Principles In Stereochemistry

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Principles In Stereochemistry

  1. 1. Principles in STEREOCHEMISTRY Prof.Dr Adel Selem By: Mahmoud Galal Zidan
  2. 2. Lecture 1
  3. 3. Historical Background •
  4. 4.
  5. 5. Acidimetric carbon atom which attached with four different function• 2-butanol
  6. 6. • 2 Cl – Butane • Lactic acid (2-Hydroxypropionic acid ) Isomerism 2n where n is the no of athemetric Carbon Carbon not athemetric because of C=O
  7. 7. Pair of enantiomers • Are two optically active isomers each one is the mirror image of the other • They have identical properties • One of them rotate the light to the right an another rotate the light to the left
  8. 8. Racemic Mixture • When two enantiomers are mixed together a rotation caused by a molecule of one isomer is exactly canceled by an equal and opposite rotation caused by a molecule of its enantiomer • Or it’s the mixture of equal amount of optical inactive .
  9. 9. Compound containing one asymmetric carbon atom • Glyceraldehyde C3H6O3 ( CnH2nOn )
  10. 10. Compound containing two dissimilar asymmetric carbon atom• aldoTetriose OH In right  D OH In left  L
  11. 11. Diastereomers (1,4) . (2,3) one of the is not mirror image to other but they are non super possible – they have different physical properties . • 2,3 dichloropentane • Amino Acid ( alanine )
  12. 12. Compound containing two similar asymmetric carbon atom • 2,3 dichloropentane
  13. 13. • Aldopentose
  14. 14. Lecture 2
  15. 15. Absolute Configuration • Chloro Bromo Iodo Methane • Mesoform : is the isomers containing plane of symmetry Plane of symmetry
  16. 16. • Glyceraldehyde
  17. 17. • Aldo Tetrose • Tartaric acid
  18. 18. • Aldopentose
  19. 19. Racemic Mixture • Formation of ( Cyano hydrides ) • Formation of ( α – halo acid )
  20. 20. • Malonic Ester
  21. 21. • Ethyl acetate

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