Transhumanism

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Transhumanism presentation was created to support the talk by Maria Konovalenko at the NMR meeting during the Estonian Magnet Week in Tallinn.
This presentation may be used a s a brief introduction to the idealogy of transhumanism that sees life being the ultimate value and seeks extending human abilities using modern technologies.

ONe of the ideas of the presentation is to show that regardless of how the existing funding of scientific research is distributed among the scientists, it is still not enough and it won't be enough unless there's a strong ideology behind scientific research. There has to be a social mandate for what the scientists are doing, only then there will be enough money. In order to form this socila mandate , the researchers have to openly talk to the public and the politicians via the media and explain clearly why their work is so much important and why it needs increased funding.

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Transhumanism

  1. 1. Transhumanism
  2. 2. Transhumanism is strivingtowards extending human abilities with the help of new technologies
  3. 3. The main human right,remand and desire is life
  4. 4. Research directions• Fighting aging• Regenerative medicine• Artificial organs• Therapeutic cloning• Longevity viruses• Cryonics• Neuromodeling and mind uploading• Artificial Intelligence
  5. 5. Fighting agingRobert Shmookler Reis Maria Blasco Alexei Moskalev extended lifespan of inscreased mouse lifespan increased drosophila a nematode 10-fold via by inserting a virus vector lifespan by activatinga mutation in the age-1 gene carrying telomerase gene GADD45 gene
  6. 6. Potential geroprotectorsMetformin 4-phenylbutyrateMelatonin GymnemosideResveratrol CycloastragenolLipoic acid Quercetin2-deoxy-D-glucose CurcuminCarnosine SpermidineAnimoguanidine Thioflavin TFisetin KempferolHydroxycitrate Rapamycin
  7. 7. The main goal of Biology of aging isdevelopment of Diagnostic platform for curing agingInsulin/IGF-1 signaling:IGF1, IGF1R, IGF-BP7, insulin, Ins-R, ILP agonissts, IRS-1, -2, AKT/PKB, PDK, PI3KI p110 α, class-I PI3Kc.s., PTEN, SHIP1, SHIP2, FOXO, FOXO1, FOXO3A, PEPCK, KlothoTGF- ß signaling:Receptor TGF-ß, SMAD1, SMAD2MAPK stress signaling:MAPK, p38MAPK, MEK1, MEK2, ERK1, ERK2, GSK3α, ß, small GTPases (e.g.RAS), SAPK/JNKMitochondrial ROS Generation:p66Shc, CLK-1, UCP-1, -2, -3Antioxidant Defenses:SKN1, p53, Mn-SOD, Cu/Zn SOD, catalases 1, 2, 3, GST-A4-4, other GSTs, VDAC1, VDAC3, Carbonylatedproteins, 4HNE-modified proteinsNutrient Sensing/Response:SIRT1, HDAC1, 3, 4, AMPK (α, ß subunits), mTOR, RSK3/S6 protein kinase, PHA-4/FOXAProtein Synthesis and Turnover:Ribosomal proteins (S6), eIF4E, eIF4G, eIF4E-BP, Proteasome 20S C2 , Ubiquitin & ubiq-proteins
  8. 8. Rapamycin extends lifespan in old mice by 14% Rapamycin blocks the activity of mTOR pathway. This leads to supression of cell growth and proliferation, autophagy activation and slowing down agingRapamycin fed late in life extends lifespan in genetically heterogeneous mice. Harrison et al. Nature. 2009 Jul 16;460(7253):392-5.
  9. 9. Regenerative medicineTissue-engineered Skin grown using the bladder pateint’s own cells
  10. 10. Our achievements in Russia 3 successful transplantations of tissue-engineered tracheas grown using the patient’s own cells on a scaffold Paolo Macchiarini, Karolinska Institute, Sweden and Vladimir Porkhanov, 1st Krasnodar Regional Hospital
  11. 11. Therapeutic cloning
  12. 12. Artificial organsArtificial AbioCor heart is equipped with an accumulator. It allows patients to be autonomous for several hours
  13. 13. Longevity virusesLongevity genes: IGF1 (tissue-specific), redox regulating genes: САТ, TXN, MSRA, SOD2, SOD1,GADD45, regulators of epigenetic state and transcription: DNMT2, FOXO3, heat shock proteins: HSPA1A, HSPA1B, other genes: PCMT1, SIRT1, PCK1, PLAU
  14. 14. Cryonics Brain Whole bodycryopreservation cropreservation
  15. 15. Neuromodeling and mind uploadingComputer model of Brain scanningnematode C.elegans
  16. 16. Artificial Intelligence IBM Watson algorythm defeated the two greatestchampions of the Jeopardy show on December 14, 2011
  17. 17. Transhumanism is ethical choiceTranshumanism is call to actionTranshumanism is goal priorityTranshumanism is rational behaviourTranshumanism is the future of the humanity
  18. 18. Main problems of transhumanism
  19. 19. Negligible financing oftranshumanist projects
  20. 20. 10 scientists need $ 60 000 000 minimum, but better $2 500 000 000 However, there is only $5 000 000 availableNo matter what organizational solution you use, no good results can be reached
  21. 21. CausesConservatismBelief in afterlifeComplexity of sciencePolitical focus on the momentaryinterests of votersTaboo on discussions about death
  22. 22. There are few transhumanism leaders in the world Ray Kurzweil Eliezer Yudkowsky Max Moore Mikhail Batin
  23. 23. Priority choice VS. Making sure the Fighting agingArtificial Intelligence is friendly
  24. 24. Fear of the scientists not to get agrant if they explicitly support radical life extension
  25. 25. Transhumanism critique«Let’s not talk about immortality and lifeextnsion, but let’s talk about healthy aging andfighting age-related diseases»«There will be overpopulation»«Everything is too complicated»
  26. 26. The most stupid generation
  27. 27. What’s the solution?
  28. 28. Join the existing transhumanist projectsPaolo Macchiarini - Aubrey de Grey - Igor Artyukhov - brain transplant removing damage cryonics Randal Koene - Craig Venter - Dean Kamen - mind uploading synthetic biology cyborgization
  29. 29. Human life extension Sebastian Zeung - Anthony Atala - research program human connectome engineering liver, kidney and other organs ben Goertzel - Gregory Fahy - Gabor Forgacs - AI development improving cryopresesrvation 3D bioprinting methods

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