The document discusses performance optimization in Clojure programming, emphasizing that programmers often waste time optimizing noncritical code, which can hinder debugging and maintenance. It suggests that only about 3% of code needs careful optimization while advocating for good design, the use of efficient algorithms, and incorporating Java and GraalVM for improved performance. Key strategies include understanding the cost of abstractions and immutability, using appropriate libraries, and benchmarking to achieve fast web applications.