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Jennifer L

  1. 1. 1 Date June 2010 I. PERSONAL Name Amanda Jennings Myers Home Phone Office Phone 305-243-3522 Home Address Current Academic Rank Assistant Professor Current Track of Appointment Tenure-Earning Track Primary Department Psychiatry Secondary or Joint Appointment Neuroscience Citizenship U.S. Email amyers@med.miami.edu Webpage labs.med.miami.edu/myers/LFuN/LFuN.html Researcher ID Amanda Myers B-1796-2010 - ResearcherID.com II. HIGHER EDUCATION Institutional May 2002 Washington University, St. Louis, MO, PhD. in Neuroscience, thesis advisor: Alison Goate, D. Phil. May 1993 University of Pennsylvania, Philadelphia, PA, BA. in Psychology May 1993. University of Pennsylvania, Philadelphia, PA, BA in Biological Basis of Behavior Non-Institutional July 2001 Human Genome Analysis: Genetic Analysis of Multifactorial Diseases, Wellcome Trust, Hinxton, UK June 1997 Neuroinflammation in Alzheimer’s Disease, World Alzheimer Conference 2000, Washington, D.C. August 1997 Experimental Genetics of the Laboratory Mouse: genetics, development and the brain, The Jackson Laboratory, Bar Harbor, Maine, III. EXPERIENCE Academic Research 11/1991-8/1992 Department of Anatomy and Chemistry, Research Assistant University of Pennsylvania, Philadelphia, PA
  2. 2. 2 8/1992-6/1994 Department of Psychiatry, Research Assistant University of Pennsylvania, Philadelphia, PA Academic Postgraduate Training 6/1995-8/2002 Department of Psychiatry and Neuroscience, Graduate Student Washington University, St. Louis, MO 9/2002-9/2006 Laboratory of Neurogenetics, Postdoc National Institute on Aging, National Institute of Health Bethesda, MD Academic Appointments I. Primary Appointments: 9/2006-present Department of Psychiatry & Behavioral Sciences Assistant Professor Miller School of Medicine, University of Miami, Miami, FL II. Secondary Appointments: 1/2007-present Johnnie B. Byrd Principle Investigator Alzheimer’s Center and Research Institute, Tampa, FL 1/2007-present Division of Neuroscience co-appointment Miller School of Medicine, University of Miami, Miami, FL 1/2010- present Interdepartmental Program in Human Genetics & Genomics co-appointment IV. PUBLICATIONS H-Index: 22 Juried or refereed journal articles or exhibitions Myers AJ, Corneveaux JJ, Allen AN, Pruzin JJ, Ramirez M, Engel A, Nalls MA, Chen K, Lee W, Chewning K, Villa SE, Meechoovet HB, Gerber JD, Frost D, Benson HL, O'Reilly S, Chibnik LB, Shulman JM, Singleton AB, Craig DW, Van Keuren-Jensen KR, Dunckley T, Bennett DA, De Jager PL, Heward C, Hardy J, Reiman EM, Huentelman MJ. Association of CR1, CLU, and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. (2010) Hum Mol Genet. Jun 9. doi:10.1093/hmg/ddq221 Webster JA, Reiman EM, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroneni D, Grover A, Rogers J, Heun R, Jessen F, Kolsch H, Heward CB, Ravid R, Hutton ML, Melquist S, Petersen RC, Caselli RJ, Papassotiropoulos A, Stephan DA, Hardy J, Myers A (2010) Whole genome association analysis shows that ACE is a risk factor for Alzheimer’s disease and fails to replicate most candidates from Meta-analysis. (2010) Int J Mol Epidemiol Genet , 1(1):19-30 Webster JA, Gibbs JR, Clarke J, Ray M, Zhang W, Holmans P, Rohrer K, Zhao A, Marlowe L, Kaleem M, McCorquodale DS III, Cuello C, Leung D, Bryden B, Nath P, Zismann VL, Joshipura K, Huentelman MJ, Hu- Lince
  3. 3. 3 D, Coon KD, Craig DW, Pearson JV, NACC-NPC, Heward CB, Reiman EM, Stephan D, Hardy J, Myers AJ (2009) Genetic control of human brain transcript expression in Alzheimer’s disease. Am J Hum Genet. Apr;84(4):445-58. Huentelman MJ, Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, Beach TG, Mastroeni D, Grover A, Ravid R, Sando SB, Aasly JO, Heun R, Jessen F, Kolsch H, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Papassotiropoulos A, Stephan DA (2008) Evidence for an association between KIBRA and late-onset Alzheimer's disease, Neurobiol Aging. Sep 11. Hong MG, Myers AJ, Magnusson PK, Prince JA. (2008) Transcriptome-wide assessment of human brain and lymphocyte senescence. PLoS ONE. Aug 20;3(8):e3024. van der Brug MP, Blackinton J, Chandran J, Hao LY, Lal A, Mazan-Mamczarz K, Martindale J, Xie C, Ahmad R, Thomas KJ, Beilina A, Gibbs JR, Ding J, Myers AJ, Zhan M, Cai H, Bonini NM, Gorospe M, Cookson MR. (2008) RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways. Proc Natl Acad Sci U S A. Jul 22;105(29):10244-9 McCorquodale D, Myers AJ. (2008) Biomarkers in the diagnosis and treatment of Alzheimer’s disease: potential and pitfalls. Biomarkers in Medicine June, Vol. 2, No. 3, Pages 209-214 Myers AJ, Gibbs JR, Webster JA, Rohrer KC, Zhao AS, Marlowe L, Kaleem M, Leung D, Bryden L, Nath P, Zismann VL, Joshipura KD, Huentelman MJ, Hu-Lince D, Coon KD, Craig DW, Pearson JV, Holmans PA, Heward CB, Reiman EM, Stephan DA, Hardy JA. (2007) A Survey of Genetic Human Cortical Gene Expression, Nat Genet. Dec;39(12):1494-9. Hamshere M, Holmans PA, Avramopoulos D, Bassett SS, Blacker D, Bertram L, Wiener H, Rochberg N, Tanzi RE, Myers A, D-Vrieze F, Go R, Fallin, D, Lovestone S, Hardy J, Goate A, O'Donovan M, Williams J, Owen MJ. (2007) Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer’s Disease, Hum Mol Genet. Nov 15;16(22):2703-12. Myers AJ, Webster JA , Pearson JV, Craig DW, Hu-Lince D, Coon KD, Zismann VL Beach T, Leung D, Bryden L, Halperin RF, Marlowe L, Kaleem M, Huentelman MJ, Joshipura KD, Walker D, Heward CB, Ravid R, Rogers J, Papassotiropoulos A, Hardy J, Reiman EM, Stephan DA (2007) SORL1 as an Alzheimer’s disease predisposition gene? Neurodegener dis. 2008;5(2):60-4. Epub 2007 Nov 1 Kaleem M, Zhao A, Hamshere M, Myers AJ. (2007) Identification of a Novel Valosin-Containing Protein Polymorphism in Late-Onset Alzheimer's Disease. Neurodegener Dis. Jul 6;4(5):376-381 Myers AJ, Reiman EM, Webster JA, Hardy J, Dunckley T, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Liang WS, Herbert RH, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroeni D, Grover A, Heward CB, Ravid R, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Kukull W, Papassotiropoulos A, Stephan DA. (2007) GAB2 Alleles Modify Alzheimer's Risk in APOE varepsilon4 Carriers. Neuron. Jun 7;54(5):713-720 De Ferrari GV, Papassotiropoulos A, Biechele T, Wavrant De-Vrieze F, Avila ME, Major MB, Myers A, Saez K, Henriquez JP, Zhao A, Wollmer MA, Nitsch RM, Hock C, Morris CM, Hardy J, Moon RT. (2007) Common genetic variation within the Low-Density Lipoprotein Receptor-Related Protein 6 and late-onset Alzheimer's disease. Proc Natl Acad Sci U S A. May 29;104(22):9434-9. Hollingworth P, Hamshere ML, Holmans PA, O'Donovan MC, Sims R, Powell J, Lovestone S, Myers A, Devrieze FW, Hardy J, Goate A, Owen M, Williams J. (2007) Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis. Am J Med Genet B Neuropsychiatr Genet. May 10; Oct 5;144B(7):841-8 Myers AJ, Coon KD, Craig DW, Webster JA, Pearson JV, Lince DH, Zismann VL, Beach TG, Leung D, Bryden L, Halperin RF, Marlowe L, Kaleem M, Walker DG, Ravid R, Heward CB, Rogers J, Papassotiropoulos A, Reiman EM, Hardy J, Stephan DA. (2007) A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.J Clin Psychiatry. Apr;68(4):613-8. Hardy J, Myers A. (2007) Genetic variability in expression of proteins and the risk of sporadic neurologic diseases. Neurology. Feb 27;68(9):632-3.
  4. 4. 4 Marlowe L, Peila R, Benke KS, Hardy J, White LR, Launer LJ, Myers A. (2006) Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk. Neurodegener Dis.;3(6):320-6 Myers AJ, Pittman AM, Zhao AS, Rohrer K, Kaleem M, Marlowe L, Lees A, Leung D, McKeith IG, Perry RH, Morris CM, Trojanowski JQ, Clark C, Karlawish J, Arnold S, Forman MS, Van Deerlin V, de Silva R, Hardy J. (2006) The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts. Neurobiol Dis. 2007 Mar;25(3):561-70. Hardy J, Pittman A, Myers A, Fung HC, de Silva R, Duckworth J. (2006) Tangle diseases and the tau haplotypes. Alzheimer Dis Assoc Disord. Jan-Mar;20(1):60-2. Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrieze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. (2006) A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Am J Hum Genet. Jan;78(1):78-88. Smemo S, Nowotny P, Hinrichs AL, Kauwe JS, Cherny S, Erickson K, Myers AJ, Kaleem M, Marlowe L, Gibson AM, Hollingworth P, O'donovan MC, Morris CM, Holmans P, Lovestone S, Morris JC, Thal L, Li Y, Grupe A, Hardy J, Owen MJ, Williams J, Goate A. (2006) Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease. Ann Neurol. Jan;59(1):21-6. Myers AJ, Kaleem M, Marlowe L, Pittman AM, Lees A, Fung HC, Duckworth J, Leung D, Gibson A, Morris CM, de Silva R, Hardy J. (2005) The H1c Haplotype at the MAPT Locus is associated with Alzheimer's Disease. Hum Mol Genet. Aug 15;14(16):2399-404. Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell T, Holmans P, Hamshere M, Turic D, Jehu L, Hollingworth P, Moore P, Bryden L, Myers A, Doil LM, Tacey KM, Gibson AM, McKeith IG, Perry RH, Morris CM, Thal L, Morris JC, O'Donovan MC, Lovestone S, Grupe A, Hardy J, Owen MJ, Williams J, Goate A. (2005) Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136(1):62-8. Hardy J, Pittman A, Myers AJ, Gwinn-Hardy K, Fung HC, de Silva R, Hutton M, Duckworth J. (2005) Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens. Biochem Soc Trans, 33(4): 582-5 Pittman AM, Myers AJ, Abou-Sleiman P, Fung HC, Kaleem M, Marlowe L, Duckworth J, Leung D, Williams D, Kilford L, Thomas N, Morris CM, Dickson DW, Wood NW, Hardy J, Lees AJ, de Silva R. (2005) Linkage disequilibrium fine-mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration. J Med Genet. Nov;42(11):837-46 Fung HC, Evans J, Evans W, Duckworth J, Pittman A, de Silva R, Myers A, Hardy J. (2005) The architecture of the tau haplotype block in different ethnicities, Neurosci Lett. Mar 29;377(2):81-4. Holmans P, Hamshere M, Hollingworth P, Rice F, Tunstall N, Jones S, Moore P, Devrieze FW, Myers A., Crook R, Compton D, Marshall H, Meyer D, Shears S, Booth J, Ramic D, Williams N, Norton N, Abraham R, Kehoe P, Williams H, Rudrasingham V, O'donovan M, Jones L, Hardy J, Goate A, Lovestone S, Owen M, Williams J. (2005) Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2005 May 5;135(1):24-32. Evans W, Fung HC, Steele J, Eerola J, Tienari P, Pittman A, Silva R, Myers A, Vrieze FW, Singleton A, Hardy J. (2004) The tau H2 haplotype is almost exclusively Caucasian in origin, Neurosci Lett., Oct 21; 369 (3):183-5 Hardy J, Myers A, Wavrant de-Vrieze F. (2004) Problems and Solutions in the Genetic Analysis of Late-Onset Alzheimer’s Disease Neurodegenerative Dis., 1:213-217 Myers AJ, Pittman AM, , Duckworth J, Bryden L, Hanson M, Abou-Sleiman P, Wood NW, Hardy J, Lees A, de Silva R. (2004) The Structure of the Tau Haplotype in Controls and in Progressive Supranuclear Palsy, Hum. Molec. Genet., 13(12):1267-74
  5. 5. 5 Busby V, Goossens S, Nowotny P, Hamilton G, Smemo S, Harold D, Turic D, Jehu L, Myers A, Womick M, Woo D, Compton D, Doil LM, Tacey KM, Lau KF, Al-Saraj S, Killick R, Pickering-Brown S, Moore P, Hollingworth P, Archer N, Foy C, Walter S, Lendon C, Iwatsubo T, Morris JC, Norton J, Mann D, Janssens B, Hardy J, O'Donovan M, Jones L, Williams J, Holmans P, Owen MJ, Grupe A, Powell J, van Hengel J, Goate A, Van Roy F, Lovestone S. (2004) Alpha-T-Catenin Is Expressed in Human Brain and Interacts With the Wnt Signaling Pathway But Is Not Responsible for Linkage to Chromosome 10 in Alzheimer's Disease. Neuromolecular Med., 5(2):133-46 Singleton A, Myers A, Hardy J. (2004) The law of mass action applied to neurodegenerative disease: a hypothesis concerning the aetiology and pathogenesis of complex disease. Hum Mol Genet., Apr 1;13 Spec No 1:R123-6 Myers AJ, Marshall H, Holmans P, Compton D, Crook RJ, Mander AP, Nowotny P, Smemo S, Dunstan M, Jehu L, Wang JC, Hamshere M, Morris JC, Norton J, Chakraventy S, Tunstall N, Lovestone S, Petersen R, O'Donovan M, Jones L, Williams J, Owen MJ, Hardy J, Goate A. (2004) Variation in the Urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD, Am J Med Genet.: Neuropsych. Genet.,Jan 1; 124B(1):29-37 Harold D, Peirce T, Moskvina V, Myers A, Jones S, Hollingworth P, Moore P, Lovestone S, Powell J, Foy C, Archer N, Walter S, Edmonson A, McIlroy S, Craig D, Passmore PA, Goate A, Hardy J, O'Donovan M, Williams J, Liddell M, Owen MJ, Jones L. (2003) Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease, Hum Genet. Aug;113(3):258-67. Myers A, Wavrant De-Vrieze F, Holmans P, Hamshere M, Crook R, Compton D, Marshall H, Meyer D, Shears S, Booth J, Ramic D, Knowles H, Morris JC, Williams N, Norton N, Abraham R, Kehoe P, Williams H, Rudrasingham V, Rice F, Giles P, Tunstall N, Jones L, Lovestone S, Williams J, Owen MJ, Hardy J, Goate A. (2002) A full genome screen for Alzheimer’s disease: Stage 2 analysis, Am. J. Med. Genet.: Neuropsych. Genet.,114 (2): 233- 242 Abraham R, Myers A, Wavrant-DeVrieze F, Hamshere ML, Thomas HV, Marshall H, Compton D, Spurlock G, Turic D, Hoogendoorn B, Kwon JM, Petersen RC, Tangalos E, Norton J, Morris JC, Bullock R, Liolitsa D, Lovestone S, Hardy J, Goate A, O'Donovan M, Williams J, Owen MJ, Jones L. (2001) Substantial linkage disequilibrium across the insulin degrading enzyme locus but no association with late-onset Alzheimer's disease, Hum. Genet., 109: 646-652 Myers AJ, Goate AM. The genetics of late onset Alzheimer’s disease. (2001) Curr. Opin. Neurol., 14: 433-440 Myers A, Holmans P, Marshall H, Kwon J, Meyer D, Ramic D, Shears S, Booth J, DeVrieze FW, Crook R, Hamshere M, Abraham R, Tunstall N, Rice F, Carty S, Lillystone S, Kehoe P, Rudrasingham V, Jones L, Lovestone S, Perez-Tur J, Williams J, Owen MJ, Hardy J, Goate AM. (2000) Susceptibility Locus for Late Onset Alzheimer’s Disease on Chromosome 10. Science 290:2304-2305 Joyce JN, Myers AJ, Gurevich E. (1998) Dopamine D2 receptor bands in normal human temporal cortex are absent in Alzheimer’s disease. Brain Res. 784: 7-17 Lendon CL, Martinez A, Behrens IM, Kosik KS, Madrigal L, Norton J, Neuman R, Myers A, Busfield F, Wragg M, Arcos M, Arango Viana JC, Ossa J, Ruiz A, Goate AM, Lopera F. (1997) The E280A PS-1 Mutation causes Alzheimer’s disease but age of onset is not modified by ApoE alleles, Human Mutation 10: 186-195 Lendon CL, Myers A, Cumming A, Goate AM, St Clair D. (1997) A polymorphism in the presenilin 1 gene does not modify risk for Alzheimer's disease in a cohort with sporadic early onset. Neuroscience Letters 228: 212-214 Joyce, J.N., Smutzer, G., Whitty, C. J., Myers, A., and Bannon, M.J. (1997) Differential Modification of Dopamine transporter and Tyrosine Hydroxylase mRNAs in midbrain of subjects with Parkinson’s, Alzheimer’s with Parkinson’s and Alzheimer’s disease, Movement Disorders 12(6): 885-897 Clark RF, Hutton M, Fuldner RA, Froelich S, Karran E, Talbot C, Crook R, Lendon C, Prihar G, He C, Korenblat K, Martinez A, Wragg M, Busfield F, Behrens MI, Myers A, Norton J, Morris J, Mehta N., Pearson, C., Lincoln, S., Baker M, Duff K, Zehr C, Perez-Tur J, Houlden H, Ruiz A, Ossa J, Lopera F, Arcos M, Madrigal L, Collinge J, Humphreys C, Ashworth T, Sarner S, Fox N, Harvey R, Kennedy A, Roques P, Cline R, Philips CA, Venter JC,
  6. 6. 6 Forsell L, Axelman K, Lilius L, Johnston J, Cowburn R, Viitanen M, Winblad B, Kosik K, Haltia M, Poyhonen M, Dickson D, Mann D, Neary D, Snowden J, Lantos P, Lannfelt L., Rossor M, Roberts GW, Adams MD, Hardy J, and Goate A. (1995) The Structure of the Presenilin 1 (S182) Gene and Identification of Six Novel Mutations in Early Onset AD Families. Nature Genetics 11: 219-222. Other works, publications and abstracts A survey of the genetic controls of Human cortical gene expression AJ Myers, JR Gibbs, JA Webster, K Rohrer, A Zhao, L Marlowe, M Kaleem, D Leung, L Bryden, P Nath, VL Zismann, K Joshipura, MJ Huentelman, D Hu- Lince, KD Coon, DW Craig, JV Pearson, P Holmans, CB Heward, EM Reiman, D Stephan, J Hardy Gordon Research Conferences, Human Genetics & Genomics, July 2007 Regional expression in neuropathologically normal tissue. AJ Myers, JR Gibbs, K Rohrer, A Zhao, J Hardy (P1- 307) International Conference Alzheimer’s Disease, Madrid, Spain July 2006 The H1c Haplotype of the MAPT Locus is associated with Autopsy Confirmed Late Onset Alzheimer’s Disease. AJ Myers, M Kaleem, L Marlowe, A Pittman, HC Fung, J Duckworth, A Gibson, CM Morris, R de Silva, JA Hardy (#332) Alzheimer's Association International Conference on Prevention of Dementia, Washington, D.C. June 2005 Microarray Profiling of Alzheimer’s Disease AJ Myers, R Gibbs, D Leung, WH Wood, D Teichberg, JA Hardy, KG Becker National Academy of Sciences, November 2004 Investigation of the Microtubule Associated Protein Tau locus. A Myers, A Pittman, HC Fung, W Evans, J Duckworth, L Marlowe, M Kaleem, J Evans, L Bryden R de Silva, A Lees, J Hardy Udall Centers Meeting, Washington, DC, November 2004 Microarray Profiling of Alzheimer’s Disease: findings based on segregation by APOE genotype. AJ Myers, R Gibbs, D Leung, WH Wood, D Teichberg, JA Hardy, KG Becker 9th International Conference on Alzheimer's Disease and Related Disorders in Philadelphia, PA July 2004 The Structure of the Tau Haplotype in Controls and in Progressive Supranuclear Palsy. A Myers, A Pittman, J Duckworth, L Bryden, M Hanson, P Abou-Sleiman, N W Wood, J Hardy, A Lees and R de Silva National Human Genome Research Institute Symposium, Gettysburg, PA Nov 2003 Follow-up of a full genome screen for Alzheimer’s disease. AJ Myers, R Abraham, V Busby, D Harold, P Holmans, S Lovestone, M O’Donovan, L Jones, J Williams, A Grupe, MJ Owen, A Goate, and J Hardy (#783) XIX International Congress of Genetics, Melborne, Australia July 2003 Searching for novel susceptibility loci for Late Onset Alzheimer’s Disease. A Myers, R Abraham, V Busby, D Harold, P Holmans, S Lovestone, M O’Donovan, L Jones, J Williams, A Grupe, MJ Owen, A Goate, and J Hardy National Institute on Aging, IRP Symposium, Baltimore, MD. March 2003 Follow-up of replicated linkage results on chromosome 10: Putative role of the urokinase plasminogen activator gene in risk for late onset Alzheimer’s disease. AJ Myers, A Mander, N Ertekin-Taner, HM Tucker, H Marshall, P Holmans, J Ronald, R Crook, P Nowotny, S Smemo, M Dunstan, M Hamshere, M O’Donovan, L Jones, J Williams, M Owen, J Hardy, S Estus, S Younkin, A Goate World Alzheimer’s Congress 2002, Stockholm, Sweden July 2002 Susceptibility locus for late onset Alzheimer’s disease on chromosome 10. AJ Myers, H Marshall, F Wavrant de- Vrieze, R Crook, P Holmans, N Williams, J Williams, M Hamshere, N Tunstall, S Lovestone, M Owen, J Hardy, A Goate (#78.8) Society of Neuroscience, 30th annual meeting, New Orleans, LA Nov 2000 Susceptibility locus for late onset Alzheimer’s disease on chromosome 10. AJ Myers, H Marshall, F Wavrant de- Vrieze, R Crook, P Holmans, N Williams, J Williams, M Hamshere, N Tunstall, S Lovestone, M Owen, J Hardy, A Goate (#464) World Alzheimer’s Congress 2000, Washington, D.C. June 2000 A full genome scan for late onset Alzheimer’s disease. J Williams, F Wavrant de-Vrieze, R Crook, P Kehoe, W Wu, A Myers, I Fenton, F Rice, R Wood, P Holmans, S Lovestone, N Tunstall, J Perez-Tur, M Hutton, S Shears,
  7. 7. 7 K Roehl, J Booth, J Hardy, A Goate, M Owen (# 231) American Society of Human Genetics, 49th annual meeting, San Francisco, CA Oct 1999 Expression of D2 receptor columns in temporal cortex of Alzheimer patients is reduced. AJ Myers and JN Joyce (# 509.5) Society of Neuroscience, 24th annual meeting, Miami, Florida, Nov 1994 Putative Classification Schema for Midget and Bipolar Cells. AJ Myers, L Chukoskie and D Calkins David Mahoney Institute of Neurological Sciences, Philadelphia, PA, April 1991 V. PROFESSIONAL Research Support A. Ongoing Federally Funded: 7/01/2009 - 6/30/2013 1R01AG034504-01 (MYERS) 2.4 calendar months NIH/NIA $ 865,727 Role: Principal Investigator The Human Brainome: genome, transcriptome and proteome interaction in human cortex Our Human Brainome project seeks to define the genome-transcriptome-proteome-phenome interactions In the cortexes of normally aged human brains and brains affected by neurodegenerative disease. B. Ongoing Private Foundation: 11/15/06-11/15/10 PROPOSALM0800448 (MYERS) 4 calendar months Johnnie B. Byrd, Sr, Alzheimer’s Center & Research Institute $145,400 Role: Principal Investigator Late onset Alzheimer’s Disease GWAS Phase II Further refinement of genome-wide association studies for late onset Alzheimer’s disease by focusing on neuropathologically confirmed cohorts C. Completed Support: 5/01/03-11/15/06 Resident Research Associateship, Neuroscience 12 calendar months National Academy of Sciences $191,000 Role: Postdoctoral Associate The search for novel susceptibility loci involved in late onset Alzheimer’s Disease. This project involved screening a late onset Alzheimer’s Disease cohort in which linkage had been mapped chromosome 9. We performed fine mapping of the valosin containing protein (VCP) gene and reported a novel polymorphism in exon 2 of this gene. Editorial Responsibilities A. Reviewer of multiple articles for the following journals, 2000-present:
  8. 8. 8 2004-present American Journal of Medical Genetics 2008-present Cerebral Cortex 2005-present Dementia and Geriatric Cognitive Disorders 2009-present Human Molecular Genetics 2009-present Journal of Alzheimer’s Disease 2005-present Journal of Gerontology 2006-present Molecular Psychiatry 2008-present Nature Methods 2004-present Neurobiology of Aging 2005-present Neuroscience Letters 2007-present Neuropsychiatric Genetics 2010-present Proceedings National Academy of Sciences USA 2010-present BMC Medical Genomics B. Invited Grant reviewer: Nov 2008 Washington University St Louis, Alzheimer’s Disease Research center, pilot grants Jan 2009 Alzheimer’s Association, pilot grants program C. Invited commentary: Alzheimer Association, Alzheimer Research Forum, 2006 D. Grant Reviews, Federal: NINDS Grand Opportunities RC2 Study Section ZNS1 SRB R41 (ad hoc), August 2009 Department of Veteran’s Affairs, BLR&D Merit Review Panel Neurobiology D (ad hoc, primary), November 2009 Professional and Honorary Organizations: 2009-present Member, American Society of Human Genetics Honors and Awards June 2004 nominated, Distinguished Mentor Award, National Institute of Health, Intramural Research Training Program May 2003 Resident Research Associateship, National Academy of Sciences, National Institute of Health April 2002 Finalist, O’Leary Prize for Outstanding Research in Neuroscience, Washington University May 2001 John Merlie Fellowship, Washington University Nov 2000 ADRC Director’s Education Award, Alzheimer’s Disease Research Center, Washington University. Post-Doctoral Fellowships 10/16/2002-11/15/2006 Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD, Resident Research Associateship (Postdoc, advisor: John A Hardy, D. Phil)
  9. 9. 9 Other Professional Activities A. International Seminars: Oct 30th, 2008 Myers, AJ The Tau Top Ten. Invited speaker, Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, Queen Square, London Oct 28th, 2008 Myers, AJ Genetic control of human brain transcript expression in Alzheimer’s disease. Invited speaker, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London Oct 30th, 2006 Myers, A.J. Genome-wide correlation of DNA variation and RNA expression within human cortex, World Congress Psychiatric Genetics, Caglari, IT July 17th, 2006 Myers, A.J. The H1c risk haplotype of the MAPT gene is over-expressed in human temporal cortex relative to the other common alleles of MAPT. International Conference on Alzheimer’s disease, Madrid, Spain. October 21st, 2004 Myers, A.J. Investigation of the MAPT locus. Invited speaker, National University of Ireland, Cork, Ireland October 10th, 2004 Myers, A.J. Investigation of the MAPT locus. X11th World Congress Psychiatric Genetics, Dublin, Ireland, co-chaired session O3, on Neurodegenerative Disorders Sept 30th, 2003 Myers, A.J. Genetic examination of risk factors for neurological disease. Invited speaker Reta Lila Institute of Neurological Sciences, London, UK Sept 25th, 2003 Myers, A.J. Genetic examination of risk factors for neurological disease. DIADEM early diagnosis of Alzheimer's disease and related dementias workshop, Athens, Greece July 1st, 2003 Myers, A.J. The search for novel risk factors involved in late onset Alzheimer's Disease. Garvin Institute, Sydney, Australia July 25th, 2001 Myers, A. J. A Two-stage multicenter full genome screen to search for novel late onset Alzheimer’s disease susceptibility loci. Wellcome Trust, Hinxton, UK B. National Seminars: April 8th, 2010 Myers AJ The Human Brainome. Invited speaker 2010 Suddath Symposium, Atlanta, GA July 28th, 2008 Myers, AJ The Tau Top Ten. Invited speaker, International Conference Alzheimer’s Disease, Chicago, IL Nov 28th, 2007 Myers, AJ SNPs that influence gene expression in the cortex. Invited speaker, Neurodegeneration Symposium, Merck Research Laboratories, Boston, MA Nov 8th, 2005 Myers, AJ The microtubule associated protein Tau locus in evolution and disease, invited speaker, Translational genome research institute, Phoenix, AZ July 25th, 2005 Myers, AJ The microtubule associated protein Tau locus in evolution and disease, invited speaker, Gordon Research Conference on Human Genetics and Genomics, Newport, RI March 31st, 2004 Myers, AJ Investigation of the MAPT locus. Ninth Annual NIA IRP Scientific Retreat, Maritime Institute of Technology, Linthicum, Maryland
  10. 10. 10 Feb 13th, 2004 Myers, AJ Genetic examination of risk factors for neurological disease. Research in progress talk, Genome Research Centre, NIA, NIH, Baltimore, MD Nov 20th, 2003 Myers, AJ The search for novel risk factors involved in late onset Alzheimer's Disease. University of Texas, Lubbock, Texas Dec 18th, 2000 Myers, AJ The genetics of Late Onset Alzheimer’s Disease. Alzheimer’s Disease Research Center, Washington University, St. Louis C. Local Seminars: Jan 28, 2009 Myers AJ Expression Quantitative Trait Loci in Alzheimer’s Disease. Invited speaker, Miami Winter Symposium, Miami, FL Nov 21, 2008 Myers AJ The tau top ten: 10 things you need to know about the genetics of MAPT and cognitive decline, Invited speaker, UK-US International Alzheimer's Disease Symposium, USF Byrd Alzheimer's Institute, Tampa, FL April 8th, 2008 Myers AJ Genomics of Alzheimer’s Disease: the functional significance of non-coding DNA variation: An emphasis on expression. Pathways in Medical Genetics seminar series, University of Miami Feb 22nd, 2008 Myers, AJ Genomics of Alzheimer’s Disease: The functional significance of non-coding DNA variation: An emphasis on expression, Invited speaker, Samuel Gershon Award, Department of Psychiatry, University of Miami, Miller School of Medicine May 25th, 2007 Myers, AJ A survey of cis genotypic human cortical gene expression. Grand Rounds, Department of Psychiatry and Behavioral Sciences, University of Miami, Miller School of Medicine, Miami, FL April 17th, 2007 Myers, AJ The Tau Top Ten. Evelyn F. McKnight Brain Institute Symposium, University of Miami, Miller School of Medicine, Miami, FL January 26th, 2007 Myers, AJ Towards a brain atlas correlating transcriptome expression profiles and DNA variation. Department of Neuroscience, University of Miami, Miller School of Medicine, Miami, FL D. Workshops, Federal: National Institute on Aging Alzheimer’s Disease Genetics Planning Meeting, August 15-16, 2007 VI. TEACHING Teaching Specialization A. Graduate: Teaching Assistant, Systems Neuroscience BIO 5651, Washington University in St Louis School of Medicine, St Louis,MO, Spring 1996 Advisor, Neu660, Seminars in Neuroscience, Department of Neuroscience, University of Miami, Miller School of Medicine, Nov 2009 B. Medical Student:
  11. 11. 11 Advisor, Intramural Research Training Program, National Institute of Health, National Institute on Aging, Bethesda MD, 7 students, 6 pre-medical and 1 medical student, Sept 2002- May 2006 Lecturer, Psychiatry Residents PGY-2s, Seminar: Psychiatry and Genetics: Part I: Concepts, Part II: Examples, Department of Psychiatry and Behavioral Sciences, University of Miami, Miller School of Medicine, Nov 2009 C. Supervisory: Thesis and Dissertation Advising/Post-doctoral student supervision QE committee member, Neuroscience Department, University of Miami, student: Uzoezi Ozomaro, April 2008 Mentor, Leadership Alliance Summer Research Early Identification Program, advisee: Cindy Cuello, Barry University, April 2008-Dec 2009 Mentor, Bridge Scholars Program (5R25GM076419-04) Advisees: Analidys Lemus, Nairi Otalora, Miami Dade College, Sept 2008-present Mentor, (co-mentor) Pathway in Medical Genetics Program Advisee: Meghan Brennan VII. SERVICE University Committee and Administrative Responsibilities Psychiatry Research Review Committee 2006-2008 Information Resources Technology Committee 2008-present Pathway in Medical Genetics Program Steering Committee 2010- present Human Genetics and Genomics Program Steering Committee 2010- present Community Activities 34th Annual Eastern-Atlantic Student Research Forum (ESRF), Miami, Florida, December 2007,Role: judge Miami Science Museum Brain Awareness week Brain Fair, Miami Florida, March 2010 Role: presenter

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