2. General info
Clinical info
1- indications
2- dosage and administration
3- CI
4- DI
5- precautions
Pharmaceutical info: dosage forms and storage
conditions
3. GENERAL INFORMATION
MOA: Cell wall synthesis inhibitor
Antibacterial spectrum: G+ organisms ( most
important MRSA and drug resistant enterococci)
4. CLINICAL INFO:
INDICATION
For serious G+ infections or those who have an
allergy to penicillin
MRSA and MRSE
Orally for life threatening Clostridium Difficile
associated colitis
With aminoglycosides for enterococcal endocarditis
5. CLINICAL INFO:
DOSAGE AND ADMINISTRATION
By slow iv infusion over 60-90 min depending on
dose
a. 500mg q.6.h over 1h or 1g bid over 100min
b. at a rate no more than 10mg/min
Preferred to be intermittent iv inf.
Dose depends on CLcr , age, and B.wt.
6. CLINICAL INFO:
DOSAGE AND ADMINISTRATION
Preparation:
1- Add 10 ml of sterile WFI to a 500 mg vial of
Vancomycin powder >> 50 mg/ml
2- Reconstituted solutions containing 500 mg vancomycin
must be diluted with at least
100 ml diluent. (NaCl soln. or Dextrose soln.)
10. PRECAUTIONS
Renal impairment
Rapid infusion
Monitor renal function and hearing
Pregnancy: BM
Breast feeding: oral absorption is poor but problems
with bowels normal flora and allergic effects have
been reported
11. PHARMACEUTICAL INFO:
DOSAGE FORM AND STORAGE CONDITIONS
Vancocin
Vancoled
500 mg vial
Store in airtight container and protect from light
13. GENERAL INFORMATION
Glycopeptide antibiotic
MOA: Cell wall synthesis inhibitor
Antibacterial spectrum: G+ organisms ( most
important MRSA and drug resistant enterococci)
14. CLINICAL INFO:
INDICATION
For serious G+ infections or those who have an allergy
to penicillin
MRSA and MRSE
Orally for life threatening Clostridium Difficile associated
colitis
For endocarditis
Treating infection of the abdominal cavity (peritonitis)
associated with peritoneal dialysis.
15. CLINICAL INFO:
DOSAGE AND ADMINISTRATION
ROA: Intraperitoneally, IM, IV (inf and bolus), po
Given once daily after the loading dose
Dose depends on age, CLcr, and wt
16. CLINICAL INFO:
DOSAGE AND ADMINISTRATION
Preperation:
1- add water from the ampoule into the vial (3ml)
2- rotate gently between hands to dissolve the
powder be careful not to form foam…. If foam
develops leave the soln to stand for 15min
3- dilute with NaCl soln, Lactate Ringers, or
Dextrose soln or NaCl with dextrose soln.
4- add lidocaine 0.5 or 1% if IM
** the final soln. is stable for about 24hrs at 2-8◦ c
(beware of contamination)