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Caveats for PCV schedules that rely on herd effects
in countries with intensive transmission
Stefan Flasche
MRF 2021 13th International Conference
3 November 2021
Conflicts of interest
None
The problem
Main burden of pneumococcal disease in first year of life
Do we need direct protection in the first year of life or could we rely on
indirect protection?
If we can, then
• Protect others via indirect protection
• Reduce costs
Caveats for indirect protection through PCV
Indirect protection  direct protection for main transmitters
Key questions:
• Who transmits?
• Duration of protection after booster?
Watch out for:
• 2p+1 vs 3p+0 cRCT in Malawi
• 1p+1 vs 3p+0 cRCT in Gambia
Qian 2021 medRxiv
Other considerations
Programmatic and logistical concerns:
• (Booster dose) coverage
• Incomplete dosing schedule
• Travel / border spill-over
• Lack of routine surveillance
MCV1 coverage
DTP3 coverage
©
WHO
2018

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Professor Stefan flasche

  • 1. Caveats for PCV schedules that rely on herd effects in countries with intensive transmission Stefan Flasche MRF 2021 13th International Conference 3 November 2021
  • 3. The problem Main burden of pneumococcal disease in first year of life Do we need direct protection in the first year of life or could we rely on indirect protection? If we can, then • Protect others via indirect protection • Reduce costs
  • 4. Caveats for indirect protection through PCV Indirect protection  direct protection for main transmitters Key questions: • Who transmits? • Duration of protection after booster? Watch out for: • 2p+1 vs 3p+0 cRCT in Malawi • 1p+1 vs 3p+0 cRCT in Gambia Qian 2021 medRxiv
  • 5. Other considerations Programmatic and logistical concerns: • (Booster dose) coverage • Incomplete dosing schedule • Travel / border spill-over • Lack of routine surveillance MCV1 coverage DTP3 coverage © WHO 2018