SlideShare a Scribd company logo

Prof Kim Mulholland @ MRF's Meningitis & Septicaemia in Adults & Children

Effectiveness of pneumococcal conjugate vaccines in developing countries https://www.meningitis.org/mrf-conference-2017

1 of 32
Download to read offline
Pneumococcal vaccines – impact
in the developing world
Kim Mulholland
Murdoch Children’s Research Institute, Melbourne
London School of Hygiene and Tropical medicine
University of Melbourne
Pneumococcal vaccines - history
• 1911 – 1st pneumococcal vaccine trial in South
Africa
• 1930-34 – 7-valent pneumococcal vaccine
protected miners against types 1,2,3,5,7,12,14
(Pub South African Inst Med Research 1935;37:7)
• 1945 – 4-valent vaccine (1,2,5,7) in US Air Force
recruits
– ↓ pneumococcal pneumonia
– ↓ pneumococcal carriage of vaccine types
(J Exp Med 1945;82:445-65)
– Licensed by Squibb, abandoned in 1951
• 1960s – Robert Austrian argued that
pneumococcus remained an important cause
of death
• 1977 – 14-valent PS vaccine licensed by Merck
• 1983 – 23-valent PS vaccine licensed
• 1986 – Trial of PS vaccine in Papua New
Guinea children published (I Riley et al)
• 1988 – work begins on pneumococcal
conjugate vaccine (NIH-Praxis Biologics)
• 1990 – Hib conjugate vaccine licensed for use
in infants
• 2000 – Gavi Alliance launched
• 2000 – 1st PCV licensed (PCV7 or Prevnar-7®,
Wyeth Vaccines)
– $57/dose
– ST1 and ST5 excluded
– PCV9 (with 1 & 5) produced and used in key trials in
Gambia and South Africa
• Around 2003 – PCV11 (Sanofi Pasteur)
abandoned midway through Philippines trial
• 2003 – Initiatives to make PCVs available
– PneumoADIP
– Advance Market Commitment
– International Finance Facility for Immunization
• 2009 – PCV7 introduced into South Africa,
Gambia and Rwanda
• 2009 – PCV7 introduced into South Africa,
Gambia and Rwanda
ES Donkor et al. Vaccination against
pneumococcus in West Africa
Int J Gen Med 2013;6:757-764
Invasive pneumococcal disease
in West Africa

Recommended

GBSS' Jane Plumb @ MRF's Meningitis & Septicaemia in Children & Adults 2017
GBSS' Jane Plumb @ MRF's Meningitis & Septicaemia in Children & Adults 2017GBSS' Jane Plumb @ MRF's Meningitis & Septicaemia in Children & Adults 2017
GBSS' Jane Plumb @ MRF's Meningitis & Septicaemia in Children & Adults 2017Meningitis Research Foundation
 
Prof Rick Malley @ Meningitis & Septicaemia in Children & Adults 2017
Prof Rick Malley @ Meningitis & Septicaemia in Children & Adults 2017Prof Rick Malley @ Meningitis & Septicaemia in Children & Adults 2017
Prof Rick Malley @ Meningitis & Septicaemia in Children & Adults 2017Meningitis Research Foundation
 
Prof David Goldblatt @ Meningitis & Septicaemia in Children & Adults 2017
Prof David Goldblatt @ Meningitis & Septicaemia in Children & Adults 2017Prof David Goldblatt @ Meningitis & Septicaemia in Children & Adults 2017
Prof David Goldblatt @ Meningitis & Septicaemia in Children & Adults 2017Meningitis Research Foundation
 
Dr Jethro Herberg @ MRF's Meningitis & Septicaemia in Children and Adults 2017
Dr Jethro Herberg @ MRF's Meningitis & Septicaemia in Children and Adults 2017Dr Jethro Herberg @ MRF's Meningitis & Septicaemia in Children and Adults 2017
Dr Jethro Herberg @ MRF's Meningitis & Septicaemia in Children and Adults 2017Meningitis Research Foundation
 
Prof James Stuart @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Prof James Stuart @ MRF's Meningitis & Septicaemia in Children & Adults 2017Prof James Stuart @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Prof James Stuart @ MRF's Meningitis & Septicaemia in Children & Adults 2017Meningitis Research Foundation
 
Dr Kirsty Le Doare @ MRF's Meningitis and Septicaemia 2019
Dr Kirsty Le Doare @ MRF's Meningitis and Septicaemia 2019Dr Kirsty Le Doare @ MRF's Meningitis and Septicaemia 2019
Dr Kirsty Le Doare @ MRF's Meningitis and Septicaemia 2019Meningitis Research Foundation
 
Dr Koonal Shah @ Meningitis & Septicaemia in Adults & Children 2017
Dr Koonal Shah @  Meningitis & Septicaemia in Adults & Children 2017Dr Koonal Shah @  Meningitis & Septicaemia in Adults & Children 2017
Dr Koonal Shah @ Meningitis & Septicaemia in Adults & Children 2017Meningitis Research Foundation
 

More Related Content

What's hot

Dr Hannah Christensen @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Dr Hannah Christensen @ MRF's Meningitis & Septicaemia in Children & Adults 2017Dr Hannah Christensen @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Dr Hannah Christensen @ MRF's Meningitis & Septicaemia in Children & Adults 2017Meningitis Research Foundation
 
Dr Caroline Trotter @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Dr Caroline Trotter @ MRF's Meningitis & Septicaemia in Children & Adults 2017Dr Caroline Trotter @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Dr Caroline Trotter @ MRF's Meningitis & Septicaemia in Children & Adults 2017Meningitis Research Foundation
 
Dr Sarah Meyer @ Meningitis & Septicaemia in Children & Adults
Dr Sarah Meyer @ Meningitis & Septicaemia in Children & AdultsDr Sarah Meyer @ Meningitis & Septicaemia in Children & Adults
Dr Sarah Meyer @ Meningitis & Septicaemia in Children & AdultsMeningitis Research Foundation
 
Dr Ado Bwaka @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Dr Ado Bwaka @ MRF's Meningitis & Septicaemia in Children & Adults 2017Dr Ado Bwaka @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Dr Ado Bwaka @ MRF's Meningitis & Septicaemia in Children & Adults 2017Meningitis Research Foundation
 
Hannah McCall - prize winning poster at MRF's Meningitis & Septicaemia in Ch...
Hannah McCall  - prize winning poster at MRF's Meningitis & Septicaemia in Ch...Hannah McCall  - prize winning poster at MRF's Meningitis & Septicaemia in Ch...
Hannah McCall - prize winning poster at MRF's Meningitis & Septicaemia in Ch...Meningitis Research Foundation
 
Helen Campbell @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Helen Campbell @ MRF's Meningitis & Septicaemia in Children & Adults 2017Helen Campbell @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Helen Campbell @ MRF's Meningitis & Septicaemia in Children & Adults 2017Meningitis Research Foundation
 
Dr Joanne Langley @ MRF's Meningitis & Septicaemia in children and Adults 2017
Dr Joanne Langley @ MRF's Meningitis & Septicaemia in children and Adults 2017Dr Joanne Langley @ MRF's Meningitis & Septicaemia in children and Adults 2017
Dr Joanne Langley @ MRF's Meningitis & Septicaemia in children and Adults 2017Meningitis Research Foundation
 
Prof Adam Finn @ MRF's Meningitis and Septicaemia 2019
Prof Adam Finn @ MRF's Meningitis and Septicaemia 2019Prof Adam Finn @ MRF's Meningitis and Septicaemia 2019
Prof Adam Finn @ MRF's Meningitis and Septicaemia 2019Meningitis Research Foundation
 
Claire Wright @ MRF's Meningitis and Septicaemia 2019
Claire Wright @ MRF's Meningitis and Septicaemia 2019  Claire Wright @ MRF's Meningitis and Septicaemia 2019
Claire Wright @ MRF's Meningitis and Septicaemia 2019 Meningitis Research Foundation
 
Dr Matthew Colidron @ MRF's Meningitis & Septicaemia in Children & Adults 2017+
Dr Matthew Colidron @ MRF's Meningitis & Septicaemia in Children & Adults 2017+Dr Matthew Colidron @ MRF's Meningitis & Septicaemia in Children & Adults 2017+
Dr Matthew Colidron @ MRF's Meningitis & Septicaemia in Children & Adults 2017+Meningitis Research Foundation
 
Prof Andrew Pollard @ MRF's Meningitis and Septicaemia 2019
Prof Andrew Pollard @ MRF's Meningitis and Septicaemia 2019Prof Andrew Pollard @ MRF's Meningitis and Septicaemia 2019
Prof Andrew Pollard @ MRF's Meningitis and Septicaemia 2019Meningitis Research Foundation
 
Dr Muhamed-Kheir Taha @ MRF's Meningitis and Septicaemia 2019
Dr Muhamed-Kheir Taha @ MRF's Meningitis and Septicaemia 2019Dr Muhamed-Kheir Taha @ MRF's Meningitis and Septicaemia 2019
Dr Muhamed-Kheir Taha @ MRF's Meningitis and Septicaemia 2019Meningitis Research Foundation
 
Prof David Stephens @ Meningitis & Septicaemia in Children & Adults
Prof David Stephens @ Meningitis & Septicaemia in Children & AdultsProf David Stephens @ Meningitis & Septicaemia in Children & Adults
Prof David Stephens @ Meningitis & Septicaemia in Children & AdultsMeningitis Research Foundation
 
Prof Rob Heyderman @ MRF's Meningitis and Septicaemia 2019
Prof Rob Heyderman @ MRF's Meningitis and Septicaemia 2019Prof Rob Heyderman @ MRF's Meningitis and Septicaemia 2019
Prof Rob Heyderman @ MRF's Meningitis and Septicaemia 2019Meningitis Research Foundation
 
Dr Mark Alderson @ MRF's Meningitis and Septicaemia 2019
Dr Mark Alderson @ MRF's Meningitis and Septicaemia 2019Dr Mark Alderson @ MRF's Meningitis and Septicaemia 2019
Dr Mark Alderson @ MRF's Meningitis and Septicaemia 2019Meningitis Research Foundation
 
Meningitis Research Foundation' current and upcoming work by Linda Glennie
Meningitis Research Foundation' current and upcoming work by Linda GlennieMeningitis Research Foundation' current and upcoming work by Linda Glennie
Meningitis Research Foundation' current and upcoming work by Linda GlennieMeningitis Research Foundation
 

What's hot (20)

Dr Hannah Christensen @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Dr Hannah Christensen @ MRF's Meningitis & Septicaemia in Children & Adults 2017Dr Hannah Christensen @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Dr Hannah Christensen @ MRF's Meningitis & Septicaemia in Children & Adults 2017
 
Dr Caroline Trotter @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Dr Caroline Trotter @ MRF's Meningitis & Septicaemia in Children & Adults 2017Dr Caroline Trotter @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Dr Caroline Trotter @ MRF's Meningitis & Septicaemia in Children & Adults 2017
 
Dr Matt Coldiron @ MRF's Meningitis and Septicaemia
Dr Matt Coldiron @ MRF's Meningitis and SepticaemiaDr Matt Coldiron @ MRF's Meningitis and Septicaemia
Dr Matt Coldiron @ MRF's Meningitis and Septicaemia
 
Dr Sarah Meyer @ Meningitis & Septicaemia in Children & Adults
Dr Sarah Meyer @ Meningitis & Septicaemia in Children & AdultsDr Sarah Meyer @ Meningitis & Septicaemia in Children & Adults
Dr Sarah Meyer @ Meningitis & Septicaemia in Children & Adults
 
Dr Ado Bwaka @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Dr Ado Bwaka @ MRF's Meningitis & Septicaemia in Children & Adults 2017Dr Ado Bwaka @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Dr Ado Bwaka @ MRF's Meningitis & Septicaemia in Children & Adults 2017
 
Hannah McCall - prize winning poster at MRF's Meningitis & Septicaemia in Ch...
Hannah McCall  - prize winning poster at MRF's Meningitis & Septicaemia in Ch...Hannah McCall  - prize winning poster at MRF's Meningitis & Septicaemia in Ch...
Hannah McCall - prize winning poster at MRF's Meningitis & Septicaemia in Ch...
 
Helen Campbell @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Helen Campbell @ MRF's Meningitis & Septicaemia in Children & Adults 2017Helen Campbell @ MRF's Meningitis & Septicaemia in Children & Adults 2017
Helen Campbell @ MRF's Meningitis & Septicaemia in Children & Adults 2017
 
Dr Suzanne Anderson
Dr Suzanne AndersonDr Suzanne Anderson
Dr Suzanne Anderson
 
Dr Joanne Langley @ MRF's Meningitis & Septicaemia in children and Adults 2017
Dr Joanne Langley @ MRF's Meningitis & Septicaemia in children and Adults 2017Dr Joanne Langley @ MRF's Meningitis & Septicaemia in children and Adults 2017
Dr Joanne Langley @ MRF's Meningitis & Septicaemia in children and Adults 2017
 
Prof Adam Finn @ MRF's Meningitis and Septicaemia 2019
Prof Adam Finn @ MRF's Meningitis and Septicaemia 2019Prof Adam Finn @ MRF's Meningitis and Septicaemia 2019
Prof Adam Finn @ MRF's Meningitis and Septicaemia 2019
 
Claire Wright @ MRF's Meningitis and Septicaemia 2019
Claire Wright @ MRF's Meningitis and Septicaemia 2019  Claire Wright @ MRF's Meningitis and Septicaemia 2019
Claire Wright @ MRF's Meningitis and Septicaemia 2019
 
Dr Matt Coldiron @ MRF's Meningitis and Septicaemia
Dr Matt Coldiron @ MRF's Meningitis and SepticaemiaDr Matt Coldiron @ MRF's Meningitis and Septicaemia
Dr Matt Coldiron @ MRF's Meningitis and Septicaemia
 
Prof Joy Lawn @ MRF's Meningitis and Septicaemia 2019
Prof Joy Lawn @ MRF's Meningitis and Septicaemia 2019Prof Joy Lawn @ MRF's Meningitis and Septicaemia 2019
Prof Joy Lawn @ MRF's Meningitis and Septicaemia 2019
 
Dr Matthew Colidron @ MRF's Meningitis & Septicaemia in Children & Adults 2017+
Dr Matthew Colidron @ MRF's Meningitis & Septicaemia in Children & Adults 2017+Dr Matthew Colidron @ MRF's Meningitis & Septicaemia in Children & Adults 2017+
Dr Matthew Colidron @ MRF's Meningitis & Septicaemia in Children & Adults 2017+
 
Prof Andrew Pollard @ MRF's Meningitis and Septicaemia 2019
Prof Andrew Pollard @ MRF's Meningitis and Septicaemia 2019Prof Andrew Pollard @ MRF's Meningitis and Septicaemia 2019
Prof Andrew Pollard @ MRF's Meningitis and Septicaemia 2019
 
Dr Muhamed-Kheir Taha @ MRF's Meningitis and Septicaemia 2019
Dr Muhamed-Kheir Taha @ MRF's Meningitis and Septicaemia 2019Dr Muhamed-Kheir Taha @ MRF's Meningitis and Septicaemia 2019
Dr Muhamed-Kheir Taha @ MRF's Meningitis and Septicaemia 2019
 
Prof David Stephens @ Meningitis & Septicaemia in Children & Adults
Prof David Stephens @ Meningitis & Septicaemia in Children & AdultsProf David Stephens @ Meningitis & Septicaemia in Children & Adults
Prof David Stephens @ Meningitis & Septicaemia in Children & Adults
 
Prof Rob Heyderman @ MRF's Meningitis and Septicaemia 2019
Prof Rob Heyderman @ MRF's Meningitis and Septicaemia 2019Prof Rob Heyderman @ MRF's Meningitis and Septicaemia 2019
Prof Rob Heyderman @ MRF's Meningitis and Septicaemia 2019
 
Dr Mark Alderson @ MRF's Meningitis and Septicaemia 2019
Dr Mark Alderson @ MRF's Meningitis and Septicaemia 2019Dr Mark Alderson @ MRF's Meningitis and Septicaemia 2019
Dr Mark Alderson @ MRF's Meningitis and Septicaemia 2019
 
Meningitis Research Foundation' current and upcoming work by Linda Glennie
Meningitis Research Foundation' current and upcoming work by Linda GlennieMeningitis Research Foundation' current and upcoming work by Linda Glennie
Meningitis Research Foundation' current and upcoming work by Linda Glennie
 

Similar to Prof Kim Mulholland @ MRF's Meningitis & Septicaemia in Adults & Children

New Vaccines in the immediate pipeline - Slideset by Professor Susanna Esposito
New Vaccines in the immediate pipeline - Slideset by Professor Susanna EspositoNew Vaccines in the immediate pipeline - Slideset by Professor Susanna Esposito
New Vaccines in the immediate pipeline - Slideset by Professor Susanna EspositoWAidid
 
National Immunization Schedule
National Immunization ScheduleNational Immunization Schedule
National Immunization ScheduleManisha Mandal
 
Prevenar e cme june 2020 & FAQs & COVID Clinic Questions
Prevenar e cme june 2020 & FAQs & COVID Clinic QuestionsPrevenar e cme june 2020 & FAQs & COVID Clinic Questions
Prevenar e cme june 2020 & FAQs & COVID Clinic QuestionsGaurav Gupta
 
Marie Pierre @ MRF's Meningitis & Septicaemia in Children & Adults 2015
Marie Pierre @ MRF's Meningitis & Septicaemia in Children & Adults 2015 Marie Pierre @ MRF's Meningitis & Septicaemia in Children & Adults 2015
Marie Pierre @ MRF's Meningitis & Septicaemia in Children & Adults 2015 Meningitis Research Foundation
 
ppt on Tdap vaccination by Dr. Alka Mukherjee - Mukherjee Hospital
ppt on Tdap vaccination by Dr. Alka Mukherjee - Mukherjee Hospitalppt on Tdap vaccination by Dr. Alka Mukherjee - Mukherjee Hospital
ppt on Tdap vaccination by Dr. Alka Mukherjee - Mukherjee HospitalMukherjeeHospital
 
Influenza Vaccination in india - Pediatrician's Perspective, May 2016
Influenza Vaccination in india - Pediatrician's Perspective, May 2016Influenza Vaccination in india - Pediatrician's Perspective, May 2016
Influenza Vaccination in india - Pediatrician's Perspective, May 2016Gaurav Gupta
 
Efficacy differences between PCV10 and PCV13 - Slideset by Professors Esposit...
Efficacy differences between PCV10 and PCV13 - Slideset by Professors Esposit...Efficacy differences between PCV10 and PCV13 - Slideset by Professors Esposit...
Efficacy differences between PCV10 and PCV13 - Slideset by Professors Esposit...WAidid
 
Elimination of meningitis A epidemics in Africa; MenAfriVac future plans
Elimination of meningitis A epidemics in Africa; MenAfriVac future plansElimination of meningitis A epidemics in Africa; MenAfriVac future plans
Elimination of meningitis A epidemics in Africa; MenAfriVac future plansMeningitis Research Foundation
 
Polio end game presentation
Polio end game presentationPolio end game presentation
Polio end game presentationGaurav Gupta
 
Potential advantages of booster containing PCV regimen - Professor Shabir Madhi
Potential advantages of booster containing PCV regimen - Professor Shabir MadhiPotential advantages of booster containing PCV regimen - Professor Shabir Madhi
Potential advantages of booster containing PCV regimen - Professor Shabir MadhiWAidid
 
SMU DPRU WEBSITE 24 Aug 2015 (1)
SMU DPRU WEBSITE 24 Aug 2015 (1)SMU DPRU WEBSITE 24 Aug 2015 (1)
SMU DPRU WEBSITE 24 Aug 2015 (1)Martin Munene Nyaga
 
VACCINATION IN PREGNANCY 25092023.pptx
VACCINATION IN PREGNANCY 25092023.pptxVACCINATION IN PREGNANCY 25092023.pptx
VACCINATION IN PREGNANCY 25092023.pptxNiranjan Chavan
 
Vaccination in women from adolescence to menopause
Vaccination in women from adolescence to menopauseVaccination in women from adolescence to menopause
Vaccination in women from adolescence to menopauseDr Meenakshi Sharma
 
Circulation of Zika virus
Circulation of Zika virusCirculation of Zika virus
Circulation of Zika virusVA Vuthy
 
Vaccines –production and application
Vaccines –production and applicationVaccines –production and application
Vaccines –production and application2624
 
Management of newborn infant born to mother suffering from
Management of newborn infant born to mother suffering fromManagement of newborn infant born to mother suffering from
Management of newborn infant born to mother suffering frommandar haval
 
Polio eradication program
Polio eradication programPolio eradication program
Polio eradication programbhabilal
 

Similar to Prof Kim Mulholland @ MRF's Meningitis & Septicaemia in Adults & Children (20)

New Vaccines in the immediate pipeline - Slideset by Professor Susanna Esposito
New Vaccines in the immediate pipeline - Slideset by Professor Susanna EspositoNew Vaccines in the immediate pipeline - Slideset by Professor Susanna Esposito
New Vaccines in the immediate pipeline - Slideset by Professor Susanna Esposito
 
National Immunization Schedule
National Immunization ScheduleNational Immunization Schedule
National Immunization Schedule
 
Prevenar e cme june 2020 & FAQs & COVID Clinic Questions
Prevenar e cme june 2020 & FAQs & COVID Clinic QuestionsPrevenar e cme june 2020 & FAQs & COVID Clinic Questions
Prevenar e cme june 2020 & FAQs & COVID Clinic Questions
 
Marie Pierre @ MRF's Meningitis & Septicaemia in Children & Adults 2015
Marie Pierre @ MRF's Meningitis & Septicaemia in Children & Adults 2015 Marie Pierre @ MRF's Meningitis & Septicaemia in Children & Adults 2015
Marie Pierre @ MRF's Meningitis & Septicaemia in Children & Adults 2015
 
ppt on Tdap vaccination by Dr. Alka Mukherjee - Mukherjee Hospital
ppt on Tdap vaccination by Dr. Alka Mukherjee - Mukherjee Hospitalppt on Tdap vaccination by Dr. Alka Mukherjee - Mukherjee Hospital
ppt on Tdap vaccination by Dr. Alka Mukherjee - Mukherjee Hospital
 
Influenza Vaccination in india - Pediatrician's Perspective, May 2016
Influenza Vaccination in india - Pediatrician's Perspective, May 2016Influenza Vaccination in india - Pediatrician's Perspective, May 2016
Influenza Vaccination in india - Pediatrician's Perspective, May 2016
 
Imunisasi BIAN
Imunisasi BIANImunisasi BIAN
Imunisasi BIAN
 
Efficacy differences between PCV10 and PCV13 - Slideset by Professors Esposit...
Efficacy differences between PCV10 and PCV13 - Slideset by Professors Esposit...Efficacy differences between PCV10 and PCV13 - Slideset by Professors Esposit...
Efficacy differences between PCV10 and PCV13 - Slideset by Professors Esposit...
 
Elimination of meningitis A epidemics in Africa; MenAfriVac future plans
Elimination of meningitis A epidemics in Africa; MenAfriVac future plansElimination of meningitis A epidemics in Africa; MenAfriVac future plans
Elimination of meningitis A epidemics in Africa; MenAfriVac future plans
 
Polio end game presentation
Polio end game presentationPolio end game presentation
Polio end game presentation
 
Potential advantages of booster containing PCV regimen - Professor Shabir Madhi
Potential advantages of booster containing PCV regimen - Professor Shabir MadhiPotential advantages of booster containing PCV regimen - Professor Shabir Madhi
Potential advantages of booster containing PCV regimen - Professor Shabir Madhi
 
SMU DPRU WEBSITE 24 Aug 2015 (1)
SMU DPRU WEBSITE 24 Aug 2015 (1)SMU DPRU WEBSITE 24 Aug 2015 (1)
SMU DPRU WEBSITE 24 Aug 2015 (1)
 
Piis1473 3099(16)30190-6
Piis1473 3099(16)30190-6Piis1473 3099(16)30190-6
Piis1473 3099(16)30190-6
 
VACCINATION IN PREGNANCY 25092023.pptx
VACCINATION IN PREGNANCY 25092023.pptxVACCINATION IN PREGNANCY 25092023.pptx
VACCINATION IN PREGNANCY 25092023.pptx
 
EPI - Copy.ppt
EPI - Copy.pptEPI - Copy.ppt
EPI - Copy.ppt
 
Vaccination in women from adolescence to menopause
Vaccination in women from adolescence to menopauseVaccination in women from adolescence to menopause
Vaccination in women from adolescence to menopause
 
Circulation of Zika virus
Circulation of Zika virusCirculation of Zika virus
Circulation of Zika virus
 
Vaccines –production and application
Vaccines –production and applicationVaccines –production and application
Vaccines –production and application
 
Management of newborn infant born to mother suffering from
Management of newborn infant born to mother suffering fromManagement of newborn infant born to mother suffering from
Management of newborn infant born to mother suffering from
 
Polio eradication program
Polio eradication programPolio eradication program
Polio eradication program
 

More from Meningitis Research Foundation (20)

Prof Rob Heyderman
Prof Rob HeydermanProf Rob Heyderman
Prof Rob Heyderman
 
Marco safadi
Marco safadiMarco safadi
Marco safadi
 
Brenda kwambana adams
Brenda kwambana adamsBrenda kwambana adams
Brenda kwambana adams
 
Professor Muhamed-Kheir Taha
Professor Muhamed-Kheir TahaProfessor Muhamed-Kheir Taha
Professor Muhamed-Kheir Taha
 
Potential use of MenABCWY vaccines
Potential use of MenABCWY vaccinesPotential use of MenABCWY vaccines
Potential use of MenABCWY vaccines
 
Dr william hanage
Dr william hanageDr william hanage
Dr william hanage
 
Dr Maria Deloria Knoll
Dr Maria Deloria KnollDr Maria Deloria Knoll
Dr Maria Deloria Knoll
 
Professor Nelesh govender
Professor Nelesh govender Professor Nelesh govender
Professor Nelesh govender
 
Professor Sir Andrew Pollard
Professor Sir Andrew PollardProfessor Sir Andrew Pollard
Professor Sir Andrew Pollard
 
Dr Manuel krone
Dr Manuel kroneDr Manuel krone
Dr Manuel krone
 
Yangyupei yang
Yangyupei yangYangyupei yang
Yangyupei yang
 
Dr Rodolfo villena
Dr Rodolfo villena  Dr Rodolfo villena
Dr Rodolfo villena
 
Sara katz
Sara katzSara katz
Sara katz
 
Dr Xin wang
Dr Xin wangDr Xin wang
Dr Xin wang
 
Professor Cal MacLennan
Professor Cal MacLennanProfessor Cal MacLennan
Professor Cal MacLennan
 
Dr Sami gottlieb
Dr Sami gottliebDr Sami gottlieb
Dr Sami gottlieb
 
Dr Lee hampton
Dr Lee hamptonDr Lee hampton
Dr Lee hampton
 
Professor Stefan flasche
Professor Stefan flascheProfessor Stefan flasche
Professor Stefan flasche
 
Professor Shrijana shrestha
Professor Shrijana shresthaProfessor Shrijana shrestha
Professor Shrijana shrestha
 
Professor David goldblatt
Professor David goldblattProfessor David goldblatt
Professor David goldblatt
 

Recently uploaded

Presentation on Cerebral Palsy and its orthotic management
Presentation on Cerebral Palsy and its orthotic managementPresentation on Cerebral Palsy and its orthotic management
Presentation on Cerebral Palsy and its orthotic managementeshasmalik27
 
Scanning electron microscope - SEM , Its applicability in rasashastra
Scanning electron microscope - SEM , Its applicability in rasashastraScanning electron microscope - SEM , Its applicability in rasashastra
Scanning electron microscope - SEM , Its applicability in rasashastraDr. Madduru Muni Haritha
 
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...bkling
 
CHRONIC IMMUNE-MEDIATED Demyelinating Neuropathies
CHRONIC IMMUNE-MEDIATED Demyelinating NeuropathiesCHRONIC IMMUNE-MEDIATED Demyelinating Neuropathies
CHRONIC IMMUNE-MEDIATED Demyelinating NeuropathiesMohamed AbdElhady
 
Cell locomotion (Ameboid/ciliary/flagellar movement)
Cell locomotion (Ameboid/ciliary/flagellar movement)Cell locomotion (Ameboid/ciliary/flagellar movement)
Cell locomotion (Ameboid/ciliary/flagellar movement)MedicoseAcademics
 
Different Export Prices of Medicinal Drugs.pdf
Different Export Prices of Medicinal Drugs.pdfDifferent Export Prices of Medicinal Drugs.pdf
Different Export Prices of Medicinal Drugs.pdfAsmaa Khalil
 
skin diseases shaffer................ppt
skin diseases shaffer................pptskin diseases shaffer................ppt
skin diseases shaffer................pptHimanshu Goyal
 
Introducing amazing Healthy habits and fitness
Introducing amazing Healthy habits and fitnessIntroducing amazing Healthy habits and fitness
Introducing amazing Healthy habits and fitnessFredrick Amos
 
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdf
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdfABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdf
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdfAbdurahmanRafeeq
 
Namburi phased spot test - NPST To identify bhasma and sindhura - A Qualitat...
Namburi phased spot test - NPST  To identify bhasma and sindhura - A Qualitat...Namburi phased spot test - NPST  To identify bhasma and sindhura - A Qualitat...
Namburi phased spot test - NPST To identify bhasma and sindhura - A Qualitat...Dr. Madduru Muni Haritha
 
Autism and Savant Syndrome|Study|The Good doctor .pptx
Autism and Savant Syndrome|Study|The Good doctor .pptxAutism and Savant Syndrome|Study|The Good doctor .pptx
Autism and Savant Syndrome|Study|The Good doctor .pptxScripted Symptoms
 
GLANDS IN THE SKIN,FUNCTIONS AND ABNORMALITIES ..pptx
GLANDS IN THE SKIN,FUNCTIONS AND ABNORMALITIES ..pptxGLANDS IN THE SKIN,FUNCTIONS AND ABNORMALITIES ..pptx
GLANDS IN THE SKIN,FUNCTIONS AND ABNORMALITIES ..pptxWINCY THIRUMURUGAN
 
Impact of Early Pregnancy---Lecture-2024
Impact of Early Pregnancy---Lecture-2024Impact of Early Pregnancy---Lecture-2024
Impact of Early Pregnancy---Lecture-2024ERWINPEJI2
 
Epidemiological Study Design, Research Design, Clinical Research
Epidemiological Study Design, Research Design, Clinical ResearchEpidemiological Study Design, Research Design, Clinical Research
Epidemiological Study Design, Research Design, Clinical ResearchDr KHALID B.M
 
Approach to maternal collapse and cardiac arrest.pptx
Approach to maternal collapse and cardiac arrest.pptxApproach to maternal collapse and cardiac arrest.pptx
Approach to maternal collapse and cardiac arrest.pptxKTD Priyadarshani
 
Macquarie Neurosurgery Journal Club 2022 PPT
Macquarie Neurosurgery Journal Club 2022 PPTMacquarie Neurosurgery Journal Club 2022 PPT
Macquarie Neurosurgery Journal Club 2022 PPTMQ_Library
 
GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing...
GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing...GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing...
GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing...Abhinav S
 
https://getneurozoom.cc/welcome#aff=musvi5
https://getneurozoom.cc/welcome#aff=musvi5https://getneurozoom.cc/welcome#aff=musvi5
https://getneurozoom.cc/welcome#aff=musvi5Hussain Syed
 
ANTI-HYPERTENSIVE DRUG - RAUWOLFIA ROOT.
ANTI-HYPERTENSIVE DRUG - RAUWOLFIA ROOT.ANTI-HYPERTENSIVE DRUG - RAUWOLFIA ROOT.
ANTI-HYPERTENSIVE DRUG - RAUWOLFIA ROOT.Divya Kanojiya
 

Recently uploaded (20)

Anti-interferon-gamma autoantibody associated immunodeficiency
Anti-interferon-gamma autoantibody associated immunodeficiencyAnti-interferon-gamma autoantibody associated immunodeficiency
Anti-interferon-gamma autoantibody associated immunodeficiency
 
Presentation on Cerebral Palsy and its orthotic management
Presentation on Cerebral Palsy and its orthotic managementPresentation on Cerebral Palsy and its orthotic management
Presentation on Cerebral Palsy and its orthotic management
 
Scanning electron microscope - SEM , Its applicability in rasashastra
Scanning electron microscope - SEM , Its applicability in rasashastraScanning electron microscope - SEM , Its applicability in rasashastra
Scanning electron microscope - SEM , Its applicability in rasashastra
 
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...
 
CHRONIC IMMUNE-MEDIATED Demyelinating Neuropathies
CHRONIC IMMUNE-MEDIATED Demyelinating NeuropathiesCHRONIC IMMUNE-MEDIATED Demyelinating Neuropathies
CHRONIC IMMUNE-MEDIATED Demyelinating Neuropathies
 
Cell locomotion (Ameboid/ciliary/flagellar movement)
Cell locomotion (Ameboid/ciliary/flagellar movement)Cell locomotion (Ameboid/ciliary/flagellar movement)
Cell locomotion (Ameboid/ciliary/flagellar movement)
 
Different Export Prices of Medicinal Drugs.pdf
Different Export Prices of Medicinal Drugs.pdfDifferent Export Prices of Medicinal Drugs.pdf
Different Export Prices of Medicinal Drugs.pdf
 
skin diseases shaffer................ppt
skin diseases shaffer................pptskin diseases shaffer................ppt
skin diseases shaffer................ppt
 
Introducing amazing Healthy habits and fitness
Introducing amazing Healthy habits and fitnessIntroducing amazing Healthy habits and fitness
Introducing amazing Healthy habits and fitness
 
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdf
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdfABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdf
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdf
 
Namburi phased spot test - NPST To identify bhasma and sindhura - A Qualitat...
Namburi phased spot test - NPST  To identify bhasma and sindhura - A Qualitat...Namburi phased spot test - NPST  To identify bhasma and sindhura - A Qualitat...
Namburi phased spot test - NPST To identify bhasma and sindhura - A Qualitat...
 
Autism and Savant Syndrome|Study|The Good doctor .pptx
Autism and Savant Syndrome|Study|The Good doctor .pptxAutism and Savant Syndrome|Study|The Good doctor .pptx
Autism and Savant Syndrome|Study|The Good doctor .pptx
 
GLANDS IN THE SKIN,FUNCTIONS AND ABNORMALITIES ..pptx
GLANDS IN THE SKIN,FUNCTIONS AND ABNORMALITIES ..pptxGLANDS IN THE SKIN,FUNCTIONS AND ABNORMALITIES ..pptx
GLANDS IN THE SKIN,FUNCTIONS AND ABNORMALITIES ..pptx
 
Impact of Early Pregnancy---Lecture-2024
Impact of Early Pregnancy---Lecture-2024Impact of Early Pregnancy---Lecture-2024
Impact of Early Pregnancy---Lecture-2024
 
Epidemiological Study Design, Research Design, Clinical Research
Epidemiological Study Design, Research Design, Clinical ResearchEpidemiological Study Design, Research Design, Clinical Research
Epidemiological Study Design, Research Design, Clinical Research
 
Approach to maternal collapse and cardiac arrest.pptx
Approach to maternal collapse and cardiac arrest.pptxApproach to maternal collapse and cardiac arrest.pptx
Approach to maternal collapse and cardiac arrest.pptx
 
Macquarie Neurosurgery Journal Club 2022 PPT
Macquarie Neurosurgery Journal Club 2022 PPTMacquarie Neurosurgery Journal Club 2022 PPT
Macquarie Neurosurgery Journal Club 2022 PPT
 
GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing...
GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing...GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing...
GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing...
 
https://getneurozoom.cc/welcome#aff=musvi5
https://getneurozoom.cc/welcome#aff=musvi5https://getneurozoom.cc/welcome#aff=musvi5
https://getneurozoom.cc/welcome#aff=musvi5
 
ANTI-HYPERTENSIVE DRUG - RAUWOLFIA ROOT.
ANTI-HYPERTENSIVE DRUG - RAUWOLFIA ROOT.ANTI-HYPERTENSIVE DRUG - RAUWOLFIA ROOT.
ANTI-HYPERTENSIVE DRUG - RAUWOLFIA ROOT.
 

Prof Kim Mulholland @ MRF's Meningitis & Septicaemia in Adults & Children

  • 1. Pneumococcal vaccines – impact in the developing world Kim Mulholland Murdoch Children’s Research Institute, Melbourne London School of Hygiene and Tropical medicine University of Melbourne
  • 2. Pneumococcal vaccines - history • 1911 – 1st pneumococcal vaccine trial in South Africa • 1930-34 – 7-valent pneumococcal vaccine protected miners against types 1,2,3,5,7,12,14 (Pub South African Inst Med Research 1935;37:7) • 1945 – 4-valent vaccine (1,2,5,7) in US Air Force recruits – ↓ pneumococcal pneumonia – ↓ pneumococcal carriage of vaccine types (J Exp Med 1945;82:445-65) – Licensed by Squibb, abandoned in 1951
  • 3. • 1960s – Robert Austrian argued that pneumococcus remained an important cause of death • 1977 – 14-valent PS vaccine licensed by Merck • 1983 – 23-valent PS vaccine licensed • 1986 – Trial of PS vaccine in Papua New Guinea children published (I Riley et al) • 1988 – work begins on pneumococcal conjugate vaccine (NIH-Praxis Biologics) • 1990 – Hib conjugate vaccine licensed for use in infants
  • 4. • 2000 – Gavi Alliance launched • 2000 – 1st PCV licensed (PCV7 or Prevnar-7®, Wyeth Vaccines) – $57/dose – ST1 and ST5 excluded – PCV9 (with 1 & 5) produced and used in key trials in Gambia and South Africa • Around 2003 – PCV11 (Sanofi Pasteur) abandoned midway through Philippines trial • 2003 – Initiatives to make PCVs available – PneumoADIP – Advance Market Commitment – International Finance Facility for Immunization
  • 5. • 2009 – PCV7 introduced into South Africa, Gambia and Rwanda
  • 6. • 2009 – PCV7 introduced into South Africa, Gambia and Rwanda ES Donkor et al. Vaccination against pneumococcus in West Africa Int J Gen Med 2013;6:757-764 Invasive pneumococcal disease in West Africa
  • 7. • 2009 – PCV7 introduced into South Africa, Gambia and Rwanda • 2009 – PCV10 licensed (Synflorix®, GSK) • 2010 – PCV13 licensed (Prevnar-13®, Pfizer) • 2011 – PCV13 introduced Gambia, S Africa • 2012 (April) – PCV13 introduced Ghana • 2016 – January-February major meningitis outbreak in Ghana – Most pneumococcus ST1
  • 8. Ghana meningitis outbreak 2016 • Dec 2015 – March 2016 • Over 12 weeks: • 567/886 suspected cases had LP • 135 confirmed meningitis • 104 pneumococcal meningitis Brenda Kwambana-Adams et al. BMC Infectious Diseases 2016;16:575
  • 9. Ghana meningitis outbreak 2016 Brenda Kwambana-Adams et al. BMC Infectious Diseases 2016;16:575
  • 10. Ghana meningitis outbreak 2016 Kwambana-Adams BA et al. BMC Infectious Diseases 2016;16:575
  • 11. Ghana pneumococcal meningitis cases Kwambana-Adams BA et al. BMC Infectious Diseases 2016;16:575 PCV introduced April 2012 6,10,14 weeks
  • 12. Do PCVs protect against ST1 in Africa? • Gambia and SA PCV9 trials (combined) – Vaccinees – 5 – Controls – 5 • Is a late (booster) dose preferable to just a primary series? – Is 2+1 superior to 3+0? • OPA data suggests much better ST1 response after booster, so…
  • 13. POET study (PCV11, GSK) OPA data 1 10 100 1000 10000 ST1 ST6B ST19F ST23F Chart Title post-primary pre-boost post-boost Vaccine 25 (2007) 1962–1968
  • 14. UK Serotype 1 disease 2+1 schedule
  • 15. Ghana pneumococcal meningitis cases Kwambana-Adams BA et al. BMC Infectious Diseases 2016;16:575 PCV introduced 4 years earlier
  • 16. Unasnwered questions • Do PCV10 and PCV13 protect individuals/communities against ST1 disease? – Is 2+1 schedule better than 3+0? • Is there a role of monovalent type 1 PCV for controlling outbreaks? – Or combined with Mening. conjugate vaccine?
  • 17. Pneumococcal conjugate vaccines • 7-valent Pnc-CRM (Prevnar7®, Wyeth/Pfizer) licensed in US, 2000 • 9-valent Pnc-CRM trialed in South Africa and Gambia, but never licensed (includes 1&5) • 11-valent vaccine from Sanofi Pasteur trialed in Philippines, but never licensed • 10-valent Pnc-Protein D (Synflorix®, GSK) licensed in Europe 2009 • 13-valent Pnc-CRM (Prevnar13®, Pfizer) licensed in US 2010
  • 18. Pneumococcal vaccines under development • Conjugate vaccines – PCV10 – Serum Institute of India (in Phase 3) – PCV10 – Panacea, India – PCV11, PCV12 – GSK – PCV15 – Merck – PCV16 – Sanofi – PCV20 – Pfizer • Other vaccines – Whole Cell vaccine (BioFarma Indonesia) – Various protein vaccines
  • 19. Pneumococcal Conjugate Vaccine national immunization programmes, 2017 * Includes partial introduction Data source: WHO/IVB Database, as of 14 April 2017 Map production Immunization Vaccines and Biologicals (IVB), World Health Organization The boundaries and names shown and the designations used on this map do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. ©WHO 2017. All rights reserved. Introduced* to date (133 countries or 68.6%) Planned introductions in 2017 (4 countries or 2.1%) Not Available, Not Introduced/No Plans (57 countries or 29.4%) Not applicable
  • 20. PCV impact studies • Options – Pre and post – ecological approach • Surveillance • Routine data (eg. UK) – Case control study • OK for IPD • Probably not OK for pneumonia – Phased introduction • Eg. Mongolia
  • 23. Ongoing PCV impact studies in Asia • Laos – PCV13 impact study • Mongolia – PCV13 pilot introduction in 2 districts of Ulaanbaatar (June 2016) • Fiji – PCV10 impact study • Nepal – PCV13 impact study • Pakistan – PCV10 impact study • India – PCV13 impact on pneumonia
  • 24. PDR Laos • Introduced PCV13 in 2013 • Pneumonia burden high – 20% of paediatric admissions • Evaluation started around the time of PCV introduction – Community carriage surveys – Monitor pnc carriage in pneumonia cases – Monitor % of IPD cases due to PCV13 types – Compare vaccinated and unvaccinated cases
  • 25. Laos – early findings • Hypoxic pneumonia was less common in vaccinated than unvaccinated children with pneumonia (12.6% vs 22.3%, p= 0.0001) • Pneumococcal carriage rates were similar between vaccinated and unvaccinated children with pneumonia (p=0.757)
  • 26. IPD cases in children under 5
  • 27. Bacterial meningitis in Beijing Children’s Hospital, China Data from Prof H Yang
  • 28. PCV impact in Mongolia
  • 29. Pre-vaccination IPD data for Mongolia 0 5 10 15 20 25 30 35 40 45 50 2010 2011 2012 2013 2014 2015 Chart Title VT non-VT Dominant serotypes: 19F – 23; 6A/B/C – 17; 9V – 11; 14 – 9; 19A – 6;
  • 30. Fiji • Population of 840,000 • Hib vaccine – 1998 • PCV – 2012 • Since 2012 meningitis remains a problem • Antibiotic abuse minimal
  • 31. In Fiji since 2012… • 13/16 meningococcal meningitis Group B • 1/14 pneumococcal meningitis cases VT 0 1 2 3 4 5 Jan Mar May Jul Sep Nov Jan Mar May Jul Sep Nov Jan Mar May Jul Sep Nov Jan Mar May Jul Sep Nov Jan 2013 2014 2015 2016 2017 No.ofmeninogococcalcases Meningococcal Cases at CWMH
  • 32. Conclusions • Pneumococcal vaccines have major potential benefits • IPD surveillance – possible in selected sites in Africa – very difficult in Asia • Impact demonstration will be demanded by the community and politicians • To be valid must be done very carefully and well in selected sites