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Presentation on Medicated Chewing Gums

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A brief Explanation about Medicated Chewing Gums

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Presentation on Medicated Chewing Gums

  1. 1. Presented to:-Mr.Hemanth Kumar Yadav,Asst.Professor,Dept.of pharmaceutics, Presented by:-JSSCP, Mysore. Tekuri Manoj Kumar, 1st M.Pharm(IP).
  2. 2. IntroductionDefinitionCompositionManufacturing processFactors affecting the release of APIApplicationsAdvantages and DisadvantagesFuture trendsConclusionReferences
  3. 3.  Chewing gum has been used worldwide since ancient times when man experienced the pleasure of chewing a variety of substances. Chewing gum can be used as a convenient modified-release drug delivery system. Commercially available medicated chewing gums are currently available for ,  pain relief,  Smoking cessation  travel illness and freshening of breath.
  4. 4. MCG’s are solid, single dosage forms with a base consisting mainly of gums that are intended to be chewed but not swallowed.Medicated Chewing Gum (MCG) is a novel drug delivery system containing masticatory gum base with pharmacologically active ingredient and intended to use for local treatment of mouth diseases or systemic absorption through oral mucosa.
  5. 5. Chewing gum provides new competitive advantages over conventional drug delivery system....  Fast onset of action  high bioavailability.  Pleasant taste.  Higher compliance (easy and discreet administration without water).  Ready for use.  High acceptance by children.
  6. 6. McG Water insoluble Water solublechewing gum base bulk portion
  7. 7. Manufacturing process Freezing,Conventional Direct drying &or treditional compression tableting method method method
  8. 8.  Components of gumbase are softened or melted and placed in a kettle mixer to which sweetners, syrups, active ingredients and other excipients are added at a definte time. The gum is then sent through a series of rollers that form into a thin, wide ribbon. During this process, a light coating of finely powdered sugar or sugar substitutes is added to keep the gum away from sticking and to enhance the flavour. In a carefully controlled room, the gum is cooled for upto 48 hours. This allows the gum to set properly. Finally the gum is cut to the desired size and cooled at a carefully controlled temperature and humidity.
  9. 9. Contact Time Factors Physicoche Inter affecting micalindividual release propertiesvariability of API of API Formulatio n factor
  10. 10.  Dose not requires water to swallow. Hence can be take anywhere. Excellent for acute medication. Counteracts dry mouth, prevents candidiasis and caries. Avoids First Pass Metabolism and thus increases the bioavailability of drugs. Fast onset due to rapid release of active ingredients in buccal cavity and subsequent absorption in systemic circulation. Stomach does not suffer from direct contact with high concentrations of active principles, thus reducing the risk of intolerance of gastric mucosa.
  11. 11.  Risk of over dosage. Sorbitol present in MCG formulation may cause flatulence, diarrhea. Additives in gum like flavouring agent, Cinnamon can cause Ulcers in oral cavity and Licorice cause Hypertension. Prolong chewing on gum may result in pain in facial muscles and earache in children. Chewing gum have been shown to adhere to different degrees to enamel dentures and fillers. Chlorhexidine oromucosal application is limited to short term use because of its unpleasant taste and staining properties to teeth and tongue.
  12. 12.  Nowadays more and more disease can be treated with NDDS. Generally it takes time for a new drug delivery system to establish itself in the market. But MCG is believed to manifest its position as a convenient and advantageous drug delivery system as it meets the high quality standards of Pharm.Industry and can be formulated to obtain different release profiles of active substances. In the future we may see that more and more drugs formulated into chewing gum in preference to other delivery systems. The reason is simple that the chewing gum delivery system is convenient , easy to administer anywhere, anytime and its pleasant taste increases the product acceptability and patient compliance.
  13. 13.  Finally it is concluded that chewing is an excellent drug delivery system for self medication and having its own merits. So in forth coming years it will be a much more common and popular drug delivery system.
  14. 14. 1. A review article published on Journal of Applied Pharmaceutical Science 02 (06); 2012: 40-54.2. Modified-Release Drug Delivery Technology by Michael and Jonathan, Vol-126, page-419.3. Journal of Pharmacy Research 2011,4(3),848-851.4. Archives of Applied Science Research, 2010, 2 (2): 79-99.5. IJPRD, 2011; Vol 4(03): May-2012(001-016).6. IJPRD/2010/PUB/ARTI/VOV-2/ISSUE-8/OCT/011.7. International Journal of Research in Pharmaceutical and Biomedical Sciences ISSN: 2229-3701.
  15. 15. Thank

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