Campylobacteriosis

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Campylobacteriosis

  1. 1. Assignment onCampylobacteriosis and Erysipelas Submitted by Chanderkant Suthar Chavda Hardik Padher Nimesh Butani Jigar
  2. 2. CAMPYLOBACTERIOSIS Synonyms Vibriosis, Epizootic abortion. It is a contagious venereal disease of cattle characterized by infertility with repeat breeding. Campylobacter” is derived from Greek word for “Curve rod” because of curved or spiral shape morphology of bacteria
  3. 3. EtiologySpecies Host & diseaseC.foetus subsp.venerealis. Endometritis, sterility, abortion in cattleC. foetus subsp.foetus. Abortion in sheep. Possible cause of enteritisC.jejuni . Abortion in sheep. Enteritis in Humans monkey Cattle, foals, dogs, cats, and fowlsC.coli Enteritis in humans, monkey and fowlC.pylori Gastritis in children and monkey
  4. 4. Susceptible host Cattle Buffaloes Sheep Goat Man
  5. 5. Mode of transmission Faeco-oral Coital Ingestion of contaminated food Waterborne Contact with contaminated poultry, livestock, or household pets
  6. 6. Pathogenesis The organisms multiply in cervix Reach up to the uterine horn and oviduct Damage cilia of epithelial lining of oviduct Interfere with fertilization
  7. 7. Pathogenesis cont.. Organisms have got obligatory respiratory mode Lowered dissolved Lower supplies Oxygen tension of required nutrients Interfere with implantation and development of embryo
  8. 8. Clinical findings Abortion in 2nd trimester(4-7months) In ewes abortion in last 6 weeks of pregnancy Retention of placenta Slight mucopurtulent discharge Pyometra Aborted foetus shows autolytic changes
  9. 9. Clinical findings cont..Aborted fetus ROP
  10. 10. Clinical findings cont.. Mucous-laden, watery, and/or bile- streaked diarrhea (with or without blood) Reduced appetite Occasional vomiting Fever and leukocytosis Body temperature may be normal
  11. 11. Lesions Mild endometritis and necrosis of cotyledons Separation of chorion with formation of hematomas Hypoxia due to placental damage Foetal death
  12. 12. Lesions cont.. Congested and edematous colons in dogs Hyperplastic epithelial glands Thickened mucosa Hemorrhagic enteritis Edematous mesenteric lymph node
  13. 13. Diagnosis1. Demonstration of organism by Gram’s staining2. Culture and isolation3. Darkfield or phage-contrast microscopy4. Vaginal mucus aggulutination test5. Indirect haemaggutination test6. FAT7. Detection of serum antibodies by ELISA
  14. 14. Treatment Following antibiotics can be used Streptomycin Chloramphenicol Tetracycline Gentamicin, Furazolidone Doxycycline
  15. 15. Control and prevention Pasteurization of milk Chlorination of drinking water In cows and heifers the disease must be treated on herd basis
  16. 16. Prevention and Control Cont.. Exposed female should be bred by AI. Infected bulls should not be kept in herd Addition of antibiotics with semen(1:25 semen: yolk citrate 500 IU penicillin 500mg streptomycin)
  17. 17. SWINE ERYSIPELAS Synonyms Diamond skin disease Rouget du proc Erysepela del cerdo Erysipelas (Greek—red skin) Ignissacer Holy fire St Anthonys fire
  18. 18. Cont.. Erysipelas is an acute streptococcus bacterial infection of the dermis, resulting in inflammation worldwide in distribution Prevalence in India is scanty in nature Urticarial form of this disease recorded in Andhra Pradesh
  19. 19. Etiology Erysipelothrix rhusiopathiae Erysipelothrix insidiosa (old name) 22 known serotypes Serotype 1 and 2 most common
  20. 20. Susceptible Host Pig (principal host ) Sheep Carnivores Birds Human
  21. 21. Predisposing factors Age Genetics Immunity Non- infectious disease Stress due to environment or management Worm infestation Concurrent infection Alkaline soil
  22. 22. Source of Infection Domestic pigs Carrier animals’ excreta-faeces, urine Contaminated water and feed Body secretions-saliva, nasal
  23. 23. Mode of Transmission Ingestion Natural infection through skin wound Biting flies Intra-uterine infection Soil contaminated with organisms
  24. 24. Pathogenesis Acute septicemia and bacteraemia Localization of organisms in organ, joint, heart valves and synovial fluid Hyperaemia of synovial membrane Proliferation of synovial villi Thickening of joint capsule Amyloidosis in pigs
  25. 25. Clinical Findings Acute:- Sudden death High rise in temp.(104-106°F), Stilly gait and get up with difficult Suspended bowl material movement Pigs remain depressed and burrow in the bedding Conjunctivitis and vomition
  26. 26. Clinical findings Cont.. Diamond skin lesions Slightly pink to dark purple area which raised and firm to touch Light to light purplish red lesions Dark purplish angry lesions may proceed to death. The course of acute form is 2-4 days
  27. 27. Diamond skin lesions in pig
  28. 28. Clinical findings cont.. Subacute Less severe manifestations Skin lesions may or may not be noticed Chronic Arthritis Mainly involved joints are hock, stifles, knee, and elbow Joints are stiff, enlarged, hot and painful Sloughing of tip of the tail and ear.
  29. 29. Signs in cattle Non-suppurative arthritis Ulceration of cartilages Lameness Fluctuating joint capsule
  30. 30. Signs in sheep Acute or chronic form of arthritis Valvular endocarditis Cutanious infection Septicemia Multifocal necrotizing alveolitis
  31. 31. Signs in man Rise in temperature Pain in the hand and fingers Blisters Inflammation of lymph glands
  32. 32. Lesions Acute cases Rhomboid lesions Septicemia Lesions are centered around the smaller vessels of the dermis and hypodermis Intravascular fibrin coagulation or thrombosis
  33. 33. Lesions cont.. Chronic cases Verrucose endocarditis Cauliflower like growth on the valves Mitral valve is more frequently affected Infarction of kidney and liver
  34. 34. Vegetative endocarditis
  35. 35. Lesions cont.. Venous congestion of lungs Pulmonary oedema. Arthritis in limbs and vertebrae joints Clear amber colour fluid in joint capsule Swelling of adjoining lymph nodes
  36. 36. Diagnosis History Clinical findings Lesions Isolation and identification of organisms Animal inoculation test
  37. 37. Diagnosis cont.. Serological diagnosis Agglutination test Avidin-biotin peroxidase technique Gel diffusion precipitation test Indirect immunoassay ELISA PCR
  38. 38. Diagnosis cont.. Differential diagnosis:- Swine fever Salmonellosis Glasser’s disease Foot rot Streptococcal endocarditis Streptococcal septicemia and arthritis
  39. 39. Treatment1. Antiserum-2. Antibiotics Penicillins Clindamycin Erythromycin3. Anti inflammatory drugs Corticosteroids-betamethasone
  40. 40. Prevention and Control Dead carcasses should be burnt properly Pasture should be kept vacant following outbreak for a month Chronically affected carrier pigs should be culled The house and premises should be strictly disinfected
  41. 41. Prevention and control cont.. Sound husbandry practices Replacement of stock should be made from clean sources. Recently purchased should be kept in isolation
  42. 42. Prevention and control cont.. Immunization Attenuated vaccine Age of vaccination is 6 to 10 weeks. Second booster dose is given 2-4 weeks later after the first vaccination. Bacterins Formalin killed whole culture of organism adsorbed in aluminium hydroxide gel
  43. 43. KHAMMA GHANI

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