Integrative transcriptomics to study non-coding RNA functions
by dr. ir. Pieter Mestdagh - Center for Medical Genetics, Ghent University
Over the last years, non-coding RNAs (e.g. microRNAs and long non-coding RNAs) have emerged as an important layer of the transcriptome. In order to elucidate their function in disease biology, multiple tools have been developed, ranging from miRNA target prediction algorithms to the more advanced integrative genomics approaches. Through the combination of multiple layers of information, integrative genomics allows a more accurate and comprehensive assessment of non-coding RNA functions in human disease. In this presentation, I will discuss different approaches on how to combine multi-level transcriptome data in order to functionally characterize non-coding RNA networks.