Table 1 : Adult propofol models
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Table 4: Predictive performance of commonly used                                            Infusion                      ...
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Farmakokinetyka TCI

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Farmakokinetyka TCI

  1. 1. Table 1 : Adult propofol models Marsh42 Schnider45 General 70 kg General model 70 kg, model (LMB calculated using weight, male height height, gender) 170 cm MODÈLES V1 V2 0.228 L/kg 0.463 L/kg 15.9 L 32.4 L 4.27 L 18.9–0.391 x (age–53) L 4.27 L 24.0 L PHARMACOCINÉTIQUES V3 2.893 L/kg 202.0 L 238 L 238 L K10(min-1) 0.119 0.119 0.443 + 0.0107 x 5 (weight– 0.384 77) – 0.0159 x (LMB–59) + 0.0062 x (height–177) K12(min-1) 0.112 0.112 0.302 – 0.0056 x (age–53) 0.375 G. Janvier K13(min-1) 0.042 0.042 0.196 0.196 K21(min-1) 0.055 0.055 [1.29-0.024 x (age–53)] / 0.067 [18.9 – 0.391 x (age–53)] Service d’Anesthésie Réanimation II, CHU de Bordeaux, K31 (min-1) 0.0033 0.0033 0.0035 0.004 Groupe Hospitalier Sud, 33604 Pessac cedex Keo(min-1) 0.26123 0.26 0.456 0.456 15/02/2008 TTPE (min) 4.5124 4.5 1.69 1.69 Table 2: Paediatric propofol models Table 3: Other models Paedfusor49† Kataria48 Model 20 kg patient Model 20 kg patient Remifentanil (Minto)53 V1 0.458 L/kg 9.2 L 0.52 L/kg 10.4 L Vc (L) 5.1 - 0.0201 x (age-40) + 0.072 x (LMB - 55) V2 1.34 L/kg 26.8 L 1.0 L/kg 20 L V2 (L) 9.82 - 0.0811 x (age-40) + 0.108 x (LMB - 55) V3 8.20 L/kg 163.9 L 8.2 L/kg 164 L V3 (L) 5.42 K10(min-1) 70 x Weight-0.3/ 0.062 0.066 0.066 K10 (min-1) [(2.6 - 0.0162 x (age-40) + 0.0191 x (LMB - 458.4 55)] / Vc K12(min-1) 0.12 0.12 0.113 0.113 K12 (min-1) [(2.05 - 0.0301 x (age-40)] / Vc K13(min-1) 0.034 0.034 0.051 0.051 K13 (min-1) [0.076 - 0.00113 x (age-40)] / Vc K21(min-1) 0.041 0.041 0.059 0.059 K21 (min-1) K12 x Vc / V2 K31 (min-1) K13 x Vc / V3 K31(min-1) 0.0019 0.0019 0.0032 0.0032 Keo (min-1) 0.595 - 0.007 x (age-40) †. This model applies to children < 16 years old Table 3: Other models Table 3:Other models Alfentanil Fentanyl (Maitre)63 (Shafer)28 Sufentanil Sufentanil (Bovill)56 (Gepts)55 Vc (L) Male: 0.111 L/kg 6.09 Female: 1.15 x 0.111 L/kg Vc (L) 0.164 L/kg 14.3 V2 (L) 12.0 28.1 V2 (L) 0.359 L/kg 63.4 V3 (L) 10.5 228 V3 (L) 1.263 L/kg 251.9 K10 (min-1) Age <= 40 years: 0.356 / Vc 0.083 K10 (min-1) 0.089 0.0645 Age < 40: 0.356 – [0.00269 x (age-40)] / Vc K12 (min-1) 0.35 0.1086 K12 (min-1) 0.104 0.4713 K13 (min-1) 0.017 0.22496 K13 (min-1) 0.077 0.0229 K21 (min-1) 0.067 0.1021 K21 (min-1) 0.16 0.0245 K31 (min-1) Age <= 40 years: 0.0126 0.00601 K31 (min-1) 0.01 0.0013 Age < 40: 0.0126 –0.000113 x (age-40) Keo (min-1) 0.12 0.112 Keo (min-1) 0.77 (125) 0.147 (125) 1
  2. 2. Table 4: Predictive performance of commonly used Infusion Propofol / Propofol / Propofol / duration afentanil sufentanil remifentanil pharmacokinetic models (min) (µg/ml; ng/ml) (µg/ml; ng/ml) (µg/ml; ng/ml) Drug Propofol Remifentanil Sufentanil Afentanil 15 Coptimal 3.25 / 99.3 3.57 / 0.17 2.57 / 4.70 Cawakening 1.69 / 65.0 1.70 / 0.10 1.83 / 1.93 Model Marsh42 Paedfusor49 Minto53 Gepts55 Maitre63 Time to awakening 8.2 9.4 5.1 (min) Investigating Coetzee98 Swinhoe Absalom49 Mertens102 Barvais103 Maitre63 60 Coptimal 3.38 / 89.7 3.34 / 0.14 2.51 / 4.78 99 author Cawakening 1.70 / 64.9 1.70 / 0.10 1.83 / 1.93 Time to awakening 12.2 11.9 6.1 MDPE (%) (min) (Médiane des -7.0 16.2 4.1 -15 -22.9 -7.9 Prediction Error) 300 Coptimal 3.40 / 88.9 3.37 / 0.14 2.51 / 4.78 MDAPE (%) Cawakening 1.70 / 64.9 1.70 / 0.10 1.86 / 1.88 (Médiane des Time to awakening 16.0 15.6 6.7 valeurs absolues 18.2 24.1 9.7 20 29.0 22.3 (min) des Prediction Error) Propofol/opioid combinations estimated by Vuyk et al to be associated with the fastest recovery Wobble (%) from anaesthesia. (Cohésion) 10.0 21.9 8.3 16 - - Coptimal represents combinations associated with a 50% probability of a response to surgical stimuli; Cawakening concentrations represent the estimated concentrations at which consciousness Divergence (%) will be regained and Times to awakening represent the estimated time from termination of the (Divergence) 6.5 -7.6 - 5 - - infusion to return of consciousness in 50% of patients. (From Vuyk157) Predicted blood propofol concentrations after a 120 min infusion Context-sensitive half-times after propofol infusions of various of propofol 4 mg kg1 h1 into a 20 kg child aged 5 yr. lengths into a 20 kg child aged 5 yr. Four pharmacokinetic models are compared. Plots represent, from top to bottom: Plots represent, from bottom to top: Marsh and Gepts Diprifusor model, mostly Marsh and Gepts Diprifusor model, mostly based on adult data; Rigby-Jones model, based on adult data ; Rigby-Jones model, paediatric, postcardiac surgery ; Paedfusor postcardiac surgery; Paedfusor and Schuttler. Thick solid line shows pooled analysis and Schuttler. Thick solid line shows pooled analysis including data from healthy including data from healthy children. children. Sneyd J.R., BJA 2004; 93: 725-36 Sneyd J.R., BJA 2004; 93: 725-36 2

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