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Transhumanism pdf


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Transhumanism pdf

  1. 1. Transhumanism
  2. 2. Transhumanism is strivingtowards extending human abilities with the help of new technologies
  3. 3. The main human right,remand and desire is life
  4. 4. Research directions Fighting aging Regenerative medicine Artificial organs Therapeutic cloning Longevity viruses Cryonics Neuromodeling and mind uploading Artificial Intelligence
  5. 5. Fighting aging Robert Shmookler Reis Maria Blasco Alexei Moskalev extended lifespan of inscreased mouse lifespan increased drosophila a nematode 10-fold via by inserting a virus vector lifespan by activating a mutation in the age-1 gene carrying telomerase gene GADD45 gene
  6. 6. Potential geroprotectors Metformin 4-phenylbutyrate Melatonin Gymnemoside Resveratrol Cycloastragenol Lipoic acid Quercetin 2-deoxy-D-glucose Curcumin Carnosine Spermidine Animoguanidine Thioflavin T Fisetin Kempferol Hydroxycitrate Rapamycin
  7. 7. The main goal of Biology of aging isdevelopment of Diagnostic platform for curing aging !Insulin/IGF-1 signaling: !IGF1, IGF1R, IGF-BP7, insulin, Ins-R, ILP agonissts, IRS-1, -2, AKT/PKB, PDK, PI3KI p110α, class-I PI3Kc.s., PTEN, SHIP1, SHIP2, FOXO, FOXO1, FOXO3A, PEPCK, KlothoTGF- ß signaling:!Receptor TGF-ß, SMAD1, SMAD2 MAPK stress signaling: !MAPK, p38MAPK, MEK1, MEK2, ERK1, ERK2, GSK3α, ß, small GTPases (e.g.RAS), SAPK/JNKMitochondrial ROS Generation: !p66Shc, CLK-1, UCP-1, -2, -3Antioxidant Defenses:!SKN1, p53, Mn-SOD, Cu/Zn SOD, catalases 1, 2, 3, GST-A4-4, other GSTs, VDAC1, VDAC3,Carbonylated proteins, 4HNE-modified proteinsNutrient Sensing/Response:!SIRT1, HDAC1, 3, 4, AMPK (α, ß subunits), mTOR, RSK3/S6 protein kinase, PHA-4/FOXAProtein Synthesis and Turnover:!Ribosomal proteins (S6), eIF4E, eIF4G, eIF4E-BP, Proteasome 20S C2 , Ubiquitin ubiq-proteins
  8. 8. Rapamycin extends lifespan in old mice by 14% Rapamycin blocks the activity of mTOR pathway. This leads to supression of cell growth and proliferation, autophagy activation and slowing down aging Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Harrison et al. Nature. 2009 Jul 16;460(7253):392-5.
  9. 9. Regenerative medicine Tissue-engineered Skin grown using the bladder pateint s own cells
  10. 10. Our achievements in Russia 3 successful transplantations of tissue-engineered tracheas grown using the patient s own cells on a scaffold Paolo Macchiarini, Karolinska Institute, Sweden and Vladimir Porkhanov, 1st Krasnodar Regional Hospital
  11. 11. Therapeutic cloning
  12. 12. Artificial organs Artificial AbioCor heart is equipped with an accumulator. It allows patients to be autonomous for several hours
  13. 13. Longevity viruses Longevity genes: IGF1 (tissue-specific), redox regulating genes: САТ, TXN, MSRA, SOD2, SOD1,GADD45, regulators of epigenetic state and transcription: DNMT2, FOXO3, heat shock proteins: HSPA1A, HSPA1B, other genes: PCMT1, SIRT1, PCK1, PLAU
  14. 14. Cryonics Brain Whole bodycryopreservation cropreservation
  15. 15. Neuromodeling and mind uploading Computer model of Brain scanning nematode C.elegans
  16. 16. Artificial Intelligence IBM Watson algorythm defeated the two greatestchampions of the Jeopardy show on December 14, 2011
  17. 17. Transhumanism is ethical choice Transhumanism is call to action Transhumanism is goal priority Transhumanism is rational behaviour Transhumanism is the future of the humanity
  18. 18. Main problems of transhumanism
  19. 19. Negligible financing oftranshumanist projects
  20. 20. 10 scientists need $ 60 000 000 minimum, but better $2 500 000 000 However, there is only $5 000 000 available No matter what organizational solution you use, no good results can be reached
  21. 21. Causes Conservatism Belief in afterlife Complexity of science Political focus on the momentaryinterests of voters Taboo on discussions about death
  22. 22. There are few transhumanism leaders in the world Ray Kurzweil Eliezer Yudkowsky Max Moore Mikhail Batin
  23. 23. Priority choice VS. Making sure the Fighting aging Artificial Intelligence is friendly
  24. 24. Fear of the scientists not to get agrant if they explicitly support radical life extension
  25. 25. Transhumanism critique «Let s not talk about immortality and lifeextnsion, but let s talk about healthy aging andfighting age-related diseases» «There will be overpopulation» «Everything is too complicated»
  26. 26. The most stupid generation
  27. 27. What s the solution?
  28. 28. Join the existing transhumanist projects Paolo Macchiarini - Aubrey de Grey - Igor Artyukhov - brain transplant removing damage cryonics Randal Koene - Craig Venter - Dean Kamen - mind uploading synthetic biology cyborgization
  29. 29. Human life extension Sebastian Zeung - Anthony Atala - research program human connectome engineering liver, kidney and other organs ben Goertzel - Gregory Fahy - Gabor Forgacs - AI development improving cryopresesrvation 3D bioprinting methods