL (“good”) cholesterol
• Prevent clotting – guards against stroke and 
  heart attack
• Keep blood pressure in check
Smoking + Drinking POTENTIATES cancer-
      causing properties of each substance




Potentially                           Potentially
reduced risk of                   increased risk
heart disease                          of cancer
11% of all breast
                                                            cancers




            ACETALDEHYDE damages genetic
            material in cells, and causes cells to grow
            too quickly
http://www.drugabuse.gov/publications/teaching-packets/brain-actions-cocaine-
    opiates-marijuana/section-ii-introduction-to-reward-system/2-reward-pathw
What are the 
                                               risks to the 
                                               liver of 
                                               chronic 
                                               alcohol use?


http://www.drugabuse.gov/publications/teaching-packets/brain-actions-cocaine-
    opiates-marijuana/section-ii-introduction-to-reward-system/2-reward-pathw
• Steatosis (fatty 
                                              liver)
                                            • Alcoholic 
                                              hepatitis
                                            • Fibrosis (scar 
                                              tissue)
90% of heavy drinkers will
develop fatty liver                         • Cirrhosis
1 in 5 will develop alcoholic                   – Jaundice, Type 
hepatitis                                         2 diabetes, Liver 
1 in 4 will develop cirrhosis                     cancer
http://www.drugabuse.gov/publications/teaching-packets/brain-actions-cocaine-
    opiates-marijuana/section-ii-introduction-to-reward-system/2-reward-pathw
NIAAA, 2011
What are the 
pancreatic 
risks of 
chronic 
heavy or 
binge 
drinking?
• Acute 
                                              pancreatitis
                                            • Chronic 
                                              pancreatitis
                                                – Pancreatic 
                                                  cancer
                                                – Type 2 diabetes
                                 Approx 5% of heavy drinkers will
                                 develop pancreatitis
http://www.drugabuse.gov/publications/teaching-packets/brain-actions-cocaine-
    opiates-marijuana/section-ii-introduction-to-reward-system/2-reward-pathw
NIAAA, 2011
Alcohol’s Effects on the Immune 
             System
Alcohol suppresses the immune system
Chronic use impairs white blood cell functioning
Impairment up to 24 hours after binge drinking
How can I tell who is at risk?
DSM 5: Proposed Revisions
  “Given the empirical evidence, the DSM‐5 
  Substance Use Disorders Workgroup  
  recommends combining abuse and 
  dependence into a single disorder of graded 
  clinical severity, with two criteria required to 
  make a diagnosis.”




www.dsm5.org
A maladaptive pattern of substance use leading to clinically 
significant impairment or distress, as manifested by 2 or more of 
the following within a 12 month period:
1.
X    Failure to fulfill major       7.
                                    X   Persistent desire or 
     obligations at school, work        unsuccessful efforts to cut 
     or home                            down/control
2.
X    Recurrent use in physically    8. Time spent in obtaining, 
                                    X
     hazardous situations               using or recovering
3.
?    Persistent 
     social/interpersonal 
                                    ?
                                    9. Important activities given 
                                        up or reduced
     problems
4.   Tolerance
                                    X
                                    10. Continued use despite 
                                        knowing that physical or 
X
5.   Withdrawal                         psychological problems will 
                                        become worse or were 
6.   Larger amounts or for 
?    longer period than                 caused
     intended                       ?
                                    11. Craving, strong desire or 
                                        urge

www.dsm5.org
Three Suggested Screening Tools

1. Quantity/Frequency
2. CAGE
3. Single Item
1. Quantity/Frequency Questions
 •     How many days per week did you drink over 
       the last month?  30
 •     On a day when you drink, how many drinks 
       do you have?  4-5
 •     How many times during the last month did 
       you drink more than 5 drinks? (binge  
       drinking) 6-7


Cooney, Zweben & Fleming, 1995
2. CAGE QUESTIONS
  1.    Have you ever felt the need to Cut down 
        on your drinking? NO
  2. Have you ever been Annoyed at criticism 
        of your drinking? YES
  3. Have you ever felt Guilty about your 
        drinking? NO
  4. Have you ever had a morning Eye 
        opener? NO
                        2 or more “yes” answers is clinically significant.

Mayfield et al., 1974
3. Single Item
     • A one‐item questionnaire developed for 
       brief screening in primary care settings.  
     • Ask client:
         How many times in the past year have you had ___ 
         or more drinks in a day?
         __ = 5 for men
6 x 12 = 72

         __ = 4 for women
       Scoring: an answer of more than 1 identifies 
         unhealthy alcohol use

 National Institute on Alcohol Abuse and Alcoholism (NIAAA): Helping Patients Who
 Drink Too Much: A Clinician's Guide 2007
Psychosocial Treatment Resources
Continuum	of	Psychosocial	
                                Treatment	Services	

                                                                                                              Highly
Minimally
Intensive
                              Levels of Treatment Intensity                                                 Intensive




                                                                                                              Custodial Care
   Prevention




                Facilitate                                Extended         Residential        Long-term
                                     Short-term
                Recovery                                  Outpatient         Social           Residential
                                     Outpatient
                 without                                Interventions        Model
                                    Self-Change
                Treatment
                                      Oriented
                                   Interventions
                                                                 Day Treatment      Residential
                             Brief              Short-term                         Hospital-Based
                          Community             Outpatient
                     Interventions (e.g..,      Therapist-
                      self-help manuals,         Directed
                      physician’s advice)     Interventions
 Mild to                                                                                               Substantial
Moderate                                     Severity of Problems                                      To Severe

                CAMH
Client‐Treatment Matching
• Lack of strong evidence by which to match clients to specific 
  treatments
• Does not mean that clients all require the same types of services
• A variety of flexible and individualized services are required
• Guidelines for selecting services are needed

                          Drug Use     Problem       Social Support
                          Severity    Multiplicity     & Stability
                            Lo            Lo              Hi
       Brief Outpatient

                           Lo-Hi        Lo-Hi           Mod-Hi
       Outpatient

       Day Treatment       Mod-Hi      Mod-Hi           Mod

        Residential        Mod-Hi      Mod-Hi            Lo



 Skinner & Martin, 1995
www.connexontario.ca
www.camh.ca
McLaughlin Information Centre
CAMH now has 'centralized access' with one doorway 
          (a front door) to ALL services
      1‐800‐463‐6273 or 416‐595‐6111
Call if you would like:
• General addiction and mental illness information 
• Information on how to obtain assessments for 
  mental health and addictions
What if the person refuses to seek help?
www.alcoholhelpcenter.net
Case Example
• Alex, 52 years old
• Drinks 7 days per week
• Approximately 40 drinks per week
How does your drinking compare with 
other Canadian men in your age group?




www.alcoholhelpcenter.net
Within the last twelve (12) months: 
• You reported drinking on approximately 
  100.0% of days in the last year. 

• You reported that you drank a total of    ? # 
  of drinks in the last year. 


www.alcoholhelpcenter.net
Within the last twelve (12) months: 
• You reported drinking on approximately 
  100.0% of days in the last year. 
• You reported that you drank a total of 2080 
  drinks in the last year. 




www.alcoholhelpcenter.net
This also means that: 

• You spent approximately   ? $ in the last 
  year, depending on where you drank (at 
  home, in a bar, etc.). 




www.alcoholhelpcenter.net
This also means that: 
• You spent approximately $10,400 in the last 
  year, depending on where you drank (at 
  home, in a bar, etc.). 




www.alcoholhelpcenter.net
• You consumed (on average) 500 calories from 
  alcohol on days that you drink. Based on the 
  total amount of drinking you had enough 
  alcohol to add roughly 59 pounds or 27 
  kilograms to your weight in the last year. 
  Note: One drink has about 100 calories and 
  3,500 calories roughly equals 1 extra pound of 
  weight. 
• You also reported that within the past year, 
  the greatest number of drinks you had on one 
  occasion was 12 drinks. 
www.alcoholhelpcenter.net
www.alcoholhelpcenter.net
www.alcoholhelpcenter.net
You reported that you weigh 160 lbs. This 
  means that: 
• If your liver is healthy, burning one drink takes you 2 
  hours. Burning four drinks takes you about 8 hours. 
  If you had ten drinks, it will take about 19 hours
  until there is no alcohol in your system. 




www.alcoholhelpcenter.net
?
• In the last year you spent about  hours under the 
  influence of alcohol (based on your typical drinking 
  during one week).




www.alcoholhelpcenter.net
• In the last year you spent about 4,004 hours 
  under the influence of alcohol (based on your 
  typical drinking during one week).




www.alcoholhelpcenter.net
Hmm…
1. A feature that
   resonated for me
2. A question I want to
   think through
3. A seed I could plant
   now
Playlist
•   La Traviata, Giusseppe Verdi: The "Drinking Song”
•   Eric Burdon and War – Spill the Wine
•   UB 40 – Red Red Wine 
•   Frank Sinatra – The Lady is a Tramp
•   Jimmy Buffett – Margaritaville
•   Garth Brooks – Friends in Low Places 
•   Amy Winehouse – Rehab
•   Frank Sinatra – One for My Baby (One for The 
    Road) 

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