2. ⢠Declare the past, diagnose the present,
fortell the future.
â Hippocrates,460-357 BC
Greek physician
Latest developments in rheumatic fever
3. Acute rheumatism
⢠Jean baptiste Bouillaud(1796-1881) argued
convincibly in 1836 that there was a âconstant
coincidence either of endocarditis or of
pericarditis with acute articular rheumatismâ
Latest developments in rheumatic fever
5. 19th
century
⢠Walterbutler cheadle,physician at hospital for
sick children,London.
⢠Rheumatic fever is an illness of relapses and
remissions
⢠Cheadle believed that most pts would suffer
from most symptomsâŚ
Latest developments in rheumatic fever
8. T duckett jones
⢠Based upon chaedles theory
⢠In contrast to cheadle,jones seperated the
diverse complaints of rheumatic fever in to
âmajorâ and âminorâ
Latest developments in rheumatic fever
11. Jones criteria
⢠Henry duckett jones
⢠Original-1944
⢠Subsequently -1956,1965
⢠Major revision-1992
⢠Reconfirmed âAHA workshop-2000
⢠AHA âcrucial-modifying,revising,publicising
jones criteria
⢠Now-AHA scientific statement -2015
Latest developments in rheumatic fever
12. Every revision increased the specificity but decreased the
sensitivity of the criteria, Jagat Narula et al. CirculationLatest developments in rheumatic fever
13. 2002â2003 WHO criteria for the diagnosis of rheumatic
fever and rheumatic heart disease (based on the
revised Jones criteria)
These revised WHO criteria facilitate the diagnosis of:
â A primary episode of RF
â Recurrent attacks of RF in patients without RHD
â Recurrent attacks of RF in patients with RHD
â Rheumatic chorea
â Insidious onset rheumatic carditis
â Chronic RHD.
Latest developments in rheumatic fever
16. why to revise 1992 criteria???
⢠ECHO
⢠There has been a limited diagnostic role of
echo in diagnosis of carditis till now
⢠To streamline in accordance with other
national and regional guidelines
⢠Subclinical carditis
Latest developments in rheumatic fever
17. why to revise 1992 criteria???
⢠Other clinical areasâŚ
⢠Monoarticular arthritis
⢠Classification of recommendations and Levels
of evidence
Latest developments in rheumatic fever
18. Key feature in AHA statement 2015
Bayesâ therom
Latest developments in rheumatic fever
26. ďIn India, rheumatic fever is endemic and
remains one of the major causes of
cardiovascular disease, accounting for
nearly 25-45% of the acquired heart
disease. ROUTRAY SN2003
ďPRIMARY ATTACK RATE OF RF
FOLLOWING STREPTOCOCCAL
PHARYNGITIS
⌠EPIDEMICS: 3%
⌠SPORADIC:0.3%
Latest developments in rheumatic fever
27. Epidemiological background
⢠For appropriate application of diagnostic
criteria for ARF
⢠Substantial decline âdeveloped nations â
â Improved hygiene
â Improved healthcare access
â Reduced crowding
â Social and economic changes
â Changes in epidemiology of specific GAS
Latest developments in rheumatic fever
28. (Modified from Parry E, Godfrey R, Mabey D, Gill G [eds]:
Principles of Medicine in Africa. 3rd ed. Cambridge, Cambridge
University Press, 2004, p 861.)
⢠4 patterns RF in 150 years.
â
A- Preantibiotic fall in the incidence of
ARF of industrialized countries
â B-Persistent high incidence RF
[Africa and south Asia].
â C-Postantibiotic fall in the incidence
of rheumatic fever in countries that
instituted comprehensive programs for
primary and secondary prevention of
rheumatic fever, such as Cuba, Costa
Rica, Martinique, and Guadeloupe.
â D-Fall and rise in the incidence of
rheumatic fever in the formerly Soviet
Republics of Central Asia.
Latest developments in rheumatic fever
29. Epidemiological background
⢠Major burden-
â low and middle income countries
â Selected indigenous populations
Also diff. of incidence noted in population within
same country(New zealand and australia)
Latest developments in rheumatic fever
30. Implications of Epidemiology
⢠Bayes therom
⢠single set of diagnostic criteria may no longer
be sufficient for all population groups and in
all geographic regions
Latest developments in rheumatic fever
31. Implications of Epidemiology
⢠Concept of low and high risk pop.
⢠Intially proposed in Australian rheumatic fever
guidelines 2012
Latest developments in rheumatic fever
32. Agent
⢠Group A beta-haemolytic streptococcus
⢠A poisonous âGASâ
Latest developments in rheumatic fever
33. 2 Hit hypothesis
Hit -1:cross reaction Hit-2:T lymphocyte invasion
⢠Epitopes on the cell wall of
Streptococcus forms cross
reacting antibodies to host
antigens
⢠The antigen and antibody
complex at the target site
invites T lymphocytes to
come out of vessel and
stimulates local epitheloid
cell to become
Anitschkoffâs cell around
the central Fibrinoid
degeneration forming
together called âAschoff-
Geipel bodiesâ
Latest developments in rheumatic fever
34. Targets of molecular mimicry
Intracellular Extracellular
⢠Cardiac myosin
⢠Brain tubulin
⢠Laminin on the endothelial
surface of the valve
⢠Lysoganglioside and
dopamine receptors in the
brain
Latest developments in rheumatic fever
35. M protein and antigens
Latest developments in rheumatic fever
36. M protein
ďź The streptococcal M-
protein extends from
the surface of the
streptococcal cell as
an alphaâhelical coiled
dimer,
ďź Shares structural
homology with cardiac
myosin and other
alpha-helical coiled
molecules, such as
Tropomyosin, keratin
and laminin(lines
valve structure and is
a target for poly
reactive antibody)
Latest developments in rheumatic fever
38. Susceptibility of host
⢠3-6% without primary Rx
⢠X5 time if family Hx positive
⢠Poor socioeconomics
⢠No hygiene
⢠Lives in crowded habitat
⢠X6 time in monozygotic
⢠X3 times in children if one
parent +
⢠2 % OF ARF INFECTIONS HAVE BEEN
FOUND TO BE FAMILIAL
Padmavathi 1962
⢠HLA-DR7 is mainly assoc.
valvular lesions in RHD pts.
(Guilherme etal.2007)
Family history is must in Rheumatic heart disease
Latest developments in rheumatic fever
39. ⢠Aschoff nodule of acute
rheumatic fever. The nodule is
composed of Anitschkow cells;
these have clear nuclei with a
central bar of chromatin, said to
resemble a caterpillar. There is a
central area of fibrin. This central
necrosis is further surrounded by
a mononuclear cell infiltrate.
Myocardial fibres adjacent to the
Aschoff body are undergoing
Fibrinoid necrosis. (Sebire NJ,
Ashworth M, Malone M, Jacques
TS [eds]: Diagnostic Pediatric
Surgical Pathology. Churchill
Livingstone, United Kingdom,
2010.)
Latest developments in rheumatic fever
40. Nonsuppurative sequel, such as RF and RHD, are
seen only after group A streptococcal infection of the
upper respiratory tract. Bramhanathan et al 2006
⢠Streptococcal skin
infection is not thought to
cause rheumatic fever.
Why???
Latest developments in rheumatic fever
41. Latest developments in rheumatic fever
Circulation. 2015;131:000-000. DOI:
10.1161/CIR.0000000000000205
42. AHA Scientific Statement
March 9, 2015
⢠low risk ARF incidence <2 per 100 000 school-
aged(5â14 years old) per year or an all aged
prevalence of RHD of â¤1 per 1000 population
per year (Class IIa; Level of Evidence C)
Latest developments in rheumatic fever
43. AHA Scientific Statement
March 9, 2015
⢠Children not clearly from a low-risk population
are at moderate to high risk depending on
their reference population (Class I; Level of
Evidence C
Latest developments in rheumatic fever
44. Carditis: Diagnosis in the Era of Widely Available
Echocardiography
⢠Classically,1992 AHA Jones-clinical diagnosis
based on auscultation of typical murmurs
⢠concept of subclinical carditis --incorporated
into other guidelines and consensus
statements as a valid rheumatic fever major
manifestation
⢠Australian guidelines 2012,New zealand guidelines 2008
Latest developments in rheumatic fever
45. Subclinical carditis
⢠refers exclusively to the circumstance in which
classic auscultatory findings of valvar
dysfunction either are not present or are not
recognized by the diagnosing clinician but
echocardiography/Doppler studies reveal
mitral or aortic valvulitis
Latest developments in rheumatic fever
46. Subclinical carditis
⢠Nearly 70% cases with polyarthralgia have
Echo evidence of carditis.
⢠Therefore, if arthralgia is taken as a minor
criterion and Echo is not done, then it leads to
gross underdiagnosis of ARF
Latest developments in rheumatic fever
47. Subcinical carditis-significance
⢠In reality if pts with polyarthralgia and
subclinical carditis are not evaluated-
â diagnosis is missed and
â ends up with RHD without receiving penicillin
prophylaxis
Latest developments in rheumatic fever
48. Clinical studies on subclinical
cardits(SC)
⢠ARF outbreak in Utah-
â Clinically carditis -64%
â SC - 27%
⢠In general >25 studies: E &D evidence of
MR/AR in ARF pts.despite absence of clinical f.
⢠Only 1 study found echo: no incremental value
Latest developments in rheumatic fever
50. Echo features of carditis
⢠M-mode features are:
⢠(1) LA,LV-are dilated, LA:AO ratio is altered.
⢠(2) Thickened mitral/aortic/tricuspid leaflets more than or
equal to 4 mm (normal less than or equal to 3 mm).
â˘
⢠2D Echo: EDV,ESV-increased and ejection fraction may or may
not be reduced. EF reduction is never severe in ARF
⢠In ARF edematous valve>4mm âseen in 93.6% cases
⢠Increased echogenicity of submitral apparatus âPLAX view
Latest developments in rheumatic fever
51. Echo features of carditis
⢠Physiological versus pathological M.regurgitation:
pathological valvular regurgitation can be easily differentiated
from physiological regurgitation by :
⢠Substantial color jet in 2 planes extending well beyond
thevalve
⢠Color jet of MR passes over the posterior wall of LA. It is a
high velocity signal in pulse Doppler, with a well defined,
dense, high velocity spectral envelope with holosystolic MR.
Latest developments in rheumatic fever
54. The efficacy of echocardiographic criterions for the diagnosis of carditis in
acute rheumatic fever.
Vijayalakshmi IB etal. Cardiol.young, 2008
Latest developments in rheumatic fever
55. 1. The mitral valve is most often involved
2. Mitral regurgitation is the most common finding on color flow imaging.
3. Mitral regurgitation in rheumatic carditis is related to ventricular dilatation
and/or restriction of leaflet mobility.
4. Rheumatic carditis does not result in congestive heart failure in the absence of
hemodynamically significant valve lesions.
5. In a quarter of patients with rheumatic carditis, valve nodules were present
that may represent echocardiographic equivalents of rheumatic verrucae
Circulation,1996
Latest developments in rheumatic fever
59. AHA 2015 recommendations
⢠1. Echocardiography with Doppler should be performed in all cases of confirmed
and suspected ARF (Class I; Level of Evidence B).
⢠2. It is reasonable to consider performing serial echocardiography/Doppler studies
in any patient with diagnosed or suspected ARF even if documented carditis is not
present on diagnosis (Class IIa; Level of Evidence C).
⢠3. Echocardiography/Doppler testing should be performed (strictly fulfilling the
findings ) to assess whether carditis is present in the absence of auscultatory
findings, particularly in moderate- to high-risk populations and when ARF is
considered likely (Class I; Level of Evidence B).
⢠4. Echocardiography/Doppler findings not consistent with carditis should exclude
that diagnosis in patients with a heart murmur otherwise thought to indicate
rheumatic carditis (Class I; Level of Evidence B)
Latest developments in rheumatic fever
60. arthritis
⢠âRheumatismâ
⢠Migratory polyarthritis-m.c but âŚleast specific
⢠with age-upto 3/4th
of pts as isolated(pediatric cardiology,anderson)
⢠Arthritis typically-non-suppurative,non deforming,large joint
(lower limbs f/b upper)
⢠Usually 1 or 2 joints are affected at a given time-each for few
hours to days
⢠Without treatment,
â as many a 16joints +
â Atleast 6 joints in half of pts.
⢠Latest developments in rheumatic fever
61. PSRA
⢠A supposedly characteristic picture of PSRA has emerged,
with significant differences from ARF.
⢠Deighton etal.- distinguishing features of PSRA:
â onset within 10 days of group A streptococcal infection, prolonged or
recurrent arthritis
â poor symptomatic response to aspirin.
Latest developments in rheumatic fever
62. Ayoub etal. Diagnostic criteria
⢠Arthritis of acute onset,
â symmetric or asymmetric,
â usually non-migratory,
â can affect any joint
â persistent or recurrent.
â At best, poorly responsive to salicylates or NSAIDs.
â Evidence of antecedent GAS infection.
â Failure to fulfill the modified Jones criteria for the
diagnosis of ARF
Latest developments in rheumatic fever
63. ⢠ARF PSRA
⢠14-21 days latency 10 days
⢠Rapid reponse no response
⢠Migratory non-migratory
⢠Transient persistant
⢠Large joints small/axial
⢠Weeks to months 1-5 days(3 wks)
⢠Assoc.other major c/f not assoc.
Latest developments in rheumatic fever
65. Is PSRA a part of spectrum???
Latest developments in rheumatic fever
66. PSRA
⢠Contraversy about secondary prophylaxis
⢠5-7% of PSRA pts.- develop RHD
⢠To be followed up carefully for several months
for carditis.
⢠Some experts recommend secondary
prophylaxis but effectiveness not well
established
⢠Netherlands study-PSRA not assoc with long
term cardiac sequelae.
Latest developments in rheumatic fever
67. Aseptic monoarthritis
⢠Studies from india,australia and fiji âmay be
imp. c/f in selected high risk pop.
⢠High risk indigenous australians-16-18% of
confirmed cases of ARF
⢠At present, consideration that monoarthritis may be
part of the ARF spectrum should be limited to
patients from moderate- to high-risk
populations(Class I; Level of Evidence C)
Latest developments in rheumatic fever
68. polyarthralgia
⢠Major criteria till 1956
⢠Need for careful history in all suspected cases
⢠The inclusion of polyarthralgia as a major
manifestation is applicable only for moderate- or
high-incidence populations and only after careful
consideration and exclusion of other causes of
arthralgia such as autoimmune,viral, or reactive
arthropathies (Class IIb; Level of Evidence C).
Latest developments in rheumatic fever
69. Other c/f:minor
⢠FEVER:
⢠1965 revision->38
⢠1992 revision>39
⢠>38 in aboriginal australians-improved
sensitivity
⢠Cutoff >37.5 -90% sensitivity in suspected.
⢠In most settings->38.5 orally
Latest developments in rheumatic fever
71. ⢠Generally, there appear to be no differences in other minor
clinical manifestations (raised CRP,ESR,prolonged PR interval
on ECG, a past h/o rheumatic fever or RHD) between that of
low- and higher-risk populations and geographies.
⢠For most populations, an ESR >60 mm in the first hour and
CRP>3.0 mg/dL are considered typical of ARF.
⢠Normal ESR and CRP prompt serious reconsideration of the
diagnosis of ARF
Latest developments in rheumatic fever
72. Evidence of preceeding strepto inf.
⢠Exceptions: chorea and indolent carditis
⢠Any 1 of the following can serve as evidence of preceding
⢠infection, per a recent AHA statement
⢠1. Increased or rising ASO titer or other streptococcal antibodies (anti-
DNASE B) (Class I;Level of Evidence B).
⢠A rise in titer is better evidence than a single titer result.
⢠2. A positive throat culture for GABHS(Class I; Level of Evidence B).
⢠3. A positive rapid group A streptococcal carbohydrate antigen test in a
child whose clinical presentation suggests a high pretest probability of
streptococcal pharyngitis (Class I; Level of Evidence B
Latest developments in rheumatic fever
73. Revision of the Jones Criteria for the Diagnosis of Acute
Rheumatic Fever in the Era of Doppler Echocardiography
A Scientific Statement From the American Heart Association
Endorsed by the World Heart Federation
Circulation. 2015;131:000-000
Latest developments in rheumatic fever
74. recurrences
⢠1. With a reliable past history of ARF or established
RHD, and in the face of documented group A streptococcal
infection, 2 major or 1 major and 2 minor or 3 minor
manifestations may be sufficient for a presumptive diagnosis
(Class IIb; Level of Evidence C).
⢠2. When minor manifestations alone are present, the
exclusion of other more likely causes of the clinical
presentation is recommended before a diagnosis of an ARF
recurrence is made (Class I; Level of Evidence C)
Latest developments in rheumatic fever
75. âPossibleâ rheumatic fever
⢠High incidence settings
⢠Where there is genuine uncertainty, it is reasonable to
consider offering 12 months of secondary prophylaxis
followed by reevaluation to include a careful history and
physical examination in addition to a repeat echocardiogram
(Class IIa; Level of Evidence C).
Latest developments in rheumatic fever
76. âPossibleâ rheumatic fever
⢠. In a patient with recurrent symptoms (particularly involving
the joints) who has been adherent to prophylaxis
recommendations but lacks serological evidence of group A
streptococcal infection and lacks echocardiographic evidence
of valvulitis, it is reasonable to conclude that the recurrent
symptoms are not likely related to ARF, and discontinuation of
antibiotic prophylaxis may be appropriate (Class IIa; Level of
Evidence C)
Latest developments in rheumatic fever
78. VACCINE ??
ORPHAN STATUS
FOCUS ON STRAINS IN DEVELOPED WORLD
PAUCITY OF CLINICAL TRIALS
COST
Latest developments in rheumatic fever
79. A vaccine for rheumatic fever
⢠In March 2010, the new Hilleman Institute (a collaboration between the Wellcome Trust
and Merck, having established an institute in India charged with developing vaccines for
less-developed countries) convened a meeting to determine if their first priority vaccine
would be for GAS..
⢠It quickly became clear that GAS vaccines would not be chosen, for the following three
reasons:
â A vaccine was not sufficiently close to phase III trials;
â The global GAS community has not worked sufficiently collaboratively; and
â The current understanding of the immunopathogenesis of GAS diseases, particularly RF/RHD, is crude, and
investigators have not taken advantage of the latest technologies.
⢠there were some positive outcomes of the meeting, :
⢠GAS vaccine- number of antigens, and there was willingness from those present to pool their
expertise and intellectual property to identify the lead antigens to be incorporated into a
combination vaccine.
⢠M protein
⢠Non M protein vaccines(C5a peptidase,SpeB-Streptococcal pyrogenic exotoxin B )
⢠This work is critical, and requires international coordination as well as funding.
Latest developments in rheumatic fever
82. ⢠But now a new initiative funded by the
⢠A new initiative funded by Australian and
New Zealand governments known as CANVAS
(Coalition to Advance New Vaccines for Group
A Streptococcus) is finally making progress
Latest developments in rheumatic fever
83. Implantable pencillin
⢠An implantable form of penicillin could be a major advance.
⢠Naltrexone implants provide a promising model,
( equivalent daily dose is similar).
Latest developments in rheumatic fever
85. Keywords in the revision 2015
AHA
⢠Subclinical carditis
⢠ECHO criteria
⢠Temperature
⢠1992 criteria misses many cases in moderate
to high risk area
⢠Assignment of recommendation and LOE.
Latest developments in rheumatic fever