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The Effect of Physical Activity on
Alzheimer’s Disease
Belinda Brown
Benefits of Physical Activity
• Benefits of regular physical activity;
 Prevents cardiovascular disease
 Increases indep...
Physical Activity Levels in Australia
Physical Activity and Cognition/Memory
Physical Activity and Dementia/Alzheimer’s Disease
How Physical Activity May Delay ...
Physical Activity and Memory
Source: Fabre et al, 2002
• French Study
• Physical and Mental
Activity improved
cognition
• ...
Physical Exercise and Cognitive Stimulation (PEACS)
• 200 participants; 50 allocated to each trial group
▫ Control Group
▫...
Lowest intensity activity = Lowest
memory score
Highest intensity activity =
Highest memory score
Our Research....
0
Physical Activity and Cognition/Memory
Physical Activity and Dementia/Alzheimer’s Disease
How Physical Activity May Preven...
0 20 40 60 80
Genetic Risk
Factors
Risk Factors
Protective Factors
High
Education
Socio-Economic
Status Factors
Life Habit...
Physical Activity and Onset Delay of AD
Source: Larson et al 2006
Those exercising
more than three
times a week, are
more ...
Our Research....
• Collecting longitudinal data every 18 months to
find out;
▫ Do individuals that exercise, have a less c...
Physical Activity and Cognition/Memory
Physical Activity and Dementia/Alzheimer’s Disease
How Physical Activity May Preven...
Decrease in Amyloid – Mouse Model
Source: Adlard, P. A. et al
The effect of exercise on Amyloid-β load in three different ...
Decrease in Amyloid – Our Research...
0
Lowest activity = highest Aβ
Highest activity = lowest Aβ
Some other ideas....
• Increase in brain-derived neurotrophic factor
(BDNF)
▫ Stimulates growth of new brain cells
▫ Impro...
• You don’t have to be an elite
athlete
• Benefits can be gained from 30
minutes exercise daily
• More pronounced benefit ...
No matter what age you are, your life-style
choices may contribute to the risk of AD
Beyond increases to cognition, physic...
The Effect of Physical Activity on Alzheimer's  Disease
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The Effect of Physical Activity on Alzheimer's Disease

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Presentation from the public lecture by Belinda Brown on 5 & 6 October 2010

Published in: Health & Medicine

The Effect of Physical Activity on Alzheimer's Disease

  1. 1. The Effect of Physical Activity on Alzheimer’s Disease Belinda Brown
  2. 2. Benefits of Physical Activity • Benefits of regular physical activity;  Prevents cardiovascular disease  Increases independence  Reduces body weight  Alleviation of depression
  3. 3. Physical Activity Levels in Australia
  4. 4. Physical Activity and Cognition/Memory Physical Activity and Dementia/Alzheimer’s Disease How Physical Activity May Delay AD
  5. 5. Physical Activity and Memory Source: Fabre et al, 2002 • French Study • Physical and Mental Activity improved cognition • Eight people per group • Only outcome was cognition
  6. 6. Physical Exercise and Cognitive Stimulation (PEACS) • 200 participants; 50 allocated to each trial group ▫ Control Group ▫ Physical Activity ▫ Cognitive Stimulation (2 programmes from POSIT Science) ▫ Combined PA+CS • Each individual undertakes; ▫ Memory tests ▫ Blood testing ▫ Activity Monitor Assessment • Sub-groups; ▫ PET brain imaging ▫ CSF collection (Lumbar Puncture) ▫ DEXA Scanning (Body Composition) ▫ Physical Fitness Assessments
  7. 7. Lowest intensity activity = Lowest memory score Highest intensity activity = Highest memory score Our Research.... 0
  8. 8. Physical Activity and Cognition/Memory Physical Activity and Dementia/Alzheimer’s Disease How Physical Activity May Prevent AD
  9. 9. 0 20 40 60 80 Genetic Risk Factors Risk Factors Protective Factors High Education Socio-Economic Status Factors Life Habits (eg smoking), hypertension, occupation, depression, head trauma Physical Activity Diet Rich social networks Mental ActivitiesDiet Protective factor at mid-life and late-life
  10. 10. Physical Activity and Onset Delay of AD Source: Larson et al 2006 Those exercising more than three times a week, are more likely to be dementia free as they age DementiaRisk More Exercise = Less Dementia Risk
  11. 11. Our Research.... • Collecting longitudinal data every 18 months to find out; ▫ Do individuals that exercise, have a less chance of developing Alzheimer’s in the future? ▫ Do individuals that go from being sedentary to physically active, still receive the benefit of reduce AD risk?
  12. 12. Physical Activity and Cognition/Memory Physical Activity and Dementia/Alzheimer’s Disease How Physical Activity May Prevent AD
  13. 13. Decrease in Amyloid – Mouse Model Source: Adlard, P. A. et al The effect of exercise on Amyloid-β load in three different brain regions of transgenic mice
  14. 14. Decrease in Amyloid – Our Research... 0 Lowest activity = highest Aβ Highest activity = lowest Aβ
  15. 15. Some other ideas.... • Increase in brain-derived neurotrophic factor (BDNF) ▫ Stimulates growth of new brain cells ▫ Improves learning and mental performance • Increase in synaptic plasticity (ability of brain to learn and remember) • Reduces risk of Cardiovascular Disease and Type II Diabetes
  16. 16. • You don’t have to be an elite athlete • Benefits can be gained from 30 minutes exercise daily • More pronounced benefit when intensity is higher
  17. 17. No matter what age you are, your life-style choices may contribute to the risk of AD Beyond increases to cognition, physical activity can aid in many aspects of health and increase function and independence

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