APS32ndAnnualScientificMeetingMay 8–11, 2013New Orleans, LA
2 Contents   2013 Scientific                                                      Contents   Program Committee            ...
Meeting Information 3Why You Should Attend                                                           Continuing EducationP...
4 Meeting InformationMeeting HighlightsStory Landis, PhD         Irene Tracey, DPhil        Keela Herr, PhD RN        Mart...
Exhibits and Posters 5ExhibitsThe APS 32nd Annual Scientific Meeting will feature more than 150 booths that showcase produ...
6 APS Annual AwardsAPS Annual AwardsPhilip A. Pizzo, MD      William E. Maixner,       Jeffrey Mogil, PhD       Carlton D....
Corporate Satellite Symposia 7Corporate Satellite Symposia                                                   Thursday, May...
8 FacultyFacultyPhillip Albrecht, PhD                             Roger Chou, MD                                     Burel...
Faculty 9Francis Keefe, PhD                                       Benjamin Morasco, PhD                                Ale...
10 Schedule of Events Wednesday, May 8                                          (120) Advancing the Science of            ...
Schedule of Events 118:30–9 am                                                      basic researchers and clinicians. Rese...
12 Schedule of Eventsputative contributors to pain disparities may hold    (312) Reducing Disability from Low             ...
Schedule of Events 13(134) Pain in Sickle Cell Disease                              factor in sensitizing nociceptors in c...
32nd Annual Scientific Meeting of the American Pain Society 2013
32nd Annual Scientific Meeting of the American Pain Society 2013
32nd Annual Scientific Meeting of the American Pain Society 2013
32nd Annual Scientific Meeting of the American Pain Society 2013
32nd Annual Scientific Meeting of the American Pain Society 2013
32nd Annual Scientific Meeting of the American Pain Society 2013
32nd Annual Scientific Meeting of the American Pain Society 2013
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32nd Annual Scientific Meeting of the American Pain Society 2013

  1. 1. APS32ndAnnualScientificMeetingMay 8–11, 2013New Orleans, LA
  2. 2. 2 Contents 2013 Scientific Contents Program Committee Meeting Information..............................................................................3 Continuing Education.......................................................................3 Robert Edwards, PhD Chair Assistant Professor Disclosure..........................................................................................3 Brigham and Women’s Hospital Meeting Highlights...........................................................................4 Charles Argoff, MD Chair-Elect Professor Exhibits and Posters..............................................................................5 Albany Medical College APS Annual Awards...............................................................................6 Beth Darnall, PhD Clinical Associate Professor Stanford University Corporate Satellite Symposia.................................................................7 Patrick Dougherty, PhD Faculty...................................................................................................8 Professor University of Texas MD Anderson Cancer Center Schedule of Events...............................................................................10 Steven George, PhD PT Associate Professor General Information............................................................................16 University of Florida Keela Herr, PhD RN AGSF FAAN Meeting Location.............................................................................16 Professor University of Iowa Paperless Meeting...........................................................................16 Derek Molliver, PhD Assistant Professor Young Investigator Travel Support................................................16 University of Pittsburgh Registration Information................................................................17 Anne Murphy, PhD Associate Professor Georgia State University APS Membership.............................................................................17 Linda Porter, PhD Session Codes.......................................................................................18 Program Director National Institute of Neurological Disorders and Stroke/National Institutes of Health Registration Form................................................................................19 Jamie Rhudy, PhD Associate Professor University of Tulsa Nalini Sehgal, MD Associate Professor University of Wisconsin Mark Wallace, MD Professor University of California San Diego Ex-Officio Roger Fillingim, PhD APS President Professor University of Florida Renee Manworren, PhD APRN PCNS-BC Lead Nurse Planner Assistant Professor University of Connecticut School of Medicinewww.APSScientificMeeting.org
  3. 3. Meeting Information 3Why You Should Attend Continuing EducationPain affects more lives than the total number of lives affected by heart dis- The APS 32nd Annual Scientific Meeting will offer continuing education (CE)ease, cancer, and diabetes combined (Institute of Medicine Report, 2011). credit for physicians, psychologists, nurses, and pharmacists. Credit will bePain is a leading cause of disability and a major public health problem. awarded for those sessions attended and evaluated. Successful comple-Moreover, the issue of ensuring appropriate interdisciplinary assessment tion requires that participants register for the meeting, attend and partici-and treatment of pain has a far-reaching impact on morbidity, mortality, pate, and complete an online evaluation. Participants will receive their CEquality of life, and economics—both of individuals and across the health- certificates immediately after they submit their evaluations online.care system. There is a continued need to connect the work of researchersstudying the science of pain with those from multiple disciplines who seek Physiciansto use the best-available evidence to treat and thus improve pain care. As The American Pain Society is accredited by the Accreditationthe United States’ premier pain meeting, the American Pain Society (APS) Council for Continuing Medical Education (ACCME) to pro-provides attendees with a unique forum for sharing advances and stan- vide continuing medical education for physicians.dards in evidence-based pain research and treatment by colleagues fromall disciplines in pain, in a setting that encourages interactions between The American Pain Society designates this live activity for a maximum ofscientists and clinicians. 17.0 AMA PRA Category 1 Credit(s)™. Physicians should claim credit com- mensurate with the extent of their participation in the activity.This meeting accomplishes that by providing you the opportunity to•• interact with the best and brightest in pain research Psychologists•• translate scientific discoveries into clinical practice The American Pain Society is approved by the American Psychological Association (APA) to provide continuing education (CE) for psychologists.•• connect with colleagues across settings and disciplines at numerous American Pain Society maintains responsibility for the program and its con- networking events, including special interest group meetings and the tent. This activity has been designated for a maximum of 17.0 hours of CE opening reception with exhibits and posters credit for psychologists for sessions attended and evaluated.•• raise questions, debate the implications, plan follow-up studies, and discuss results Nurses•• discuss your own research and clinical observations The American Pain Society is accredited as a provider of con-•• meet with more than 400 poster presenters to learn about their work tinuing nursing education by the American Nurses Credentialing and future research directions Center’s (ANCC’s) Commission on Accreditation.•• visit an extensive number of exhibit booths featuring products and ser- This activity has been designated for up to 18.5 contact hours. vices specifically designed for professionals who study and treat pain. Pharmacists The American Pain Society is accredited by the Accreditation Council forWho Should Attend Pharmacy Education (ACPE) as a provider of continuing phar-The APS 32nd Annual Scientific Meeting is intended for physicians, nurses, macy education. Up to 17.0 credit hours (1.70 CEUs) will bebasic scientists, pharmacists, psychologists, and other healthcare profes- awarded and a statement of credit provided upon submission ofsionals who make up the interdisciplinary pain community. Generalists and a completed evaluation.specialists will benefit from a wide range of topics and faculty presentingbasic, translational, and clinical research and treatment advancements. Disclosure It is the policy of APS that the planners, faculty, and this provider disclose the existence of any significant financial interest or other relationships they and/or their spouse/partner may have with the manufacturers of any commercial products or services relating to the topics presented in the educational activity. APS also requires disclosure of the intent to discuss unlabeled uses of a commercial product or investigational use of a product not yet approved for this purpose. It is theWhat You Can Expect to Gain responsibility of the Scientific Program Committee to review potential conflicts of interest as submitted in the disclosure form and resolve such conflicts. Resolving the conflict ensures that the content ofThe APS 32nd Annual Scientific Meeting will offer current information about the activity is aligned with the interests of the public. Detailed disclosure information will be publishedthe diagnosis, treatment, and management of acute pain, chronic cancer in course materials. Learners will also be informed when no relevant financial relationships exist.and noncancer pain, and recurrent pain. Presentations are designed toenhance research or clinical skills pertinent to pain management and will Disclaimer The material presented in this activity represents the opinion of the speakers and not necessarily the views of APS.feature content appropriate for professionals at several experience levels.The meeting is an arena for interdisciplinary exchange among pain scien- Statement of Non-Endorsement Accredited status does not imply endorsement by APS or the ACCME,tists and healthcare professionals. By participating in this meeting, attend- ACPE, ANCC, or APA of any commercial products displayed in conjunction with this activity.ees can expect to achieve the following objectives:1. Describe various pain management models.2. ritique current basic science and clinical and psychological research C with regard to their applicability to practice.3. valuate new trends, techniques, therapies, and diagnostic procedures E in pain research and management.4. Assemble a network of professional colleagues.There are no prerequisites for participation in this activity. www.APSScientificMeeting.org
  4. 4. 4 Meeting InformationMeeting HighlightsStory Landis, PhD Irene Tracey, DPhil Keela Herr, PhD RN Martin Koltzenburg, Jeffrey Mogil, PhD William Maixner, PhD Emeran Mayer, MDKeynote Speaker FRCA AGSF FAAN MD FRCP Frederick W. L. DDS Global Year Against Plenary Speaker Plenary Speaker Plenary Speaker Kerr Basic Science Wilbert E. Fordyce Pain Speaker Research Speaker Clinical LecturerWednesday, May 8 11 am–12:30 pm 10:30 am–Noon 9–9:30 am2:30–4:30 pm Symposia Symposia (107) Global Year Against PainSpecial Interest Group (SIG) LectureMeetings 12:45–2 pm 12:15–1:30 pm Chronic Visceral Pain: The Long Corporate Satellite Lunch Symposia Corporate Satellite Lunch Symposia Path to Better Treatments4:30–6 pm Emeran Mayer, MDOpening Reception with Exhibits 2:15–3:45 pm 1:45–3:15 pmand Posters Symposia Symposia 9:30–9:45 am Break6–8 pm 3:45–5:15 pm 1:45–5 pmClinical and Basic Science Data Break with Exhibits and Posters Workshops 9:45–11:15 amBlitz Symposia 5:15–6:15 pm 3:30–5 pmThursday, May 9 SIG Meetings Symposia 11:30 am–2:30 pm7:45–8 am Special Learning Opportunity: RiskGathering and Introductions 6:30–8 pm 5:30–7:30 pm Evaluation and Mitigation President’s Recognition Reception Basic Science Research Dinner Strategies (REMS) for Extended-8–8:30 am The Future of Drug Discovery for Release and Long-Acting Opioids This session is open to all meeting attend-(100) State of the Society Friday, May 10 Pain ees. Please indicate your plans to attend Space is limited. Preregistration isRoger Fillingim, PhD 7:30–8 am required. by marking this session on the registra-APS President (103) Plenary Lecture tion form. Pain and Aging: Translating8:30–9 am Assessment Knowledge Into Saturday, May 11(101) Keynote Address Practice 8–8:30 amThe Future of Pain Research: Keela Herr, PhD RN AGSF FAAN (105) Frederick W. L. Kerr BasicChallenges and Opportunities Science Research LectureStory Landis, PhD 8–8:30 am Mice Are People, Too: Social (104) Plenary Lecture Modulation of and by Pain in9–9:30 am Mechanisms Controlling Laboratory Rodents(102) Plenary Lecture Nociceptor Excitability and How Jeffrey Mogil, PhDWhy Image Pain? They Can Be Targeted for PainIrene Tracey, DPhil FRCA Relief 8:30–9 am Martin Koltzenburg, MD FRCP (106) Wilbert E. Fordyce Clinical9:30–11 am LectureBreak with Exhibits and Posters* 8:45–10:15 am Phenotypic and MolecularAuthor-Attended Poster Session Break with Exhibits and Posters* Approaches to Translational Pain(Odd-Numbered Posters) Author-Attended Poster Session Medicine (Even-Numbered Posters) William Maixner, PhD DDS*Posters ending in odd numbers will be presented on Thursday, and posters ending in even numbers will be presented on Friday.www.APSScientificMeeting.org
  5. 5. Exhibits and Posters 5ExhibitsThe APS 32nd Annual Scientific Meeting will feature more than 150 booths that showcase products andservices specifically designed for interdisciplinary leaders in the study and treatment of pain. By visiting Exhibitthe exhibit floor, you will experience firsthand the technology, products, and services that can help you and Postermanage your professional goals and strategic objectives and keep you and your organization at the fore- Schedulefront of your field. Exhibitors will feature products and information in the following areas:•• alternative delivery systems •• laboratory/diagnostic testing •• pharmaceuticals Wednesday, May 8•• clinical research •• medical devices •• publishing 4–6 pm•• clinical trial management •• medical equipment and •• software Exhibits Open•• education supplies 4:30–6 pm Opening Reception with2013 Exhibitors* Exhibits and Posters•• Algo-md •• Grunenthal USA, Inc. •• Pain Disparities SIG•• Allergan •• INSYS Therapeutics, Inc. •• Pain Medicine News Thursday, May 9•• American Chronic Pain •• MEDTOX Laboratories •• Philips Respironics 9–11 am Association •• Millennium Laboratories •• Practical Pain Management Exhibits Open•• Bako Dermatopathology •• National Center for •• Premier Research Services Complementary and Alternative •• Quest Diagnostics 9:30–11 am•• Calloway Labs Medicine/National Institutes of •• Regenesis Biomedical Break with Exhibits and•• Depomed, Inc. Health (NCCAM/NIH) Posters •• Teva•• Gideons International, The •• Nektar Therapeutics •• Zogenix, Inc. 3:30–5:30 pm*As of 12/12/12 Exhibits Open 3:45–5:15 pm Break with Exhibits andPosters PostersThe 32nd Annual Scientific Meeting will feature two author-attended poster sessions. Chosen from a largenumber of submissions, the more than 400 selected posters represent the best innovations and researchin the study and treatment of pain. Poster abstracts selected for presentation at the annual meeting will Friday, May 10be available online in a searchable database to allow registrants to plan their poster viewing in advance 8:30–10:15 amof the meeting. The abstracts are scheduled to be available online in April 2013. To search and view the Exhibits Openabstracts, visit APSScientificMeeting.org.Poster abstracts selected for presentation at the meeting will be published in a supplemental issue of The 8:45–10:15 amJournal of Pain, the official journal of APS. All attendees will receive this supplemental issue. Break with Exhibits and Posters This meeting has inspired me to share the findings from these sessions with my patients and colleagues and encourage other colleagues to become more active in their understanding of pain.” –2012 Meeting Attendee www.APSScientificMeeting.org
  6. 6. 6 APS Annual AwardsAPS Annual AwardsPhilip A. Pizzo, MD William E. Maixner, Jeffrey Mogil, PhD Carlton D. Dampier, Laura Simons, PhD Penney Cowan Charles E. Inturrisi, PhD DDS MD CPI PhDJohn and Emma Bonica Public Service Award John C. Liebeskind Early Career Scholar AwardPhilip A. Pizzo, MD Laura Simons, PhDThe John and Emma Bonica Public Service Award honors outstanding con- The John C. Liebeskind Early Career Scholar Award was named in 1998tributions by an individual or organization to the field of pain through public to honor the memory of John C. Liebeskind, PhD, a past president of APSeducation, dissemination of information, public service, or other efforts to who was a noted pain researcher, scientist, and teacher. The Early Careerfurther knowledge about pain. The award is named for John Bonica, a lead- Scholar Award recognizes early career achievements that have made out-ing force in the development of the pain treatment movement, and his wife, standing contributions to pain scholarship.Emma. Elizabeth Narcessian Award for OutstandingWilbert E. Fordyce Clinical Investigator Award Educational AchievementsWilliam E. Maixner, PhD DDS Penney CowanThe Wilbert E. Fordyce Clinical Investigator Award and Lecture were es- The Elizabeth Narcessian Award was named in memory of Elizabethtablished in 1995 to recognize and honor career achievement in clinical Narcessian, MD, a noted educator on the appropriate use of opioids, pa-research on pain. The award has been named for Wilbert E. Fordyce, PhD, tient assessment, and approaches to rehabilitation of patients devastatedthe first recipient of this honor. by chronic pain. The award recognizes outstanding contributions highlight- ing dedication or innovation in education in the field of pain.Frederick W. L. Kerr Basic Science Research AwardJeffrey S. Mogil, PhD Distinguished Service AwardThe Frederick W. L. Kerr Basic Science Research Award and Lecture were Charles E. Inturrisi, PhDestablished in 1987 in honor of Frederick W. L. Kerr, a founder of APS, to The Distinguished Service Award recognizes outstanding and dedicatedrecognize individual excellence and achievement in pain scholarship. Since service to APS.then, the Kerr medallion has been presented to 26 outstanding pain pro-fessionals—researchers and clinicians—whose career achievements have Kathleen Foley Journalist Awardmade important contributions to the field of pain. The Kathleen Foley Journalist Award recognizes excellence in reporting pain-related topics. The award honors the work of journalists whose cover-Jeffrey Lawson Award for Advocacy in Children’s age of events, scientific discoveries, and patient-care issues and policiesPain Relief contributes to furthering public awareness and understanding of pain andCarlton D. Dampier, MD CPI pain-related issues.The Jeffrey Lawson Award was established in 1996 in memory of JeffreyLawson, whose mother, Jill, brought the practice of performing surgery andother procedures on children without the benefit of analgesia to the atten-tion of professional organizations. The award recognizes advocacy effortsto improve the management of pain in children. Honoring Excellence The 2013 Clinical Centers of Excellence (CCOE) and annual recognition awards will be presented at the President’s Recognition Reception taking place on Thursday, May 9, 6:30–8 pm. The evening’s events will include a cocktail reception, remarks from the APS President, and an awards presentation. The following awards will be presented: John and Emma Bonica Public Service Award, Wilbert E. Fordyce Clinical Investigator Award, Frederick W. L. Kerr Basic Science Research Award, Jeffrey Lawson Award for Advocacy in Children’s Pain Relief, John C. Liebeskind Early Career Scholar Award, Elizabeth Narcessian Award for Outstanding Educational Achievements, Distinguished Service Award, Kathleen Foley Journalist Award, and the CCOE in Pain Management Awards. The Sharon S. Keller Chronic Research Pain Program grant recipients will also be recognized, and the Future Leaders in Pain Research grant recipients will be in attendance.www.APSScientificMeeting.org
  7. 7. Corporate Satellite Symposia 7Corporate Satellite Symposia Thursday, May 9, 2013Corporate satellite symposia will be offered in conjunction with the APS 12:45–2 pmAnnual Scientific Meeting. These independently sponsored, commercially Non-CME Corporate Satellite Symposiasupported symposia are open to registrants of the APS 32nd AnnualScientific Meeting. The program has been reviewed by the APS Scientific Unmet Needs in the Treatment of Chronic Pain: Filling the Treatment andProgram Committee and approved after determining the topic to be pre- Knowledge Gapsented is relevant to the audience and complementary to the official APS Hydrocodone is often used to treat chronic pain patients, but clinical con-program. There is no fee to attend a symposium, but preregistration is cerns including acetaminophen-related toxicity, inconvenient dosing, andrequired. Seating will be available at no charge to those responding on large pill counts demonstrate the need for an extended-release hydroco-a first-come, first-served basis. Program details are subject to change. done analgesic free of acetaminophen. Unmet medical needs, clinical con-Speakers are subject to change. Additional satellite programming will be siderations, and opportunities to improve patient care will be discussed.announced as information becomes available. Visit APSScientificMeeting. This activity is funded through an educational grant from Zogenix, Inc.org for the most current information. The 4 Ps of Pain: Pain, Pleasure, and the Politics of PrescribingThe 32nd Annual Scientific Meeting includes APS-sponsored educationalsessions as well as sessions that occur outside of the official APS pro- Perry G. Fine, MD; Steven D. Passik, PhD; Kenneth L. Kirsh, PhDgram. Sessions occurring outside of the official program include any This highly interactive meeting will begin with a strategic overview of thecorporate satellite breakfast and lunch sessions and educational product pain care environment in the United States. We discuss the evolution oftheaters located in the exhibit hall. APS has a defined process for ensuring neuroscience to where we now see chronic pain as a disease, and howthat the official meeting program is free of commercial bias. This process clinicians and caregivers can optimally help patients in the current “opioidincludes identifying and resolving perceived conflicts of interest on behalf crisis.” We review what has happened in Kentucky and how systems of careof APS faculty members. Attendees will find full disclosure information for have changed and discuss how to navigate legislative and complex careevery official faculty member in the meeting’s program book, distributed on systems while focusing on helping patients. We discuss the future of painsite at the meeting. This information should also be provided to attendees care and whether new opioids can provide safer solutions. We concludewithin each of the satellite and product theater events that are offered for with practical advice on how to optimize care for a range of patient types.continuing education credit. Attendees are encouraged to communicate This activity is funded through an educational grant from Nektar Therapeutics.with the Scientific Program Committee (SPC) about situations in which of-ficial APS faculty make statements that are commercial in nature about APS will provide lunch to all meeting attendees in conjunctionproducts, services, drugs, or devices. Attendees should be advised that with these events.sessions that are not an official part of the APS educational program aremanaged outside of the SPC’s purview, and in some cases, these sessionsmay be commercial in nature if they are not being offered for continuingeducation credit by the supporting company or organization. www.APSScientificMeeting.org
  8. 8. 8 FacultyFacultyPhillip Albrecht, PhD Roger Chou, MD Burel Goodin, PhDAssistant Professor Associate Professor Assistant ProfessorAlbany Medical College Oregon Health Science University University of Alabama at BirminghamDennis Ang, MD MS David Clark, MD PhD Harry Gould, MD PhDAssociate Professor Associate Professor ProfessorWake Forest Baptist Medical Center Stanford University Louisiana State University Health Sciences CenterKristin Archer, PhD DPT Michael Clark, PhD Henry Greely, JDAssistant Professor Clinical Director, Pain Program DirectorVanderbilt University Medical Center James A. Haley Veterans Hospital Center for Law and the Biosciences Stanford UniversityCharles Argoff, MD Daniel Clauw, MDProfessor Professor Monika Haack, PhDAlbany Medical College University of Michigan Instructor Beth Israel Deaconess Medical CenterPaul Arnstein, PhD RN Ricardo Cruciani, MD PhDClinical Nurse Specialist for Pain Relief Vice-Chairman Steven Hanling, CDR MC USNMassachussetts General Hospital Beth Israel Medical Center Director Naval Medical Center San Diego Pain Medicine CenterJennifer Ault, PT DO PhD Carlton Dampier, MDNeurologist Assistant Dean for Clinical Research Kenneth Hargreaves, DDS PhDSutter Health East Bay Region Emory University School of Medicine Professor University of Texas Health Science Center at SanDayna Loyd Averitt, PhD MSci Elizabeth Dansie, PhD AntonioPrincipal Investigator Research Scientist IIIU.S. Army Institute of Surgical Research University of Washington Afton Hassett, PsyD Associate Research ScientistDeclan Barry, PhD Luda Diatchenko, PhD University of MichiganAssistant Professor Associate ProfessorYale University School of Medicine University of North Carolina School of Dentistry Chris Herndon, PharmD Associate Professor Diana Bautista, PhD Sulayman Dib-Hajj, PhD Southern Illinois University EdwardsvilleAssistant Professor Research Scientist Keela Herr, PhD RN AGSF FAANUniversity of California, Berkeley Yale School of Medicine Professor and Chair, Adult GerontologyInna Belfer, MD PhD Patrick Dougherty, PhD University of IowaAssociate Professor Professor Mark Hoon, PhDUniversity of Pittsburgh University of Texas MD Anderson Cancer Center Chief, Molecular Genetics UnitAndreas Beutler, MD Gregory Dussor, PhD National Institute of Dental and CraniofacialAssistant Professor Assistant Professor Research/National Institutes of HealthMayo Clinic University of Arizona College of Medicine W. Michael Hooten, MDJan Magnus Bjordal, PhD Robert Edwards, PhD Associate ProfessorProfessor Instructor Mayo ClinicUniversity of Bergen Brigham and Women’s Hospital Michael Iadarola, PhDRobert Blakesley, PhD Michele Farrington, BSN RN CPHON Chief, Neurobiology and Pain Therapeutics SectionAssociate Investigator University of Iowa Hospitals and Clinics National Institute of Dental and CraniofacialNational Human Genome Research Institute Research/National Institutes of Health David Fiellin, MDChas Bountra, PhD Professor Mark Ilgen, PhDProfessor Yale School of Medicine Associate ProfessorUniversity of Oxford University of Michigan David Fishbain, MDPatricia Brandon, RN-BC Professor Eufemia Jacob, PhD RNClinical Coordinator University of Miami Miller School of Medicine Assistant ProfessorOchsner Medical Center UCLA School of Nursing Fern FitzHenry, PhD RNTim Brennan, MD PhD Assistant Professor Robert Jamison, PhDProfessor Vanderbilt University ProfessorUniversity of Iowa Brigham and Women’s Hospital/Harvard Medical Marcie Fowler, PhD SchoolLuis Buenaver, PhD Research Physiologist/Principal InvestigatorAssistant Professor U.S. Army Institute of Surgical Research Michael Jankowski, PhDJohns Hopkins University Assistant Professor Julie Fritz, PT PhD ATC Cincinnati Children’s Hospital Medical CenterClaudia Campbell, PhD Professor Michael Jarvis, PhDAssistant Professor University of Utah College of Health Senior Research FellowJohns Hopkins University Rollin Gallagher, MD MPH Abbott LaboratoriesJames Campbell, MD Clinical Professor Mark Jensen, PhDProfessor University of Pennsylvania ProfessorJohns Hopkins University Steve George, PT PhD University of WashingtonSusan Carlton, PhD Associate Professor Ru-Rong Ji, PhDProfessor University of Florida ProfessorUniversity of Texas Medical Branch at Galveston Toni Glover, MSN FNP-BC Duke University Medical CenterDaniel Carr, MD Research Nurse Practitioner Jordan Karp, MDProfessor University of Florida Associate ProfessorTufts University School of Medicine Michael Gold, PhD University of PittsburghGreg Carter, MD MS Associate Professor Susmita Kashikar-Zuck, PhDProfessor University of Pittsburgh Associate ProfessorUniversity of Washington Cincinnati Children’s Hospital Medical Centerwww.APSScientificMeeting.org
  9. 9. Faculty 9Francis Keefe, PhD Benjamin Morasco, PhD Alexander Samoshkin, PhDProfessor Assistant Professor Postdoctoral Research AssociateDuke University Medical Center Portland Veterans Administration Medical Center University of North Carolina at Chapel HillBenjamin Keeney, PhD Beth Murinson, MD Seddon Savage, MD MSResearch Fellow Assistant Professor Medical DirectorDartmouth College Johns Hopkins School of Medicine Dartmouth College Geisel School of MedicineJan Kemp, PhD RN Jennifer Murphy, PhD Michael Schatman, PhD CPENational Mental Health Director for Suicide Prevention Clinical Director Executive DirectorVeterans Health Administration Chronic Pain Rehabilitation Program–James A. Haley Foundation for Ethics in Pain CareMartin Koltzenburg, MD FRCP Veterans Hospital Brian Schmidt, MD DDS PhDProfessor Susan Murphy, ScD OTR ProfessorUniversity College London Assistant Professor New York UniversityStory Landis, PhD University of Washington Kimberly Sibille, PhDDirector Andrea Nackley, PhD Research Assistant ProfessorNational Institute of Neurological Disorders and Assistant Professor University of FloridaStroke/National Institutes of Health University of North Carolina School of Dentistry Gary Slade, DDPH PhD BDScJon Levine, MD PhD David Patterson, PhD ProfessorProfessor Professor University of North Carolina School of DentistryUniversity of California, San Francisco University of Washington Kathleen Sluka, PhD PTAmy Lischko, PhD Dennis Paul, PhD ProfessorAssociate Professor Professor University of IowaTufts University School of Medicine Louisiana State University Health Sciences Center Michael Smith, PhDLouis-Etienne Lorenzo, PhD Mark Pitcher, PhD Associate ProfessorResearch Associate Postdoctoral Fellow Johns Hopkins UniversityLaval University McGill University Wally Smith, MDSean Mackey, MD PhD Michael Polydefkis, MD MHS ProfessorAssociate Professor Associate Professor Virginia Commonwealth University School of MedicineStanford University Johns Hopkins University Nomita Sonty, PhD MPhilWilliam Maixner, PhD DDS Frank Porreca, PhD Associate Clinical ProfessorProfessor Professor Columbia UniversityUniversity of North Carolina School of Dentistry University of Arizona Mark Sullivan, MD PhDPatrick Mantyh, PhD Theodore Price, PhD ProfessorProfessor Assistant Professor University of WashingtonUniversity of Arizona University of Arizona Yuan-Xiang Tao, PhDRenee Manworren, PhD APRN PCNS-BC Elizabeth Rahn, PhD Associate ProfessorAssistant Professor Postdoctoral Scholar Johns Hopkins University School of MedicineUniversity of Connecticut School of Medicine University of Alabama at Birmingham David Thomas, PhDAnthony Mariano, PhD Barbara Rakel, PhD RN Program DirectorActing Chief, Pain Services Assistant Professor National Institute on Drug Abuse/National InstitutesVA Puget Sound Health Care System University of Iowa of HealthBrook Martin, PhD MPH Lorraine Reeves Irene Tracey, DPhil FRCAInstructor Founder and Director ProfessorDartmouth College Chronic Pain Advocacy League University of OxfordEmeran Mayer, MD Frank Rice, PhD Dennis Turk, PhDDirector Professor ProfessorOppenheimer Center for Neurobiology of Stress Albany Medical College University of WashingtonJohn McBeth, PhD Joseph Riley, PhD Todd Vanderah, PhDReader in Epidemiology Professor ProfessorUniversity of Manchester University of Florida University of ArizonaLance McCracken, PhD Edgar Alfonso Romero-Sandoval, MD PhD Edgar Walters, PhDProfessor Assistant Professor ProfessorKing’s College London Dartmouth Medical School University of Texas Medical School at HoustonChristina McCrae, PhD CBSM Edgar Ross, MD Thomas Ward, MDAssociate Professor Assistant Professor ProfessorUniversity of Florida Harvard Medical School Dartmouth Medical SchoolLaura McGhee, PhD Sarah Ross, PhD Tabitha Washington, MD MSScientific Director Assistant Professor Assistant ProfessorDefense and Veterans Center of Integrative Pain University of Pittsburgh Dartmouth-Hitchcock Medical CenterManagement, U.S. Army Michael Salter, MD PhD Anna Wilson, PhDSalimah Meghani, PhD MBE CRNP Professor Assistant ProfessorAssistant Professor University of Toronto Oregon Health Science UniversityUniversity of Pennsylvania Dino Samartzis, DSc Joseph Zastrow, MD FAAFPJeffrey S. Mogil, PhD Research Assistant Professor Associate Clinical ProfessorProfessor University of Hong Kong University of North Carolina Chapel HillMcGill University www.APSScientificMeeting.org
  10. 10. 10 Schedule of Events Wednesday, May 8 (120) Advancing the Science of (124) Pharmacotherapy Quality The meeting will include updates from the SIG as2:30–4:30 pm The goals of this SIG are to create an interdis- well as cochair nominations and two 20-minuteSIG Meetings ciplinary forum to advance the science of qual- educational presentations with time built in for(119) Nursing Issues ity as it relates to pain management, enhance questions and answers.Rapid reports of four research topics will be the identification and understanding of quality Update on Migraine Treatmentmoderated by Maureen Cooney, DNP FNP BC. measures in pain, and facilitate the creation and Richard Wenzel, PharmDParticipants will discuss the nursing implications dissemination of innovative pain management Opioid-Induced Hyperalgesia and Tolerancerelated to each of the following topics: quality improvement methodologies and resourc- James B. Ray, PharmD CPE es. One such method is a global registry. PAINDo Self-Reported Analgesic Barriers Translate (125) Psychosocial Research OUT is a quality improvement and registry proj-into Objective Analgesic Adherence for Cancer ect endorsed by IASP and run by a group of 17 A brief business meeting to update members onPain? academic and clinical sites throughout Europe any major issues and hold an election for a co-Salimah Meghani, PhD MBE CRNP with several participating sites in the U.S. Brief chair will be followed by the fourth annual SIGThis presentation will report on whether self- presentations by Debra Gordon and Julio Gonza- Young Investigator Poster Award presentation.reported analgesic barriers translate into lez of the current status of and opportunities for The winner(s) will present research in a platformobjective adherence to analgesia for African joining PAIN OUT will be followed by discussion. session. The last portion of the meeting will fea-Americans and whites. Analgesic barriers were The benefits of participating in the registry, such ture three or four brief presentations address-elicited using the Barriers Questionnaire. as benchmarking, research opportunities, and ing pain and the developmental spectrum, withPostoperative Pain Time from Severe to Mild: access to an electronic knowledge library, will be an emphasis on psychosocial implications andEffect of Frequent and Multimodal Interventions intervention. Experts in pediatric and aging pain discussed.Fern FitzHenry, PhD RN research including Francis Keefe, PhD; JosephManagement of postoperative pain remains a (121) Clinical Trials Riley, PhD; and Kevin Vowles, PhD, will give 5- tochallenge despite continued attention by accred- The SIG will discuss reducing the risk of failure 10-minute presentations, which will be followediting and standards organizations. This presen- in analgesic clinical trials with two presentations: by a discussion session with this panel.tation will report on a retrospective study that An Evidence-Based Approach to Improving As-analyzed data from the electronic records of say Sensitivity in Clinical Trials (126) Pain Rehabilitationpostsurgical acute pain episodes for a 2.5-year Nathaniel Katz, MD MS This SIG’s current focus is on creating aware-period at an academic medical center. ness among patients, providers, legislators, and Applying the Principles of Improved Assay Sen- payers regarding best practices; providing treat-The Pain Care Quality Study: One Hospital’s sitivity in Analgesic Drug Development Neil Singla, MD ment recommendations to utilization review andExperiencePatricia Brandon, RN-BC employers/payers; describing business practices (122) Geriatric Pain that both promote and prevent patients from re-Nurses play a critical role in promoting quality A 30-minute journal club session, Management of ceiving such evidence-based care; and identify-pain management by assisting patients in es- Moderate-Severe Persistent Pain in Older Adults: ing tools, such as wireless telemedicine, mobiletablishing a realistic comfort goal, administering A Conundrum, will highlight this article about is- health, and personalized and genomic medicine,analgesics and adjunctive measures as needed, sues related to managing persistent pain in older as a means to extend pain rehabilitation through-evaluating effects, and advocating for patients. persons and highlight best practice recommenda- out the United States and worldwide.This presentation will report on a study that as- tions, key management issues, and implicationssessed patients’ perception about the quality of of ongoing analgesic management concerns. The 4:30–6 pmpain management. cochairs will facilitate a discussion with SIG mem- Opening Reception with ExhibitsAtomized Lidocaine Prior to Nasogastric Tube bers. A 60-minute business meeting will follow. It and PostersPlacement will include elections of officers and a review ofMichele Farrington, BSN RN CPHON the SIG’s mission statement and awards, among 6–8 pmThis presentation will report on a project to de- other topics. Clinical and Basic Science Data Blitzvelop and implement an evidence-based practiceto decrease discomfort and distress associated (123) Pain and Disparities Thursday, May 9with placement of nonemergent nasogastric (NG) This SIG promotes advocacy, education, policies,tubes in adult and pediatric patients. Patients programs, and research to eliminate the unequal 7:45–8 amwho need an NG tube inserted are now screened burden of pain among racial minorities and un- Gathering and Introductionsby bedside nurses for appropriate use of atom- derserved populations and to optimize the qual- ity of life for all persons with pain. The SIG is 8–8:30 amized lidocaine.The Nursing Issues SIG meeting has been designated for very interactive and includes discourse with sea- (100) State of the Societycontinuing nursing education. Nurses can earn 1.5 con- soned researchers and experts in pain care dis- Roger Fillingim, PhDtact hours and 1.5 pharmacology hours. Nurses must at- APS Presidenttend the SIG meeting and complete the Nursing Issues parities as well as presentations of new ideas bySIG section of the online evaluation in order to receive young investigators. The SIG offers a platform tocredit. generate new ideas and enables individuals to collaborate on projects.www.APSScientificMeeting.org
  11. 11. Schedule of Events 118:30–9 am basic researchers and clinicians. Researchers (305) Herbal Marijuana in Pain Med-(101) Keynote Address K will present and discuss recent advances in pain icine: Science, Practice, Policy, and mechanisms at the molecular and cellular levels. Ethics T K 1.5 CE RxThe Future of Pain Research: Chal- Michael Schatman, PhD CPE (Moderator); Greglenges and Opportunities (301) Primary Afferent Hyperexcit- Carter, MD MS; Elizabeth Rahn, PhD; SeddonStory Landis, PhD ability Drives Chronic Pain B K Savage, MD MSThis keynote address will highlight recent scien- Susan Carlton, PhD (Moderator); Edgar Walters, Medical marijuana is increasingly becoming antific findings and significant advances in pain re- PhD; Tim Brennan, MD PhD; Patrick Dougherty, accepted potential treatment for many pain con-search and explore how they might inform future PhD ditions. However, confusion regarding its appro-research needs and goals. The challenges faced Although hypersensitivity of primary sensory af- priate use as a treatment, prejudices based onby pain researchers and funding agencies in set- ferent neurons is a well-known correlate of some the drug’s recreational use history, and policyting priorities in a time of fiscal uncertainty will forms of chronic pain, the degree to which chron- and ethical issues continue. In addition to edu-also be discussed. Identifying and implement- ic pain and persistent central sensitization de- cating attendees about the science behind theing the next most important steps for the future pend upon ongoing drive from hyperexcitable practice, this symposium will address theseof pain research and the potential role of volun- primary afferents has been in dispute. Moreover, concerns, allowing attendees to make better-teers, private foundations and industry, private the role of chronic spontaneous activity in prima- informed decisions about medical marijuana’sand public funders, patients, and healthcare pro- ry nociceptors in driving chronic pain has been potential use.viders in moving forward will be discussed.  underestimated. The speakers will provide sev- eral lines of evidence documenting persistent (306) Pain Management in Wounded9–9:30 am primary afferent input in a variety of chronic pain Service Members: A Department of(102) Plenary Lecture K states. Defense Perspective T K Laura McGhee, PhD (Moderator); Dayna LoydWhy Image Pain? (302) Co-Occurring Chronic Pain Averitt, PhD MSci; Marcie Fowler, PhD; StevenIrene Tracey, DPhil FRCA and Substance Use Disorders: Clini- Hanling, CDR MC USNRelating specific neurophysiological, chemical, cal Challenges and Promising Treat- The pain conditions and comorbidities expe-and anatomical measures to perceptual chang- ment Approaches C K 1.5 CE Rx rienced by injured service members and thees in pain experiences induced by peripheral or Rollin Gallagher, MD MPH (Moderator); Benjamin challenge of pain management by the militarycentral sensitization, genetic, cognitive, emotion- Morasco, PhD; Robert Jamison, PhD; Declan medical system offer an opportunity to inform Barry, PhDal, contextual, or pharmacological factors and pain management and medical research. Thisidentifying their site of action within the human This symposium will review different approaches session describes ongoing basic and clinicalcentral nervous system has been a major goal for managing co-occurring chronic pain and sub- pain research being conducted within the U.S.for scientists, clinicians, and the pharmaceuti- stance use disorders. Department of Defense. The research programscal industry. Identifying noninvasively where such (303) Improving Pain Education in represented in this session will focus on theinfluences occur along the pain neuraxis for an Medical, Pharmacy, Nursing, and unique challenges in pain management faced byindividual and relating this to his or her specific Dental Schools in the United States the military medical system; novel therapeuticmultifactorial pain experience or pain relief has T K options currently being explored, including com-both neuroscientific relevance and potential diag- David Thomas, PhD (Moderator); Beth Murinson, plementary and alternative medicine techniques;nostic value. This lecture will address what pain MD; Chris Herndon, PharmD; Paul Arnstein, PhD and the translation of these therapies into clini-imaging does and does not tell us and its poten- RN cal tools and practice.tial for providing a fuller understanding of pain This session will highlight the efforts of the Na-perception in health and disease. tional Institutes of Health Pain Consortium’s 12:45–2 pm Centers of Excellence in Pain Education (Co- Corporate Satellite Lunch Symposia9:30–11 am EPEs) to enhance pain education in medical, APS will provide lunch to all meeting attendees in con-Break with Exhibits and Posters junction with these events. nursing, dental, and pharmacy schools acrossAuthor-Attended Poster Session the United States. The CoEPEs pain education 2:15–3:45 pm(Odd-Numbered Posters) portal will be described in terms of its stage of Symposia development, how one operates it, and what it11 am–12:30 pm has to offer to educators and healthcare provid- (307) Ethnic and Racial DisparitiesSymposia ers in the pain field. Speakers will also review in Pain: Biobehavioral and Psychoso- current problems in pain education and ways the cial Correlates C K(300) Rita Allen Foundation Schol- Robert Edwards, PhD (Moderator); Burel Goodin, CoEPEs and other organizations are trying to ad-ars in Pain: Frontiers in Basic Pain PhD; Claudia Campbell, PhD; Toni Glover, MSN dress them.Research B C K FNP-BCEdgar Alfonso Romero-Sandoval, MD PhD (304) Insight into the Neuropathic This session will highlight the multifactorial na-(Moderator); Yuan-Xiang Tao, PhD; Sarah Ross, Aspect of Cancer Pain B K 1.5 CE Rx ture of ethnic/racial disparities in pain to helpPhD; Michael Jankowski, PhD Todd Vanderah, PhD (Moderator); Patrick Mantyh, further the understanding of how such dispari-This symposium will bring together 2011 and PhD; Brian Schmidt, MD DDS PhD ties arise. Biobehavioral and psychosocial fac-2012 American Pain Society/Rita Allen Founda- This symposium will focus on understanding tors have been shown to partially underlie sometion Scholars in Pain to report on their ongoing some of the causes of cancer pain and the thera- of the consistently observed ethnic and racialresearch, which covers areas of interest to both peutics being developed to attenuate such pain. disparities in pain-related outcomes. TheseClassification: B Basic Science C Clinical T Translational CE Rx This session is eligible for pharmacology hours for nurses.Activity Type: K Knowledge A Application
  12. 12. 12 Schedule of Eventsputative contributors to pain disparities may hold (312) Reducing Disability from Low (130) Genetics and Painpromise as important and modifiable treatment Back Pain: Highlights of Primary, This year’s meeting will begin with an award giv-targets that could help to mitigate ethnic and ra- Secondary, and Tertiary Prevention en to recognize the outstanding work of a juniorcial disparities in the experience of pain. C K investigator/trainee selected from poster ab- Steve George, PT PhD (Moderator); Julie Fritz, PT stracts pertaining to genetics and pain. Next,(308) Profiling the Pain Transcrip- PhD ATC; Kristin Archer, PhD DPT Jeffrey S. Mogil, PhD, this year’s Kerr Award re-tome with RNA-Seq B K Disability can be prevented before an episode cipient, will review novel, unexpected, and/orMichael Iadarola, PhD (Moderator); Andreas of back pain occurs (primary prevention), during clinically relevant findings published in the areaBeutler, MD; Robert Blakesley, PhD an acute episode (secondary prevention), or dur- of genetics and pain over the past year andInvestigation of what genes within the dorsal root ing a chronic episode (tertiary prevention). The highlight how such findings could potentially in-ganglion (DRG) and the spinal cord are changed purpose of this session is to highlight models of fluence the direction of the field. Following theby nerve injury or tissue damage and the degree primary, secondary, and tertiary prevention of low presentations, time will be allotted for overallof alteration has provided insight into the pro- back pain. The three speakers included in this discussion regarding the growth and direction offound nature of the relationship between genes session will review specific findings from each the SIG, including ways to build the membershipand pain. The advent of massively parallel DNA prevention domain and provide a general consid- and expand activities.sequencing methods provides a new level of ge- eration of how findings from a particular domainnetic definition at both the genomic and transcrip- (131) Measurement of Pain and Its inform the larger body of knowledge on preven-tome levels. This symposium will address the Impact tion of disability from low back pain.processes of transcriptome regulation in the DRG, The meeting of the SIG will includespinal cord, and peripheral tissue; how to use the 3:45–5:15 pm •• a report on activities over the year and chang-information from high-throughput sequencing; and es in the SIG activities, including reporting on Break with Exhibits and Posterswhat this information can tell us. a survey of measurement practices 5:15–6:15 pm (309) From Receptors to Pain: The •• a report on the current activities of theMolecular Dynamics of Pain T K Special Interest Group (SIG) ACTTION Public Private partnership1.0 CE Rx Meetings •• presentation of new analyses from theLuda Diatchenko, PhD (Moderator); Michael (127) Basic Science ACTTION-Baseline pain measurement variabil-Salter, MD PhD; Kenneth Hargreaves, DDS PhD; Three early-career scholars will give brief pre- ity and implications for the improvement ofAlexander Samoshkin, PhD sentations on their recent work. In addition, the clinical trial assay sensitivity.This symposium will focus on molecular mecha- SIG’s liaisons to the APS Board of Directors andnisms of pain receptors activation and signaling. the Scientific Program Committee will give brief (132) Pain Education The 2011 Institute of Medicine Relieving Pain(310) Transcutaneous Electrical reports on APS activities over the past year, and in America report has called for revolutionaryNerve Stimulation: Mechanisms and SIG members will have an opportunity to provide changes in the way we educate health profes-Strategies for Effectiveness B K ideas for the SIG’s activities over the coming sionals, the public, and policy makers aboutKathleen Sluka, PhD PT (Moderator); Barbara year, including the 2014 Basic Science Din- pain. This forum will allow leaders in the field toRakel, PhD RN; Jan Magnus Bjordal, PhD ner Symposium. A 2013–2014 cochair will be discuss available resources, high-priority needs,The goal of this symposium is to review and dis- elected. and the tactics underway to address needed re-cuss the evidence on transcutaneous electrical (128) Complementary and Alterna- form. Cochairs Paul Arnstein, PhD RN, and Larrynerve stimulation (TENS; i.e., mechanisms and tive Medicine Driver, MD, will facilitate discussion on the trans-effectiveness), including what we know about the The Complementary and Alternative Medicine formational education programs needed. Davidmost effective TENS application methods and (CAM) SIG will meet officially for the first time to Thomas, PhD, and Donna Messersmith, PhD, willoutcomes measures, to direct future clinical tri- engage the contributions of a broader spectrum discuss the support of the National Institutes ofals and use for a variety of pain conditions. of the membership to enhance scientific and Health to develop Centers of Excellence in Pain(311) Coverage and Reimbursement clinical discussion, evaluation, and exploration Education (CoEPEs) as part of this effort, andReform Initiatives: Similarities, Dif- of CAM therapies. The format for the inaugural the ways in which the CoEPEs plan to work withferences, and Implications for Pa- meeting will be informal. others in the pain field to enhance pain educa-tients with Chronic Pain Conditions tion in medical, dental, nursing, and pharmacy (129) EthicsC K schools. The Industry Conundrum: Ethical Consider-Brook Martin, PhD MPH (Moderator); Benjamin ations Regarding Industry Funding of APS (133) Pain in Infants, Children, andKeeney, PhD; Daniel Carr, MD; Amy Lischko, PhD The panel presentation and discussion will ad- AdolescentsThe purpose of this session is to introduce at- dress the emergent concerns regarding con- The APS SIG for Pain in Infants, Children, andtendees to the design, implementation, and early flict-of-interest issues in pain education, with an Adolescents will hold a Pediatric Pain Researchexperiences of accountable care organizations, emphasis on developing a means of funding that Blitz, which will consist of 10-minute presen-bundled payment programs, health information minimizes actual and apparent conflicts of inter- tations of new research. We will also use theexchanges, and health insurance exchanges. est within APS. This program will involve a panel meeting to announce the 2013 recipient of theThe expert panelists will demystify how these that leads audience discussion with members of Pediatric Young Investigator Research Award.programs may influence the management of pa- the panel, including representatives from industry,tients with chronic pain conditions. APS, and the Pain Ethics Community.www.APSScientificMeeting.org
  13. 13. Schedule of Events 13(134) Pain in Sickle Cell Disease factor in sensitizing nociceptors in chronic pain- (316) To Do or Not to Do: Does Posi-This SIG seeks to foster the development of a ful conditions such as osteoarthritis. Much less tive Psychology Have the Answer formultidisciplinary community that brings together a is known about the mechanisms encoding the Chronic Pain? C Kdiverse group of pain researchers including basic magnitude of noxious stimuli. Nomita Sonty, PhD MPhil (Moderator); Lancescientists, clinicians, and other health profession- How can basic science advances be harnessed McCracken, PhD; Francis Keefe, PhDals to increase the knowledge of pain in sickle for clinical practice? Antibodies neutralizing NGF Psychological approaches to chronic pain havecell disease (SCD). have proven analgesic activity in many clinically tended to emphasize pathology such as cata-Catherine Bushnell, PhD, will discuss the effects important inflammatory pain states and will po- strophizing, depression, fear, and avoidance andof chronic pain on the structure and function of tentially enhance our treatment repertoire. Selec- have largely ignored personal and community re-the central nervous system in chronic pain and tive blockers of NaV1.7 are in development with silience in adaptation. The “positive psychology”the implications of these findings for pain in the aim to selectively suppress action potential approach focuses on strengths and positive attri-SCD. Her presentation will be followed by discus- propagation in nociceptors without affecting oth- butes that enable optimal functioning. The posi-sions of other ongoing pain research and clinical er sensory modality or causing weakness. tive psychology or strength-based approach totrials by SIG members. chronic pain is attracting increased attention and 8:45–10:15 am yielding data. This session will examine this ap-(135) Palliative Care Break with Exhibits and Posters proach in the context of chronic pain, look at cur- rent evidence, and consider if there is a basis for Author-Attended Poster Session scientific progress in this focus on the positive. (Even-Numbered Posters) Friday, May 10 (317) Now More Than Ever, Voltage- 10:30 am–Noon Gated Na+ Channels as a Viable Tar-7:30–8 am Symposia get for the Treatment of Pain(103) Plenary Lecture K T K .5 CE Rx (313) Accelerated Cellular Aging inPain and Aging: Translating Assess- Michael Gold, PhD (Moderator); Michael Jarvis, Musculoskeletal Conditions: Explor-ment Knowledge into Practice PhD; Sulayman Dib-Hajj, PhDKeela Herr, PhD RN AGSF FAAN ing Increased Risk for Morbidity C K This session will provide an update on recentProviding quality pain care to the burgeoning advances in our understanding of the role of Daniel Clauw, MD (Moderator); Afton Hassett,older adult population rests on the ability to rec- voltage-gated Na+ channels in the pain associ- PsyD; Kimberly Sibille, PhD; John McBeth, PhDognize, measure, and consistently monitor pres- ated with peripheral tissue injury, injury-induced The focus of this session will be to explore theence, severity, and impact of pain. This requires changes in the efficacy of therapeutic interven- evidence for an increased risk for morbidity anduse of valid and reliable tools, both for cognitive- tions, and the identification of channel subtype mortality in chronic pain associated with muscu-ly capable and impaired patients. Recognizing selective blockers for the treatment of pain. loskeletal conditions and present preliminary evi-and evaluating pain in those unable to self-report Speakers in this symposium will focus on Na+ dence supporting a role for accelerated cellularis challenging and critical questions remain. Evi- channel beta subunits as well as the alpha sub- aging as indexed by shortened telomere length.dence for best-practice pain assessment in old- units NaV1.7 and NaV1.8.er adults able to self-report will be discussed, (314) Pain, Stress, and Inflamma-followed by consideration of tools that have tion: Clinical Implications and Indi- (318) Skin Does Matter: New In-been developed to improve pain assessment in vidual Differences T K sights into How Skin Analysis Maypersons with advanced cognitive impairment. Robert Edwards, PhD (Moderator); Joseph Riley, Aid in Identifying Pain MechanismsEfforts to translate the science of pain assess- PhD; Jon Levine, MD PhD; Gary Slade, DDPH PhD and Predictors of Treatment Out-ment to improve pain treatment and outcomes BDSc come T Kwill be explored. An agenda for future research Pro- and anti-inflammatory systems appear to Charles Argoff, MD (Moderator); Frank Rice, PhD;will be proposed to inspire and guide progress in contribute to the vast majority of persistent pain Phillip Albrecht, PhD; Michael Polydefkis, MD MHSimproving recognition and evaluation of pain in syndromes via multiple mechanisms. However, a Recent translational research has led to excit-all older adults. variety of individual-difference factors, from the ing new data concerning peripheral pain mecha- psychosocial (e.g., stress) to the genetic, can nisms within the skin. These data have led to8–8:30 am modulate these processes. This symposium will new insight into potential pain mechanisms for(104) Plenary Lecture focus on the clinical implications of these inter- various painful conditions, including painful di- relationships for shaping outcomes in groups abetic neuropathy, complex regional pain syn-Mechanisms Controlling Nociceptor drome, and fibromyalgia, as well as to new pain such as patients with musculoskeletal or orofa-Excitability and How They Can Be assessment tools. Such research has also fo- cial pain and older adults.Targeted for Pain Relief K cused on the potential for such findings to helpMartin Koltzenburg, MD FRCP (315) Opioid Cessation: Why, When, predict treatment outcomes and develop newImpressive progress has been made regarding and, Especially, How C K 1.5 CE Rx treatments for various painful conditions. Thesethe molecular and cellular mechanisms of trans- Michael Clark, PhD (Moderator); Jennifer Murphy, translational efforts may enhance a basic sci-duction. Transient receptor potential channels PhD; W. Michael Hooten, MD; Anthony Mariano, PhD entist’s ability to better understand the mech-have been identified as one of the major class- This presentation will assist providers in efforts anisms of a variety of pain conditions and aes of ion channels that endow nociceptors with to terminate opioid therapy responsibly and ap- clinician’s ability to evaluate and treat patientsthermal or chemical sensitivity. Nerve growth fac- propriately when such termination is clinically with pain of diverse types.tor (NGF) has now been identified as a pivotal indicated.Classification: B Basic Science C Clinical T Translational CE Rx This session is eligible for pharmacology hours for nurses.Activity Type: K Knowledge A Application