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Bill Faloon's RAADfest 2022 Keynote Presentation slides about Age Reversal

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Bill Faloon's RAADfest 2022 Keynote Presentation slides about Age Reversal

  1. 1. Most slides available for review at: www.age-reversal.net Age Reversal Update William Faloon October 6th 2022 RAADfest 2022
  2. 2. 2 0 2 2 1. Research findings since last year's RAADfest. 2. What is an “optimized diet?” 3. New life extension drugs. 4. Key to super longevity! 5. Clinical trials targeting systemic regeneration. 6. “Live Forever” via transhumanism. Advancing Towards Immortality Regeneration Targeted Clinical Trials New Anti Aging Drugs Key to Super Longevity
  3. 3. The Centenarian Surge Total number of Americans aged 100 or older: Year 1980: 32,000 Year 2010: 53,000 Year 2020: 92,000 Year 2060: 600,000 (projected) https://www.prb.org/resources/u-s-population-is-growing-older/
  4. 4. Huge Decline in Age-Adjusted Death Rate https://budgetmodel.wharton.upenn.edu/issues/2016/1/25/mortality-in-the-united-states-past-present-and-future Penn Wharton Budget Model based on CDC/National Center for Health Statistics United States Mortality Rate, 1900-2013 Death Rates Plummet
  5. 5. https://budgetmodel.wharton.upenn.edu/issues/2016/1/25/mortality-in-the-united-states-past-present-and-future Significantly Fewer Deaths in 65+ Nearly 70% of Overall Improvements in Mortality Since 1990 have been Contributed by the Elderly
  6. 6. https://www.prb.org/resources/u-s-population-is-growing-older/ February 19, 2020 | Source: U.S. Census Bureau, decennial censuses and vintage 2017 population projections (2020-2060). 187% increase Americans > age 64 1980 to 2020 U.S. Population by Age Group (millions), 1900 to 2060 Number in Millions is unprecedented in U.S. history
  7. 7. I am Licensed Funeral Director and Embalmer Most of my 1970s-1980s clients (corpses) would have LIVED with today’s technologies.
  8. 8. Life Expectancy in the United States in 2020 9-Year Disparity in Human Longevity
  9. 9. The Highest Life Expectancy? 80.7 Years in Hawaii Aug 23, 2022 71.9 years Higher life expectancies in California, Utah, Minnesota and Massachusetts. Bottom states include West Virginia, Louisiana Alabama, Oklahoma, and Kentucky. https://abcnews.go.com/Health/life-expectancy-dropped-2020-us-state-due-covid/story?id=88698742
  10. 10. November 28, 2021 https://www.cbsnews.com/news/can-we-reset-our-biological-clocks/
  11. 11. A$3BillionBetonFindingtheFountainofYouth “they believe they have glimpsed the outline of an answer to the question of how to reverse the process of cellular aging. They have also recruited a star- studded scientific cast to help them track that answer down.” This list includes 4 Nobel prize winners, including the discoverer of Yamanaka factors, Dr. Yamanaka himself. January 22, 2022 Economist.com/science-and-technology/a-3bn-bet-on-finding-the-fountain-of-youth/21807244
  12. 12. HowTechBillionairesAreTryingToReverseTheAgingProcess If They Could Turn Back Time: Jeff Bezos and Peter Thiel are pouring huge sums into startups aiming to keep us all young – or even cheat death. And the science isn’t as far-fetched as you might think. https://www.theguardian.com/science/2022/feb/17/if-they-could-turn-back-time-how-tech-billionaires-are-trying-to-reverse-the-ageing-process Feb. 19, 2022
  13. 13.  Once-faltering paws gripped objects with renewed strength.  Hearts and livers of rats regained youthful vitality.  Fuzzy memories sharpened.  Biological age had been cut in half. “It was as if someone had turned back time.” April 30, 2022 “GrowingYounger:RadicalInsights IntoAgingCouldHelpUsReverse It” April 30,2022|https://www.newscientist.com/issue/3384/
  14. 14. - July 19, 2022
  15. 15. June 7 2022 https://www.technologyreview.com/2022/06/07/1053132/saudi-arabia-slow-aging-metformin/ The oil kingdom fears that its population is aging at an accelerated rate and hopes to test drugs to reverse the problem. First up might be the diabetes drug metformin. Saudi Arabia Plans To Spend $1 Billion A Year Discovering Treatments To Slow Aging of its oil wealth supportingbasic research on the biology of aging and findingwaysto extend the number of years people live in good health $1 BILLION A YEAR has started a not-for-profit organization called the Hevolution Foundation that plans to spend up to “ ”
  16. 16. Scientists sequence the complete human genome for the first time Mar. 31, 2022 https://www.cnn.com/2022/03/31/health/first-complete-human-genome-sequence The Human Genome Project sequenced 92% of the human genome (2003) Scientists struggled to decipher the remaining 8% ~100scientistteamunveilscompletehumangenome(2022) Firsttimehumangenomehasbeensequencedinitsentirety Fresh insights into cancer, birth defects and aging
  17. 17. https://www.newscientist.com/article/2335495-immortal-jellyfish-genes-identified-that-may-explain-their-long-lives/ Aug.29,2022 “By performing a DNA comparison of two similar jellyfish species, researchers have found the genes that could stop and reverse ageing in immortal jellyfish…” “…the immortal jellyfish had twice as many copies of genes associated with DNA repair and protection…The jellyfish also had unique mutations that stunted cell division and prevented telomeres – chromosomes’ protective caps – from deteriorating.”
  18. 18. C = Clustered R = Regularly I = Interspaced S = Short P = Palindromic R = Repeats CRISPR Gene Therapy
  19. 19. https://www.genengnews.com/t-cells/crispr-engineers-stronger-t-cells-for-immunotherapy Aug 25, 2022 One Gene Edit Kills More Tumor Cells
  20. 20. Rapid Transition from Animal Findings to Clinical Trials “CRISPR cure for High Cholesterol enters first Human Trial” May 2021- One-time CRISPR shot lowers LDL cholesterol by 60% in monkeys. The base edit knocks out the PCSK9 gene, to enable more LDL to be removed. July 2022- Human trial launches using nanoparticles to deliver CRISPR genetic instructions to cells to knock out PCSK9 in people with familial hypercholesterolemia. Nature 2021, DOI: 10.1038/s41586-021-03534-y https://bigthink.com/health/crispr-cholesterol-gene-therapy/
  21. 21. “…mice with progeria that got the gene-editing treatment lived more than twice as long as the untreated mice.” | Jan. 7, 2021 CRISPR Gene-Editing Treatment
  22. 22. CRISPR Gene-Editing Treatment An untreated progeria mouse at 7.5 months of age, with a thin, grayish coat, pronounced spinal curvature, and low activity levels. Untreated progeria mice have an average lifespan of 7.1 months. Three treated progeria mice at 11 months of age, with healthy coats, no apparent spinal curvature, and normal activity levels. The treated progeria mice had an average lifespan of 17 months. CRISPR-Edited Progeroid Mice Unedited Progeroid Mouse https://www.wsj.com/articles/crispr-gene-editing-treatment-could-point-way-to-fix-for-deadly-aging-disease-11609950054
  23. 23. Transcription factors turn our genes “on” and “off ”...so, they are expressed in the right cell, at the right time, and in the right amount. Key to Super Longevity
  24. 24. Transcription factors can enable old cells to be reprogrammed into embryonic cells capable of developing into all tissues of the body. Transcription factors are proteins that help turn specific genes "on" or "off" by binding to DNA. Groups of transcription factors can turn a gene on/off in specific parts of the body. Transcription factors that are repressors decrease transcription. Transcription factors that are activators boost a gene’s transcription.
  25. 25. The Nobel Prize in Physiology or Medicine 2012 These transcription factors are called: “Yamanaka Factors” Four specific genes encode transcription factors that can convert somatic cells into pluripotent stem cells that can propagate indefinitely. nobelprize.org/prizes/medicine/2012/yamanaka
  26. 26. February 28, 2021  This 2021 published review and additional investigations summarize age-reversal impact of cell reprograming.  Human trials being investigated  Funded by Bill Faloon and other charitable donors “When cells were reprogrammed with a 6-factor cocktail the (degenerative) alterations were fully reversed and cells fully rejuvenated.” https://www.aging-us.com/article/202712/text
  27. 27. March 7, 2022 Scientists Reverse Aging in Mice
  28. 28. March 11, 2022 “Anti-Aging Breakthrough: https://scitechdaily.com/anti-aging-breakthrough-cellular-rejuvenation-therapy-safely-reverses-the-aging-process-in-mice/ Cellular rejuvenation therapy safely reverses signs of aging in mice. Credit: Salk Institute Cellular Rejuvenation Therapy Safely Reverses the Aging Process in Mice”
  29. 29. March 9, 2022 “Newresearchbythe SalkInstitutehasshown cellularrejuvenation therapysafelyreverses signsofaginginmice.” https://www.drugtargetreview.com/news/101826/scientists-have-shown-ageing-process-can-be-safely-and-effectively-reversed-in-mice/ “Scientists have shown aging process can be safely and effectively reversed in mice”
  30. 30. https://www.dailymail.co.uk/sciencetech/article-10589031/Scientists-REVERSE-ageing-mice-using-cellular-rejuvenation-technique.html • Experts injected mice with molecules called the Yamanaka transcription factors • Treatment period of seven to 10 months was effective for restoring youthfulness • The 'safe' treatment could one day help humans wind back their biological clock
  31. 31. March 7, 2022 https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/ Mar. 7, 2022 “Scientistssafelyandeffectivelyreversetheagingprocessinmiddle-aged andelderlymicebypartiallyresettingtheircellstomoreyouthfulstates.”
  32. 32. • Partial cell reprogramming in live (in vivo) mice • OSKM (“Yamanaka”) transcription factors used • Longeradministrationdemonstrateduniquebenefits • No toxicity or increase in cancer detected Partial Cell Reprogramming Safe https://www.nature.com/articles/s43587-022-00183-2 https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/
  33. 33. • Long-termcell reprogrammingresults in “younger”skin age. • Skin cells divide more rapidly. • Lower inflammation and reduced senescent-associated secretory phenotypes in treated animals. • No data collected on lifespan, exercise, memory, or muscle. Cell Rejuvenation in Live Mice https://www.nature.com/articles/s43587-022-00183-2 https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/
  34. 34. March 7, 2022 “In both the kidneys and skin, the epigenetics of treated animals more closely resembled epigenetic patterns seen in younger animals.” “…theyfoundthatthemice,inmanyways,resembledyoungeranimals.” https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/
  35. 35. Human Skin Cells Rejuvenated By 30 Years With New Aging-Reversal Method When applied to skin cells of three donors aged 38, 53, and 53,theresearchersfoundthattheirmethodwoundbackthe fibroblasts’ epigenetic clock by about 30 years. Reprogrammed cells produced more collagen & migrated to wound areas faster than untreated fibroblasts. Pointing to significant reversal of age-related functional decline. A new method of utilizing Yamanaka factors called “maturation phase transient reprogramming” (MPTR) now allows for significant age reversal “without loss of cell identity.” April 8th, 2022 | elifesciences.org/articles/71624
  36. 36. > 2006: cell reprogramming demonstrates cellular rejuvenation. > 2011: Rejuvenation induced in very old human cells (in vitro) > 2022: 100% of Human Genome sequenced. > 2022: Aging partially reversed in live mice (in vivo) > 2022: Research underway to rejuvenate old humans. Prior biology doctrine: Cell aging irreversible…rejuvenation not possible. Cellular Reprogramming --> Rewriting the Rules of Biology | https://pubmed.ncbi.nlm.nih.gov/33627519
  37. 37. Step 1: Remove old cells from circulating blood. Step 2: Use transcription factors to transform the autologous old cells back to youthful structure/function. Step 3: Human project initiated in 2022: Reinfuse the reprogrammed autologous stem cells to induce systemic regeneration. Research using Autologous Stem Cells + Transcription Factors Pilot studies are evaluating safety and regenerative efficacy
  38. 38. Clinical Trials Center in Florida
  39. 39. Anti-Aging Clinical Trials Building 200, Suite 205 13940 US Hwy 441 The Villages, FL 32159 Betterhumans.org
  40. 40. • $100,000 approx. monthly expenditure Betterhumans.org • Funded by tax deductible donations • Stocked with expensive "kits", primers, reagents, assays, etc. • Five scientists working 6-7 days a week Biomedical Lab in Central Florida A 501(c)(3) non- profit organization. Donations are tax deductible!
  41. 41. Betterhumans DNA/RNA/DNA Methylation Sequencing Room
  42. 42. Betterhumans Mass Spectrometry Room
  43. 43. Health and Longevity Biomarker Assay Facility
  44. 44. Full Time Scientists Who Work at Betterhumans to Find Ways to Reverse Aging
  45. 45. Construction of New Research Facility in Texas Betterhumans new facility will be a 28,000 sq. ft Age Reversal Vivarium and Diagnostic Lab. Pictured is the construction of four of the six planned 20’ by 40’ lab rooms.
  46. 46. Senolytics Update October 6, 2022
  47. 47. Senescent cells accumulate with normal aging and: Removing Senescent Cells Confers Healthy Longevity
  48. 48. Senolytics are compounds that selectively destroy senescent cells.
  49. 49. Aug. 24th, 2022 272 papers for 2021 alone “Senolytics” Publications increase from near zero in 2013 to 850 by mid-2022. https://pubmed.ncbi.nlm.nih.gov/?term=senolytic
  50. 50. Current Experimental Dasatinib Dose Schedule Afterreviewingcontraindicationswithyourdoctor,considerthefollowing ONCEmonthly: Repeat each month. Do not take rapamycin week you take senolytic. Rapamycin may impede senolysis. Register for updates at: age-reversal.net Day One: Dasatinib 100 mg Theaflavins 275 mg Quercetin 25 mg (bioavailable) Fisetin 56 mg (bioavailable) Day Two: Repeat Day One doses unless dasatinib side effects manifest.
  51. 51. Oct.13,2021 https://www.nature.com/articles/s41598-021-99852-2 Highly selective marker of cellular senescence present on membranes of senescent cells targets specific delivery of senolytic drugs into senescent cells. nature “Non-senescent cells were not affected by either antibody, confirming the specificity of the treatment. …” A Vaccine to Eliminate Senescent Cells!
  52. 52. A Vaccine Eliminates Senescent Cells https://www.longevity.technology/a-vaccine-for-aging-that-eliminates-senescent-cells Dec. 13, 2021
  53. 53. Senolytics described in new book. https://medium.com/@bdajess/drug-that-increases-human-lifespan-to-200-years-is-in-the-works-edb3a1a64af1 “A fascinating look at how scientists are working to help doctors treat the aging process itself, helping us all to lead longer, healthier lives.” — Sanjay Gupta, MD “I don’t think there is any kind of absolute cap on how long we can live.” — Dr. Andrew Steel British Computational Biologist
  54. 54. Intermittent Fasting Update 16 hours fasted 8 hours fed
  55. 55. https://www.nejm.org/doi/full/10.1056/NEJMra1905136 EffectsofIntermittentFasting onHealth, Aging, andDisease Dec. 26, 2019 Abdominal fat Blood pressure Stress resistance Glucose regulation Human benefits of intermittent fasting: Heart rate Endurance Cognition Inflammation IMPROVEMENTS IN ALL THESE KEY MARKERS AND MORE
  56. 56. Intermittent Fasting Can Help Manage Metabolic Disease Sep.22,2021 Eating calories within a consistent window of 8-10 hours is powerful strategy to prevent-manage chronic diseases. Endocr Rev, bnab027,| https://doi.org/10.1210/endrev/bnab027 Sept. 22, 2021 Funded by National Institute of Diabetes and Digestive and Kidney Diseases, National Institute on Aging, National Cancer Institute, Larry l. Hillblom Foundation, Wu Tsai Human Performance Alliance, U.S. Department of Defense and Federal Emergency Management Agency; September 22, 2021 Intermittent fasting can improve sleep and quality of life as well as reduce the risk of obesity, diabetes, heart disease. Genes, hormones & metabolism rise/fall at different times of the day. (Eating randomly makes us prone to diseases.)
  57. 57. Front. Nutr., 18 October 2021 | https://doi.org/10.3389/fnut.2021.669325 Oct. 18, 2021  Body weight  Fat mass  Body mass index  Blood pressure  Waist circumference  Fasting glucose  Total Cholesterol  Fasting insulin  Triglycerides  Insulin resistance Compared to controls, intermittent fasting groups decreased:
  58. 58. University of Illinois-Chicago researchers say intermittent fasting can produce clinically significant weight loss, reductions in inflammation, blood pressure, and cholesterol. https://medicalxpress.com/news/2021-10-intermittent-fasting-worksfor-weight-loss.html “Research review shows intermittent fasting works…” Oct. 12, 2021
  59. 59. Scientific Reports | (2020) 10:18341 | https://doi.org/10.1038/s41598-020-73767-w “Intermittent fasting from dawn to sunset for 4 consecutive weeks induces anticancer serum proteome response & improves metabolic syndrome” • 7.25 pounds of weight loss • 8.8 mmHg reduction in blood pressure • Significant increase in tumor suppressor/anticancer proteins • Significant decrease in several tumor promoter/pro-cancer proteins • Increasing a protein called calreticulin (by around 16 times) • Calreticulin enhances IgG response to a SARS-CoV spike protein natureresearch No eating/drinking between dawn & dusk…14-15 hours a day: Oct. 27, 2020
  60. 60. https://cancerdiscovery.aacrjournals.org/content/12/1/90 Cancer patients took up a five-day, plant-based, calorie-restricted (low-carb/protein) diet. It resulted in reduced median plasma glucose concentration by 18.6%, serum insulin by 50.7% and serum IGF-1 by 30.3%. The reduced plasma glucose, insulin and IGF-1 was found to be crucial to down-regulating immunosuppressive myeloid cells and enhancing intra-tumor T cell cytotoxicity. “…our results provide first evidence that five-day FMD produces systemic immunological effects that are associated with the activation of several antitumor immune programs at the tumor level in human cancers.”
  61. 61. September 2022 Pilot studies are evaluating safety and regenerative efficacy “Exceptional tumor responses to fasting-mimicking diet combined with standard anticancer therapies…” Five of 101 patients enrolled with advanced, poor prognosis solid neoplasms: 1extensivestagesmallcelllungcancer; 1metastaticpancreaticadenocarcinoma; 1 metastatic colorectal cancer; 2metastatictriple-negativebreastcancer Achievedcompleteandlong-lasting tumorresponses whentreatedwith combination cyclicfasting mimicking dietandstandard systemic treatments. https://pubmed.ncbi.nlm.nih.gov/35810555/
  62. 62. Prevention Magazine > Intermittent Fasting > Metformin > DNA methylation tests > Sirtuin activation > Young plasma transfer > Senolytic drugs RAADfest presented all these findings' years ago. September 2021 favorably describes: (Prevention Magazine initially hostile to anti-aging medicine)
  63. 63. Radical Interventions are Going Mainstream AtthecheckoutcounterofWholeFoods,amagazine displays what we’ve been advocating for years. August 22, 2022 More of what you learn at RAADfest is going mainstream.
  64. 64. 60% (in middle-aged mice) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/
  65. 65. “In middle-aged mice, just 3 months of high-dose rapamycin treatment was sufficient to increase life expectancy up to 60%. When taken late in life, rapamycin increases lifespan by 9-14% [155], despite the dosage being suboptimal. This possibly equates to more than 7 years of human life.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/
  66. 66. IncreasedFidelityofProteinSynthesisExtendsLifespan The paper’s authors emphasize that the baseline rate of error in protein synthesis can be hundreds of thousands of times more then the DNA mutation rate. Making it a major neglected aspect of aging. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00417-4 “We show that anti-aging drugs such as rapamycin, Torin1, and trametinib reduce translation errors, and that rapamycin extends further organismal longevity in RPS23 hyper-accuracy mutants. This implies a unified mode of action for diverse pharmacological anti-aging therapies.” November 2,2021
  67. 67. Rapamycin Human Study Receives $485,000 Funding  Randomized, placebo-controlled trial into the safety/efficacy of rapamycin in reducing clinical measures of aging in an older adult population.  Two differing doses: 5 mg or 10 mg of rapamycin one time a week or placebo.  Primary Outcome Measure: Changes in visceral fat as measured by (DXA) scan.  Secondary Outcomes: Range of clinical measures, e.g. bone density, blood tests, etc.  > 50 people enrolled at $360 each (original cost before donations was $1,200). March 5th, 2022 Sponsor: AgelessRx Collaborator: University of California, Los Angeles Principal investigators: James Watson, M.D. and Sajad Zalzala, M.D. https://www.agelessrx.com/pearl Toenrolllogonto:
  68. 68. Effect of Rapamycin to Improve Cardiac Function in Frail Older Adults  To see if rapamycin will improve heart's ability to pump by improving oxygen consumption.  Pilot, proof-of-concept study. Patients 60 years or older with invasively proven heart failure.  Subjects with hsCRP levels ≥2mg/L will undergo treatment with open label rapamycin.  Efficacy outcomes will be measured at baseline and at 6 months.  Safety will be assessed by remote video monitoring.  Rapamycin levels (≤ 4ng/mL) measured twice-a-month first month/ then monthly for 5 months. April 2022 Principal investigator: Mandeep Singh------------Sponsor: Mayo Clinic https://clinicaltrials.gov/ct2/show/NCT04996719
  69. 69. “The Rapamycin Human Longevity Open Registry is a worldwide initiative to collect data on individuals using rapamycin for longevity through a series of online surveys in order to build the largest and most comprehensive global collection of information on this topic to date. It is the first online patient-driven registry for rapamycin usage, with individuals taking the drug driving the collection of data.” www.Rapamycin.io >> << To Help Enhance Research Efforts VISIT:
  70. 70. “Our goal is to assess the impact of rapamycin use on healthy people and disseminate these findings for the benefit of everyone.” - Dr. Matt Kaeberlein, Dr. Jonathan An and Dr. Alan Green This research has been funded by an Impetus Grant University of Washington Rapamycin Study https://rapamycinstudy.org/
  71. 71. SurgingRapamycinScientificInterest 1720 Rapamycin or Rapalog Studies Listed On ClinicalTrials.gov https://www.rapamycin.news/t/rapamycin-searches-on-google-up-900-this-year/874 As of July 2022: • Rapamycin Google searches up 900% this year compared to all last year. • 203 published rapamycin/title studies • 114 published sirolimus/title studies
  72. 72. - VIA PARABIOSIS Young blood circulated into old animals enables system wide benefits… But no reversal of immune senescence January 15, 2015 https://www.nature.com/articles/517426a - -
  73. 73. › Older partners paired with young rats lived for four-to-five months longer than controls. › This life span extension is the equivalent of 10-12 human years. › Source: New York Academy of Sciences, (1972 Nov) Vol. 34, No. 7, pp. 582-7. › in 1972 researchers at the University of California studied the life spans of old–young circulatory connected rat pairs.
  74. 74. https://www.newscientist.com/article/2112829-blood-from-human-teens-rejuvenates-body-and-brains-of-old-mice/ Mice treated with young human plasma appeared to have created more new cells in their brain. November 15, 2016 “Young human plasma treatment can increase neurogenesis.”
  75. 75. https://www.newscientist.com/article/2311876-we-may-now-know-why-young-blood-can-have-rejuvenating-effects/ Packages of RNA and proteins that bud off from cells have reversed some signs of aging in mice, and they may account for the rejuvenating effects of young blood. March10,2022 “…itreversedseveralsignsofaging, includingboostingmusclestrength andhairgrowthandimproving coordinationandendurance.”
  76. 76. https://doi.org/10.1016/j.stem.2022.04.017 Heterochronic Parabiosis Induces Stem Cell Revitalization and Systemic Rejuvenation Across Aged Tissues June 2nd, 2022 Research Highlights: Youthful hematopoietic stem cell function restored. “Rejuvenatingfactors”identified in youngblood. Immune senescence of lymphocytes mitigated.
  77. 77. Shortage of Regulatory Immune Cells Implicated in Sepsis Mortality Feb. 15, 2022 In a mouse model, sepsis was associated with significant depletion of hematopoietic stem and progenitor cells (HSPCs) and mortality within 5–7 days. HSPC infusion restored HSPC levels and saw an increase in myeloid-derived suppressor cells and a dampening of systemic inflammation thought to cause the 50-60% overall survival improvement. Sepsis accounts for 1 in 5 deaths worldwide and is a common final pathway for many disease processes such as cancer, diabetes, and cardiovascular disease. elifesciences.org/articles/74561
  78. 78. September 02, 2022 | https://doi.org/10.1111/acel.13696 September 2nd, 2022
  79. 79. “Umbilical cord plasma concentrate has beneficial effects on DNA methylation GrimAge and human clinical biomarkers” Human Study • Each injection equivalent to 100 mL umbilical cord plasma infusion. September 02, 2022 | https://doi.org/10.1111/acel.13696 • 18 human participants average age 74 years. • Safety-efficacy evaluated with blood tests + GrimAge® epigenetic clock. • Weekly injection of umbilical cord plasma concentrate into muscle for 10 weeks. (Fourumbilicalcordsusedtoproduceeachweeklyinjection.)
  80. 80. • GrimAge®: -0.78yearsyounger(predictorofdeathrisk) • 30% of 90 biomarkers changed beneficially, zero negatively • No significant side effects • Kidney function: 7% improvement measured by eGFR (+ 5) • Phenotypic Age Score biomarkers such as RDW and MCV improved, reducing predicted age September 2nd, 2022 https://onlinelibrary.wiley.com/doi/10.1111/acel.13696
  81. 81. Clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-021-01112-7 Academic.oup.com/biomedgerontology/article/76/5/741/5992253 “DNAm GrimAge is a strong predictor of mortality independent of genetic influences among female twin pairs.” 1 “GrimAge Outperforms Other Epigenetic Clocks in the Prediction of Age-Related Clinical Phenotypes and All-Cause Mortality.”2 2021 findings corroboratedata published 2019-2020 1. 2. NewStudiesDemonstratePredictivePowerofEpigeneticClocks
  82. 82. https://www.lyfspn.com/#Pilot In the Bay Area, Lyfspn has initiated a plasmapheresis human clinical trial that aims to demonstrate the rejuvenation and lifespan improving potential that was previously shown in animal models. DobriKiprov,M.D.,H.P.(ASCP),Co-founderofLyfspn https://longevity.technology/news/be-part-of-bringing-plasmapheresis-to-trial/
  83. 83. Buck Institute for Research on Aging https://www.buckinstitute.org/ “The Buck is a collective of the world’s top scientists in the field of aging who are sharing their methods and expertise to find ways to help everyone lead fuller, healthier lives by ending age-related disease.”
  84. 84. Offshore AgeReversalResearch Nassau, Bahamas (and other countries) Updates onoffshorestudy options at: www.age-reversal.net Nassau
  85. 85. Age Reversal Clinical Project - Bahamas
  86. 86. age-reversal.net For Offshore Clinical Research Updates:
  87. 87. Daily Deaths of Americans > age 64: https://www.cdc.gov/nchs/fastats/older-american-health.htm 6,800 Human Lives Lost
  88. 88. Experimental Human Age Reversal Interventions Urgent Need to Rapidly Accelerate Clinical Trials
  89. 89. Bridging the Longevity Gap Urgent Need to Reform Clinical Trial Regulations
  90. 90.  England approves metformin:1957  FDA approves metformin: 1994  37-year delay caused millions of American deaths.  65 years later most people don’t know metformin is anti-aging drug. Regulatory Barriers Must be Abolished! Deadly Delays…Urgent Need for Reform
  91. 91. 1906-2022 = 116 Years of Needless Deaths
  92. 92. Petition FDA-Congress to Amend Clinical Trial Constraints age-reversal.net/FDA
  93. 93. Life Extension® versus the FDA
  94. 94. A Multi-Decade Battle
  95. 95. FDA Surrenders in 1996 This was the first time the FDA has been forced to give up on a criminal prosecution. https://www.lifeextension.com/magazine/1996/9/freedom By February 1996, Federal Judge Daniel Hurley dismissed all 56 criminal charges against Saul Kent and William Faloon. This victory goes beyond winning in court. The FDA's defeat is a victory for everyone who cherishes freedom in healthcare.
  96. 96. Free updated chapters available at LifeExtension.com
  97. 97. Petition FDA-Congress to Amend Clinical Trial Constraints age-reversal.net/FDA
  98. 98. Lyndon Johnson Prematurely Died Due to Technology Delay •First heart attack age 46 (1955) •Suffered chronic angina pain •Resigned re-election age 59 (1968) •Dead age 64 years (1973) (Treatments to reverse coronary blockage lacking)
  99. 99. Alive Because of Biomedical Technology Bill Clinton Coronary Bypass Age 58 In 2004 Coronary Stent Age 63 In 2010 George W. Bush Coronary Stent Age 67 in 2013 Dick Cheney Coronary Bypass Age 47 In 1988 Coronary Stent Age 59 in 2000 Ventricular Assist Age 69 in 2010 Heart Transplant Age 71 in 2012 Age 76 Today Age 81 Today Age 76 Today
  100. 100. Age-reversal science is rapidly advancing. We are in similar predicament as LBJ in 1955-1973. Good News:
  101. 101. Age-standardized death rate rate from heart disease per 100,000 people dropped: Huge Reduction in Heart Disease Deaths From: 520 in 1969 To: 167 in 2014 68% decline over 45 years
  102. 102. “Declining Risk of Sudden Death in Heart Failure." New England Journal of Medicine. 2017;377(1):41-51. Clinical trials spanning 1995 to 2014 show: 44% decline of sudden death in heart failure patients Sharp Decline in Heart Failure Death Rates Leading cause of age-related death markedly reduced in just 19 years!
  103. 103. Heart Failure Deaths Surge in Young Adults Mortalitywithheartfailure involvementin Americansaged15-44yearsincreaseby: 33.8% Journal of the American Medical Association https://jamanetwork.com/journals/jamacardiology/article-abstract/2794437 July 27, 2022 2012-2019
  104. 104. Front page Wall Street Journal: January 15, 2020 Obesity epidemic causing heart disease rates to soar higher, especially in those under age 65
  105. 105. https://vividmaps.com/obesity-united-states/
  106. 106. Combat Excess Body Fat with: Diet + Drugs
  107. 107. “Overweight people lost 35 to 52 pounds on newly approved diabetes drug…” June 7, 2022 https://www.cnn.com/2022/06/06/health/weight-loss-drug-diabetes-wellness/index.html  “Almost 40% of individuals lost a quarter of their body weight…  The middle range of weight loss for people in this new study was 49 pounds…  It'stherangeofweightlossthatwetypically thinkonlypossible through surgery.”
  108. 108. Tirzepatide Once Weekly for the Treatment of Obesity https://www.nejm.org/doi/full/10.1056/NEJMoa2206038 June 4, 2022 In a 72-week obesity trial, 50% of participants in the 10-mg and 15-mg tirzepatide groups had:  Weight loss in non-diabeticswas 15% - still substantial  A reduction in body weight of 20% or more, as compared with 3% in the placebo group.  Improvements in all cardiometabolic measures.
  109. 109. First Oral Version: Rybelsus First Approved: 2019 Subcutaneous Injectable Versions: Byetta, Lyxumia, Victoza, Trulicity & Mounjaro Approved GLP-1 Agonists (7 mg or 14 mg tablets)
  110. 110. Glucagon-like peptide-1 (GLP-1) agonist drugs function via multiple mechanisms to:  Reduce body fat.  Improve cardiovascular risk factors.  Combatmetabolicdisorders like type II diabetes & fatty liver disease GLP-1 Agonist Drugs https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484915/figure/f1-jomes-26-155/
  111. 111. Oneweekeachmonth,modestlow–carb,verylow–proteindiet: June 5, 2022 | https://doi.org/10.1210/clinem/dgac197 Effects of Six-Month Periodic Fasting in Patients With Type 2 Diabetes & Diabetic Nephropathy  22 pounds of weight loss  1.4% decrease in A1C  59% improved insulin sensitivity  67% of people ADietPlanof: Day1 ≈1100calories Days2–5≈ 700calories Day6≈Normalintake 22 pounds of weight loss 1.4% decrease in A1C 59% improved insulin sensitivity 67% of people reduced diabeticdrug dose Resulted in:
  112. 112. “Changing your diet could add up to 13 years to your life…” Feb. 9, 2022 https://www.cnn.com/2022/02/08/health/longer-life-diet-wellness/index.html
  113. 113. https://doi.org/10.1371/journal.pmed.1003889 “When changing from a typical Western to an optimized diet, the largest gains in LE could be made by eating more legumes, whole grains, and nuts, as well as eating less red meat and processed meat, with gradual reduction in effect with increasing age.” Key Finding Components of an Optimized Diet Feb. 8, 2022 Some Legume Choices
  114. 114. Feb. 08, 2022 | https://doi.org/10.1371/journal.pmed.1003889 Legumes Whole Grains Nuts Red Meat Processed Meat Sweetened Drinks Refined Grains Eggs Fish Fruit Vegetables Life expectancy gains in order of significance Optimized Diet = 10 to 13 more years at age 20 Feb. 8, 2022 Switching to an optimal diet from age 20 years onward is modeled to increase life expectancy by: 13.0 years for men 10.7 years for women
  115. 115. Switching to an optimal diet from age 60 years onward is modeled to increase life expectancy by: Feb. 08, 2022 | https://doi.org/10.1371/journal.pmed.1003889 Legumes Whole Grains Nuts Red Meat Processed Meat Sweetened Drinks Refined Grains Eggs Fish Fruit Vegetables Life expectancy gains in order of significance 8.8 years for men 8.0 years for women Optimized Diet = 8-year lifespan increase at age 60 Feb. 8, 2022
  116. 116. Feb. 8, 2022 | https://doi.org/10.1371/journal.pmed.1003889 Legumes Whole Grains Nuts Red Meat Processed Meat Sweetened Drinks Refined Grains Eggs Fish Fruit Vegetables Life expectancy gains in order of significance Optimized Diet = 2.6-3.9 more years at age 80 Feb. 8, 2022 Switching to an optimal diet from age 80 years onward is modeled to increase life expectancy by: 2.7 to 3.9 years for men 2.6 to 3.4 years for women
  117. 117. •Chickpeas •Peanuts •Black beans •Green peas •Lima beans https://www.webmd.com/food-recipes/health-benefits-legumes •Kidney beans •Black-eyed peas •Navy beans •Pinto beans •Lentils Legumes — a class of vegetables that includes beans, peas and lentils:
  118. 118. Foods to Reduce or Avoid Re  Red meat  Overcooked meats  Butter  Processed red meat (hot dogs, bacon)  Cured ham (nitrite/nitrite preserved meats)  Most frozen meals  Soda, desserts, candy  Most processed foods  Sugars  Refined grains (white bread/white grain pasta)  Excess salt https://www.foodnetwork.com/healthy/articles/what-foods-are-not-allowed-on-mediterranean-diet
  119. 119. August 1st, 2022 28% faster rate of global cognitive decline 25% faster rate of executive function decline (56% of calories consumed in U.S. come from ultra processed foods.) People who ate the most ultra processed foods compared to those who ate the least had a: https://www.cnn.com/2022/08/01/health/ultraprocessed-food-dementia-study-wellness/index.html https://www.nbcnews.com/health/health-news/highly-processed-food-linked-faster-cognitive-decline-rcna40999
  120. 120. Jun. 30, 2021 https://www.ahajournals.org/doi/10.1161/JAHA.120.019158 Mediterranean Diet Reduces Risk of Sudden Cardiac Death Study of 21,000 people over 9.8 years reveals: Diet high in fried foods, organ meats and processed meats regularly had a 46% higher risk of sudden cardiac death compared to those with least adherence. Those who most closely followed the traditional Mediterranean diet had a 26% lower risk of sudden cardiac death than those with the least adherence. Mediterranean diet defined as high in vegetables and whole grains, low intake of meat, high intake of marine omega-3s.
  121. 121. “Will We Ever Cheat Death and Become Immortal With Mind Uploading?” “…scientists,researchers, andtechcompaniesareworkingtowardsmakingminduploadingareality.” December 7th,2021 https://interestingengineering.com/science/cheating-death-and-becoming-immortal-with-mind-uploading
  122. 122. Result is super-intelligencethat advances our abilities to incomprehensive levels. Ray Kurzweil’s Exit Plan to Immortality • Survive until year 2045. • Singularity enables neocortex to merge with cloud-based artificial intelligence. • Neocortex/AI enters limitless self- improvement cycles.
  123. 123. “Synchronized pairs of laser pulses drive the fastest logic gates ever made, which could eventually give computers a million-fold speed boost” https://newatlas.com/electronics/fastest-ever-logic-gates-computers-million-times-faster-petahertz/ May 11, 2022 “By zapping graphene and gold with laser pulses, the new logic gates are a million times faster than those in existing computers, demonstrating the viability of “lightwave electronics.”
  124. 124. Current computers use electronic currents for logic gates that produce delays in processing that amount to the order of nanoseconds, light-based logic gates could reduce processing delays down to femtoseconds. Which would move processing speed possibilities from Gigahertz (GHz) all the way to Petahertz (PHz). https://www.nature.com/articles/s41586-022-04565-9 = 0.000000000000001 Seconds Femtoseconds = 0.000000001 Seconds Nanoseconds May 11, 2022 Once Again, Barriers Are Broken, The Impossible Becoming Possible
  125. 125. July 30th, 2021 https://www.cnbc.com/2021/07/30/elon-musks-neuralink-backed-by-google-ventures-peter-thiel-sam-altman.html Elon Musk’s Brain Computer Startup Raises $205 Million from Google Ventures & Others Neuralink is trying to develop high-bandwidth brain implants that can communicate with phones and computers. Total investment in the company now stands at $363 million.
  126. 126. April 9th, 2022 https://www.cnbc.com/2022/04/08/elon-musk-humans-could-eventually-download-their-brains-into-robots.html Elon Musk says humans could eventually download their brains into robots — and Grimes thinks Jeff Bezos would do it “ElonMusksays a lot of seeminglyfantastical things.Forexample: The billionaireTesla and SpaceX CEO seemsto believethathumanswill eventually be able to by downloading their brains into robots” LIVE FOREVER,
  127. 127. August 31, 2022 “… the device is implanted near the area of the brain that controls movement.” “Signals captured by a receiver in the chest are sent wirelessly to a device that decodes thoughts into commands for a digital device.” https://www.cbsnews.com/news/can-we-reset-our-biological-clocks/
  128. 128. https://www.wsj.com/articles/how-brain-computer-interfaces-could-restore-speech-and-help-fight-depression-11662129229 Brain-Computer Interface Published Research Doubled in 5Years | Sept. 2, 2022 Fueling some of this activity are the availability of more powerful computers, improvements in artificial intelligence, and the further miniaturization of devices that can be implanted into the brain…” “The amount of research in brain-computer interfaces has been growing steadily in recent years…In 2021, there were almost 600 studies, compared to roughly 340 in 2016. Dr. Chang shows a brain-computer interface. He paired the technology with AI to help paralyzed patients communicate.
  129. 129. ► Co-founder of medical device maker Boston Scientific Corp. Tens of thousands of employees. ►Dead at age 80 from cancer. ► Boston Scientific: “a pioneer who helped shape the field of minimally invasive surgery.” ► He focused much of his philanthropy on education and marine causes. Who missed the longevity boat? Peter Michael Nicholas (1941 – 2022) Expiration date: May 14, 2022 Net Worth > $4 billion https://www.bloomberg.com/news/articles/2022-05-16/peter-nicholas-co-founder-of-boston-scientific-dies-at-80
  130. 130. ► Canadian businessman, philanthropist, and owner of the National Hockey League Ottawa Senators. ► Founder of one of Canada's largest publicly traded pharmaceutical companies. ► One of the richest residents of Barbados. Who missed the longevity boat? Eugene Melnyk (1959 – 2022) Expiration date: May 28, 2022 Net Worth > $1.2 billion https://www.forbes.com/sites/carolschram/2022/03/29/ottawa-senators-owner-eugene-melnyk-dies-at-age-62/ ►Died at age 62… Five years after a liver transplant.
  131. 131. Who Missed the Longevity Boat https://www.forbes.com/profile/edward-johnson-iii/ EdwardJohnsonIII(1930-2022) Net worth > $11.5 billion Expiration date: Mar. 23, 2022 ► Edward “Ned” Johnson III, former CEO of Fidelity Investments. ► When he took over in 1977, Fidelity had $3.9 billion in assets under management. ► The firm now holds more than $11 trillion in assets. ► Johnson donated his wealth mostly anonymously, some named places include the Museum of Fine Arts in Boston & the Peabody Essex Museum in Massachusetts.
  132. 132. ►Billionaire Ray-Ban owner and one of Italy’s wealthiest business figures. ►Went from childhood in orphanage to amass a fortune…one of most famous rags-to-riches stories in Italy’s post-war recovery. ►Died at age 87. Who missed the longevity boat? https://www.forbes.com/sites/carolschram/2022/03/29/ottawa-senators-owner-eugene-melnyk-dies-at-age-62/ Leonardo Del Vecchio (1935 – 2022) Expirationdate:June18,2022 Net Worth > $25.7 billion
  133. 133. Who missed the longevity boat? Chuck Bundrant (1942 - 2021) Expiration date: Oct 17, 2021 net worth > $1.3 billion https://www.kdlg.org/post/trident-founder-chuck-bundrant-remembered-industry- risk-taker-who-emphasized-personal#stream/0 Founded Trident seafood company Boosted Alaskan pollock fish sales 40 times in U.S. Died at age 79 from Parkinson’s
  134. 134. Who missed the longevity boat? Walter Scott (1921 - 2021) Expiration date: Sep, 25, 2021 net worth > $6 billion https://www.3newsnow.com/news/local-news/former-kiewit-ceo-walter-scott-jr-dead-at-90 Omaha businessman and philanthropist. Past top executive of Peter Kiewit Sons Inc. construction firm. Helped oversee Warren Buffett’s Berkshire Hathaway. Died of undisclosed causes at age 90.
  135. 135. Frank Hasenfratz (1935-2022) Expiration date: Jan. 8, 2022 Net worth ~ $1 billion https://www.wsj.com/articles/hungarian-refugee-founded-car-parts-maker-linamar-in-canada-11643122802 Frank fled communist Hungary, arriving in Canada at age 22, as a penniless refugee. He founded what became Linamar at age 29. Linamar is now Canada's second largest auto parts manufacturer, with 26,000 employees in 17 countries at the time of his death. Died at age 86 from cancer. Who missed the longevity boat?
  136. 136. John Arrillaga Sr. (1937-2022) Expiration date: Jan. 24, 2022 Net worth ~ $2.5 billion https://www.wsj.com/articles/real-estate-developer-made-early-bets-on-silicon-valley-11643382026 John began buying land and developing office buildings in the 1960s in an area south of San Francisco that became known as Silicon Valley. He cofounded the commercial real-estate firm Peery Arrillaga, which eventually attained more than 20 million square feet of holdings as the valley boomed. Died of undisclosed causes at age 84. Who missed the longevity boat?
  137. 137. Fayez Sarofim (1929-2022) Expiration date: May 27, 2022 Net worth ~ $1.6 billion https://www.forbes.com/profile/fayez-sarofim/     Who missed the longevity boat? ►Founded investment management firm, largest shareholder of Kinder Morgan, part owner of the Houston Texans NFL team. ►Supported medical innovation and donated Baylor College of Medicine, Texas Heart Institute, MD Anderson and more. ►Dead at the age of 93.
  138. 138. Who Missed the Longevity Boat Robert Brockman, founded Universal Computer Systems which merged with Reynolds and Reynolds, providing computer systems to nearly all car dealerships and other services to healthcare/insurance companies. Dead at Age 81. nypost.com/2022/08/06/software-developer-robert-brockman-dies-amid-tax-evasion-case/ RobertBrockman(1941-2022) Net worth > $7.7 billion Expiration date: Aug. 5, 2022
  139. 139. Who Missed the Longevity Boat Herbert Kohler Jr. was an American billionaire businessman, a member of the Kohler family, the former CEO & the executive chairman of the Kohler Company, which is best known for its plumbing products, golf courses and resorts, with the latter two fields of business directly entered into under his chairmanship. https://www.cnn.com/2022/09/06/business/kohler-death-wisconsin/index.html HerbertKohlerJr.(1939-2022) Net worth > $8.8 billion Expiration date: Sep. 3, 2022 Dead at Age 83.
  140. 140. ► Rakesh Jhunjhunwala began his career with the equivalent of about $420 to invest in 1985. ► His long-term investments in well-managed companies earned him unofficial title of India’s Warren Buffett. ► Forbes recently estimated his net worth at $5.8 billion. Who missed the longevity boat? RakeshJhunjhunwala1960-2022 Expiration date: Aug. 14, 2022 Net Worth > $5.8 billion https://www.wsj.com/articles/rakesh-jhunjhunwala-known-as-indias-warren-buffett-has-died-at-age-62-11660918869 Dead at age 62 of a Heart Attack
  141. 141. Fasting Glucose: 80 to 86 mg/dL Fasting Insulin: <5.0 to 7.0 ulU/ml Hemoglobin A1C: 5.0 to 5.4% Know Your Glycemic Blood Markers Target Interventions to Achieve:
  142. 142. Heart attack, stroke, cancer, dementia associated with BIOLOGICAL AGE Reference: Heron, M. Deaths: Leading Causes for 2017. National Vital Statistics Reports. June 24, 2019; Volume 68, Number 6. https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_06-508.pdf Aging: Our #1 Risk Factor
  143. 143. Blood Tests at RAADcity Reference: "An epigenetic biomarker of aging for lifespan and healthspan", Aging (Albany NY) 10(4) 573-591 (2018 Apr 18). CBC/Chemistry + C-reactive protein provides surrogate measure of your BIOLOGICAL AGE
  144. 144. Levine-Horvath Phenotypic Age Model No Cost to RAADfest Attendees ►‘Phenotypic Age’ estimate based on clinical measures of 9,926 adults with complete biomarker (blood test) data ►Analyzed data from over 23 years of mortality follow-up ►Advanced computational/statistical methods used to identify 9 phenotypic blood test markers to predict morbidity/mortality risk https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940111
  145. 145. • Physiological Age • Functional Age • Biological Age http://www.longlonglife.org/en/transhumanism-longevity/aging/measure-of-aging/measuring-aging-physiological-age/ Phenotypic Age helps predict future morbidity-mortality It is also described as:
  146. 146. Bill’s calculated phenotypic (biological) age 11.12 younger than chron age and difference Albumin 4.5 g/dL Creatinine 0.93 mg/dL Glucose 95 mg/dL CRP 0.27 mg/L Lymphocytes 29% MCV 93 fL RDW 12.7% Alka phosphatase 40 u/L White Blood Cells 3.8 WBC 3.8 = 11.12-year younger phenotypic age compared to chronological age “An epigenetic biomarker of aging for lifespan and healthspan”- www.ncbi.nlm.nih.gov/pmc/articles/PMC5940111 Blood result calculate implied phenotypic (biological) age of Bill Faloon as shown below:
  147. 147. Commercial Lab: $572 LifeExtension®: $77 + Phenotypic Age at no cost Blood Tests to Calculate Phenotypic Age: A1C + Lipids + Fasting Insulin Complete Blood Count-Chemistry and C-reactive protein Added tests:
  148. 148. Target Fasting Blood Glucose 80 mg/dL to 86 mg/dL What are Optimal Blood Sugar Levels? And target… Hemoglobin A1C: 5.0-5.4% Fasting Insulin: <5.0-7.0 uIU/ml
  149. 149. Vincent Stona 1955-2022 A Needless Death Urgent Need for Patient Empowerment Dedicated RAADfest & Longevity Supporter
  150. 150. SGLT2 Inhibitors Potential Anti-Aging Strategy SGLT2 = Sodium-Glucose Cotransporter2 These drugs inhibit SGLT2 in kidneys to flush away excess glucose:
  151. 151. Sodium-Glucose in Sodium-Glucose out Normal or SGLT2 Inhibitor More Sodium-Glucose removed in Urine Kidneys return about 100% of Glucose to Circulation SGLT2 inhibitors redirects Sodium-Glucose to Urine
  152. 152. Prescription Drug Lets You Urinate Away Excess Salt and Sugar Sodium-Glucose Cotransporter-2 (SGLT2) inhibitors approved to treat type II diabetes. SGLT2 inhibitors block a kidney receptor that recovers glucose and sodium from filtered blood. Enables some sodium-glucose to urinate out.
  153. 153. PERSISTENTLY ELEVATED GLUCOSE Glycation of Proteins https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951818/ High Blood Glucose Contributes to Glycation
  154. 154. https://news.cornell.edu/stories/2021/03/excess-blood-sugar-promotes-clogging-arteries-study “Excess sugar in the blood, the central feature of diabetes, can react with immune proteins to cause myriad changes in the immune system, including inflammatory changes that promote atherosclerosis.” March 23rd, 2021
  155. 155. Some of the Many Dangers of High Glucose:  Atherosclerosiswhichcausesreducedbloodflow,arterial blockages and contributes to high blood pressure.1  Endothelial dysfunction which can damage every organ. Most visibly eyes, kidneys, heart, brain & peripheral nerves.4,5  Oxidative stress and inflammation which increases risk of cancer.2,3  Reduced insulin sensitivity and metabolic dysfunction which cause increased body fat and high cholesterol.6 https://pubmed.ncbi.nlm.nih.gov/32155866/ https://pubmed.ncbi.nlm.nih.gov/31757028/ https://pubmed.ncbi.nlm.nih.gov/31242027/ https://pubmed.ncbi.nlm.nih.gov/25126408/ https://pubmed.ncbi.nlm.nih.gov/26566492/ 2. 1. 4. 5. 6. https://pubmed.ncbi.nlm.nih.gov/28098811/ 3.
  156. 156. SGLT2 Inhibitors reduce GLUCOSE and more to delay aging!
  157. 157. https://onlinelibrary.wiley.com/doi/10.1002/0471266949.bmc277 SGLT2 inhibitors show potentialto protectagainstdiabetic nephropathy: 1) Improved glycemic control and lower blood pressure. 2) Reducedglomerular hyperfiltration 3) Decreased inflammation-fibrosis of proximal tubular cells in response to hyperglycemia, and albuminuria. SGLT2 Inhibitors Benefit the Kidneys
  158. 158. Aug. 17, 2017 Ten Thousand Patient NEJM Study Finds Multiple Major Benefits of SGLT-2 Inhibitors https://www.nejm.org/doi/10.1056/NEJMoa1611925 ThosetakingaSGLT2inhibitorwere27%lesslikelytoprogress toalbuminuria(proteininurine)comparedtoplacebo. Regression of albuminuria occurred 70% more frequently in the SGLT2 inhibitor group, indicating an improvement in advanced stage chronic kidney failure patients. Among type II diabetic patients taking a SGLT2 inhibitor, there were 40% fewer instances of a massive drop in eGFR, a need for kidney dialysis or transplant, or death from kidney causes compared to the placebo arm.
  159. 159. Pathophysiologyofdiabetickidneydisease:impactofSGLT2inhibitors https://www.nature.com/articles/s41581-021-00393-8 Known Kidney Benefits as of 2021:
  160. 160. https://link.springer.com/article/10.1007/s00125-021-05424-4 SGLT2 inhibitor associatedwith50% reducedincidenceofKidney Stones
  161. 161. https://www.nature.com/articles/s41591-021-01536-x SGLT2 inhibitors Benefit the Heart ⬇ Microvascular Dysfunction ⬇ Inflammation & Oxidative Stress ⬆ Myocardial Energy Production ⬆ Systemic Endothelial Function ⬆ Fatty Acid Oxidation (heart muscle) ⬆ Insulin Sensitivity (heart muscle)
  162. 162. The Danger of High Sodium Intake The main danger of salt can concisely be understood as: higher salt = higher blood pressure. Salt’s overall effect on the vasculature similar to sugar, but in a reversed order: • High glucose damages the arteries which leads to high blood pressure. • High sodium directly causes high blood pressure, which leads to damaged arteries. https://pubmed.ncbi.nlm.nih.gov/27757935/ Deadly synergy from high glucose + high sodium. Combination danger exceeds the sum of the two.
  163. 163. Managing Cardiovascular & Kidney Disease https://www.nejm.org/doi/full/10.1056/NEJMra2115011 May 26th, 2022 “SGLT2 inhibitors are responsible for major paradigm shifts in the care of patients with or at high risk for heart failure, progression of chronic kidney disease, or both. Theseagentsalsoreducetheriskofend-stagekidneydisease inpatientswithtype2diabetesandchronic kidneydisease.” SGLT2 inhibition improves cardiovascular outcomes in patients with heart failure …regardless of whether the patients have type 2 diabetes…
  164. 164. https://pubmed.ncbi.nlm.nih.gov/27009625/ Meta-analysis of 57 Clinical Trials Finds: Clinical Cardiovascular Benefits of SGLT2 Inhibitors 37%reduceddeathfromcardiovasculardisease 56% reduced all-cause mortality and 49% reduced risk of cardiovascular disease compared to insulin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485030/ 39%reducedriskofheartfailurehospitalization 37k Patient Swedish Study Finds: 309k Patient Study Finds: https://pubmed.ncbi.nlm.nih.gov/28522450/
  165. 165. 1. https://pubmed.ncbi.nlm.nih.gov/32854852/ SGLT2 inhibitors Benefit the Brain “Our findings revealed a previously unobserved association between ≥3 years SGLT2 inhibitor use and improved cognitive scores globally and in language domain and executive function.” 2. https://content.iospress.com/articles/journal-of-alzheimers-disease/jad215678 Type 2 diabetes increases Alzheimer’s risk. SGLT2 inhibitors being studied to prevent or reduce progress of Alzheimer's pathology.1 Results from separate clinical study:2
  166. 166. The Clinical Effects of SGLT2 Inhibitors on Cancer Development https://pubmed.ncbi.nlm.nih.gov/33562380/ SGLT2 Inhibitors are fairly novel drugs, being first approved by the FDA for use in 2013, long term clinical studies still don’t exist and early studies found little correlation between its use and overall cancer risk. https://pubmed.ncbi.nlm.nih.gov/34929299/ 2022 meta-analysis of 20 Clinical Trials Finds: SGLT2 inhibitors linked to 65% reduction in cancer risk in hyperglycemic patients. Note:
  167. 167. https://pubmed.ncbi.nlm.nih.gov/28763435/ |https://pubmed.ncbi.nlm.nih.gov/29205334/ SGLT2 inhibitor-therapy induces AMPK-mediated cell cycle arrest and apoptosis in breast and thyroid cancer cells. SGLT2 Inhibitors Slow Cancer Growth https://pubmed.ncbi.nlm.nih.gov/33068934/ |https://pubmed.ncbi.nlm.nih.gov/35148777/ Canagliflozin(SGLT2inhibitor)blocksComplex-Iincellularrespiration, limiting cellular proliferation of prostate & lung cancer cells. https://pubmed.ncbi.nlm.nih.gov/27689018/ Dapagliflozin (SGLT2 inhibitor) regulates the cell cycle, apoptosis & reduces glucose uptake in renal cell carcinoma and canagliflozin doesthesameinhepatocellularcarcinomaandwasshowntoreduce tumor growth & angiogenesis in a tumor graft model in mice. SGLT2inhibitorsslow cancer by reducingglucosesystemically & directly- many cancers expressSGLT2tohelp uptakeglucose
  168. 168. https://pubmed.ncbi.nlm.nih.gov/31546918/
  169. 169. Placebo (n=995) JARDIANCE 10 mg (n=999) JARDIANCE 25 mg (n=977) Urinary tract infection 7.6% 9.3% 7.6% UTIs*: Males 3.2% 3.6% 4.1% UTIs*: Females 16.6% 18.4% 17.0% Female genital mycotic infections 1.5% 5.4% 6.4% Upper respiratory tract infection 3.8% 3.1% 4.0% Increased urination 1.0% 3.4% 3.2% Dyslipidemia 3.4% 3.9% 2.9% Arthralgia 2.2% 2.4% 2.3% Male genital mycotic infections 0.4% 3.1% 1.6% Nausea 1.4% 2.3% 1.1% https://pro.boehringer-ingelheim.com/us/products/jardiance/t2d/safety Side Effects of Jardiance® (SGLT2 inhibitor) in Diabetics
  170. 170. SGLT2 inhibitor drug Risks versus Benefits Risks Increased incidence:  Urinary tract infections  Increased urination  Fungal Infections  Thirst/constipation  Bone loss? Benefits  Heart disease  Cancer  Kidney disease  Cognitive decline  Cardiovascular death  Inflammation  Hypertension  Severe type II diabetes  Kidney stones  All-cause mortality versus Decreased incidence: Bone loss may be mitigated by vitamin D or prescription drug activated vitamin D (calcitriol)
  171. 171. FDA Approved SGLT2 Inhibitor Drugs
  172. 172. How Effective are SGLT-2 Inhibitors in Non-Diabetics? 4 76 90 81 0 10 20 30 40 50 60 70 80 90 100 Placebo 10 25 100 4 31 49 56 62 79 0 10 20 30 40 50 60 70 80 90 0.5 2.5 10 25 50 100 Jardiance in Type II Diabetics Jardiance in “Healthy Patients” Dose (mg) Dose (mg) Urinary Glucose Grams/Day Urinary Glucose Grams/Day https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927118
  173. 173. Target Fasting Blood Glucose 80 mg/dL to 86 mg/dL And target… Hemoglobin A1C: 5.0-5.4% Fasting Insulin: <5.0-7.0 uIU/ml
  174. 174. Vincent Stona 1955-2022 A Needless Death Urgent Need for Patient Empowerment Dedicated RAADfest & Longevity Supporter
  175. 175. “Want to Live Forever? There's No Theoretical Limit to Human Lifespan, New Study Says” “Humans can probably live to at least 130, and possibly well beyond, though the chances of reaching such super old age remain vanishingly small, according to new research. The outer limit of the human lifespan has long been hotly debated, with recent studies making the case we could live up to 150 years, or arguing that there is no maximum theoretical age for humans. The new research, published Wednesday in the Royal Society Open Science journal, wades into the debate by analyzing new data on supercentenarians – people aged 110 or more – and semi- supercentenarians, aged 105 or more.” https://www.sciencealert.com/study-suggests-that-theoretically-we-should-be-able-to-live-forever https://royalsocietypublishing.org/doi/10.1098/rsos.202097 September 29th 2021
  176. 176. March 7, 2022 “Scientists Can Reverse the Aging Process in Middle-Aged Mice” https://www.earth.com/news/scientists-can-reverse-the-aging-process-in-middle-aged-mice/
  177. 177. More People Are Living Longer increase in number of Americans reaching since year “Mortality Among Centenarians in the United States 2000-2014” Centers for Disease Control and Prevention; January/July 2016 AGE 100 43% 2000
  178. 178. https://www.wsj.com/articles/can-you-fight-aging-scientists-are-testing-drugs-to-help-11641913275 Can You Fight Aging? Scientists Are Testing Drugs to Help “Academic research centers and biotechnology companies are piling into the antiaging field in pursuit of the longevity dream. They are backed in part by a $3 billion annual budget for the U.S. National Institute of Aging as well as some high-profile billionaires and other venture capital investors.” | Jan 11, 2022
  179. 179. Human Age Reversal Project $1,080,300 Goal: Statistically Significant Human Age Reversal age-reversal.net/donate
  180. 180. Fund Research with Tax-Deductible Donations Human Age Reversal Project Make checks payable to: Human Age Reversal Project 3600 West Commercial Blvd. Ft. Lauderdale, FL 33309 Or donate online: age-reversal.net/donate
  181. 181. 8,000B.C.–1899A.D. 1900 –2022A.D. Time in Perspective (Recorded Human History) More progress has occurred since 1900 than in prior 8,000 years of recorded human history.
  182. 182. “Tiny Swimming Robots Treat Deadly Pneumonia in Mice” Sep. 22, 2022 anoengineers at the University of California San Diego have developed microscopic robots, called microrobots, that can swim around in the lungs, deliver medication and be used to clear up life-threatening cases of bacterial pneumonia. In mice, the microrobots safely eliminated pneumonia-causing bacteria in the lungs and resulted in 100% survival. By contrast, untreated mice all died within three days after infection. Published Sept. 22, 2022 in Nature Materials. https://today.ucsd.edu/story/tiny-swimming-robots-treat-deadly-pneumonia-in-mice
  183. 183. Commercial Lab: $572 LifeExtension®: $77 + Phenotypic Age at no cost Blood Tests to Calculate Phenotypic Age: A1C + Lipids + Fasting Insulin Complete Blood Count-Chemistry and C-reactive protein Added tests:
  184. 184. 2 0 2 2 1. Research findings since last year's RAADfest. 2. What is an “Optimized diet?” 3. New life extension drugs. 4. Key to super longevity! 5. Clinical trials targeting systemic regeneration. 6. “Live Forever” via transhumanism. Advancing Towards Immortality Regeneration Targeted Clinical Trials New Anti Aging Drugs Key to Super Longevity
  185. 185. These slides available for review at: www.age-reversal.net AgeReversalUpdate William Faloon October 6th 2022 RAADfest 2022

Editor's Notes

  • In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.
  • In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.
  • In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927118/ <- empagliflozin also comparative IC50’s
    https://sci-hub.se/https:/doi.org/10.1111/j.1463-1326.2011.01517.x <- IC50s
  • In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.

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