Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

newer drug delivery systems

653 views

Published on

Brief description about advances in drug delivery system.

Published in: Health & Medicine
  • Be the first to comment

newer drug delivery systems

  1. 1. Newer drug delivery systems Dr. Manjeeta Gupta Department of Pharmacology MIMER Medical College Friday, July 8, 2016 1 Department of Pharmacology MIMER Medical College Talegaon Dabhade
  2. 2. Newer drug delivery systems ACKNOWLEDGEMENTS - Principal - Members Staff Research Society - Faculty members & PG students (Pharmacology) - Scientists & researches whose work was a source of inspiration & information for this presentation Friday, July 8, 2016 2 Department of Pharmacology MIMER Medical College Talegaon Dabhade
  3. 3. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 3 New drug or New delivery??
  4. 4. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 4
  5. 5. Friday, July 8, 2016 5 Department of Pharmacology MIMER Medical College Talegaon Dabhade Oral drug delivery systems
  6. 6. Osmotic drug delivery system Friday, July 8, 2016 6 Department of Pharmacology MIMER Medical College Talegaon Dabhade Nifedipine Chlorpheniramine (Salt) Before After
  7. 7. Hydrodynamic drug delivery system Friday, July 8, 2016 7 Department of Pharmacology MIMER Medical College Talegaon Dabhade Valrelease tablet-Diazepam Liquid formulation ↓ Collapsible drug container ↓ Absorbent layer ↓ (Water) Hydrodynamic pressure ↓ Release of drug
  8. 8. Friday, July 8, 2016 8 Department of Pharmacology MIMER Medical College Talegaon Dabhade Gastroretentive drug delivery system Absorptive window Acyclovir Bisphosphonates Captopril Furosemide Metformin Gabapentin Levodopa Baclofenac Ciprofloxacin
  9. 9. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 9
  10. 10. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 10 Undertrial - Hepatitis B, Norwalk virus for diarhoea, Rabies, Corona virus for gastroenteritis
  11. 11. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 11 Transdermal drug delivery system
  12. 12. Transdermal therapeutic system Drug Reservoir Contact Adhesive Drug release membrane Department of Pharmacology MIMER Medical College Talegaon Dabhade Friday, July 8, 2016 12
  13. 13. Diclofenac Pain relief (Pain in terminal stages of malignancies and other pains) Fentanyl, buprenorphine (Opioids) Lidocaine Herpes Zoster (Pain relief) Scopolamine Motion sickness Nicotine patch Smoking cessation Clonidine (Catapres) Hypertension Nitroglycerine Angina Friday, July 8, 2016 13 Department of Pharmacology MIMER Medical College Talegaon Dabhade
  14. 14. Vitamin B12 Anaemia (Avoiding multiple injections / Daily oral treatment) Methylphenidate (Daytrana) ADHD (2006) Rivastigmine (Exelon) Alzheimer disease (2007) 5-hydroxytryptophan (2014) Depressive disorder Selegiline (2006) (Emsam) Friday, July 8, 2016 14 Department of Pharmacology MIMER Medical College Talegaon Dabhade
  15. 15. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 15 Pellet Implant Estradiol & Testosterone Implants
  16. 16. Friday, July 8, 2016 16 Department of Pharmacology MIMER Medical College Talegaon Dabhade Use of ultrasonic waves (1-3 MHz) for enhancement of migration of drug molecule through skin Hydrocortisone in arthritis Sonophoresis
  17. 17. Intranasal drug delivery system Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 17 Vortical flow principle Rotational motion + Particles also move in directions opposite to each other Forceful, deeper, wider penetration Better bioavailability
  18. 18. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 18 Mucosal automizatio n device Nitroglycerine Progesterone Estradiol Testosterone Naloxone Oxytocin Desmopressin Dihydro-ergotamine Calcitonin
  19. 19. Microprocessor-controlled vibrating mesh Nebulizer (Amikacin for pneumonia – local action) Friday, July 8, 2016 19 Department of Pharmacology MIMER Medical College Talegaon Dabhade
  20. 20. Intraperitoneal Nebulizer Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 20 Ropivacaine ---- Pain control after laparoscopic cholecystectomy A double-blind, randomized, placebo-controlled trial http://bja.oxfordjournals.org, September 11, 2014
  21. 21. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 21 Microneedle drug delivery system
  22. 22. Friday, July 8, 2016 22 Department of Pharmacology MIMER Medical College Talegaon Dabhade Influenza vaccine Hepatitis B vaccine Lidocaine Parathormone Desmopressin Vitamin B
  23. 23. Friday, July 8, 2016 23 Department of Pharmacology MIMER Medical College Talegaon Dabhade -Bare metal stent coated with drug-polymer matrix -Local, controlled delivery - Prevents re-stenosis Sirolimus - eluting coronary stent – (CYPHER) Paclitaxel - eluting coronary stent – (TAXUS ) Drug Eluting Stents
  24. 24. Sutures Sutures impregnated with antimicrobial agent • Polyglactin 910 (absorbable suture material coated with antiseptic agent Triclosan) • Monofilament sutures: Monocryl & PDS (for both gram positive & gram negative organisms) • Under clinical trial Friday, July 8, 2016 24 Department of Pharmacology MIMER Medical College Talegaon Dabhade
  25. 25. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 25
  26. 26. Ophthalmology Friday, July 8, 2016 26 Department of Pharmacology MIMER Medical College Talegaon Dabhade
  27. 27. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 27 Lacrisert -Treatment of dry eye keratitis - Drug : Hydro-propyl cellulose Retisert -Treatment of chronic infectious uveitis - Drug : Fluocinolone acetonide
  28. 28. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 28 Drug : Gancyclovir Drug : Latanoprost
  29. 29. Friday, July 8, 2016 29 Department of Pharmacology MIMER Medical College Talegaon Dabhade
  30. 30. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 30 Insulin Pen Insulin jet
  31. 31. Department of Pharmacology MIMER Medical College Talegaon Dabhade Friday, July 8, 2016 31
  32. 32. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 32 Insulin pump
  33. 33. Inhaled Insulin • Approved (Jan.2006) • Short-actinginsulin • Tocontrolpost-prandialhyperglycemia Friday, July 8, 2016 33 Department of Pharmacology MIMER Medical College Talegaon Dabhade
  34. 34. Oral Insulin: a long awaited dream.. !! Phase 2 & 3 clinical trials IN-105 (Biocon India) NN-1952 (Novo nordisk) ORMD-0801(Oramed) Pharmfilm (MonoSol, Midatech) - transbuccal Oral-lyn (Generex) - buccal spray Friday, July 8, 2016 34 Department of Pharmacology MIMER Medical College Talegaon Dabhade
  35. 35. Patient- Controlled Analgesia Programmable device For pain relief Terminal stages of malignancies Friday, July 8, 2016 35 Department of Pharmacology MIMER Medical College Talegaon Dabhade
  36. 36. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 36
  37. 37. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 37 Doxorubicin (Doxil) – Kaposi’s sarcoma Amphotericin B – Serious Systemic fungal infections Paclitaxel (Abraxane) – Metastatic breast Ca (2005), Non small cell lung Ca (2012) Advanced pancreatic Ca (2013)
  38. 38. Concept of Nanomedicine Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 38 NANO
  39. 39. Friday, July 8, 2016 39 Department of Pharmacology MIMER Medical College Talegaon Dabhade Medical application of nanotechnology Nano-sized (1-100 nanometers) particles Diagnosis, prevention & treatment of diseases To gain complete understanding of complex patho- physiology of disease
  40. 40. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 40 Gold nanoparticles -Generation of free radicals - Killing of cancer cells
  41. 41. Carbon nanotubules Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 41 Enhanced solubility Efficient tumour targeting/drug delivery
  42. 42. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 42 Nano-Erythrosomes Carry proteins, enzymes & macromolecules Liver tumours, parasitic & enzymatic diseases
  43. 43. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 43 Genetic transfer system Under Phase 3 trial for Adenovirus & HIV
  44. 44. Imagine……. • An injectable microfilm goes into the body • Releases a drug layer by layer • Over a period of ………. long time • Long ? How much long ?? • 1 week? 1 month? 6 months ??? STILL LONGER… • More than a year • Give anti-TB drug only once, and Will it be done? Friday, July 8, 2016 44 Department of Pharmacology MIMER Medical College Talegaon Dabhade
  45. 45. Future will be unimaginably different ?? • Biodegradable nanoscale film - Targeted Controlled delivery • Pain medications - Release the drug for more than 14 months • Professor Paula Hammond • Koch Institute for Integrative Cancer Research at – • Massachusetts Institute of Technology – Cambridge- USA • http://pub.mims.com/India/topic/medical-tribune-in/new-te . accessed 26 Sept 2014 Friday, July 8, 2016 45 Department of Pharmacology MIMER Medical College Talegaon Dabhade
  46. 46. Friday, July 8, 2016 Department of Pharmacology MIMER Medical College Talegaon Dabhade 46

×