Sodium/Potassium Pump

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Sodium/Potassium Pump

  1. 1. The Sodium-Potassium Pump (Na+/K+ - ATPase) <ul><li>A specific case of active transport </li></ul><ul><li>This is one of the best examples of active transport in animal cells </li></ul><ul><li>This pump transports Na+ ions out of the cell and K+ ions into the cell. Thus keeping the intracellular concentration of Na low compared to outside, and the intracellular concentration of K high </li></ul><ul><li>The pump is driven by hydrolysis of ATP </li></ul><ul><li>It uses about 30% of the energy available to any one animal cell! </li></ul><ul><li>The pump is a transmembrane carrier protein made up of 4 subunits (2 large and 2 small) </li></ul>
  2. 2. <ul><li>Structure: has 3 binding sites for sodium ions, 2 binding sites for potassium ions and a phosphorylation site to accept a phosphate from ATP </li></ul><ul><li>2 different conformations of protein are possible. This is controlled by the phosphorylation state of the protein </li></ul><ul><li>Hydrolysis of one ATP molecule fuels the export of 3 Na+ ions and the import of 2 K+ ions </li></ul><ul><li>Can work as fast as 300 Na+ ions per second if required! </li></ul><ul><li>[Sodium-Potassium Pump Diagram] </li></ul><ul><li>Sodium Potassium Pump Animation </li></ul>

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