Optimization techniques

12,042 views

Published on

describes the various optimization techniques and parameters and its applications in pharmaceutical industry

Published in: Health & Medicine, Technology
3 Comments
46 Likes
Statistics
Notes
  • Kindly send me your presentation to drambia@yahoo.com
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • kindly send me presentation at sandeepslahoti@gmail.com
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • The entire SEO process works in two types of optimization methodologies i.e. On-Page and Off-Page SEO. Both methods have their own distinct processes and variety to rank websites in the top search results.

    The process begins with SEO on page optimization SEO optimized content that is added, Meta Tags are created and so on. Once the entire SEO page is complete, the off-page SEO optimization starts. Off-Page SEO optimization is that activities are carried out to ensure the relevant links back to the site to make the website relevant towards the search engines.

    All SEO experts following different strategy to achieve good results. However, there are a few pages out of the activities that are used in almost every SEO professional working in this industry. Some of them are:.

    - Submission Directory - There are many directories available on the Internet, where SEO team presents titles containing specific keywords, description and website link. In short, a small brief about the company or product or service is provided in the directory submission.

    -. Social Bookmarking - The SEO team seeks relevant social bookmarking sites where you can make your own website or links for a link back to the site.

    -. Commenting Forum - Web forums are used to generate traffic to websites. Therefore, through participation in Internet forums, SEO experts include links to web sites as a signature in your response.

    -. Posting stories - there are hundreds of article directories relevant Press Release Directories authentic and most visited blog directories on the Internet. SEO professionals publish and present quality content written with specific keywords in the respective directories.

    -. Deep linking - SEO services also work to promote internal web pages on the Internet. To do so, submit the URLs of web pages in different directories internal and shipping options link.

    - Generation of RSS feeds, and presentations - For all visitors about generating RSS feeds and frequent updates used presentation. In this sense, any updates made to the website or post any new information through blogs or news stories, etc is directly updated via emails to visitors.

    -. Social Networking - It is the platform where different users and different can communicate, post messages and share information on various products, services, industries, relationships, etc. This is another way of diverting traffic to other private sites. SEO experts create fan page after social networking sites and regularly send the link to promote web links.

    Finally, a road link, road link and two methods of 3-way link used to promote and publicize the website link among the various websites around the internet world. All technical aspects of these and many more are involved in the promotion and dissemination of links to web sites on the Internet.
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
No Downloads
Views
Total views
12,042
On SlideShare
0
From Embeds
0
Number of Embeds
19
Actions
Shares
0
Downloads
0
Comments
3
Likes
46
Embeds 0
No embeds

No notes for slide
  • OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSING OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSING
  • OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSING OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSING
  • Optimization techniques

    1. 1. S.R. College of Pharmacy Optimization Techniques in Pharmaceutical Formulation and Processing P. Raja Abhilash, M.pharm (Ph.D.) Assistant professor, S.R. college of pharmacy.
    2. 2. Contents • Introduction • Optimization Parameters • Classic Optimization • Statistical Design • Applied Optimization Methods • Use of Computers for Optimization • Applications • Conclusion • References
    3. 3. INTRODUCTIONOPTIMIZATIONIt is defined as follows: choosing the best element from some set of availablealternatives.• In Pharmacy word “optimization” is found in the literature referring to any study of formula.• In development projects pharmacist generally experiments by a series of logical steps, carefully controlling the variables and changing one at a time until satisfactory results are obtained. This is how the optimization done in pharmaceutical industry.• OPTIMIZATION is an act, process, or methodology of making design, system or decision as fully perfect, functional or as effective as possible.• Optimization of a product or process is the determination of the experimental conditions resulting in its optimal performance. 3
    4. 4. Optimization Parameters Optimization parameters Variable types Problem types Independent variables Unconstrained Dependent variables Constrained
    5. 5. Problem types in optimization Unconstrained Constrained no restrictions are restrictions are placed placed on the system on the systemeg: preparation of hardest eg: preparation of hardesttablet without any disintegration tablet which has the ability of or dissolution parameters. disintegrate in less than 15min
    6. 6. variables in optimization Independent Dependent variables variablesdirectly under the control responses that are developed of formulator due to the independent variables eg: eg: disintegrant level disintegration time compression force hardness binder level weight uniformity lubricant level thickness
    7. 7. response surface curve • Once the relationship between the variable and the response is known, it gives the response surface as represented in the Fig. 1. Surface is to be evaluated to get the independent variables, X1 and X2, which gave the response, Y. Any number of variables can be considered, it is impossible to represent graphically, but mathematically it can be evaluated. Fig I; response surface curve
    8. 8. Classic Optimization •Classical optimization is done by using the calculus to basic problem to find the maximum and the minimum of a function. •The curve in the Fig. 2. represents the relationship between the response Y and the single independent variable X and we can obtain the maximum and the minimum. By using the calculus the graphical represented can be avoided. If the relationship, the equation for Y as a function of X, is available [Eq. (1)]: Y = f(X) ---eqn (1) Figure 2. Graphic location of optimum (maximum or minimum)
    9. 9. Classic Optimization • When the relationship for the response Y is given as the function of two independent variables, X1 and X2 , Y = f(X1, X2) •Graphically, there are contour plots (Fig. 3.) on which the axes represents the two independent variables, X1 and X2, and contours represents the response Y. Here the contours are showing the response. (contour represents the connecting point showing the peak level of response) Figure 3. Contour plot. Contour represents values of the dependent variable Y 9
    10. 10. Optimization Techniques • The techniques for optimization are broadly divided into two categories: (A) simultaneous method: Experimentation continues as optimization study proceeds. E.g.: a. Evolutionary Operations Method b. Simplex Method (B) sequential method: Experimentation is completed before optimization takes place. E.g.: a. Mathematical Method b. Search Method • In case (B), the formulator has to obtain the relationship between the response and one or more independent variables. • This includes two approaches: Theoretical Approach & Empirical Approach.
    11. 11. Optimization Strategy: Problem definition Selection of factors and levels Design of experimental protocol Formulating and evaluating the dosage form Prediction of optimum formula Validation of optimization
    12. 12. Factorial Designs Full factorial designs: Involve study of the effect of all factors(n) at various levels(x) including the interactions among them with total number of experiments as Xn .  SYMMETRIC  ASYMMETRIC Fractional factorial designs: It is a fraction ( 1/xp ) of a complete or full factorial design, where ‘p’ is the degree of fractionation and the total number of experiments required is given as xn-p .
    13. 13. Factorial DesignsPictorial representation , where each point represents the individual experiment
    14. 14. Applied optimization methods A. Evolutionary Operations (EVOP) B. Simplex Method C. Lagrangian Method D. Search Method A. canonical analysis
    15. 15. A. Evolutionary operations (EVOP) • Most widely used method of experimental optimization in fields other than pharmaceutical technology.. • Experimenter makes very small changes in formulation repeatedly. • The result of changes are statistically analyzed. If there is improvement, the same step is repeated until further change doesn’t improve the product. • Can be used only in industries and not on lab scale.
    16. 16. B. Simplex Method • It was introduced by Spendley et.al, which has been applied more widely to pharmaceutical systems. • A simplex is a geometric figure, that has one more point than the no. of factors. so, for two factors ,the simplex is a triangle. 1 • It is of two types: A. Basic Simplex Method B. Modified Simplex Method 2 3 • Simplex methods are governed by certain rules.
    17. 17. Basic Simplex Method 9 10 Rule 1 : s8 s7 s9 7 11 The new simplex is formed s6 8 s10 by keeping the two vertices s5 from preceding simplex with 5 6 12 best results, and replacing s4 s3 the rejected vertex (W) with (N) 1 4 its mirror image across the s2 (R) line defined by remaining s1 two vertices. 2 3 (W) (B)
    18. 18. Basic Simplex Method (W) 9 10 (W) Rule 2 : s8 s7 s9 7 11 When the new vertex in a s6 8 s10 simplex is the worst s5 response, the second lowest 5 6 12 response in the simplex is s4 s3 (W) eliminated and its mirror (N) 1 4 image across the line; is s2 (R) defined as new vertices to s1 form the new simplex. 2 3 (W) (B)
    19. 19. Basic Simplex Method (W) 9 10 (W) Rule 3 : s8 When a certain point is s7 s9 retained in three successive 7 11 s6 8 s10 simplexes, the response at s5 this point or vertex is re 5 6 12 determined and if same s4 s3 (W) results are obtained, the (N) 1 4 point is considered to be the s2 (R) best optimum that can be s1 obtained. 2 3 (W) (B)
    20. 20. Basic Simplex Method (W) 9 10 (W) Rule 4 : s8 If a point falls outside the s7 s9 boundaries of the chosen 7 11 s6 8 s10 range of factors, an s5 artificially worse response 5 6 12 should be assigned to it and s4 s3 (W) one proceeds further with (N) 1 4 rules 1 to 3. This will force s2 (R) the simplex back into the s1 boundaries. 2 3 (W) (B)
    21. 21. Modified Simplex Method •It was introduced by Nelder-Mead in 1965. •This method should not be confused with the simplex algorithm of Dantzig for linear programming. •Nelder-Mead method is popular in chemistry, chemical engg., pharmacy etc. •This method involves the expansion or contraction of the simplex formed in order to determine the optimum value more effectively.
    22. 22. Modified Simplex Method E1 • If response at R1 > B, R1 expansion of simplex to E1. N •If response at N<= R1<=B, C1 no expansion or contraction is done. •If response at R1<N, contraction of the simplex is B done. W
    23. 23. C. Lagrangian Method • It represents mathematical method of optimization. • Steps involved: 1.Determine the objective function. 2. Determine the constraints. 3. Introduce the Lagrange Multiplier (λ) for each constraint. 4. Partially differentiate Lagrange Function (F). 5. Solve the set of simultaneous equations. 6. Substitute the resulting values into objective function.
    24. 24. Lagrangian Method (polynomial model) Total Cost = 3x2 + 6y2 – xy ------ objective function determined! Subject to: x+y = 20 ------------- constraints determined! We can rewrite the condition as, 0 = 20-x-y ------- This has to be embedded in objective function LTC = 3x2 + 6y2 – xy + λ ( 20 -x - y) ---------- Lagrange multiplier (λ) introduced LTC = 3x2 + 6y2 – xy + 20 λ - x λ - y λ --------- Lagrange function (F) Partial differentiation done! Now solve the simultaneous equations
    25. 25. Lagrangian Method 6x – y - λ = 0 x – 12y + λ = 0 7x - 13y = 0 i.e. 7x = 13y so Insert in any of the simultaneous equations
    26. 26. Lagrangian Method Total Cost = 3x2 + 6y2 – xy ------ objective function We have determined using Lagrange function, x= 13 and y= 7 Substituting these values in the objective function, Total Cost = 3x2 + 6y2 – xy Total Cost = 3(13)2 + 6(7)2 – (13)(7) Total Cost = 507 + 294 – 91 Hence the total cost to produce 20 units is $ 710
    27. 27. Example for the Lagrangian Method • The active ingredient , phenyl- propanolamine HCl, was kept at a constant level, and the level of the levels of disintegrant (corn starch) and lubricant (stearic acid) were selected as the independent variables. X1 and X2. the dependent variables include tablet hardness, friability,invitro release rate, and urinary excretion rate in human subject. • A graphic technique may be obtained from the polynomial equations, as follows:
    28. 28. Lagrangian Method (contour plots) (a) Tablet Hardness (b) Dissolution (c) Feasible solution indicated by crosshatched area.
    29. 29. D. Search methods• Unlike the Lagrangian method, do not require differentiability of the objective function.• It can be used for more than two independent variables.• The response surface is searched by various methods to find the combination of independent variables yielding an optimum.• select a system• select variables: independent and dependent• Perform experiments and test product• Submit data for statististical and regressional analysis• Set specifications for feasibility program• Select constraints for grid research• Evaluate grid search printout as contour plots
    30. 30. Example for the Search methods Independent Variables Dependent Variables X1 = Diluent ratio Y1 = Disintegration time X2= Compressional force Y2= Hardness X3= Disintegrant levels Y3 = Dissolution X4= Binder levels Y4 = Friability X5 = Lubricant levels Y5 = Porosity
    31. 31. Search methods • The first 16 trials are represented by +1 and -1. • The remaining trials are represented by a -1.547, zero or 1.547 • The type of predictor equation used in this example is :
    32. 32. Search methods The output includes plots of a given responses as a function of all five variables. 32
    33. 33. Search methods Contour plots for (a) disintegration time (b) tablet hardness (c) dissolution response (d) tablet friability. 33
    34. 34. E. Canonical Analysis Canonical analysis, or canonical reduction, is a technique used to reduce a second-order regression equation, to an equation consisting of a constant and squared terms, as follows: Y = Y0+λ1W12+λ2W22+…….
    35. 35. Canonical Analysis. In canonical analysis or canonicalreduction, second-order regressionequations are reduced to a simplerform by a rigid rotation and translation of the response surface axes inmultidimensional space, as shown inFig.14 for a two dimension system. 35
    36. 36. Use of Computers for optimization • Statistical Analysis Systems (SAS) • RS/Discover • eCHIP • Xstat • JMP • Design Expert • FICO Xpress Optimization Suite • Multisimplex
    37. 37. Applications • Formulation and Processing • Clinical Chemistry • HPLC Analysis • Medicinal Chemistry • Studying pharmacokinetic parameters • Formulation of culture medium in microbiology studies.
    38. 38. Conclusion • Optimization techniques are a part of development process. • The levels of variables for getting optimum response is evaluated. • Different optimization methods are used for different optimization problems. • Optimization helps in getting optimum product with desired bioavailability criteria as well as mass production. • More optimum the product = More $$ the company earns in profits!!!
    39. 39. References • Joseph B. Schwartz. Optimization techniques in product formulation. Journal of the Society of Cosmetic Chemists. (1981) Vol 32; p: 287-301. • Gilbert S. Banker, Christopher T. Rhodes. Modern Pharmaceutics. 4th edition. CRC Press. (2002); p: 900-928. • Optimization. 2012. In Merriam-Webster Online Dictionary. Retrieved March 07, 2012, from http://www.merriam-webster.com/dictionary/optimization • N. Arulsudar, N. Subramanian & R.S.R. Murthy. Comparison of artificial neural network and multiple linear regressions in the optimization of formulation parameters of leuprolide acetate loaded liposomes. Journal of Pharmacy & Pharmaceutical Sciences. (2005) Vol. 8(2); p: 243-258. • Roma Tauler, Steven D. Brown, Beata Walczak. Comprehensive Chemometrics: Chemical and Biochemical data analysis. Elsevier. (2009); p: 555-560. • Khaled S. Al-Sultan, M.A. Rahim. Optimization in Quality Control. Springer. (1997); p: 6-8. • Donald H.Mc Burney, Theresa L.White. Research Methods. 7th edition. Thomson Wadsworth. (2007); p: 119. • Rosilene L. Dutra, Heloisa F. Maltez, Eduardo Carasek, Development of an on-line preconcentration system for zinc determination in biological samples, Talanta, (2006) Vol 69(2), p:488-493.

    ×