Gastric cancer: epidemiology
Almost one million new cases of stomach cancer estimated to have
occurred in 2012 (952,000 cases, 7% of the total), the fifth most
common malignancy in the world, after the lung, breast, colorectum
Globocan IARC 2012
Third leading cause of cancer death in both sexes worldwide (723,000 deaths,
9% of the total). Highest estimated mortality rates in Eastern Asia (24 per
100,000 in men, 9.8 per 100,000 in women), lowest in Northern America (2.8
and 1.5, respectively). High mortality rates are also present in Central and
Eastern Europe, and in Central and South America.
Hereditary diffuse gastric cancer (HDGC).
Vogelaar et al. Hereditary Cancer in Clinical Practice 2012, 10:18
The role of diet in gastric cancer: still an
Berretta M et al. Front Biosci
(Landmark Ed). 2012 Jan 1;17:1640-7.
• Fruit and vegetables
• Salt and salted food
• Vitamins and mineral
• Nitrate, nitrite and nitrosamines
High dietary salt intake
exacerbates Helicobacter pylori-
induced gastric carcinogenesis.
Gaddy JA et al 2013 Infect Immun.
Natural history of H. pylori infection
Sipponen et al.1993
H. pylori and Cancer Collaborative Group, 2001
Association between Helicobacter pylori infection and
non-cardia gastric cancer