GABRIEL G. HADDAD, M.D. CURRICULUM VITAE PERSONAL HOME ...

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GABRIEL G. HADDAD, M.D. CURRICULUM VITAE PERSONAL HOME ...

  1. 1. GABRIEL G. HADDAD, M.D. CURRICULUM VITAE PERSONALHOME ADDRESS P.O. Box 5000, PMB 162 Rancho Santa Fe, CA 92067OFFICE ADDRESS University of California, San Diego Rady Children’s Hospital of San Diego Department of Pediatrics Office of the Chairman 115 Leichtag Building 9500 Gilman Drive, Mailcode 0735 San Diego, CA 92093-0735 Phone: 858-822-4740 Fax: 858-534-6972 E-mail: ghaddad@ucsd.eduMARITAL STATUS Married, three children EDUCATION & TRAINING1965 – 1969 B.S., Biology/Chemistry, American University of Beirut, Beirut, Lebanon1969 – 1974 M.D., Intern & Jr. Resident, American University of Beirut, Beirut, Lebanon1974 - 1975 Senior Resident in Pediatrics University of Texas Medical Center Houston, Texas1975 - 1978 Fellow, Pediatric Pulmonary Division Columbia University, College of Physicians & Surgeons CURRENT APPOINTMENTS UNIVERSITY Professor of Pediatrics and Neuroscience University of California, San Diego School of Medicine Chairman, Department of Pediatrics HOSPITAL Physician-in-Chief and Chief Scientific Officer Rady Children’s Hospital of San Diego
  2. 2. PROFESSIONAL EXPERIENCE1978 - 1984 Columbia University, College of Physicians & Surgeons Assistant Professor of Pediatrics1980 - 1988 Columbia University, College of Physicians & Surgeons Department of Pediatrics Director, Sleep Physiology Laboratory1988 Columbia University, College of Physicians & Surgeons Associate Professor of Pediatrics1988 - July 1990 Yale University School of Medicine Associate Professor of Pediatrics Director, Section of Respiratory Medicine Chief of Clinical Service, Respiratory MedicineJuly 1990 - July 2002 Yale University School of Medicine Professor of Pediatrics Director, Section of Respiratory Medicine Chief of Clinical Service, Respiratory MedicineJuly 1993 - July 2002 Yale University School of Medicine Professor of Cellular & Molecular Physiology (Joint Appointment)July 2002 – August 2005 Albert Einstein College of Medicine Professor of Pediatrics and Neuroscience University Chairman, Department of Pediatrics The Children’s Hospital at Montefiore Pediatrician-in-ChiefAugust 2005 - University of California, San Diego School of Medicine Professor of Pediatrics& Neuroscience Chairman, Department of Pediatrics Rady Children’s Hospital of San Diego Physician-in-Chief SABBATICALSJuly 1986 –June 1987 Sabbatical Year University of Iowa Department of Physiology & Biophysics Laboratory of Dr. Peter GettingJan. 1996 –Dec. 1996 Sabbatical Year Yale University School of Medicine Boyer Center for Molecular Medicine Department of Genetics Laboratory of Tian Xu, Ph.D. 2
  3. 3. BOARD CERTIFICATION1980 American Board of Pediatrics License in the states of Connecticut, New York and California AWARDS AND HONORS1972 Alpha Omega Alpha Honor Medical Society1976 - 1979 Parker B. Francis Fellowship Award The Francis Families Foundation1977 - 1978 Milton Singer Fellow Columbia University College of Physician & Surgeons1979 - 1982 Edward Livingston Trudeau Scholar Award American Lung Association1985 - 1990 Established Investigator Award American Heart Association1991 Pediatric Faculty Teaching Award Yale University School of Medicine1992 Award for Excellence in Pediatric Research American Academy of Pediatrics2001 Parker B. Francis Distinguished Alumnus Fellow of the Year The Francis Families Foundation2002 Recognition for Scientific Accomplishments Award American Thoracic Society2005 Julius H. Comroe Jr. Distinguished Lectureship International Union Physiological Sciences Meeting2008 Elected to the Association of American Physicians2009-2010 Elected to the 2009-2010 Best Doctors in America PROFESSIONAL ACTIVITIES TEACHING Physiology Course First Year Medical Students Yale University School of Medicine Introduction to Medicine, Lung Module Second Year Medical Students Yale University School of Medicine Interdepartmental Neuroscience Program: Seminars for Graduate Students 3
  4. 4. Yale University School of Medicine Teaching Rounds, Developmental Biology M.D./Ph.D. Students Yale University School of Medicine Teaching Chairman Rounds Pediatric Residents Albert Einstein College of Medicine MD/PhD and Genetics graduate student seminars Albert Einstein College of Medicine Students Interested in Pediatrics First-year Medical Students University of California, San Diego Medical Scientists Training Program University of California, San Diego Professors Rounds University of California, San Diego Rady Children’s Hospital, San Diego Oxygen Biology Group Pediatric Postdoctoral Fellows, Students & Principal Investigators University of California, San Diego Rady Children’s Hospital, San Diego Fellow Research Conferences Pediatric Fellows University of California, San Diego Rady Children’s Hospital, San Diego Faculty Research Conferences Pediatric Postdoctoral Fellows and Faculty University of California, San Diego Rady Children’s Hospital, San Diego Medical students/Pharmacy Students Genetics Course Organized the Genetics course this past year (2008-2009) Gave a number of talks as part of the course (2008-2009) Genetics Course Director for Medical and Pharmacy Students (2009-2010) EDITORIAL APPOINTMENTS1983 -1995 Editorial Board, Journal of Applied Physiology1989 - 1993 Associate Editor, Journal of Applied Physiology1993 - 1998 Associate Editor, Pediatric Research1999 - 2002 Consulting Editor, Journal of Applied Physiology 4
  5. 5. COMMITTEESAcademic:1992 - 1994 Member, Yale University School of Medicine Committee on Priorities and Planning/Tenure Allocation1998 – 2001 Scholar Awards Committee, Yale University School of Medicine1999 – 2002 Senior Appointments and Promotions Committee, Yale University School of Medicine2002 – 2005 Member, Committee of Professors (Promotions Committee) Albert Einstein College of Medicine2002 – 2005 Member, Rank subcommittee, University Department of Pediatrics Albert Einstein College of Medicine2002 – 2005 Member, Senate Council Albert Einstein College of Medicine2005 – present Ex-Officio Member, Board of Trustees Rady Children’s Hospital, San Diego2005 – present Member, Board of Directors Children’s Specialists of San Diego2005 – present Member, President’s Council/Executive Team Rady Children’s Hospital, San Diego2005 – present Member, Medical Executive Committee Rady Children’s Hospital, San Diego2005 – present Member, Board of Trustees, Medical Affairs Committee Rady Children’s Hospital, San Diego2005 – present Board of Governors/Clinical Strategies and Operations Committee University of California, San Diego2005 – present Stem Cell Academic Working Group University of California, San Diego2005 – present EngMed Initiative Executive Committee University of California, San Diego2005 – present Board of Governors Committee University of California, San Diego2008-present Institute of Engineering in Medicine Advisory Committee University of California, San Diego2008-present Master of Advanced Studies (MAS) Advisory Committee University of California, San Diego 5
  6. 6. 2009-present The Institute for Genomic Medicine Advisory Committee University of California, San Diego2010-present Health Sciences Faculty Development Committee University of California, San Diego School of MedicineNational/International:1982 - 1983 NICHD Study Section Embryology and Human Development1983 NICHD Conference Future Research in SIDS1984 NIH reviewer SBI Research1985 & 1990 NIHLB site visitor Program Project, Cleveland1987 NIHLB conference, Session Chairman Developmental Neurobiology of Breathing1988 NIHLB conference Respiratory muscle fatigue1988 NICHD conference, subcommittee chairman Future Research in SIDS1988 - Present Respiratory Neurobiology & Sleep Section American Thoracic Society - Long Term Planning Committee - Secretary for Assembly (1991-1992) - Chair of Assembly (1995 - 1997)1991 Session Chair, International Conference on Sleep and Cardiorespiratory Control, Paris, France, September 1991.1992 Member, Long Range Planning Committee, American Thoracic Society1992 Session Co-Chairman and organizer: Brain hypoxia and the regulation of breathing. American Thoracic Society Meeting, Miami, FL, May, 1992.1992 NICHD, Consultant, Steering Committee, Review of apnea monitors, July, 1992.1992 NIH ad hoc Study Section, Lung Biology and Pathology, July 1992.1993 Chair, Session on Neurobiology. Society of Pediatric Research Meeting, Washington, DC, May, 1993.1993 Session Co-Chair, “How the carotid body senses hypoxia”. American Thoracic Society Meeting, San Francisco, CA, May, 1993.1993 Chair, NIH ad hoc Study Section, Lung Biology and Pathology, December, 1993.1994 - 1996 Vice President 6
  7. 7. Pediatric Pulmonary Training Directors Association (PEPTDA)1995 – 1997 Chairman, Section of Respiratory Neurobiology and Sleep, American Thoracic Society1995 - 1997 American Thoracic Society Board of Directors1996 Member, Revenue Development Committee, American Lung Association1996 - 2002 Clinical Research Advisory Committee March of Dimes Birth Defects Foundation1996 American Thoracic Society Leadership Retreat and Board of Directors Meeting, Orlando, FL, February 28-31, 1996.1997 - 1998 Planning Committee, American Thoracic Society1997 “Neurocognitive function in children with obstructive sleep apnea”. Co-organizer, NIH-American Thoracic Society Workshop, Washington, D.C. March 17, 1997.1998 Co-chair and organizer, Sponsored by the NIH-NHBLI and the American Thoracic Society Workshop – “Molecular and Genomic Effects of Tissue Oxygen Deprivation in Sleep Apnea”. Also, Session Moderator – “Hypoxia and Neuronal Injury”. Rockville, MD, September 24-25, 1998.2002 Session Chair, Winter Conference on Brain Research (WCBR). Snowmass, CO, January 26-February 2, 2002.2002 External Advisory Committee Member - Specialized Neuroscience Program, Howard University College of Medicine. Washington, D.C., April 3-4, 2002.2003 Nominating Committee for President of the American Thoracic Society, January, 20032003 ACGME (American Academy of Sleep Medicine) Ad Hoc Committee Member. Chicago, Illinois, January 13, 2003.2001 – 2006 External Advisory Committee Member - Specialized Neuroscience Program, Howard University College of Medicine. Washington, D.C., March 26-27, 2003.2004 – 2005 Member, American Thoracic Society Awards Committee2006 - present Chairman, Data Safety and Monitoring Board for Sickle Cell Anemia, HLB Institute, National Institute of Health Ph.D. ADVISOR/THESIS COMMITTEE MEMBER1981 Thesis Committee Member for PhD thesis of I. Gopal. "Spectral analysis of RR interval". Columbia University.1986 Thesis Committee Member for PhD thesis of H.J. Jeng. "Statistical analysis of the electromyogram". Columbia University. 7
  8. 8. 1988 Advisor for PhD thesis of Sharon Akabas. "Oxidative enzyme induction". Columbia University.1993 Thesis Committee Member for PhD thesis of Charlotte Youngson. “Characterization of the O2-sensing mechanism in pulmonary neuro-epithelial bodies and their role as hypoxia-sensitive airway chemoreceptors”. University of Toronto.1996 Advisor for PhD thesis of Theodore Reichley Cummins. "Molecular Pathophysiology of a mutant sodium channel". Yale University.1997 Advisor for PhD thesis of John Patrick OReilly. "Hypoxia in the Central Nervous System: Electrophysiologic Responses and the Role of Na+ channels". Yale University.2000 Thesis Committee Member for PhD thesis of Lei Xu. Yale University.2003 Advisor for PhD thesis of Vernon Ruffin. “The Gardos channel and responsiveness to hypoxia in an oocyte system”. Howard University.2006 - present PhD Advisor, DeeAnn Visk, Biology graduate student, UCSD2006 - 2008 Thesis Committee Member for PhD of Jake Feala, UCSD2008-present PhD Advisor, Erilynn Russo, Biomedical Sciences graduate student, UCSD2008-present Thesis Committee Member for Daniel Popa, UCSD INVITED SPEAKER/VISITING PROFESSORSHIPS / SELECTED NATIONAL PRESENTATIONS (1991 – PRESENT)Visiting Professor, Karolinska Institute, Department of Pediatrics and Physiology, Sweden, September, 1991.Visiting Professor, University of Oklahoma, Department of Physiology and Program in Neurobiology, April, 1992.Visiting Professor, University of Colorado, Department of Pediatrics, Division of Pulmonary Medicine, May, 1992.Invited speaker and Session chair, Chair, Session on O2 sensing and chemoreceptors; Presented, “Role of Na+current and transport during anoxia: Developmental aspects”. Wellcome Trust, England, October 16-21, 1992.Invited speaker, NIH-INSERM Meeting, "How neurons can survive O2 deprivation: ion channel mechanisms”.Nancy, France, September 7-9, 1992.Invited speaker, Winter Conference on Brain Research “ATP-sensitive K+ channels and brain anoxia”. Vancouver,British Columbia, January, 1993.Invited speaker, Experimental Biology Meeting. “Cardio-respiratory interactions during sleep in early life”. NewOrleans, LA, March, 1993.“Developmental neuronal sensitivity to anoxia: Role of extra-cellular calcium and sodium”. Presented at the Societyfor Pediatric Research Meeting, Washington, DC, May, 1993.“Development and distribution of voltage-sensitive sodium channels in the rat CNS”. Presented at the Society forPediatric Research Meeting, Washington, DC, May, 1993. 8
  9. 9. Invited speaker, American Thoracic Society Meeting. “Cellular mechanisms of effect of hypoxia on hypoglossalmotoneurons”. San Francisco, CA, May, 1993.Invited speaker, University of Toronto Research Institute. “Neuronal survival during O2 deprivation”. Toronto,Canada, May, 1993.“Hypoxia activates an ATP- and Ca++ -sensitive K+ channel in canthal neurons”. Presented at the XXXII Congress ofthe International Union of Physiological Sciences, Glasgow, Scotland, August, 1993.Invited speaker, Howard University. International Symposium on “Ventral brainstem mechanisms and controlfunctions”. Washington, DC, November, 1993.“Effect of anoxia on intracellular pH in isolated newborn and mature rat hippocampal CA1 neurons”. Presented atthe Society for Pediatric Research Meeting, Washington, DC, November, 1993.“Cloning of a glutamate transporter from human brain”. Presented at the Society for Neuroscience Meeting,Washington, DC, November, 1993.“Cloning of a novel human brain ion channel highly similar to KATP channel in rat kidney”. Presented at the Societyfor Neuroscience Meeting, Washington, DC, November, 1993.“Different responses of brainstem and cortical neurons to graded hypoxia”. Presented at the Society for NeuroscienceMeeting, Washington, DC, November, 1993.“Anoxia induces an increase in intracellular sodium in primary neocortical neuronal cultures”. Presented at theSociety for Neuroscience Meeting, Washington, DC, November, l993.Invited speaker, Twelfth Conference on Apnea of Infancy. “Control of respiration in early life: Molecular,Integrated and Practical Issues”. Annenberg Center at Eisenhower, Rancho Mirage, CA, January, 1994.Invited speaker, American Pediatric Society and the Society for Pediatric Research Meeting. “Respiratory andPulmonary Adaptation to Birth”. Seattle, WA, May, 1994.Invited speaker, 29th Middle East Medical Assembly. “Overview of SIDS”. Beirut, Lebanon, May, 1994.Invited speaker, 29th Middle East Medical Assembly. Naji Sahyoun Memorial Lecture: “Brain hypoxia and neuronalsurvival strategies”. Beirut, Lebanon, May, 1994.“Anoxia increases intracellular sodium in neurons”. Presented at the American Thoracic Society Meeting, Boston,MA, May, 1994.“Brain hypoxia: Role and molecular characterization of ATP-sensitive potassium channels in neuronalmembranes”. Presented at the American Thoracic Meeting, Boston, MA, May, 1994.“Is neonatal neuronal resistance to anoxia due to decreased glutamate sensitivity?” Presented at the AmericanThoracic Society Meeting, Boston, MA, May, 1994.“Increased neuronal sensitivity to acute hypoxia in rats after long-term exposure to a reduced oxygenenvironment”. Presented at the American Thoracic Society Meeting, Boston, MA, May, 1994.Invited speaker, 3rd International Symposium on Hypoxia. “Brain Hypoxia: Role and molecular characterization ofATP-sensitive potassium channels in neuronal membranes”. Berlin, September, 1994.“Adenosine activates a glilbenclamide-sensitive K+ current in postsynaptic neurons”. Presented at the Society forNeuroscience Meeting, Miami, FL, November, 1994. 9
  10. 10. “Increased neuronal sensitivity to acute hypoxia in rats after long-term exposure to a reduced oxygen environment.Presented at the Society for Neuroscience Meeting, Miami, FL, November, 1994.“Anoxia causes cleavage and rearrangement of cytoskeletal proteins in rat cortical neurons”. Presented at the Societyfor Neuroscience Meeting, Miami, FL, November, 1994. “Neonatal CA1 neurons do not respond to glutamate concentrations that kill adult neurons: Time-lapse confocalstudies in vitro. Presented at the Society for Neuroscience Meeting, Miami, FL, November, 1994.“Different responses of cortical and brainstem neurons to graded hypoxia”. Presented at the American ThoracicSociety Meeting, Seattle, WA, May, 1995.“Drosophila melanogaster survive prolonged periods of anoxia”. Presented at the American Thoracic Society, Seattle,WA, May, 1995.American Thoracic Society Leadership Retreat and Board of Directors Meeting, Orlando, FL, February 28-31,1996.Invited speaker, The Society for Gynecologic Investigation Symposium. “Do Na+ dependent exchanges play a rolein anoxic injury in the mammalian CNS”. Philadelphia, PA, March 23, 1996.Invited participant, American Lung Association/American Thoracic Society, Respiratory, Neurobiology and SleepWorkshop, Bethesda, MD, May 3, 1996.American Thoracic Society Board of Directors Meeting, New York, New York, May 20-21, 1996.Invited speaker, ISN Forefront Symposium, Oxygen sensing on the cellular and molecular level. “ChemoreceptorFunction”. Regensburg, Germany, June 22-29, 1996.Invited speaker, The American Physiological Society Conference on the Neural Control of Breathing: Molecular toOrganismal Perspectives. “Hypoxic effects on the CNS neurons”. Madison, WI, July 21-25, 1996.Invited speaker, APS Intersociety Meeting, Integrative Biology of Exercise. “Nerve growth during development:Implications for exercise in children”. Vancouver, British Columbia, October 16-19, 1996.Invited speaker, Oxygen regulation of ion channels and gene expression workshop. “Ion channel function duringhypoxia: Direct and indirect modulation”. Madrid, Spain November 24-26, 1996.“Effect on amiloride and its derivatives on the electrical properties of hippocampal CA1 neurons at rest and duringanoxia”. Presented at the Society for Neuroscience Meeting, Washington, DC, November 16-21, 1996.Invited speaker, Oxygen Regulation International Meeting. “Ion channel function during hypoxia: Direct and indirectmodulation”. Madrid, Spain, November 22-26, 1996.Co-organizer and speaker, NIH-American Thoracic Society Workshop. “Neurocognitive function in children withobstructive sleep apnea”. Washington, DC, March 17, 1997.“Genetic determination of anoxic tolerance in Drosophila melanogaster flies”. Presented at the DrosophilaResearch Conference, Chicago, IL, April, 1997.“Genetic determination of anoxic tolerance in Drosophila melanogaster flies”. Presented at the AmericanThoracic Society Meeting, San Francisco, Ca, May, 1997.Invited speaker, International Society on oxygen transport to tissue meeting (ISOTT). “Genetic basis for anoxiatolerance in Drosophila melanogaster". Milwaukee, WI, August 21, 1997. 10
  11. 11. "Genetic basis for anoxia tolerance in Drosophila melanogaster. Presented at the Society for NeuroscienceMeeting, New Orleans, LA, October 25-30, 1997.“Modulation of the sodium hydrogen exchanger: Effect of development and hypoxic stress. Presented at the Society forNeuroscience Meeting, New Orleans, LA, October 25-30, 1997.“Modulation of the calcium-activated potassium channels in excised patches by low oxygen”. Presented at theSociety for Neuroscience Meeting, New Orleans, LA, October 25-30, 1997.Studies on anoxia tolerance and susceptibility. Presented at the Cellular and Molecular Physiology DepartmentRetreat, Woods Hole, MA, November 14-16, 1997.Use of Drosophila melanogaster in anoxia tolerance. Presented at the Interdepartmental Neuroscience ProgramRetreat (INP), Woods Hole, MA, February, 1998.Invited speaker, University of Pennsylvania Medical Center, Center for Sleep and Respiratory Neurobiology."Drosophila melanogaster: A model system to study nerve cell response to O2 deprivation”. Philadelphia, PA,February 27, 1998.“Genetic basis of hypoxia-anoxia tolerance in Drosophila melanogaster”. Presented at the Experimental BiologyMeeting, San Francisco, CA, April 18-22, 1998.Invited speaker, Penn State College of Medicine. “Molecular basis for anoxia tolerance: Use of Drosophila as a modelsystem”. Hershey, PA, May 7, 1998.Invited speaker, Membrane Transport Research Group Workshop. “O2 sensors”. Montreal, Canada, May 21-22,1998.Invited participant, NIH - SIDS Pathogenesis – Approaches to Identifying High Risk Infants Working GroupMeeting. Lake Arrowhead, Ca, September 13-16, 1998.Co-chair and organizer, sponsored by the NIH-NHLBI and the American Thoracic Society Workshop – “Molecularand Genomic Effects of Tissue Oxygen Deprivation in Sleep Apnea”. Session Moderator – “Hypoxia and NeuronalInjury”. Rockville, MD, September 24-25, 1998.Guest Lecturer, Research Update in Neurosciences for Neurosurgeons Course (RUNN). “Fruit fly genes andneuronal tolerance to hypoxia”. Woods Hole, MA, October 20-29, 1998.Invited participant, The RSV-Asthma Link: The Emerging Story Conference sponsored by the American ThoracicSociety. Washington, D.C., November 6-7, 1998.“Cloning and genetic analysis of Drosophila melanogaster HIF1β homolog, a hypoxia-regulated transcriptionfactor”. Presented at the Society for Neuroscience Meeting, Los Angeles, CA, November 7-12, 1998.“Developmental and stress-induced profile of two CNS pH regulatory proteins: The Na/H exchanger and theNa/HCO3 cotransporter”. Presented at the Society for Neuroscience Meeting, Los Angeles, CA, November 7-12,1998.“Effects of hypoxia on embryonic Drosophila neurons in culture. Presented at the Society for NeuroscienceMeeting, Los Angeles, CA, November 7-12, 1998.“pH regulation of CA1 neurons isolated from NHE-1 null mice”. Presented at the Society for NeuroscienceMeeting, Los Angeles, CA, November 7-12, 1998. 11
  12. 12. “Differential effects of chronic hypoxia on neuronal and astrocytic glutamate transporters in developing ratbrains”. Presented at the Society for Neuroscience Meeting, Los Angeles, CA, November 7-12, 1998.Invited guest, Middle Eastern & Mediterranean Pediatric Society Meeting. “Asthma Pathogenesis”. AmericanUniversity of Beirut, Beirut, Lebanon, April 15-17, 1999.Invited guest, Middle Eastern & Mediterranean Pediatric Society Meeting. “Obstructive Sleep Apnea”. TheAmerican University of Beirut, Beirut, Lebanon, April 15-17, 1999.“A rat chronic hypoxia model: Differential responses of various organs to oxygen (O2) deprivation”. Presented atthe ALA/ATS International Conference, Chicago, IL, April 24-29, 1999.“The effect of oxygen deprivation on the cell cycle of Drosophila melanogaster embryos”. Presented at thePediatric Academic Societies’ Annual Meeting (APS/SPR), San Francisco, CA, May 1-4, 1999.“Tolerance to O2 deprivation: Genetic basis using a Drosophila model system”. Presented at the PediatricAcademic Societies’ Annual Meeting (APS/SPR), San Francisco, CA, May 1-4, 1999.Invited speaker, Cardeza Foundation for Hematologic Research and Division of Hematology, Jefferson MedicalCollege, Thomas Jefferson University, Research Seminar. “Tolerance to lack of O2: A model approach in the fruitfly”. Philadelphia, PA, May 12, 1999.Invited participant, Oxygen Sensing: Molecule to Man Symposium, University of Pennsylvania Medical Center.“Oxygen deprivation of rat hippocampal neurons”. Philadelphia, PA, June 24-28, 1999.Session Chair, Ion Channel Structures & Function Conference. Yale University School of Medicine, Department ofPediatrics and Boyer Center for Molecular Medicine, July 16-18, 1999.Member, Site Visit Team, National Institutes of Health, National Center for Research Resources, Bethesda, MD.Review Application for a General Clinical Research Center (GCRC). University of Virginia, Charlotttesville,Virginia, July 21-22, 1999.Invited lecturer, Research Update in Neuroscience for Neurosurgeons (RUNN) Course. “Neuronal response tolack of oxygen”. Marine Biology Laboratory, Woods Hole, MA, October 9-17, 1999.Invited Speaker, Veterans Memorial Medical Center, Department of Neurology. “Drosophila melanogaster as aanimal model to study anoxia tolerance”. West Haven, CT, March 1, 2000.Visiting Professor/Invited speaker, Shanghai Medical University. "NHE in anoxia"; "Na+, K+ channelsand their role in anoxia"; "Tolerance of Drosophila melanogaster to anoxia"; "RNA editase and its role in anoxia",Shanghai, China, June 22 - 30, 2000.Invited speaker, Research Update in Neuroscience for Neurosurgeons (RUNN) Course, "Fly Genes and Resistanceto Hypoxia". Marine Biology Laboratory, Woods Hole, MA, October 16, 2000.Invited participant, NHLBI RFA Investigator Coordination Meeting, "Oxygen Sensing During IntermittentHypoxia". National Institutes of Health, Bethesda, MD, January 22, 2001.Invited speaker, Case Western Reserve University - Rainbow Babies & Childrens Hospital. Neonatal PhysiologyCourse - "Molecular and cellular basis for neuronal responses to hypoxia". Pediatric Research Conference -"Genes that protect against hypoxic injury: Use of genetic model systems". Cleveland, OH, January 25 - 26, 2001.Invited reviewer, University of Pennsylvania, Center for Sleep and Respiratory Neurobiology, External Review.Philadelphia, PA, January 30-31, 2001. 12
  13. 13. Invited speaker, St Lukes Hospital of Kansas City - "Tissue hypoxia and mechanisms of Cellular Injury". KansasCity, MO, May 18, 2001.Invited participant, NHLBI RFA Investigator Coordination Meeting, "Oxygen Sensing During IntermittentHypoxia". National Institutes of Health, Bethesda, MD, February 11, 2002.Invited speaker, Howard University, Department of Physiology and Biophysics. “Understanding mammaliancellular response to hypoxia using Drosophila as a genetic model”. Washington, D.C., February 12, 2002.Invited speaker, Neuroscience Program Retreat. “Understanding oxygen sensing and response to O2 deprivationusing a genetic model”. Marine Biology Laboratory, Woods Hole, MA, February 15-17, 2002.Invited Professor session moderator, Eastern Society for Pediatric Research. “Preparing for a Career as aPediatrician-Scientist”. Hyatt Regency Hotel, Greenwich, CT, March 9, 2002.Invited speaker, Ion Channels and Hypoxia Symposium. “Effect of hypoxia on neuronal sodium channels”.Experimental Biology 2002, New Orleans, LA, April 20-24, 2002.Invited speaker, American Thoracic Society International Conference. “Understanding mammalian cellularresponses to hypoxia using Drosophila as a genetic model”. Atlanta, GA, May 17-22, 2002.Invited speaker, Sleep & Breathing Symposium. Session – Adaptation to Altitude: Brain Hypoxia and GeneResponse. Reykjavik, Iceland, May 31-June 2, 2002.Invited speaker, International Union of Pharmacology (IUPHAR) Congress of Pharmacology. “Oxygen-sensitivechannels in the CNS”. San Francisco, CA, July 7-12, 2002.Invited speaker, International Congress of Pathophysiology. “Drosophila Melanogaster: A genetic model forstudying anoxia tolerance”. Budapest, Hungary, July 3-10, 2002.Ad Hoc Committee Member, ACGME American Academy of Sleep Medicine Meeting. Chicago, Illinois, January13, 2003.Invited speaker, National Institutes of Health (NIH/NICHD). “Tissue hypoxia and cell injury: old questions butsome new answers”. Bethesda, MD, January 30, 2003.External Advisory Committee Member, Specialized Neuroscience Meeting. Howard University, Washington, DC,March 26 - 27, 2003.Advisory Board Member, COBRE Grant External Advisory Board Meeting. University of Louisville, Louisville,KY, June 24 – 25, 2003.Invited speaker, Journal of Experimental Biology Symposium- Defenses against Brain Hypoxia: Molecule toOrganism. “Drosophila: Genetic model of neuronal hypoxia tolerance”. Tuscany, Italy, September 13-17, 2003.Invited speaker, Sickle Cell Disease Advisory Committee. National Institutes of Health (NIH/NHLBI). “Sleepdisturbances and hypoxemia in the pediatric population”. Bethesda, MD, November 3, 2003.Invited speaker, Grand Rounds, Bronx-Lebanon Hospital Center. “Pediatric Asthma – Challenges and Advances”.Bronx, New York, April 13, 2004.Invited speaker, Grand Rounds, New York University School of Medicine. “Lessons from flies: Understandingmammalian responses to hypoxia”. New York, NY, June 2, 2004.Invited speaker, University of Iowa. “Tissue (brain) hypoxia and cell injury: Some insights from invertebrates”.Iowa City, IA, June 22, 2004. 13
  14. 14. Invited speaker, SIDS International Conference. “Mechanisms of hypoxia cell death or tolerance: insights fromgenetic models”. Edmonton, Alberta, Canada, July 2-6, 2004.Invited speaker, XXII International Congress of Entomology. “Genetic mechanisms underlying anoxia tolerance ininsects”. Brisbane, Australia, August 15-21, 2004.Distinguished APS Julius Comroe Speaker, Experimental Biology Meeting. “Tolerance to low O2: Lessons frominvertebrate genetic models.” San Francisco, CA, April 1-5, 2005.Invited speaker, Pediatric Grand Rounds. “Hypoxic Brain Injury.” UCSD, La Jolla, CA, November 4, 2005.Invited Moderator/Organizer, 47th Annual Drosophila Research Conference. “Gas sensing and responses inDrosophila.” Houston, Texas, April 1, 2006.Chairman, NIH/NHLBI DSMB Meeting. “Pulmonary Complications of Sickle Cell Disease DSMB”. NationalInstitutes of Health, Bethesda, MD, January 12, 2006.Invited speaker, J. Christian Gillin Sleep Seminar. "Sleep, intermittent hypoxia, and CNS injury." UCSD, La Jolla,CA, June 6, 2006.Invited speaker, Inflammation, Degeneration and Regeneration from Basic Mechanisms to Clinical ManifestationsInternational Symposium. “Hypoxic neuronal injury: insights from vertebrate and invertebrate models.”Magdeburg, Germany, November 30, 2006.Invited speaker, Pulmonary, Critical Care and Sleep Medicine Grand Rounds at University Hospitals CaseMedical Center. “Hypoxia: From flies, to mammals, and humans.” Case Western Reserve University, Cleveland,OH, February 16, 2007.Invited speaker, Department of Physiology. “Genetic basis for Hypoxia tolerance for susceptibility: insights usinginvertebrates.” UCSD, La Jolla, CA, February 23, 2007.Invited speaker, Hypoxia Conference. “Selection for hypoxia tolerance in Drosophila.” Lake Louise, Canada,February 28, 2007.Invited speaker, 5th Lung Science Conference. “HIF-independent hypoxia induced gene regulation and proteinmodification.” Taormina, Italy, March 23, 2007.Invited speaker, Biomedical & Clinical Research Center Seminar. “Hypoxic cell injury: insights from vertebratesand invertebrates” UCSD, La Jolla, CA, April 4, 2007.Invited speaker, Basic Science Lecture. “Insights from Drosophila: Hypoxia-sensing and cell injury.” LAC Harbor– UCLA Medical Center, UCLA School of Medicine, Los Angeles, CA, April 10, 2007.Invited speaker, Department of Surgery Grand Rounds. “Hypoxic tissue injury: insights from vertebrates andinvertebrates.” UCSD, La Jolla, CA, April 11, 2007.Invited speaker, Experimental Biology 2007, Respiratory Control in Insects: Integration from the Gene to theOrganism. “Genetic basis for hypoxia tolerance in Drosophila melanogaster.” Washington, DC, April 29, 2007.Invited speaker, Medical Grand Rounds, "Hypoxia and CNS injury: newer insights from vertebrates andinvertebrates". UCSD, La Jolla, CA, May 2, 2007.Invited speaker, Residents/Intern Seminar, “Cilia and Primary Ciliary Dyskinesia.” UCSD, La Jolla, CA,September 6, 2007. 14
  15. 15. Invited speaker, Burnham Institute for Medical Research, “Flying high at low O2 with Drosophila.” September 20,2007.Invited speaker, “Hypoxia Tolerance: Insights from Drosophila melanogaster”, Loma Linda University, LomaLinda, CA, February 14, 2008.Invited speaker, Physiology Seminar. “Hypoxic Cell Injury: Insights from Invertebrate Models." EmoryUniversity, Atlanta, GA, April 10, 2008.Invited speaker, American Thoracic Society Annual Meeting. “Hypoxia Effects on the Developing Brain." Toronto,Ontario, Canada, May 16, 2008.Invited speaker, American Thoracic Society Annual Meeting. “An Evolutionary Approach to Hypoxic Adaptation."Toronto, Ontario, Canada, May 18, 2008.Invited speaker, Southern California Drosophila Conference, “Tolerance to alterations in environmental oxygen inDrosophila melanogaster”, University of California, Irvine, Irvine, CA, September 5, 2008.Invited speaker and Conference Organizer, New York Academy of Sciences Conference, Hypoxia andConsequences: From Molecule to Malady, “Insights from an Invertebrate Model: Role of Specific GeneticPathways in Survival to Extreme Hypoxia”, New York, NY, March 12, 2009.Invited speaker, Southern California Stem Cell Consortium, San Diego, CA, April 9, 2009.Invited speaker, American Thoracic Society Annual Meeting, “Hypoxia and Hypercapnia in Sleep: The Good andthe Bad”, San Diego, CA, May 18, 2009.Invited speaker, PRISM (Progress in the Science of Medicine) Lecture Series, UCSD, La Jolla, CA, October 9,2009.Invited Keynote speaker at ISOTT, Cleveland Ohio, July 6-8, “Flying high with flies: Insights from a genetic modelsystem”, July 6, 2009.Invited speaker 2010 Keystone Symposium on Hypoxia: Molecular Mechanisms of Oxygen Sensing and ResponsePathways, Jan 19 - Jan 24, 2010, Keystone, CO. EXTERNAL REVIEWER American Journal of Physiology Regulatory, Integrative and Comparative Physiology Lung Cellular and Molecular Physiology Cell Physiology American Journal of Respiratory and Critical Care Medicine Brain Research, Molecular Brain Research Comparative Biochemistry and Physiology Cortex Diabetes European Journal of Neuroscience European Journal of Physiology FASEB Journal Journal of Applied Physiology Journal of Clinical Investigation Journal of Membrane Biology Journal of Neurochemistry Journal of Neurophysiology 15
  16. 16. Journal of Neuroscience Journal of Physiology Neuropharmacology Neuroscience Neuroscience Letters Open Journal of Neuroscience Pediatric Pulmonology Pediatric Research Physiologic Genomics Proceedings of the National Academy of Sciences Trends in Neuroscience PLoS Genetics PLoS One ASSOCIATIONS AND SOCIETIES (Member since): 1978 American Thoracic Society 1980 American Physiological Society 1982 Society for Pediatric Research 1983 American Association for the Advancement of Science 1985 Society for Neuroscience 1985 American Heart Association 1991 Biophysical Society 1991 New York Academy of Sciences 1993 American Pediatric Society 1995 Society for General Physiologists 1996 Pediatric Pulmonary Training Directors Association 1997 The American Society for Cell Biology 1997 The Genetics Society of America 2003 Fellow, New York Academy of Medicine 2004 American Society of Cell and Molecular Biology 2006 Association of Medical School Pediatric Departments 2007 American Academy of Pediatrics 2008 Association of American Physicians GRANT SUPPORT -Active Ongoing Research Support5 P01 HD 32573 (PI, Haddad) 12/01/96–07/31/10NIH Total support: $6,441,769Hypoxia in development: Injury and adaptation mechanismsThe major goals of Project 1 are focused on voltage-sensitive Na+ channels and excitability in hypoxia. Thisproject will investigate the electrophysiologic response to hypoxia in rat cortical neurons. Core A will provideadministrative support and it will facilitate intellectual interactions.1 R01 NS 37756 (PI, Haddad) 01/01/2000–04/30/10NIH Total Support: $1,475,404Molecular Basis of Cell Tolerance to O2 DeprivationThe major goals of this grant are to identify, map and clone the genes that seem to be responsible and critical forrecovery to O2 deprivation in Drosophila melanogaster using a genetic mutagenesis screen and ascertain the roleof these genes at cellular and whole fly levels using several assays (e.g. ectopic expression, cell function under 16
  17. 17. various conditions etc.).1R21HL093611 (PI, Haddad) 4/1/09-3/31/11NIH Total Support: $275,000Resistance to oxidant injuryIn this proposal, we are studying the reasons why flies that have been selected experimentally over manygenerations resist very high O2 levels. Since the majority of disease genes in humans are present in flies,studying flies and the mechanisms that operate in these organisms becomes important and useful. Indeed, in thepast we have been able to use fly genes to make human cells more resistant to certain stresses. Pending Research Support1P01HL098053 (Haddad P.I.)NIH/NHLBI (Haddad) 07/01/10-06/30/15Molecular mechanisms of hypoxia tolerance and susceptibilityRole on Projects: Program Project – P.I. Project 1 – P.I. Core A – P.I. Core C – Co-InvThis PPG is dedicated to the understanding of how tissues die or survive when animal or human tissues aredeprived of oxygen. This is basic for many disease states such as obstructive sleep apnea, and cardio-respiratorydiseases (e.g., Asthma and Sickle cell disease as well as COPD). We employ two animal models, one beingsusceptible and the other tolerant to low O2 to understand the differences and be able to render mammalian tissuesthat are sensitive to low O2 much more resistant to it.1R01GM089897 (Haddad P.I.) 7/1/10-6/30/15NIH Total Support: $1,250,000Genetic Dissection of Hypoxia ToleranceThis application addresses questions that will lead to our basic understanding of how flies, which are tolerant tolow O2, manage to escape from cell and tissue damage when they are exposed to low O2. Furthermore, when wedevelop a framework for our understanding of tolerance and learning from flies, we will engineer cells or tissuesfrom mammals that will be much more tolerant to low O2. (Completed Research Support of the previous 3 years)5 P01 HD 32573 (PI, Haddad) 02/10/95 - 11/30/04NIH/ NICHD Total support: $3,696,500Program Project - Hypoxia in development: Injury and adaptation mechanismsProject 1 - Na+ channels & excitability in hypoxiaThe major goals of Project 1 are focused on voltage-sensitive Na+ channels and excitability in hypoxia. Thisproject will investigate the electrophysiologic response to hypoxia in rat cortical neurons. Core A will provideadministrative support and it will facilitate intellectual interactions.1 R01 HL 66327 (PI, Haddad) 09/30/00 - 08/31/04NIH/ NHLBI Total Support: $700,000Cyclical Hypoxia: Susceptibility to neuronal injuryThe goals of this project are to study cyclical hypoxia and determine the cellular and molecular mechanisms that can lead tocell injury (or adaptation and survival). In order to be consistent, and because cortical neurons have been shown to bevulnerable to hypoxic exposure, this work will be focused on the neocortex.1 R01 NS 37756 (PI, Haddad) 01/01/00 – 12/31/04 17
  18. 18. NIH/NINDSMolecular Basis of Cell Tolerance to O2 DeprivationThe major goals of this grant are to identify, map and clone the genes that seem to be responsible and critical forrecovery to O2 deprivation in Drosophila melanogaster using a genetic mutagenesis screen and ascertain the roleof these genes at cellular and whole fly levels using several assays.1 P01 NS42202 (PI, Kaczmarek, PI Haddad on Project 4) 07/01/01 – 06/30/06NIH Total Support: $4,886,610Hypoxia induces inhibition of BK(Ca) channel: Role and MechanismsThe major goals of this project are to study BK(Ca) channels and understand how they sense O2 lack and the rolethey play in hypoxic responses in both brainstem and neocortical neurons in mice and humans.2 R01 HD34852 (PI, Xia) 04/01/02 - 03/31/07NIH Total Support: $1,125,000Hypoxia & Neuronal excitability: Cellular mechanismsThe major goals of this project are to investigate the modulation of neuronal excitability and Na+ channelexpression and the mechanisms by which Na+ channels are up regulated during chronic hypoxia.Role: Collaborator BIBLIOGRAPHY Original Published Articles1. Haddad GG, Hajjar E, and Abufaisal K. Hyperosmolar, hyperglycemic, non-ketotic coma. Lebanese Med J, 26: 277-286, 1973.2. Sanjad SA, Haddad GG, and Nassar VH. Nephropathy an underestimated complication of methicillin therapy. J Pediatr, 84: 873-877, 1974.3. Haddad GG and Mellins RB. The role of airway receptors in the control of respiration in infants. A review. J Pediatr, 91: 281-286, 1977.4. Haddad GG, Mazza NM, Defendini RF, Blanc WA, Driscoll JM, Epstein MA, Epstein RA and Mellins RB. Congenital failure of automatic control of ventilation, gastrointestinal motility and heart rate. Medicine 57: 517- 526, 1978.5. Haddad GG, Krongrad E, Law HS, Mazza NM, Epstein MAF, Katz JB, Epstein RA, and Mellins RB. Effect of sleep state on QT intervals in normal infants. Pediatr Res, 13: 139-141, 1979.6. Haddad GG, Epstein MAF, Epstein RA, Mazza NM, Mellins RB, and Krongrad E. The QT interval in aborted SIDS infants. Pediatr Res, 13: 136-138, 1979.7. Haddad GG, Epstein RA, Epstein MAF, Leistner HL, Marino PA, and Mellins RB. Maturation of ventilation and ventilatory pattern in normal sleeping infants. J Appl Physiol, 46: 998-1002, 1979.8. Mazza NM, Epstein MAF, Haddad GG, Law HS, Mellins RB, and Epstein RA. Relation of beat to beat variability to heart rate in normal sleeping infants. Pediatr Res, 14: 232-235, 1980.9. Haddad GG, Epstein RA, Epstein MAF, Leistner HL, and Mellins RB. The R-R interval and R-R variability in normal infants during sleep. Pediatr Res, 14: 809-811, 1980.10. Leistner HL, Haddad GG, Epstein RA, Lai TL, Epstein MAF, and Mellins RB. Heart rate and heart rate variability in aborted SIDS infants. J Pediatr, 97: 51-55, 1980.11. Haddad GG, Leistner HL, Epstein RA, Epstein MAF, Grodin WK, and Mellins RB. C02-induced changes in 18
  19. 19. ventilation and ventilatory pattern in normal sleeping infants. J Appl Physiol, 48: 684-688, 1980.12. Epstein, RA, Epstein MAF, Haddad GG, and Mellins RB: Practical implementation of the barometric method for measurement of tidal volume. J Appl Physiol, 49: 1107-1115, 1980.13. Haddad GG, Walsh EM, Leistner HL, Grodin WK, and Mellins RB. Abnormal maturation of sleep of states in infants with aborted Sudden Infant Death Syndrome. Pediatr Res, 15: 1055-1057, 1981.14. Haddad GG, Leistner HL, Lai TL, and Mellins RB. Ventilation and ventilatory pattern during sleep in aborted SIDS infants. Pediatr Res, 15: 879-883, 1981.15. Gopal IS and Haddad GG. Automatic detection of eye movements in REM sleep using the electroculogram. Am J Physiol, 241: R217-R221, 1981.16. Haddad GG, Gandhi MR, and Mellins RB. Maturation of the ventilatory response to hypoxia in puppies during sleep. J Appl Physiol, 52: 309-314, 1982.17. Haddad GG, Lai TL, Epstein MAF, Epstein RA, Leistner HL, and Mellins RB. Breath to breath variations of rate and depth of ventilation in normal sleeping infants. Am J Physiol, 243: R164-R169, 1982.18. Haddad GG, Lai TL, and Mellins RB. Determination of the ventilatory pattern in REM sleep in normal infants. J Appl Physiol, 53(1): 52-56, 1982.19. Martin E, Bazzy AR, Gandhi MR, and Haddad GG. An investigation in the venous drainage of the diaphragm of the sheep. Invest Radiol, 18: 272-274, 1983.20. Leistner HL, Haddad GG, Lai TL, and Mellins RB. Heart rate pattern during sleep in an infant with congenital prolongation of the QT interval (Romano-Ward syndrome). Chest, 84: 191-194, 1983.21. Haddad GG, Gandhi MR, Hochwald G, and Lai TL. Enkephalin induced changes in ventilation and ventilatory pattern in unanesthetized adult dogs. J Appl Physiol, 55: 1311-1320, 1983.22. Bazzy AR, Haddad GG, Chang SL, and Mellins RB. Respiratory pauses during sleep in near-miss Sudden Infant Death Syndrome. Am Rev Respir Dis, 128: 973-976, 1983.23. Haddad GG, Bazzy AR, Chang SL, and Mellins RB. Heart rate pattern during respiratory pauses in normal infants during sleep. J Dev Physiol, 6: 329-337, 1984.24. Haddad GG, Jeng HJ, Lee SH, and Lai Tl. Rhythmic variations in the R-R interval during sleep and wakefulness in puppies and dogs. Am J Physiol, 247 (Heart & Circ): H67-H73, 1984.25. Bazzy AR and Haddad GG. Diaphragmatic fatigue in the unanesthetized adult sheep. J Appl Physiol, 57: 182- 190, 1984.26. Haddad GG, Schaeffer JI, and KJ Chang. Opposite effects of the delta- and mu- opioid receptor agonists on ventilation in conscious adult dogs. Brain Res, 323: 73-82, 1984.27. Sadoul N, Bazzy AR, Akabas SR, and Haddad GG. Ventilatory response to fatiguing and non-fatiguing resistive loads in awake sheep. J Appl Physiol, 59(3): 969-978, 1985.28. Schaeffer JI and Haddad GG. Regulation of ventilation and oxygen consumption by delta- and mu- opiod receptor agonists. J Appl Physiol, 59(3): 959-968, 1985.29. Haddad GG, Jeng HG, and Lai TL. Effect of endorphins on heart rate, and blood pressure in adult dogs. Am J Physiol, 250: H796-H805, 1986. 19
  20. 20. 30. Bazzy AR, Korten JB, and Haddad GG. Increase in electromyogram low-frequency power in non-fatigued contracting skeletal muscle. J Appl Physiol, 61 (3): 1012-1017, 1986.31. Donnelly DF and Haddad GG. Respiratory changes induced by prolonged laryngeal stimulation in awake piglets. J Appl Physiol, 61: 1018-1024, 1986.32. Haddad GG, Jeng HJ, Bazzy AR, and Lai TL. Within breath electromyographic changes during loaded breathing in adult sheep. J Appl Physiol, 61: 1316-1321, 1986.33. Donnelly DF and Haddad GG. Effect of graded anesthesia on laryngeal-induced central apnea. Respir Physiol, 66: 235-245, 1986.34. Haddad GG and Lasala PA. Effect of parasympathetic blockade on ventilatory and cardiac depression induced by opioids. Respir Physiol 67: 101-114, 1987.35. Haddad GG, Jeng HJ, Lai TL, and Mellins RB. Determination of sleep state in infants using respiratory variability. Pediatr Res, 21 (6): 556-562, 1987.36. Haddad GG, Jeng HJ, and Lai Tl. Heart rate variability during respiratory pauses in puppies and dogs. Pediatr Res, 22(3): 306-311, 1987.37. Moessinger AC, Singh M, Donnelly DF, Haddad GG, Collins MJ, and James LS. The effect of prolonged oligohydramnios on fetal lung development, maturation and ventilatory pattern in newborn guinea pigs. J Dev Physiol, 9: 419-427, 1987.38. Bazzy AR, Akabas SR, and Haddad GG. Respiratory muscle response to load and glycogen content in type I and II fibers. Exp Neurol, 101: 17-28, 1988.39. Sanocka UM, Donnelly DF, and Haddad GG. Cardiovascular and neurophysiologic changes during graded duration of apnea in piglets. Pediatr Res, 23: 402-407, 1988.40. Schaeffer JI and Haddad GG. Ventilatory response to moderate and severe hypoxia in adult dogs: role of endorphins. J Appl Physiol, 65: 1383-1388, 1988.41. Akabas SR, Bazzy AR, DiMauro S, and Haddad GG. Metabolic and functional adaptation of the diaphragm to training with resistive loads. J Appl Physiol, 66: 529-535, 1989.42. Rosen CL, Cote A, and Haddad GG. Effect of enkephalins on cardiac output and regional blood flow distribution in the conscious dog. Am J Physiol, 256: H1651-H1658, 1989.43. Bazzy AR, Pang LM, AKabas SR, and Haddad GG. O2 metabolism of the sheep diaphragm during flow resistive loaded breathing. J Appl Physiol, 66: 2305-2311, 1989.44. Singh M, Rosen CL, Chang KJ, and Haddad GG. Plasma B-casomorphin-7 immunoreactive peptide increases after milk intake in newborn but not in adult dogs. Pediatr Res, 26: 34-38, 1989.45. Korten JB and Haddad GG. Respiratory Waveform Pattern Recognition Using Digital Techniques. Comput Biol Med, 19 (4): 207-217, 1989.46. Haddad GG and Getting PA. Repetitive firing properties of neurons in the ventral region of the nucleus tractus solitarius. In-vitro studies in adult and neonatal rat. J Neurophysiol, 62: 1213-1224, 1989.47. Donnelly DF and Haddad GG. Prolonged apnea and impaired survival in piglets after sinus and aortic nerve section. J Appl Physiol, 68(3): 1048-1052, 1990.48. Cote A and Haddad GG. Effect of sleep on regional blood flow distribution in piglets. Pediatr Res, 28: 218-222, 20
  21. 21. 49. Haddad GG and Donnelly DF. O2 Deprivation induces a major depolarization in brainstem neurons in the adult but not in the neonatal rat. J Physiol (London), 429: 411-428, 1990.50. Haddad GG, Donnelly DF, and Getting PA. Biophysical properties of hypoglossal neurons in-itro: intracellular studies in adult and neonatal rats. J Appl Physiol, 69: 1509-1517, 1990.51. Xia Y and Haddad GG. Ontogeny and distribution of opioid receptors in the rat brainstem. Brain Res, 549: 181-193, 1991.52. Jiang C and Haddad GG. The effect of anoxia on intracellular and extracellular potassium activity in hypoglossal neurons in-vitro. J Neurophysiol, 66: 103-111, 1991.53. Feldman JD, Bazzy AR, Cummins TR, and Haddad GG. Developmental changes in neuromuscular transmission in the rat diaphragm. J Appl Physiol, 71(1): 280-296, 1991.54. Cummins TR, Donnelly DF, and Haddad GG. Effect of metabolic inhibition on the excitability of isolated hippocampal CA1 neurons: Developmental aspects. J Neurophysiol, 66: 1471-1482, 1991.55. Xia Y and Haddad GG. Major differences in CNS sulfonylurea receptor distribution between the rat (newborn, adult) and turtle. J Comp Neurol, 314: 278-289, 1991.56. Jiang C, Agulian S, and Haddad GG. O2 tension in adult and neonatal brain slices under several experimental conditions. Brain Res, 568: 159-164, 1991.57. Jiang C, Xia Y, and Haddad GG. Role of ATP sensitive K+ channels during anoxia: Major differences between rat (newborn, adult) and turtle neurons. J Physiol (London), 448: 599-612, 1992.58. Jiang C, Agulian S, and Haddad GG. Cl- and Na+ homeostasis during anoxia in hypoglossal neurons: intracellular and extracellular in-vitro studies. J Physiol (London), 448: 697-708, 1992.59. Xia Y, Jiang C, and Haddad GG. Oxidative and glycolytic pathways in rat (newborn, adult) and turtle brain: Role during anoxia. Am J Physiol, 262: R595-603, 1992.60. Donnelly DF, Jiang C, and Haddad GG. Comparative responses of brainstem and hippocampal neurons to O2 deprivation: in vitro intracellular studies. Am J Physiol, 262: L549-554, 1992.61. Sanocka UM, Donnelly DF, and Haddad GG. Auto-Resuscitation: A survival mechanism in piglets. J Appl Physiol, 73: 749-753, 1992.62. Xia Y and Haddad GG. Ontogeny and distribution of GABAA receptors in rat brainstem and rostral brain regions. Neuroscience, 49(4): 973-989, 1992.63. Rosen CL, DAndrea L, and Haddad GG. Adult criteria for obstructive sleep apnea do not identify children with serious obstruction. Am Rev Respir Dis, 146: 1231-1234, 1992.64. Jiang C and Haddad GG. Differential responses of neocortical neurons to glucose and/or O2 deprivation in the human and rat. J Neurophysiol, 68(6): 2165-2173, 1992.65. Friedman JE and Haddad GG. Major differences in Ca2+i between neonatal and adult rat CA1 neurons in response to anoxia: Role of Cao2+ and Nao+. J Neurosci, 13(1): 63-72, 1993.66. Rosen CL, Schecter WS, Mellins RB, and Haddad GG. Effect of Acute Hypoxia On Metabolism And Ventilation In Awake Piglets. Respir Physiol, 91: 307-319, 1993. 21
  22. 22. 67. Marks JD, Donnelly DF, and Haddad GG. Adenosine-induced inhibition of vagal motoneuron excitability: receptor subtype and mechanisms. Am J Physiol, 264(8): L124-L132, 1993.68. Cummins TR, Jiang C, and Haddad GG. Human neocortical excitability is decreased during anoxia via sodium channel modulation. J Clin Invest, 91: 608-615, 1993.69. Cummins TR, Agulian SK, and Haddad GG. Oxygen tension clamp around single neurons in-vitro: A computerized method for studies on O2 deprivation. J Neurosci Methods, 46: 183-189, 1993.70. Pincus SM, Cummins TR, and Haddad GG. Heart rate control in normal and aborted-SIDS infants. Am J Physiol, 264(33): R638-R646, 1993.71. Young RS, During MJ, Donnelly DF, Aquila WJ, Perry VL, and Haddad GG. Effect of anoxia on excitatory amino acids in brain slices of rats and turtles: In vitro microdialysis study. Am J Physiol, 264(33): R716-719, 1993.72. Xia Y and Haddad GG. Neuroanatomical distribution and binding properties of saxitoxin sites in the rat and turtle CNS. J Comp Neurol, 330: 363-380, 1993.73. Jiang C and Haddad GG. Short periods of hypoxia activate a K+ current in central neurons. Brain Res, 64: 352-356, 1993.74. Kwei S, Jiang C, and Haddad GG. Acute anoxia-induced alterations in MAP2 immunoreactivity and neuronal morphology in rat hippocampus. Brain Res, 620: 203-210, 1993.75. Haddad GG and Jiang C. Mechanisms of anoxia-induced depolarization in brainstem neurons: in-vitro current and voltage clamp studies in the adult rat. Brain Res, 625: 261-268, 1993.76. DAndrea L, Rosen CL, and Haddad GG. Severe hypoxemia in children with upper airway obstruction during sleep does not lead to significant changes in heart rate? Pediatr Pulm, 16: 362-369, 1993.77. Xia Y, Eisenman D, and Haddad GG. Sulfonylurea receptor expression in rat brain: Effect of chronic hypoxia during development. Pediatr Res, 34: 634-641, 1993.78. Xia Y and Haddad GG. Voltage-sensitive Na+ channels increase in number in newborn rat brain after in utero hypoxia. Brain Res, 635: 339-344, 1994.79. Friedman JE and Haddad GG. Removal of extracellular sodium prevents anoxia-induced injury in rat CA1 hippocampal neurons. Brain Res, 641: 57-64, 1994.80. Cummins TR, Xia Y, and Haddad GG. Functional properties of rat and human neocortical voltage-sensitive sodium currents. J Neurophysiol, 71(3): 1052-1064, 1994.81. Xia Y and Haddad GG. Postnatal development of voltage-sensitive Na+ channels in rat brain. J Comp Neurol, 345: 279-287, 1994.82. Narayan D, Krishnan SN, Upender M, Ravikumar TS, Mahoney MJ, Dolan TF, Teebi AS, and Haddad GG. Unusual inheritance of Primary Ciliary Dyskinesia (Kartageners Syndrome). J Med Genet, 31: 493-496, 1994.83. Jiang C and Haddad GG. A direct mechanism for sensing low oxygen levels by central neurons. Proc Nat’l Acad Sci, USA, 91: 7198-7201, 1994.84. Jiang C, Cummins TR, and Haddad GG. Membrane ionic currents and properties of freshly dissociated rat brainstem neurons. Exp Brain Res, 100: 407-420, 1994.85. Jiang C, Sigworth FJ, and Haddad GG. O2 deprivation activates an ATP-inhibitable K+ channels in substantia 22
  23. 23. nigra neurons. J Neurosci, 14: 5590-5602, 1994.86. Friedman JE and Haddad GG. Anoxia induces an increase in intracellular sodium in rat central neurons. Brain Res, 663: 329-334, 1994.87. Jiang C and Haddad GG. Oxygen deprivation inhibits a K+ channel independently of cytosolic factors in central neurons. J Physiol (London), 481.1: 15-26, 1994.88. Krishnan SN and Haddad GG. Cloning of glucose transporter-3 (GLUT 3) from rat brain, Life Sciences, 56(14): 1193-1199, 1995.89. Xia Y, Warshaw JB and Haddad GG. Chronic hypoxia causes opposite effects on glucose transporter 1 mRNA in mature versus immature rat brain. Brain Res, 675: 224-230, 1995.90. OReilly JP, Jiang C, and Haddad GG. Major differences in response to graded hypoxia between hypoglossal and neocortical neurons. Brain Res, 683: 179-186, 1995.91. Krishnan SN, Desai T, Ward DC and Haddad GG. Isolation and chromosomal localization of a human ATP- regulated potassium channel. Human Genet, 96: 155-160, 1995.92. OReilly JP and Haddad GG. Chronic hypoxia in vivo renders neocortical neurons more vulnerable to subsequent acute hypoxic stress. Brain Res, 711: 203-210, 1996.93. Bevensee MO, Cummins TR, Haddad GG, Boron WF and Boyarsky G. pH regulation in single CA1 neurons acutely isolated from the hippocampi of immature and mature rats. J Physiol (London), 494.2: 315-328, 1996.94. Marks JD, Friedman JE and Haddad GG. Vulnerability of CA1 neurons to glutamate is developmentally regulated. Dev Brain Res, 97(2): 194-206, 1996.95. Jiang C and Haddad GG. Modulation of K+ channels by intracellular ATP in human neocortical neurons. J Neurophysiol, 77: 93-102, 1997.96. Haddad GG. K+ ions and channels: Mechanisms of sensing O2 deprivation in central neurons. Kidney Intl, 51: 467-472, 1997.97. Krishnan SN, Sun Y-A, Mohsenin A, Wyman RJ and Haddad GG. Behavioral and electrophysiologic responses of Drosophila melanogaster to prolonged periods of anoxia. J Insect Physiol, 43(3): 203-210, 1997.98. Ma E and Haddad GG. Anoxia regulates gene expression in the central nervous system of Drosophila melanogaster. Mol Brain Res, 46: 325-328, 1997.99. Chidekel AS, Friedman JE and Haddad GG. Anoxia-induced neuronal injury: Role of Na+ entry and Na+- dependent transport. Exp Neurol, 146: 403-413, 1997.100. Ma E and Haddad GG. Expression and localization of Na+/H+ exchangers in rat central nervous system. Neuroscience, 79(2): 591-603, 1997.101. Haddad GG, Sun Y-A, Wyman RJ and Xu T. Genetic basis of tolerance to O2 deprivation in Drosophila melanogaster. Proc Nat’l Acad Sci, USA, 94: 10809-10812, 1997.102. OReilly J, Cummins TR and Haddad GG. Oxygen deprivation inhibits Na+ current in rat hippocampal neurones via protein Kinase C. J Physiol (London), 503.3: 479-488, 1997.103. Fung M-L and Haddad GG. Anoxic-induced depolarization in CA1 hippocampal neurons: Role of Na+- dependent mechanisms. Brain Res, 762: 97-102, 1997. 23
  24. 24. 104. Xia Y, Warshaw JB and Haddad GG. Effect of chronic hypoxia on glucose transporters in heart and skeletal muscle of immature and adult rats. Am J Physiol, 273(42): R1734-1741, 1997.105. Friedman JE, Chow EJ and Haddad GG. State of actin filaments is changed by anoxia in cultured rat neocortical neurons. Neuroscience, 82(2): 421-427, 1998.106. Chow E and Haddad GG. Differential effects of anoxia and glutamate on cultured neocortical neurons. Exp Neurol, 150: 52-59, 1998.107. Croning MDR and Haddad GG. Comparison of brain slice chamber designs for investigations of oxygen deprivation in-vitro. J Neurosci Meth, 81: 103-111, 1998.108. Banasiak KJ and Haddad GG. Hypoxia-induced Apoptosis: Effects of severity of hypoxia and role of p53 in neuronal cell death. Brain Res, 797: 295-304, 1998.109. Haddad GG. Mechanisms of anoxia tolerance. A novel approach using a Drosophila model system. Adv Exp Med Biol, 454: 273-280, 1998.110. Ma E, Xu T and Haddad GG. Gene regulation by O2 deprivation: An anoxia-regulated novel gene in Drosophila Melanogaster. Mol Brain Res, 63: 217-224, 1999.111. Yao H, Ma E, Gu XQ and Haddad GG. Intracellular pH regulation of CA1 neurons in Na+/H+ isoform 1 mutant mice. J Clin Invest, 104: 637-645, 1999.112. Liu H, Moczydlowski E and Haddad GG. O2 deprivation inhibits Ca2+ -activated K+ channels via channels via cytosolic factors in mice neocortical neurons. J Clin Invest, 104: 577-588, 1999.113. Ma E and Haddad GG. A Drosophila Cdk5α-like molecule and its possible role in response to O2 deprivation. Biochem Biophys Res Comm, 261: 459-463, 1999.114. Banasiak BJ, Cronin T and Haddad GG. bcl-2 prolongs neuronal survival in graded hypoxia. Mol Brain Res, 72: 214-225, 1999.115. Gu XQ and Haddad GG. Drosophila neurons respond differently to hypoxia and cyanide than rat neurons. Brain Res, 845(1): 6-13, 1999.116. Xia Y and Haddad GG. Effect of prolonged O2 deprivation on Na+ channels: Differential regulation in adult versus fetal rat brain. Neuroscience, 94(4): 1231-1243, 1999.117. Ma E and Haddad GG. Isolation and characterization of the hypoxia-inducible factor 1β in Drosophila melanogaster. Mol Brain Res, 73: 11-16, 1999.118. Fung M-L, Croning MDR and Haddad GG. Sodium homeostasis in hippocampal slices during oxygen and glucose deprivation: Role of voltage-sensitive sodium channels. Neurosci Lett, 5;275(1): 41-44, 1999.119. Xia Y, Fung M-L, O’Reilly J and Haddad GG. Increased neuronal excitability after long term O2 deprivation is mediated mainly by sodium channels. Mol Brain Res, 76: 211-219, 2000.120. Banasiak KJ, Xia Y and Haddad GG. Mechanisms underlying hypoxia-induced neuronal apoptosis. Prog Neurobiol, 62(3): 215-249, 2000.121. Schmitt BM, Berger UV, Douglas RM, Bevensee MO, Hediger MA, Haddad GG and Boron WF. Na/HCO3 cotransporters in rat brain: Expression in Glia, Neurons and Choroid Plexus. J Neurosci, 20(18): 6839-6848, 2000.122. Gu XQ, Yao H and Haddad GG. Effect of extracellular HCO3- on Na+ channel characteristics in hippocampal 24
  25. 25. CA1 neurons. J Neurophysiol, 84: 2477-2483, 2000.123. Zhang J, Haddad GG and Xia Y. δ-, But not μ- and κ-, opioid receptor activation protects neocortical neurons from glutamate-induced excitotoxic injury. Brain Res, 885(2): 143-153, 2000.124. Novotny EJ, Ariyan C, Mason GF, OReilly J, Haddad GG and Behar KL. Differential increase in cerebral cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitro. Brain Res, 888(2): 193-202, 2001.125. Douglas RM, Schmitt BM, Xia Y, Bevensee MO, Biemesderfer D, Boron WF and Haddad GG. Sodium- Hydrogen exchangers and Sodium-Bicarbonate transporters: Ontogeny of protein expression in the rat brain. Neuroscience, 102(1): 217-228, 2001.126. Ma E, Gu XQ,, Wu X, Xu T and Haddad GG. Mutation in pre-RNA editase markedly attenuates neuronal tolerance to O2 deprivation in Drosophila melanogaster. J Clin Invest, 107(6): 685-693, 2001.127. Douglas RM, Xu T and Haddad GG. Cell cycle progression & cell division are sensitive to hypoxia in Drosophila melanogaster embryos. Am J Physiol, 280(5): R1555-R1563, 2001.128. Gu XQ, Yao H and Haddad GG. Increased neuronal excitability and seizures in the Na+/H+ exchanger null mutant mouse. Am J Physiol, 281(2): C496-503, 2001.129. Xia Y and Haddad GG. Major difference in the expression of μ- and δ- opioid receptors between turtle and rat brain. J Comp Neurol, 436(2): 202-210, 2001.130. Gu XQ and Haddad GG. Decreased neuronal excitability in hippocampal neurons of mice exposed to cyclic hypoxia. J Appl Physiol, 91(3): 1245-1250, 2001.131. Yao H, Gu XQ, Douglas RM and Haddad GG. Role of Na+/H+ exchanger during O2 deprivation in mouse CA1 neurons. Am J Physiol, 281(4): C1205-1210, 2001.132. Haddad GG and Ma E. Neuronal tolerance to O2 deprivation in Drosophila: Novel approaches using genetic models. Neuroscientist, 7(6): 538-550, 2001.133. Chen Q-F, Ma E, Behar KL, Xu T and Haddad GG. Role of trehalose phosphate synthase in anoxia tolerance and development in Drosophila melanogaster. J Biol Chem, 277(5): 3274-3279, 2002.134. Gibney GT, Zhang J, Douglas RM, Haddad GG and Xia Y. Na+ - Ca2+ exchanger expression in the developing rat cortex. Neuroscience, 112(1): 65-73, 2002.135. Vicencio AG, Eickelberg O, Stankewich MC, Kashgarian M and Haddad GG. Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia. J Appl Physiol, 93(3): 1123-1130, 2002.136. Ma E, Tucker MC, Chen Q and Haddad GG. Developmental expression of dADAR and its enzymatic activity in Drosophila melanogaster. Brain Res Mol Brain Res, 102(1-2): 100-104, 2002.137. Xia Y, Zhao P, Xue J, Gu XQ, Sun X, Yao H and Haddad GG. Na+ channel expression and neuronal function in the Na+/H+ exchanger 1 Null Mutant Mouse. J Neurophysiol 89(1): 229-236, 2003.138. Yao H, Gun XQ and Haddad GG. The role of HCO3--dependent mechanisms in pHi regulation during O2 deprivation. Neuroscience, 117(1): 29-35, 2003.139. Lai JCK, White BK, Buerstatte CR, Haddad GG, Novotny Jr. EJ and Behar KL. Chronic hypoxia in development selectively alters the activities of key enzymes of glucose oxidative metabolism in brain regions. Neurochem Res, 28(6): 933-940, 2003. 25
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  27. 27. 157. Haddad, GG. Tolerance to low O2: Lessons from invertebrate genetic models. Exper Physiol. 91(2):277-82, 2006.158. Kanaan A, Farahani R, Douglas RM, LaManna JC and Haddad GG. Effect of chronic continuous or intermittent hypoxia and re-oxygenation on cerebral capillary density and myelination. Am J Physiol Regul Integr Comp Physiol. 290(4):R1105-14, 2006.159. Douglas RM, Lai JCK, Bian S, Cummins L, Moczydlowski E, and Haddad GG. The Calcium-Sensitive Potassium Channel (BK/Maxi K) is present in the Inner Mitochondrial Membrane of Rat Brain. Neuroscience, 139(4):1249-61, 2006.160. Li G, Vicencio AG, Ryu J, Zhou D, Xue J, Kanaan A, Gavrialov O and Haddad GG. Effect of Carbon Dioxide on Neonatal Mouse Lung: A Genomic Approach. J Appl Physiol 101(6):1556-64, 2006.161. Iacobas DA, Fan C, Iacobas S, Spray DC, and Haddad GG. Transcriptomic changes in developing kidney exposed to chronic hypoxia. Biochem Biophys Res Commun, 13;349(1):329-38, 2006.162. Sun X, Zhou D, Zhang P, Moczydlowski E, Haddad GG. Beta-Subunit-Dependent Modulation of Hslo BK Current by Arachidonic Acid. J Neurophysiol, 97(1):62-9, 2007.163. Yao H, Shu Y, Wang J, Brinkman BC, and Haddad GG. Factors influencing cell fate in the infarct rim .J Neurochemistry, 100(5):1224-33, 2007.164. Douglas R, Miyasaka N, Takahashi K, Latuszek-Barrantes A, Haddad GG, and Hetherington H. Chronic intermittent but not constant hypoxia decreases NAA/Cr ratios in mouse hippocampus. Am J Physiol Regul Integr Comp Physiol, 292(3):R1254-9, 2007.165. Gu XQ, Kanaan A, Yao H, and Haddad GG. Chronic high inspired CO2 decreases excitability of mouse hippocampal neurons. J Neurophysiol, 97(2):1833-8, 2007.166. Huang H and Haddad GG. The Drosophila dMRP4 regulates responsiveness to O2 deprivation and development under hypoxia. Physiol Genomics, 29(3):260-6, 2007.167. Scafidi S, Douglas RM, Farahani R, Banasiak KJ and Haddad GG. Prostaglandin transporter expression in mouse brain during development and in response to hypoxia. Neuroscience, 146(3):1150-7, 2007.168. Gu XQ, Siemen D, Parvez S, Cheng Y, Xue J, Zhou D, Sun X, Jonas EA and Haddad GG. Hypoxia increases BK channel activity in the inner mitochondrial membrane, Biochem Biophys Res Commun, 358(1):311-6, 2007.169. Xue J, Zhou D, Yao H, Gavrialov O, McConnell MJ, Gelb BD and Haddad GG. Novel functional interaction between Na+/H+ exchanger 1 and tyrosine phosphatase SHP-2. Am J Physiol Regul Integr Comp Physiol, 292(6):R2406-16, 2007.170. Zhou D, Xue J, Chen J, Morcillo P, Lambert JD, White KP and Haddad GG. Experimental selection for Drosophila survival in extremely low O2 environments. PLOS One, 2(5) e490, 2007.171. Yao H, Sun X, Gu X, Wang J and Haddad GG. Cell death in the ischemic infarct rim. J Neurochemistry, 103(4):1644-53, 2007.172. Chen LM, Choi I, Haddad GG, Boron WF. Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain. Am J Physiol Regul Integr Comp Physiol. 293(6):R2412-20, 2007.173. Kanaan A, Douglas RM, Alper SA, Boron WF and Haddad GG. Effect of chronic elevated carbon dioxide on 27
  28. 28. the expression of acid-base transporters in the neonatal and adult mouse. Am J Physiol Regul Integr Comp Physiol, 293(3):R1294-302, 2007.174. Xue J, Zhou D, Yao H, Haddad GG. Role of transporters and ion channels in neuronal injury under hypoxia. Am J Physiol Regul Integr Comp Physiol. 294(2):R2451-7, 2008.175. Sun X, Yao H, Zhou D, Gu X, Haddad GG. Modulation of hSlo BK current inactivation by fatty acid esters of CoA. J Neurochemistry, 104(5):1394-403, 2008.176. Zhou D, Wang J, Zapala MA, Xue J, Schork NJ, Haddad GG. Gene expression in mouse brain following chronic hypoxia: role of sarcospan in glial cell death. Physiol Genomics, 32(3):370-9, 2008.177. Ruffin VA, Gu XQ, Zhou D, Douglas RM, Sun X, Trouth CO, Haddad GG. The sodium-activated potassium channel Slack is modulated by hypercapnia and acidosis. Neuroscience, 151(2):410-8, 2008.178. Alejandre-Alcazar MA, Michiels-Corsten M, Vicencio AG, Reiss I, Ryu J, de Krijger RR, Haddad GG, Tibboel D, Seeger W, Eickelberg O, Morty RE. TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. Dev Dyn., 237(1):259-69, 2008.179. Farahani R., Kanaan A, Gavrialov O, Brunnert S, Douglas R, Morcillo P, and Haddad GG. Differential effects of chronic intermittent and constant hypoxia on postnatal growth and development. Pediatric Pulmonology, 43(1):20-8, 2008.180. Ruis J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M.. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature, 453(7196):807-11, 2008.181. Iacobas DA, Fan C, Iacobas S, Haddad GG. Integrated transcriptomic response to cardiac chronic hypoxia: translation regulators and response to stress in cell survival. Funct Integr Genomics, 8(3):265-275, 2008.182. Cheng Y, Gu XQ, Bednarczyk P, Wiedemann FR, Haddad GG, Siemen D. Hypoxia increases activity of the BK-channel in the inner mitochondrial membrane and reduces activity of the permeability transition pore. Cell Physiol Biochem. 22(1-4):127-136, 2008.183. Chen LM, Haddad GG, Boron WF. Effects of chronic continuous hypoxia on the expression of SLC4A8 (NDCBE) in neonatal versus adult mouse brain. Brain Res. 1238:85-92, 2008.184. Zhou D, Xue J, Lai JC, Schork NJ, White KP, Haddad GG. Mechanisms Underlying Hypoxia Tolerance in Drosophila melanogaster: hairy as a metabolic switch. PLoS Genet. 4(10):e1000221, 2008.185. Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckhardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS. Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell. 133(2):223-234, 2008.186. Yao H, Felfly H, Wang J, Zhou D, Haddad GG. DIDS protects against neuronal injury by blocking Toll-like receptor 2 activated-mechanisms. J of Neurochem. 108(3):835-846, 2009.187. Azad P, Zhou D, Russo E, Haddad GG. Distinct Mechanisms Underlying Tolerance to Intermittent and Constant Hypoxia in Drosophila melanogaster. PLosOne 4(4):e5371, 2009.188. Zhou D, Visk DW, Haddad GG. Drosophila, a golden bug, for the dissection of the genetic basis of tolerance and susceptibility to hypoxia. Pediatr Res. 66(3):239-247, 2009.189. Guma M, Rius J, Duong-Polk KX, Haddad GG, Lindsey JD, Karin M. Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. Proc Natl Acad Sci U S A. 106(21):8760-8765, 2009. 28
  29. 29. 190. Feala JD, Coquin L, Zhou D, Haddad GG, Paternostro G, McCulloch AD. Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis. BMC Syst Biol. 2009 Sep 9;3:91.191. Sun X, Yao H, Wang J, Haddad GG. Insulin/PI3K signaling protects dentate neurons from oxygen-glucose deprivation in organotypic hippocampal slice cultures. J. Neurochem. 2009 Oct 26.192. Iacobas DA, Iacobas S, Haddad, GG. Heart rhythm genomic fabric in hypoxia. In Press, Biochem Biophys Res Commun. 2009. Original Manuscripts in Revision or Submitted193. Gu XQ, Ma E and Haddad GG. The role of pre-mRNA editing on Na+ channel function in Drosophila melanogaster.194. Robert M. Douglas, Amjad Kanaan, Maria del Carmen Rivero, Laura L. Dugan, Gabriel G. Haddad, Sameh S. Ali . Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction.195. Huiwen W. Zhao, Dan Zhou, Victor Nizet, Steven A.Wasserman, and Gabriel G. Haddad . Decreased JNK phosphorylation protects against oxidant–induced death in Drosophila melanogaster.196. Julie Ryu, Gregory P. Heldt, Mary Nguyen, Orit Gavrialov, Gabriel G. Haddad. Chronic hypercapnia alters lung function through changes in matrix composition in mouse pups. Reviews and Chapters197. Epstein RA, Haddad GG, Epstein RA, Epstein MAF, Mazza NM, Law HS, Katz JS, and Mellins RB. Breath- to-breath control of ventilation in normal infants during sleep. In: Regulation of Respiration during Sleep and Anesthesia. Edited by RS Fitzgerald, H Gautier, and S Lahiri. Plenum Press, New York, pp. 85-92, 1978.198. Haddad GG, Leistner HL, Epstein RA, Epstein MAF, and Mellins RB. Abnormal cardio- respiratory function in infants with aborted Sudden Infant Death Syndrome during sleep. International Symposium on Fetal and Neonatal Physiologic Measurements, Oxford. Pitman Medical Limited, pp. 188-193, 1980.199. Mellins RB and Haddad GG. Sudden Infant Death Syndrome. In: Nelson Textbook of Pediatrics, 12th Edition. Saunders, PA, pp. 1770-1773, 1983.200. Haddad GG and Mellins RB. Cardiorespiratory aspects of SIDS: In: An overview in Sudden Infant Death Syndrome. Edited by JT Tildon, LN Roeder and A Steinschneider. Academic Press, New York, pp. 357-374, 1983.201. Haddad GG, Schaeffer JI, and Bazzy AR. Postnatal maturation of the ventilatory response to hypoxia. In: Hypoxia, Exercise and Altitude. Alan R. Liss Inc., New York, pp. 39-50, 1983.202. Mellins RB and Haddad GG. Respiratory control in early life: An overview. In: Hypoxia, Exercise and Altitude. Alan R. Liss Inc., New York, pp. 3-15, 1983.203. Mellins RB and Haddad GG. Cardiorespiratory control in Sudden Infant Death Syndrome. In: Hypoxia, Exercise and Altitude. Alan R. Liss Inc., New York, pp. 51-56, 1983.204. Haddad GG and Mellins RB. Hypoxia and respiratory control in early life. Annu Rev Physiol, 46: 629-643, 29
  30. 30. 1984.205. Haddad GG. Control of Breathing in Children. In: Contemporary Issues in Pulmonary Disease. Edited by NH Edelman and T Santiago. Churchill Livingstone Inc., pp. 57-80, 1986.206. Haddad GG and Akabas SR. Adaptation of respiratory muscles to acute and chronic stress: Considerations on energy and fuels. Clin Chest Med 7: 79-89, 1986.207. Haddad GG, Bazzy AR, and Pang LM. Response of respiratory muscles to acute loading in adult sheep. In: Respiratory Muscles and their Neuromotor Control. Edited by GC Sieck, SC Gandevia and WE Cameron. Alan R. Liss, New York, pp. 307-316, 1987.208. Mellins RB and Haddad GG. Sudden Infant Death Syndrome. In: Nelson Textbook of Pediatrics 13th Edition. Saunders, PA, pp. 1480-1482, 1987.209. Haddad GG and Donnelly DF. Chemo-baroreceptors - brainstem interactions: critical role in early life. In: Sudden Infant Death Syndrome: Cardiorespiratory mechanisms and interventions. New York Academy of Sciences, pp. 221-227, 1988.210. Haddad GG. Failure of the respiratory neuromuscular pump in awake sheep. In: Sudden Infant Death Syndrome: Risk factors and basic mechanisms. Section 4, Respiratory Control. Edited by RM Harper and HJ Hoffman. PMA Publ. Co., New York, pp. 379-386, 1988.211. O’Brodovich HM and Haddad GG. The functional basis for pulmonary pathology, In: Kendigs 5th edition, Disorders of the Respiratory Tract in Children. Edited by V Chernick. WB Saunders, PA, pp. 3-47, 1990.212. Dekin MS and Haddad GG. Membrane and cellular properties in oscillating networks: implications for respiration. In: J Appl Physiol, invited article, 69: 809-821, 1990.213. Haddad GG and Bazzy AR. Respiratory muscle function: Implications for ventilatory failure. In: Basic Mechanisms of Pediatric Respiratory Disease: Cellular and Integrative, Section III. Edited by V Chernick and RB Mellins. B.C. Decker, Inc,, Philadelphia, PA, pp. 100-113, 1991.214. Haddad GG. Cellular and membrane properties of brainstem neurons in early life. In: Developmental Neurobiology of breathing. Lung Biology in Health and Disease, Vol. 53. Edited by GG Haddad and J Farber. New York, Marcel Dekker, pp. 155-175, 1991.215. Haddad GG and Rosen CL. Ventilatory response to hypoxia: Integrated, cellular and molecular aspects. In: Developmental Neurobiology of breathing. Lung Biology in Health and Disease, Vol. 53. Edited by GG Haddad and J Farber. Marcel Dekker, New York, pp. 591-614, 1991.216. Donnelly DF and Haddad GG. Carotid chemotransduction: Mechanisms & development. Symposium on Sleep and Cardio Respiratory Control. John Libbey Eurotext Limited, France, 217: 35-43, 1991.217. Haddad GG and Pérez-Fontán J Julio. The Respiratory System. In: Nelson Textbook of Pediatrics. Edited by Behrman and Vaughan. Saunders, PA, 15th Edition, pp. 1035-1045, 1992.218. Haddad GG. The multi-faceted sudden infant death syndrome: Controversies and Hope. Curr Opin Pediatr, invited article, 4(3): 426-430, 1992.219. Haddad GG and Jiang C. Neuronal membrane properties during O2 deprivation: In vitro intracellular studies. In: Respiratory Control: Peripheral and Central Mechanisms. Edited by D Speck, M Dekin, Revelette WR and D Frazier. pp. 12-14, 1993.220. Haddad GG and Jiang C. O2 deprivation in the central nervous system: On mechanisms of neuronal response, differential sensitivity and injury. Prog Neurobiol, 40: 277-318, 1993.221. Haddad GG, Donnelly DF, and Bazzy AR. Developmental Control of Respiration: Neurobiological Basis. In: 30
  31. 31. Regulation of breathing. Lung Biology in Health and Disease. Edited by JA Dempsey and AI Pack. New York, Marcel Dekker, (Vol. 79) pp. 743-785, 1994.222. Haddad GG and Jiang C. Mechanisms of neuronal survival during hypoxia: ATP-sensitive K+ channels. Biol of Neonate, 65: 160-165, 1994.223. Haddad GG. Response of Brainstem & Cortical Neurons to O2 Deprivation. In: Ventral Brainstem Mechanisms and Control of Respiration and Blood Pressure. Edited by O Trouth. New York, Marcel Dekker, (Vol. 82) pp. 639-651, 1995.224. Haddad GG. Developmental and Pathophysiologic Aspects of respiratory control. In: Ventral Brainstem Mechanisms and Control of Respiration and Blood Pressure. Edited by O Trouth. Marcel Dekker, New York, (Vol. 82) pp. 695-700, 1995.225. Haddad GG. O2 deprivation in tolerant & non-tolerant organisms: Phylogeny and ontogeny. In: Tissue Oxygen: Developmental, Molecular & Integrated Function. Edited by Gabriel G. Haddad and George Lister. Marcel Dekker, New York, Vol. 95, pp. 573-594, 1996.226. Haddad GG. Membrane proteins and transport during O2 deprivation. In: Tissue Oxygen: Developmental, Molecular & Integrated Function. Edited by Gabriel G. Haddad and George Lister. Marcel Dekker, New York, Vol. 95, pp. 81-99, 1996.227. Haddad GG and Pérez-Fontán J Julio. Development of the Respiratory System. In: Nelson Textbook of Pediatrics. Edited by Behrman, Kliegman and Arvin. Saunders, PA, 15th Edition, pp. 1165-1167, 1996.228. Haddad GG. Regulation of Respiration. In: Nelson Textbook of Pediatrics. Edited by Behrman, Kliegman and Arvin. Saunders, PA, 15th Edition, pp. 1167-1170, 1996.229. Haddad GG and Pérez-Fontán J Julio. Respiratory Function and Approach to Respiratory Disease. In: Nelson Textbook of Pediatrics. Edited by Behrman, Kliegman and Arvin. Saunders, PA, 15th Edition, pp. 1170-1177, 1996.230. Haddad GG and Pérez-Fontán J Julio. Respiratory Failure. In: Nelson Textbook of Pediatrics. Edited by Behrman, et al,. Saunders, PA, 15th Edition, pp. 1177-1180, 1996.231. Haddad GG and Pérez-Fontán J Julio. Defense Mechanisms and Metabolic Functions of the Lung. In: Nelson Textbook of Pediatrics. Edited by Behrman, et al. Saunders, PA, 15th Edition, pp. 1180-1181, 1996.232. Rosen CL and Haddad GG. Obstructive sleep apnea and hypoventilation in children. In: Nelson Textbook of Pediatrics. Edited by Behrman, Kliegman and Arvin. Saunders, PA, 15th Edition, pp. 1195-1197, 1996.233. Haddad GG. Central hypoventilation syndromes. In: Nelson Textbook of Pediatrics. Edited by Behrman, Kliegman and Arvin. Saunders, PA, 15th Edition, pp. 1260-1261, 1996.234. Haddad GG. O2-sensing in neurons: direct and indirect modulation of ion channels. International Workshop on Oxygen Regulation of Ion Channels and Gene Expression. Madrid, Spain, pg. 55, 1996.235. Haddad GG and Jiang C. O2-sensing mechanisms in excitable cells: Role of plasma membrane K+ channels. Annu Rev Physiol, Invited article, 59: 23-43, 1997.236. Donnelly DF and Haddad GG. Possible role of neuroepithelial bodies as airway chemoreceptors. In: Cellular and Molecular Biology of Airway Chemoreceptors. Medical Intelligence Unit, Molecular Biology Series. Edited by E. Cutz. R.G. Landes Co., Austin, TX, pp. 35-45, 1997.237. Haddad GG. Oxygen sensing in neurons: Direct and indirect modulation of ion channels. In: Oxygen Regulation of Ion Channels and Gene Expression. Edited by J Lopez-Barneo and EK Weir. Futura Publishing Co., Armonk, NY, pp. 285-293, 1998. 31

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