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Clinical Trials Update
William Faloon
RAADFest
October 2021
Where We Are with
Human Age Reversal
Aging has been delayed and reversed
in animal models.
Human data show partial age del...
Thousands of People Engaging in Different
Experimental Age Reversal Interventions
How Do We Validate What’s Working?
Betterhumans Human Research
Clinical Trials Medical Office Opens October 2021
Clinical Trials Center in Florida
Betterhumans Clinical Trials Medical Office
TheVillages, Florida
Betterhumans Clinical Trials: Exam Rooms
GE Luna Prodigy X Dexa Scan
 Visceral fat
 Bone density
 Muscle mass
Visceral fat
Bone density
Muscle mass
Measures:
Sterile Hood-Centrifuges to Process Blood
at BetterHumans Clinical Trials Office
for Immediate Assays
Betterhumans laboratory measures:
Horvath Clocks (DNA methylation/Epigenetic
Aging), using Illumina iScan sequencers.
Ex...
Betterhumans DNA/RNA/DNA Methylation Sequencing Room
Betterhumans Mass Spectrometry Room
Health and Longevity Biomarker Assay Facility
"Exosomes" Scientist, Monal Sharma, PhD working at Betterhumans Lab
Biogerontology Researcher James Clement in Front of 10,000 Square Foot Church being
Converted to advanced Analytical Test ...
Inside 10,000 Square Foot Church Before Remodeling Commences
2022 Betterhumans Projects List
1) Epigenetic-reprogramming exosomes derived from placental MSCs to suppress chronic infla...
Rapamycin Human Study
Receives $485,000 Funding
 Randomized, placebo-controlled trial into the safety/efficacy of rapamyc...
Dr. Alan Green at his practice in Little Neck, NY
now has >700 patients using rapamycin with >
100 patients adding dasatin...
Dr. Alan Green’s Senolytic Protocol
 Dasatinib: 100 mg a day for 3 days
 Quercetin: 1000 mg a day for 3 days
 Fisetin: ...
New York-based biotech raises $60 million to develop a
pipeline of companies and therapeutics to treat diseases of
aging…
...
“Put simply, I want to
live forever! And in
perfect health!
And it is my sincere
belief that we will
achieve the means to
...
https://longevity.technology/senescence-reversing-start-up-lands-1-3m-in-funding/
Senescence-reversing start-up lands
£1.3...
Experimental Human Age Reversal Interventions
How We Plan to Rapidly Assess Efficacy
New logo for non-profit human research group
funded by Bill Faloon and related entities
www.VitalityInAging.org/
Human Interventions Clinical Trial:
VIAging Deceleration Trial
www.VitalityInAging.org/
VIAging Deceleration Trial Using Metformin,
Dasatinib, Rapamycin and Nutritional
Supplements
Sponsor:
Vitality in Aging Re...
VIAging Deceleration Trial
To indicate your interest in enrolling log on to: www.VitalityInAging.org/
 Recruit 50 people ...
VIAging Deceleration Trial
?
metformin
dasatinib/quercetin/fisetin
infusions, patches, precursors
rapamycin, glucosamine
resveratrol, reduce calorie in...
Human Age Reversal Project
$1,080,300
Goal: Statistically Significant
Human Age Reversal
Fund Research with Tax-Deductible Donations
Human Age Reversal Project
Make checks payable to:
Human Age Reversal Project
...
Urgent Need for Consensus
On Effective Interventions
Human
Age-Reversal
Pathway to Super Longevity
Aging Science: Where Were We 12 Years Ago?
( . . . in our understanding and treatment options for aging)
Manhattan Beach S...
Huge Advances in 12 Years
No Way to Reverse Aging
Manhattan Beach Summit Attendees
November 2009
Many Potential Methods
20...
( Roadmap to Accelerated Human Age Reversal
• Early 1900s. High blood pressure NOT considered a
“DISEASE” – no need for tr...
Learning from History
• Fact: FDR died at age 63 of hypertension – a
condition his doctors thought “normal for his age”.
•...
Began in 1948 with 5,209 adults in Framingham, Massachusetts
Prior to Framingham little was known about
hypertension/cardi...
Enormous Decrease in Cardiovascular Deaths
1. “Trends and Patterns of Geographic Variation of Cardiovascular Mortality 198...
Similarities between FDR’s death in 1945
& Death from age-related disease in 2021
• 1945 – FDR dies of hypertension.
• 194...
Lyndon Johnson Prematurely Aged
and Died Due to Technology Delay
•First heart attack at age 46 (1955)
•Suffered chronic an...
Alive Because of Biomedical Technology
Bill Clinton
Coronary Bypass Age 58
In 2004
Coronary Stent Age 63
In 2010
George W....
Reasons for 50% decline
in Cardiac Deaths
•Healthier Diet/Lifestyle
•Better Prevention Techniques
•Improved Emergency Resp...
Life Extension’s Role in Declining
Cardiovascular Deaths
1981: DHEA replacement
1981: Homocysteine reduction
1983: Low-dos...
Thousands of People Engaging in Different
Experimental Age Reversal Interventions
How Do We Validate What’s Working?
Age Management Telehealth Physicians
www.age-reversal.net
Modeled on Framingham Heart Study
Purpose: Validate What Works t...
1) Age Management Blood Test Panel with Omega-3 Index
2) Online questionnaires, consent, data capture
3) Consultation with...
Online telehealth service extracts data from
CBC/metabolic panel plus C-Reactive Protein
test report, then calculates the ...
They then used the measures to calculate implied
phenotypic (biological) age and others shown in
the spreadsheet below (Bi...
Morgan Levine PhD and Steve Horvath PhD
discovered standard blood test measures
correlate with DNA methylation age:
• Albu...
Some features of the online data
management and analysis system:
• Calculates Levine/Horvath implied phenotypic (biologica...
Graphs showing how subject is progressing:
These graphs show Phenotypic Age, C-Reactive
Protein, albumin moving in positiv...
AGE MANAGEMENT
TELEHEALTH PHYSICIANS
Physicians will see patients via the telehealth portal for this case
series study.
Th...
Problems reported by many of our
members who would like to visit a
physician to reduce their biological ages:
• Can’t find...
AGE MANAGEMENT
TELEHEALTH PHYSICIANS
PRIMARY OBJECTIVE: Use a telehealth platform to conduct single case
studies where doc...
https://www.wsj.com/articles/a-cancer-patients-brutal-commute-11626129627?mod=searchresults_pos2&page=1
July 12, 2021
“She...
Analogy: Framingham Heart Study and
Age Management Telehealth Study
Age Management Telehealth Study
seeks to do for aging ...
metformin
dasatinib/quercetin/fisetin
infusions, patches, precursors
rapamycin
resveratrol, reduce calorie intake
Induce a...
Bridging the Longevity Gap
Bureaucratic Delays Impede Progress
 Apolipoprotein B
 Omega-3-Index
 Homocysteine
 C-Reactive Protein
 LDLparticle number
 Total cholesterol
 LDL chol...
More Tests on Next Slide
AgeManagement TestPanel
Omega-3 Index + Full Fatty Acid Profile
Omega-3 Fatty Acids
• Omega-3 Ind...
More Tests on Next Slide
AgeManagement TestPanel
Glycemic Control Blood Profile
Insulin
Hemoglobin A1C
Ferritin
Insuli...
More Tests on Next Slide
AgeManagement TestPanel
Hormones +Vitamin D + Binding Protein
 IGF-1 (growth hormone)
 IGF1BP3 ...
More Tests on Next Slide
AgeManagement TestPanel
Kidney and Liver Function Biomarkers
 eGFR
 LDH
 AST
 ALT
 GGT
 Bil...
More Tests on Next Slide
AgeManagement TestPanel
Blood Mineral-Electrolyte Balance
Potassium
Magnesium
Ferritin (iron s...
More Tests on Next Slide
AgeManagement TestPanel
Blood Oxygen Carrying Capacity
 MCV (meancorpuscularvolume)
 MCH (meanc...
More Tests on Next Slide
AgeManagement TestPanel
Circulating Immune Cell Count
 Immature cells
 White blood cells
 Imma...
AgeManagement TestPanel
For Men
PSA
(prostate-specific antigen)
Commercial Lab Price: $3,000
TeleHealth Price: $495
Age Management BloodTest Panel
age-reversal.net
Tragedy of Lost Data
*Critical Need for
Age Management Blood Tests
Baseline and Annual Follow-Ups
Experimental Therapies N...
Age Management Blood Test Panel
The Telehealth Study Price of $495 available until Nov 5th, 2021 at:
www.age-reversal.net
...
Who missed the longevity boat?
Eli Broad
(1933 - 2021)
Expiration date: Apr. 30, 2021
net worth > $6.8 billion https://en....
Urgent Need for Consensus
On Effective Interventions Age-Reversal
Pathway to Super Longevity
Bridging the Longevity Gap
Urgent Need to Reform Clinical Trial Regulations
Copyright ©Life Extension®. Confidential and proprietary.
How I Fund Age Reversal Research
Supplement Sales Support Rejuve...
age-reversal.net
For information about current
regenerative medicine research:
Clinical Trials Update
William Faloon
RAADFest
October 2, 2021
Clinical Trials Update by Bill Faloon at RAADfest 2021
Clinical Trials Update by Bill Faloon at RAADfest 2021
Clinical Trials Update by Bill Faloon at RAADfest 2021
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Clinical Trials Update by Bill Faloon at RAADfest 2021

  1. 1. Clinical Trials Update William Faloon RAADFest October 2021
  2. 2. Where We Are with Human Age Reversal Aging has been delayed and reversed in animal models. Human data show partial age delay and reversal using existing therapies. Clinical trials urgently needed to validate current approaches.
  3. 3. Thousands of People Engaging in Different Experimental Age Reversal Interventions How Do We Validate What’s Working?
  4. 4. Betterhumans Human Research Clinical Trials Medical Office Opens October 2021
  5. 5. Clinical Trials Center in Florida
  6. 6. Betterhumans Clinical Trials Medical Office TheVillages, Florida
  7. 7. Betterhumans Clinical Trials: Exam Rooms
  8. 8. GE Luna Prodigy X Dexa Scan  Visceral fat  Bone density  Muscle mass Visceral fat Bone density Muscle mass Measures:
  9. 9. Sterile Hood-Centrifuges to Process Blood at BetterHumans Clinical Trials Office for Immediate Assays
  10. 10. Betterhumans laboratory measures: Horvath Clocks (DNA methylation/Epigenetic Aging), using Illumina iScan sequencers. Expression of 20,000 genes using Ion Torrent whole-Transcriptome RNA sequencing. Pro- and anti-inflammatorycytokine levelsusing immunofluorescence assays(also measures some SASPs – senescent cellsecretoryphenotypes). NAD+ measurements by mass spectrometer (40 times more sensitive than a few years ago). Precise Evaluation of Biologial Age
  11. 11. Betterhumans DNA/RNA/DNA Methylation Sequencing Room
  12. 12. Betterhumans Mass Spectrometry Room
  13. 13. Health and Longevity Biomarker Assay Facility
  14. 14. "Exosomes" Scientist, Monal Sharma, PhD working at Betterhumans Lab
  15. 15. Biogerontology Researcher James Clement in Front of 10,000 Square Foot Church being Converted to advanced Analytical Test Lab to Measure Effects of Age Reversal Interventions Betterhumans new lab near Tyler Texas
  16. 16. Inside 10,000 Square Foot Church Before Remodeling Commences
  17. 17. 2022 Betterhumans Projects List 1) Epigenetic-reprogramming exosomes derived from placental MSCs to suppress chronic inflammation; 2) Individually-grown autologous iPS cells from MSCs and HSCs for restoration of aged bone marrow; 3) Reduction/reversal of Advanced Glycation End products via dietary and compound interventions; 4) Measurement and reduction of bacterial and viral blood loads in elderly subjects; 5) Transplantation of mitochondria from autologous iPS cells; 6) Replacement of misfolded and glycosylated circulating proteins in elderly subjects; 7) Continue studies to inexpensively replenish NAD+ levels in elderly subjects; 8) Continue studies to inexpensively remove senescent cells, along with measurements of SASP cytokines; 9) Measure effects of rapamycin for others on autophagy, mTOR suppression and epigenetic profiles As of August 1st,2021 email communication (wwws.Betterhumans.org)
  18. 18. Rapamycin Human Study Receives $485,000 Funding  Randomized, placebo-controlled trial into the safety/efficacy of rapamycin in reducing clinical measures of aging in an older adult population.  Two differing doses: 5 mg or 10 mg of rapamycin one time a week or placebo.  Primary Outcome Measure: Changes in visceral fat as measured by (DXA) scan.  Secondary Outcomes: Range of clinical measures, e.g. bone density, blood tests, etc.  20 people enrolled at $360 each (original cost before donations was $1,200). Sponsor: AgelessRx Collaborator: University of California, Los Angeles Principal investigators: James Watson, M.D. and Sajad Zalzala, M.D. June 18, 2021 To enroll log on to: https://www.agelessrx.com/pearl
  19. 19. Dr. Alan Green at his practice in Little Neck, NY now has >700 patients using rapamycin with > 100 patients adding dasatinib, fisetin and quercetin . Dr. Green’s Anti-Aging Cocktail 1) Rapamycin 2) Dasatinib 3) Fisetin 4) Quercetin Now in Clinical Use: https://senolyticstreatment.com/
  20. 20. Dr. Alan Green’s Senolytic Protocol  Dasatinib: 100 mg a day for 3 days  Quercetin: 1000 mg a day for 3 days  Fisetin: 1500 mg day for 3 days https://senolyticstreatment.com/ These are maximum doses. Patients determine sensitivity with smaller doses. For diseases like Alzheimer's, cardiomyopathy, pulmonary fibrosis, emphysema, fatty liver, chronic kidney disease, metabolic syndrome, obesity, frailty: 1-2 of these senolytic treatments a month For lifespan and healthspan: 4 treatments a year (3-month) interval
  21. 21. New York-based biotech raises $60 million to develop a pipeline of companies and therapeutics to treat diseases of aging… Cambrian Biopharma has 3 major categories of aging at the top of its to-do list: 1) Tackle intracellular dysfunction (things that go wrong inside cells, such as mutating DNA or shrinking telomeres); 2) Cellular dysfunction (whole-cell level problems, such as senescence or energy pathway break down); 3) Tissue level dysfunction (stem cells exhaustion, chronic inflammation, or breakdown of tissue architecture). February 9, 2021 https://longevity.technology/cambrian-biopharma-exits-stealth-with-60m-and-affiliate-ipo/
  22. 22. “Put simply, I want to live forever! And in perfect health! And it is my sincere belief that we will achieve the means to do this within the next 20-30 years.” https://longevity.technology/david-sinclair-to-co-chair-200-m-spac/ $200 million Biotech SPAC March 11, 2021 Christian Angermayer, Chairman & Co-Founder of Cambrian Biopharma
  23. 23. https://longevity.technology/senescence-reversing-start-up-lands-1-3m-in-funding/ Senescence-reversing start-up lands £1.3M in funding March 12, 2021 University of Exeter spin-out SENISCA has developed a platform for the development of oligonucleotide-based medicines that reverse cellular senescence and “reset the cellular aging clock.” The company revealed it was looking for around £950k in initial seed funding, so the nicely oversubscribed round indicates strong investor interest. 12
  24. 24. Experimental Human Age Reversal Interventions How We Plan to Rapidly Assess Efficacy
  25. 25. New logo for non-profit human research group funded by Bill Faloon and related entities www.VitalityInAging.org/
  26. 26. Human Interventions Clinical Trial: VIAging Deceleration Trial www.VitalityInAging.org/
  27. 27. VIAging Deceleration Trial Using Metformin, Dasatinib, Rapamycin and Nutritional Supplements Sponsor: Vitality in Aging Research Group, Inc. Brief Summary: “This study aims to assess the safety and efficacy of study drugs and supplements on clinical (structural and functional) signs of aging and to explore/identify other possible biological measures of aging.” Information provided by (Responsible Party): Vitality in Aging Research Group, Inc. https://clinicaltrials.gov/ct2/show/NCT04994561?term=04994561&draw=2&rank=1
  28. 28. VIAging Deceleration Trial To indicate your interest in enrolling log on to: www.VitalityInAging.org/  Recruit 50 people 65 years of age or older in South Florida  Funded by Human Age Reversal Project and BioFutures, LLC  18-month study using at least 4 interventions simultaneously  This clinical trial fully funded---no cost to study participants
  29. 29. VIAging Deceleration Trial ?
  30. 30. metformin dasatinib/quercetin/fisetin infusions, patches, precursors rapamycin, glucosamine resveratrol, reduce calorie intake Induce autophagy Advance to “biologics”, i.e., exosomes, perinatal tissues, growth hormone et al. glucosamine, rapamycin, diet Express sirtuins Suppress excess mTOR Boost cellular AMPK Reduce senescent cells Replenish NAD+
  31. 31. Human Age Reversal Project $1,080,300 Goal: Statistically Significant Human Age Reversal
  32. 32. Fund Research with Tax-Deductible Donations Human Age Reversal Project Make checks payable to: Human Age Reversal Project 3600 West Commercial Blvd. Ft. Lauderdale, FL 33309 Or donate online: age-reversal.net/donate
  33. 33. Urgent Need for Consensus On Effective Interventions Human Age-Reversal Pathway to Super Longevity
  34. 34. Aging Science: Where Were We 12 Years Ago? ( . . . in our understanding and treatment options for aging) Manhattan Beach Summit November 2009 NO Validated Method to Reverse Aging in Humans 2009
  35. 35. Huge Advances in 12 Years No Way to Reverse Aging Manhattan Beach Summit Attendees November 2009 Many Potential Methods 2009 2021
  36. 36. ( Roadmap to Accelerated Human Age Reversal • Early 1900s. High blood pressure NOT considered a “DISEASE” – no need for treatment. • 1932. Franklin D. Roosevelt – At age 50, had high blood pressure. • 1932-1945. FDR’s blood pressure worsened as he gradually developed signs of heart failure. • 1945. FDR died of untreated hypertension (hemorrhagic stroke). At the time of his death, his blood pressure was 300/140 mm Hg. Died at age 63 Franklin D. Roosevelt’s Premature Death
  37. 37. Learning from History • Fact: FDR died at age 63 of hypertension – a condition his doctors thought “normal for his age”. • Reaction: As a result of FDR’s untimely death, doctors started questioning the conventional wisdom about hypertension. • Result: FDR’s death was a major reason why the Framingham Heart Study was proposed and funded.
  38. 38. Began in 1948 with 5,209 adults in Framingham, Massachusetts Prior to Framingham little was known about hypertension/cardiovascular risks Doctors did not know how to prevent heart attacks Atherosclerosis was thought to be unavoidable aspect of aging Framingham Heart Study Millions of Lives Saved
  39. 39. Enormous Decrease in Cardiovascular Deaths 1. “Trends and Patterns of Geographic Variation of Cardiovascular Mortality 1980-2014” Journal of the American Medical Association (JAMA); May 16th 2017 Between 1980 and 2014 ` -50% Decrease in Deaths from Heart Disease
  40. 40. Similarities between FDR’s death in 1945 & Death from age-related disease in 2021 • 1945 – FDR dies of hypertension. • 1945 – Hypertension not recognized as a disease. • 1945 – Cause of hypertension not well understood. • 1950s – Progress begins for treating hypertension... • 2021 – Millions die from aging. • 2021 – Aging barely recognized as disease by medical establishment. • 2021 – Molecular causes of aging increasingly being understood. • 2021 – Discovery of treatments for aging to ↑ health span/lifespan.
  41. 41. Lyndon Johnson Prematurely Aged and Died Due to Technology Delay •First heart attack at age 46 (1955) •Suffered chronic angina pain •Resigned re-election at age 59 •Dead at age 64 years (1973) (Conventional Treatments Lacking)
  42. 42. Alive Because of Biomedical Technology Bill Clinton Coronary Bypass Age 58 In 2004 Coronary Stent Age 63 In 2010 George W. Bush Coronary Stent Age 67 in 2013 Dick Cheney Coronary Bypass Age 47 In 1988 Coronary Stent Age 59 in 2000 Ventricular Assist Age 69 in 2010 Heart Transplant Age 71 in 2012
  43. 43. Reasons for 50% decline in Cardiac Deaths •Healthier Diet/Lifestyle •Better Prevention Techniques •Improved Emergency Response •Coronary Artery Bypass Surgery •Coronary Artery Stenting These approaches not developed or widely practiced in LBJ’s era. Coronary Artery Bypass Graft Quadruple Bypass
  44. 44. Life Extension’s Role in Declining Cardiovascular Deaths 1981: DHEA replacement 1981: Homocysteine reduction 1983: Low-dose aspirin 1983: Coenzyme Q10 1996: Public access to blood tests We defied conventional reference ranges for optimal glucose, LDL, blood pressure.
  45. 45. Thousands of People Engaging in Different Experimental Age Reversal Interventions How Do We Validate What’s Working?
  46. 46. Age Management Telehealth Physicians www.age-reversal.net Modeled on Framingham Heart Study Purpose: Validate What Works to Delay/Reverse Aging Long term and ongoing No upper age threshold At least 10- Year study period
  47. 47. 1) Age Management Blood Test Panel with Omega-3 Index 2) Online questionnaires, consent, data capture 3) Consultation with telehealth age management physician 4) Continual updates on your biological age To indicate your interest: www.age-reversal.net (Select “Telehealth Study” link from Home Page) Purpose: Collect data to assess predictive value of biomarkers Age Management Telehealth Physicians Case Study
  48. 48. Online telehealth service extracts data from CBC/metabolic panel plus C-Reactive Protein test report, then calculates the implied phenotypic (biological) age values, as well as estimated DNAm Age, and others. Assess Your Biological Age! Age Management Telehealth Physicians Case Study To indicate your interest: www.age-reversal.net Select “Telehealth Study" link from Home Page
  49. 49. They then used the measures to calculate implied phenotypic (biological) age and others shown in the spreadsheet below (Bill Faloon’s most recent) Bill’s calculated phenotypic (biological) age 11.12 younger than chron age and difference
  50. 50. Morgan Levine PhD and Steve Horvath PhD discovered standard blood test measures correlate with DNA methylation age: • Albumin • Creatinine • Glucose • C-reactive Protein • Lymphs (Lympocyte) • MCV (Mean Cell Volume) • RDW (Red Cell Dist Width) • Alkaline Phosphatase • WBC (White Blood Cells) Reference: "An epigenetic biomarker of aging for lifespan and healthspan", Aging (Albany NY) 10(4) 573-591 (2018 Apr 18). (Life Extension® price for CBC/Chem + C-reactive protein: $77)
  51. 51. Some features of the online data management and analysis system: • Calculates Levine/Horvath implied phenotypic (biological) age and others –useful measures to track progress • Easy to see “timeline” – before and after biomarker results, therapies and notes • Charts showing biological marker progress • Easy-to-enter • Lab test results • Therapies • Notes • For many LabCorp PDF lab test reports, data can be extracted and automatically uploaded into the system
  52. 52. Graphs showing how subject is progressing: These graphs show Phenotypic Age, C-Reactive Protein, albumin moving in positive directions after age reversal interventions.
  53. 53. AGE MANAGEMENT TELEHEALTH PHYSICIANS Physicians will see patients via the telehealth portal for this case series study. They will be trained in innovative age management therapies. Physicians will assist in inducing biological age reversal in the way they best see fit for each subject’s individual needs. (Personalized medicine.) To indicate your interest: www.age-reversal.net
  54. 54. Problems reported by many of our members who would like to visit a physician to reduce their biological ages: • Can’t find a QUALIFIED age management physician in their local area • Commute time takes too long • Would rather not travel to a doctor’s office. Solution: AGE MANAGEMENT TELEHEALTH PHYSICIANS
  55. 55. AGE MANAGEMENT TELEHEALTH PHYSICIANS PRIMARY OBJECTIVE: Use a telehealth platform to conduct single case studies where doctors and patients visit remotely via video. Various interventions assessed as to their safety and efficacy in inducing biological age reversal and improved general health. END RESULT SEEKING: Better understanding and refinement of regenerative interventions using a clinical (doctor/patient) telehealth setting. To indicate your interest: www.age-reversal.net Select “Telehealth Study" link from Home Page
  56. 56. https://www.wsj.com/articles/a-cancer-patients-brutal-commute-11626129627?mod=searchresults_pos2&page=1 July 12, 2021 “She doesn’t have to go all the way to the doctor’s office, a 5½-hour drive each way. She can drive 3½ hours, cross the border into Massachusetts, pull over, and have a telemedicine visit “A Cancer Patient’s Brutal Commute”
  57. 57. Analogy: Framingham Heart Study and Age Management Telehealth Study Age Management Telehealth Study seeks to do for aging what the Framingham Study did for our scientific understanding of heart disease and hypertension.
  58. 58. metformin dasatinib/quercetin/fisetin infusions, patches, precursors rapamycin resveratrol, reduce calorie intake Induce autophagy Advance to “biologics”, i.e., exosomes, perinatal tissues, growth hormone et al. glucosamine, rapamycin, diet Express sirtuins Suppress excess mTOR Boost cellular AMPK Reduce senescent cells Replenish NAD+
  59. 59. Bridging the Longevity Gap Bureaucratic Delays Impede Progress
  60. 60.  Apolipoprotein B  Omega-3-Index  Homocysteine  C-Reactive Protein  LDLparticle number  Total cholesterol  LDL cholesterol  HDL cholesterol  Triglycerides  T. Chol/HDL Ratio  Est. Heart Disease Risk + Conventional Risk Factors More Tests on Next Slide AgeManagement TestPanel Cardiac and Inflammatory Blood Markers Added RiskFactors  Small dense LDL  LDL size  Insulin Resistance  VLDL cholesterol  HDLparticle number
  61. 61. More Tests on Next Slide AgeManagement TestPanel Omega-3 Index + Full Fatty Acid Profile Omega-3 Fatty Acids • Omega-3 Index • Alpha-Linolenic • Eicosapentaenoic (EPA) • Docosapentaenoic-n3 (DPA) • Docosahexaenoic (DHA) Omega-6 Fatty Acids • Linoleic + Gamma-Linolenic • Eicosadienoic • Di-homo-gamma-linolenic • Arachidonic • Docosatetraenoic • Docosapentaenoic-n6 Monounsaturated Fats • Palmitoleic • Oleic • Eicosenoic • Nervonic Saturated Fatty Acids • Myristic • Palmitic • Stearic • Arachidic • Behenic • Lignoceric Trans Fatty Acids • Trans Palmitoleic • Trans Oleic • Trans Linoleic • Trans Fat Index Fatty Acid Ratios  AA: EPA ratio  Omega-6 to- Omega-3 ratio
  62. 62. More Tests on Next Slide AgeManagement TestPanel Glycemic Control Blood Profile Insulin Hemoglobin A1C Ferritin Insulin Resistance Score Glucose Diabetes Risk Markers
  63. 63. More Tests on Next Slide AgeManagement TestPanel Hormones +Vitamin D + Binding Protein  IGF-1 (growth hormone)  IGF1BP3 (binding protein)  DHEA-S  Free Testosterone  Total Testosterone  Estradiol  Progesterone  TSH (thyroid)  Free T3 and Free T4  Vitamin D 25-Hydroxy Hormone Effectiveness Profile
  64. 64. More Tests on Next Slide AgeManagement TestPanel Kidney and Liver Function Biomarkers  eGFR  LDH  AST  ALT  GGT  Bilirubin  Albumin  Globulin  A/G ratio  Creatinine  BUN/Creatinine  BUN  Total protein  Alkaline Phosphatase Measures of Organ Function
  65. 65. More Tests on Next Slide AgeManagement TestPanel Blood Mineral-Electrolyte Balance Potassium Magnesium Ferritin (iron storage) Measures of Mineral-Electrolyte Balance Calcium Iron Chloride Sodium
  66. 66. More Tests on Next Slide AgeManagement TestPanel Blood Oxygen Carrying Capacity  MCV (meancorpuscularvolume)  MCH (meancorpuscularhemoglobin)  RDW (redcelldistributionwidth)  MCHC (meancorpuscularhemoglobinconcentration)  Platelets  Hematocrit  Hemoglobin  Red blood count  Ferritin (ironstorage)
  67. 67. More Tests on Next Slide AgeManagement TestPanel Circulating Immune Cell Count  Immature cells  White blood cells  Immature granulocytes  Neutrophils (% and absolute)  Lymphocytes (% and absolute)  Monocytes (% and absolute)  Eosinophils (% and absolute)  Basophils (% and absolute)
  68. 68. AgeManagement TestPanel For Men PSA (prostate-specific antigen)
  69. 69. Commercial Lab Price: $3,000 TeleHealth Price: $495 Age Management BloodTest Panel age-reversal.net
  70. 70. Tragedy of Lost Data *Critical Need for Age Management Blood Tests Baseline and Annual Follow-Ups Experimental Therapies Need Meticulous Validation To inquire about Age Management Telehealth Physicians study: age-reversal.net
  71. 71. Age Management Blood Test Panel The Telehealth Study Price of $495 available until Nov 5th, 2021 at: www.age-reversal.net Results help assist your physician to identify degenerative aging factors. Age Management Telehealth Study Quest Labs Telehealth Physicians Study $3,000 $495
  72. 72. Who missed the longevity boat? Eli Broad (1933 - 2021) Expiration date: Apr. 30, 2021 net worth > $6.8 billion https://en.wikipedia.org/wiki/Eli_Broad • American billionaire philanthropist. • Funded genomics research to advance understanding of the biology of human disease. • Funded Regenerative Medicine and Stem Cell Research at USC.
  73. 73. Urgent Need for Consensus On Effective Interventions Age-Reversal Pathway to Super Longevity
  74. 74. Bridging the Longevity Gap Urgent Need to Reform Clinical Trial Regulations
  75. 75. Copyright ©Life Extension®. Confidential and proprietary. How I Fund Age Reversal Research Supplement Sales Support Rejuvenation Projects
  76. 76. age-reversal.net For information about current regenerative medicine research:
  77. 77. Clinical Trials Update William Faloon RAADFest October 2, 2021

In this 2021 RAADfest presentation, Bill Faloon updates the audience about human age-reversal clinical trials.

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