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Blood Products and
By b conrad
When should you consider rbc
How do you treat iron
Desferrioxamine or venesection
Desferrioxamine mesilate is an iron chelating
Can be given with the transfusion
How often do you do obs whilst
giving a transfusion?
Every ½ hour
1 unit will raise an Hb by how
For red cells and platelets
which is universal donor and
Platelets- O= universal reciever AB= universal donor
(Abs are in the plasma)
RBC- O= universal donor AB= universal reciever
What is FFP used for?
Note- ffp carries all the risks of blood transfusion
Which product is used as
replacement in abdominal
Contains no coagulation factors
Used in hypovolaemia- burns, shock, multiple organ
Colloids are an alternative (dextrans, gelatin,
Note- colloids have high molecular weight molecules
that largely remain in the intravascular space, so
create a greater oncotic pressure. (see colloids paper
List 6 early (<24h) reactions of
Acute haemolytic reaction
Tranfusion-related acute lung injury (TRALI)
What are the clinical features
of Acute haemolytic reaction?
ABO incompatible -> intravascular haemolysis
Atypical antibodies from previous transfusions or
pregnancy ->intra or extravascular haemolysis with
anaemia, jaundice, splenomegaly, fever
How do you manage acute
Check identity and name on unit
Send unit + FBC, U&E, clotting, cultures and urine
Keep IV line open with 0.9% saline
List delayed (>24h)
complications of transfusion?
Infections- viruses, hepatitis, hiv, bacteria, protozoa,
Post transfusion purpura
What is Direct Coombs test
and Indirect Coombs test?
Direct Coombs= test for autoimmune haemolytic
Indirect Coombs= prenatal testing of pregnant
women, and in testing blood prior to a blood
transfusion. It detects antibodies against RBC’s that
are present unbound in the patients’s serum.
What type of red blood cells is
used for neonates?
Fresh whole blood (<5 days post-collection)
What is Autologous donation?
Patients donate their own blood prior to a major
surgery. Several sessions. They receive iron.
Donations are screened for infection in the usual way.
How many donors are needed
for one bag of platelets? Do
platelets need to be cross
5x1010 platelets in 50-60ml
Shelf life 4-6 days
5 pooled units
Group ABO and Rh compatible but not cross matched
When does a patient possibly
<50 x 109/L if bleeding or going for surgery
<10 x 109/L if infection or bleeding
Who needs irradiated
Stem cell transplant recipients