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Other antihypertensive agents <ul><li>Centrally-acting drugs (methyldopa, moxonidine) </li></ul><ul><li>Direct vasodilator...
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  1. 1. Other antihypertensive agents <ul><li>Centrally-acting drugs (methyldopa, moxonidine) </li></ul><ul><li>Direct vasodilator (hydralazine, minoxidil) </li></ul><ul><li>Poorly tolerated </li></ul><ul><li>- headache, palpitation, edema </li></ul><ul><li>- drug-induced lupus syndrome (hydralazine) </li></ul><ul><li>- hirsutism in women (minoxidil) </li></ul><ul><li>Used when other treatments have failed </li></ul><ul><li>Used in special conditions (pregnancy) </li></ul>Moxonidine 200 mg once daily – 300 mg twice daily Hydralazine 25-5- mg twice daily Minoxidil 2.5-50 mg in 1-2 doses Adapted from: Oparil S and Weber MA. Hypertension.Elsevier/Sanders 2nd ed. 2005; L ip G and Bakris G. Handbook Hypertension Management. CMG 2006 For Internal Use Only