Dangers of Sun exposure

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Presentation by Dra Karen Zapata Boquete Panama 4 Sept 2012

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Dangers of Sun exposure

  1. 1. Karen Zapata MontenegroDermatology and Dermatology surgery CSS
  2. 2. IntroductionUV Radiation ConceptUV radiation damagePhotoprotection
  3. 3. Concept
  4. 4. • Isaac Newton.1666 • “Colors phenomenon” • William Herschel.1800 • Infrared radiation • Johann Ritter.1801 • Ultraviolet radiation Diffey B. Methods. 2002; 28: 4-13
  5. 5.  Ultraviolet light or ultraviolet radiation?  “beyond violet”  Exposure to UV and its several sequellae ◦ 1932 Copenhaguen  UVCMaverakis E, et al. Journal of Autoimmunity. 2010; 34: 47-57
  6. 6. Less than 9% UV
  7. 7. UV radiation Elliptical orbit◦ 3.4 % perihelion (January 3) ◦ Aphelion (July 5) ◦ 7% UVR variation
  8. 8. Hour UV Month Sun Radiation of thePosition year Geographic position
  9. 9. UVB causes 80% skin damage Clouds Chlorofluorocarbondecrease decreases ozone layer UVradiation UVB 5%UVA 95% Maverakis E, et al. Journal of Autoimmunity. 2010; 34: 47-57
  10. 10. UV-B indexMeasure of the amount UVR at the surface, during maximum radiation Scale 0-11 1 unit = 25 miliWatt/m2
  11. 11. 90% 5% 15-30%Snow Desert area
  12. 12. Energy Climatic source changesLiving Photosynthesisforms Food Chain
  13. 13. Elevates mood and improves energy
  14. 14. Vitamin D production 5 to 20 minutes of daily exposure
  15. 15. Skin cancer
  16. 16. Mutagenic effects Skin cancer Immune Eye Damage systemalteration
  17. 17. Immune System alterationICAM-1
  18. 18. DNAMelanin Mutagenic effects Malignancy
  19. 19. GeneticsFamily EnvironmentHistory
  20. 20. Outdoor activities UV artificial sources Ozone layerAn estimaded 3.5 millions of new cases each year in USA. 1/5 during lifetime. The most common skin cancer. Camp et al. Semin Cutan Med Surg. 2011; 30: 6-13
  21. 21.  Most common cancer in humans  3-8% of annual increase since 1960  Firm association with UV exposure  40 -50% recurrent CBC  80% older than 60 yearMadan V, Lear J, Szeimies R. Lancet. 2010; 375:373-85
  22. 22. • Intermittent exposureCBC • Childhood exposure • Chronic exposureCEC
  23. 23. Annual incidence 3-7% increase More related with 7.89 to 22.52 since 1970 mortality for each 100000Kanavy H, Gerstenblith M. Seminars in cutaneous Medicine and surgery. 2011; 222-8
  24. 24. Melanoma geographical distribution is bigger next to thisarea. 1% decrease in ozone layer increase melanomamortality 1-2%. Kanavy H, Gerstenblith M. Seminars in cutaneous Medicine and surgery. 2011; 222-8
  25. 25. Indoor tanningChronic and Skin cancer riskintermittent factor since 2009
  26. 26. High-altitude regions tend to have a highermelanoma rate that may be related to thehigher UV fluences (J/cm2) noted at these sites
  27. 27. Other diseases
  28. 28. Key points
  29. 29. Gilaberte Y, González S. Actas Dermo-Sifiliográficas. 2010; 101: 659-72
  30. 30. Gilaberte Y, González S. Actas Dermo-Sifiliográficas. 2010; 101: 659-72
  31. 31.  Sunscreens are photochemical systems that absorb or reflect UV radiation. Frequently use of sunscreens is the best photoprotection strategy. The first sunscreen was marketed in 1930 Actually there are 28 chemical filters in Australia, 26 in Europe and 14 in USA. Kockler J, Oelgemoller M, Robertson S, Glass B. Journal of Photochemistry and Photobiology. 2012; 1-17
  32. 32. UVR Dispersion Absorption Reflection Chemical or physical filters
  33. 33.  La capacidad de eritema depende ◦ Longitud de onda de radiación ◦ Fotosensibilidad del individuo ◦ DEM uso estudios observacionales MED protected SPF = ---------------- MED unprotected Kockler J, Oelgemoller M, Robertson S, Glass B. Journal of Photochemistry and Photobiology. 2012; 1-17
  34. 34.  La capacidad de eritema depende ◦ Longitud de onda de radiación ◦ Fotosensibilidad del individuo ◦ DEM uso estudios observacionales MPD protected UVA FP = ---------------- MPD unprotectedDPM: dosis de pigmento mínima Kockler J, Oelgemoller M, Robertson S, Glass B. Journal of Photochemistry and Photobiology. 2012; 1-17
  35. 35. FILTROS ACCIÓN ESPECTROINORGÁNICOS- FÍSICOSDióxido de titanio al 25% 350 UVA, UVBÓxido de cinc al 25% 350 UVA, UVBORGÁNICOS - QUÍMICOSFiltros para UVABenzofenonasOxibenzonas al 6% 288-325 UVB, UVA IISulisobenzonas al 10% 366 UVADioxibenzona al 3% 352 UVADibenzolimetanosAvobenzona 3% 360 UVA1AntralatosMedalimato al 3% 340 UVAIIEcamsul (mexorilo SX) 345 UVB, UVAÁcido terephtalilidenodiaalcanforsulfínico al 10%
  36. 36. FILTROS ACCIÓN ESPECTROFiltros para UVBAminobenzoatos (derivados del PABA)PABA al 1 5% 283 UVBPadimato O (octil dimetil PABA) al 8% 311 UVBCinamatosCinoxato al 3% 289 UVBOctinoxate (octil metoxicinamato) al 7.5% 311 UVBSalicilatosOctilsalate (octil salicilato) al 5% 307 UVBHomosalat (homentil salicilato) al 15% 306 UVBTrolamina salicilato al 12% 306 UVBOtrosOctocrileno al 10% 303 UVB, UVAIIEnsulizolo al 4% 310Metileno-bis-benzotriazolila 305- UVB, UVATetrametilbutifenol (Tinosorb M) al 10% 360 Filtro inorgánico y orgánicoBis-etilhexiloxifenol metoxifenil triazina 310-(Tinosorb S) al 10% 340 Moreno M, Moreno L. Rev Asoc Colomb Dermatol. 2009; 10: 1-9
  37. 37.  SPF 30 (97.5 UVB) ◦ 370nm  High UVA protection 20 min before and 2 - 3 hours SPF 30UVA highprotection
  38. 38. 50- 80% solar damage is Correct solar protectionbefore 18 Walker D. Journal of Pediatric nursing. 2011 Article in press
  39. 39. Dark colors, nylon andUPF higher than 40 polyester
  40. 40. DFMO: difluorometilornitina Camp et al. Semin Cutan Med Surg. 2011; 30: 6-13

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