Not just for pain
But
More……………………………………………..

Aspirin
Hybrid

A new approach for cancer prevention and control
No matter ...
Therapeutic compounds, such as aspirin, are most
stable in a crystalline form, but can display poor
aqueous solubility and...




We believe there isn't one way to beat cancer - there
are hundreds. For nearly 7 years, we've been
committed to find...


1. A pharmaceutical composition for treatment of
conditions in mammals which are responsive to COX2 inhibition which co...
Rational



Acetylsalicylic acid may just keep cancers away, or so suggests a report
released in the U.K. medical journal...
Rational



"Aspirin - which deactivates an enzyme associated with
inflammation - offers a plausible means of reducing th...
Rational



Inflammation is believed to contribute to a
variety of cancers. Long-term inflammation leads
to abnormal cell...
Rational





The scientists who developed the new drug decided
including NO and H2S probably had dual benefits, so they...
Rituxan - $3 billion
 Avastin - $2.66 billion
 Herceptin - $1.66 billion
 Gleevec - $1.51 billion
 Eloxatin - $1.2 bil...







Proof of concept>>>>>>>>>>Completed
R&D>>>>>>>>>>>>>>>>>>Completed
Pilot scale >>>>>>>>>>>>> Completed
Lab. Te...









Scale Manufacturing
Animal efficacy: Drug Interactions
IND
Phase I
Phase III
License submission
18)

Dual
...






Our hybrid is designed to control inflammation
Water soluble
Synergistic effect
Potentiating each other
Potenti...
Dual
Action
Prostaglandin production is increased by VEGF-D+ which is produced by
metastatic cancer cells. Increased prostaglandin lea...
Hybrid

Hybrid

Hybrid

No matter how easy cancer treatment may become, it is preferable to prevent cancer

Dual
Action
Dual
Action
Facts
Nanocarriers serve as ideal delivery solutions for combination
therapy which is required for effectively treating MD...
No matter how easy cancer treatment may
become, it is preferable to prevent cancer

Dual
Action
Available Brands
Currently, intravenous aspirin is not approved for use in the
United States. The poor solubility of aspir...
Aspirin crystals

Aspirin nano

Dual
Action
ARACHIDONIC ACID

ARACHIDONIC ACID

IL6
Cox-II

Cox-I

ASPIRIN
PROSTAGLANDINS
INFLAMMATION
Dual
Action

Cox-II

Cox-I

ASC...
Dual
Action
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Aspirin as nanomedicine

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A new advanced aspirin
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Aspirin as nanomedicine

  1. 1. Not just for pain But More…………………………………………….. Aspirin Hybrid A new approach for cancer prevention and control No matter how easy cancer treatment may become, it is preferable to prevent cancer Dual Action Mewa Singh 609-902-7128 mewasinghsandhu@hotmail.com
  2. 2. Therapeutic compounds, such as aspirin, are most stable in a crystalline form, but can display poor aqueous solubility and slow dissolution rates. These properties impart the tendency to reduce the bioavailability of the active pharmaceutical ingredient (API), thereby slowing absorption.  A safe solution from Meda Biotech
  3. 3.   We believe there isn't one way to beat cancer - there are hundreds. For nearly 7 years, we've been committed to finding the right combination for cancer prevention that is safe and effective and of low cost At the same time, it should support patient with therapies to boost immune system, reduce pain and improve quality of life Dual Action
  4. 4.  1. A pharmaceutical composition for treatment of conditions in mammals which are responsive to COX2 inhibition which comprises in combination an effective amount of a COX-2 inhibitor and low-dose aspirin, wherein said low-dose of aspirin is equivalent to less than 75 milligrams per day of aspirin, for simultaneous, sequential or separate use wherein said condition is selected from the group of acute coronary ischemic syndrome, thrombosis, thromboembolism, thrombic occlusion and reocclusion, transient ischemic attack, myocardial infarction and first or subsequent thrombic stroke. Dual Action
  5. 5. Rational  Acetylsalicylic acid may just keep cancers away, or so suggests a report released in the U.K. medical journal Lancet on December 7, 2010. The researchers looked at a great deal of data to come to their conclusion, with Dr. Peter M. Rothwell and colleagues examining records from 25,570 patients who had taken part in eight trials (“Effect of Daily Aspirin on Longterm Risk of Death Due to Cancer.”) Can Low-Dose Acetylsalicylic Acid Prevent Cancer? | Suite101.com http://www.suite101.com/news/more-benefit-from-daily-lowdose-aspirin-cancer-prevention-a317573#ixzz1v8Nw2ldT Nanosgroup AspirinHybrid is one step ahead of this game plan Dual Action
  6. 6. Rational  "Aspirin - which deactivates an enzyme associated with inflammation - offers a plausible means of reducing the inflammation that is part of cancer progression," he wrote about study results. "Effects of aspirin were strongest for cancers of the gastrointestinal tract, where aspirin exerts its most direct effects. This study reaffirms a potential role for aspirin in both cancer prevention and treatment, and suggests new directions for anticancer drug development. Read more at Suite101: Can Low-Dose Acetylsalicylic Acid Prevent Cancer? | Suite101.com http://www.suite101.com/news/more-benefit-from-daily-lowdose-aspirin-cancer-prevention-a317573#ixzz1v8QWf1Ix No matter how easy cancer treatment may become, it is preferable to prevent cancer Dual Action
  7. 7. Rational  Inflammation is believed to contribute to a variety of cancers. Long-term inflammation leads to abnormal cell growth, or dysplasia. Examples include inflammation from infection. HPV can lead to cervical cancer and Hepatitis B puts individuals at risk for liver cancer. http://digitaljournal.com/article/320418#ixzz1v 8h3lpMY No matter how easy cancer treatment may become, it is preferable to prevent cancer Dual Action
  8. 8. Rational   The scientists who developed the new drug decided including NO and H2S probably had dual benefits, so they came up with the „NOSH aspirin‟. The combination of studies related to aspirin for stopping cancer makes the possibility of the hybrid, powerful, gastrointestinal protective aspirin for development as an anti-cancer drug intriguing. http://digitaljournal.com/article/320418#ixzz1v8hwNjSv http://digitaljournal.com/article/320418#ixzz1v8hFF3L0 No matter how easy cancer treatment may become, it is preferable to prevent cancer Dual Action
  9. 9. Rituxan - $3 billion  Avastin - $2.66 billion  Herceptin - $1.66 billion  Gleevec - $1.51 billion  Eloxatin - $1.2 billion  Alimta - $1.04 billion  Erbitux - $703.3 million  Velcade - $692.7 million  Xeloda - $647.6 million  Tarceva - $564.2 million Dual Action None for prevention or control
  10. 10.      Proof of concept>>>>>>>>>>Completed R&D>>>>>>>>>>>>>>>>>>Completed Pilot scale >>>>>>>>>>>>> Completed Lab. Testing>>>>>>>>>>>>>Completed Animal Studies>>>>>>>>>>>Ongoing Exit-1st- $100M  Manufacturing Process>Under development GMP product >>>>>>>>>>>>Needed Clinical-I  Bioequivalence>>>>>>>>>>> Needed   $1M Invested With time Exit-2nd- $250M Dual Action $3M Needed
  11. 11.        Scale Manufacturing Animal efficacy: Drug Interactions IND Phase I Phase III License submission 18) Dual Action 1st year (2014) (2015) (2016) (2017-
  12. 12.      Our hybrid is designed to control inflammation Water soluble Synergistic effect Potentiating each other Potential to surpass existing aspirin brands Dual Action No matter how easy cancer treatment may become, it is preferable to prevent cancer
  13. 13. Dual Action
  14. 14. Prostaglandin production is increased by VEGF-D+ which is produced by metastatic cancer cells. Increased prostaglandin leads to dilation of lymphatic vessels allowing cancer cells to spread. Aspirin prevents cancer by inhibiting prostaglandin production, narrowing lymphatic vessels, restricting spread of cancer. Dual Action No matter how easy cancer treatment may become, it is preferable to prevent cancer
  15. 15. Hybrid Hybrid Hybrid No matter how easy cancer treatment may become, it is preferable to prevent cancer Dual Action
  16. 16. Dual Action
  17. 17. Facts Nanocarriers serve as ideal delivery solutions for combination therapy which is required for effectively treating MDR cancer. The benefits of nanocarriers include, (1) they can be engineered to achieve multiple effects using one system; (2) nanocarriers improve the therapeutic index of drugs and can alter the pharmacokinetic profile of agents; (3) they preferentially accumulate in the tumor environment thanks to the EPR effect and their capacity to be conjugated to targeting moieties; and (4) nanocarriers avoid drug efflux by preferentially localizing agents in the peri-nuclear region of a cell, away from membrane localized efflux pumps. Dual Action
  18. 18. No matter how easy cancer treatment may become, it is preferable to prevent cancer Dual Action
  19. 19. Available Brands Currently, intravenous aspirin is not approved for use in the United States. The poor solubility of aspirin in water and its rapid hydrolysis in the plasma to salicylic acid and acetic acid have limited its intravenous use. Attempts have been made in the past to produce an aspirin product having an acceptable solubility, but none have proven to be totally satisfactory. For example, the introduction of Bayer aspirin, as well as Disprin (distributed in the United Kingdom), into water results in the formation of a cloudy suspension indicative of incomplete dissolution in water. Aspro Clear (distributed in Australia and New Zealand and marketed throughout Europe) imparts a non-cloudy, snow globe effect in water for more than three minutes after the tablets have effervesced. Dual Action Our Hybrid is unique and works much better and faster
  20. 20. Aspirin crystals Aspirin nano Dual Action
  21. 21. ARACHIDONIC ACID ARACHIDONIC ACID IL6 Cox-II Cox-I ASPIRIN PROSTAGLANDINS INFLAMMATION Dual Action Cox-II Cox-I ASCURIN PROSTAGLANDINS INFLAMMATION
  22. 22. Dual Action

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