Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Anemia introduction - medicaldump.com

3,685 views

Published on

Published in: Health & Medicine, Technology
  • Be the first to comment

Anemia introduction - medicaldump.com

  1. 1. Anemia - Introduction
  2. 2. Normal ErythropoiesisKidney Bone marrow Multi-potent stem cell Epo mRNA Erythroid stem cell Epo Oxygen sensor 3-4 days Blood vessel Peripheral blood RBC survival 100-120 days
  3. 3. Anemia• Understanding anemia – Disease - to be treated on its own merits – Condition - a secondary manifestation of another disease – Symptoms depend on severity/acuity• Causes – Decreased production – Blood loss – Hemolysis
  4. 4. Laboratory Evaluation of Anemia• Complete blood count• Peripheral smear• Reticulocyte count – Relative reticulocyte count ♦ Percent of all RBC (normal 0.8%–1.5%) – Absolute reticulocyte count ♦ Relative reticulocyte count x RBC count ♦ Normal 50,000–75,000/µl ♦ Examples: 6 1.1% x 4.96 x10 = 55,000/l 6 12.2% x 2.05 x10 = 250,000/l
  5. 5. Classification of Anemia Based on RBC Kinetics and Size MCV Microcytic Normocytic MacrocyticRetic Low Common Common Commoncount High Uncommon Common Uncommon
  6. 6. Microcytic Hypochromic Anemia: Diagnosis• Mild (MCV > 70 fl) • Severe (MCV < 70 ) – Iron deficiency – Iron deficiency – Thalassemia – Thalassemia – Lead toxicity – Sideroblastic anemia – Anemia of chronic disease
  7. 7. Macrocytic Anemia with Low Reticulocyte Count• Megaloblastic anemia – Vitamin B12 deficiency – Folate deficiency• Non-megaloblastic macrocytic anemia – Liver disease – Hypothyroidism – Drug-induced (DNA synthesis block) – Myelodysplastic syndrome

×